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Opiates and prescription meds are a common cause of low T in men.  In this study with men with metabolic dysfunction and opiate induced low T, Testosterone therapy did not worsen inflammatory/metabolic markers.  Of note, this study did not find improvement in the metabolic and inflammatory markers as other studies have shown.

we need to get away from expert opinion statements like this. Not that their conclusions are incorrect; but it promotes laziness among physicians.  We physicians need to take control over the data by which we practice medicine and the only way we can do that is to read it.

This post is only on the concept of subcutaneous Testosterone as an effective alternative to IM.

HRT improves MetS.  Oral estrogen increased CRP and protein S, but not transdermal.

androgen deficiency syndrome and metabolomics

To be read