Skip to main content

Home/ Dr. Goodyear/ Group items tagged growth hormone

Rss Feed Group items tagged

Filter: All | Bookmarks | Topics Simple Middle
Nathan Goodyear

https://www.endocrine.org/~/media/endosociety/Files/Publications/Clinical%20Practice%20... - 0 views

www.endocrine.org/...-Practice-Guideline-NonCME.pdf

HGH GH human growth hormone growth hormone

shared by Nathan Goodyear on 04 Nov 14 - No Cached
  • Nathan Goodyear on 04 Nov 14
     
    Current recommendations on HGH origin, evaluation, and therapy.
Nathan Goodyear

Role of Growth Hormone in Breast Cancer - 0 views

academic.oup.com/...3098660

breast cancer growth hormone GH

shared by Nathan Goodyear on 12 Aug 19 - No Cached
  • Nathan Goodyear on 12 Aug 19
     
    Growth hormone plays critical role in breast cancer: promotes angiogenesis, stimulated mTOR, promotes chemoresistance, promotes breast stem activity, promotes metastasis via increase in epithelial to mesenchymal transition...
Nathan Goodyear

Which Patients Do Not Require a GH Stimulation Test for the Diagnosis of Adult GH Defic... - 0 views

press.endocrine.org/...jcem.87.2.8216

HGH GH human growth hormone growth hormone IGF-1

shared by Nathan Goodyear on 04 Nov 14 - No Cached
  • Four studies have reported that the probability of GHD (peak GH criteria ranging from < 2.3 to < 5 μg/liter) in patients with three to four PHDs ranges from 91% to 100%
  • 95% accuracy by the presence of either three or more PHDs or a serum IGF-I concentration less than 84 μg/lite
  • adult GHD could be predicted with 95% accuracy by the presence of either three or four PHDs or a serum IGF-I concentration less than 84 μg/liter
  • ...5 more annotations...
  • Hypopituitary adults with GHD have been reported to have normal serum IGF-I levels in 37–70% of patients in various studies (5, 9, 18, 21, 22). This is owing in part to the fact that multiple factors regulate serum IGF-I concentrations including nutritional status; hepatic and renal function; and circulating concentrations of thyroid hormone, androgens, and estrogens
  • changes in concentrations of IGF-binding proteins (IGFBPs) influence the total concentration of IGF-I in plasma
  • Among patients with an IGF-I sd score above −1 in the present study, 46% had a peak GH less than 2.5 μg/liter and 67% had a peak GH less than 5 μg/liter.
  • In summary, adult GHD can be predicted with 95% accuracy by the presence of either three or four PHDs or a serum IGF-I concentration less than 84 μg/liter
  • We propose that adult patients with three or four PHDs (three or four of the following deficiencies: TSH, ACTH, gonadotropins [LH and/or FSH], and AVP [central diabetes insipidus]) do not require a GH stimulation test to make the diagnosis of adult GHD
  • Nathan Goodyear on 04 Nov 14
     
    Insulin Tolerance Test is the gold standard for HGH diagnosis, but this an unpopular test do to long list of side effects.  This study finds a 95% accuracy for IGF-1 less than 84 with 3 or more coexisting pituitary hormone deficiencies.
Nathan Goodyear

http://download.springer.com/static/pdf/189/art%253A10.1007%252Fs12020-014-0327-6.pdf?a... - 0 views

download.springer.com/...1007%252Fs12020-014-0327-6.pdf

GH growth hormone growth hormone IGF-1 cardiovascular heart hormones

shared by Nathan Goodyear on 30 Jun 14 - No Cached
  • Nathan Goodyear on 30 Jun 14
     
    Nice review of GH hormone and its positive role in the cardiovascular system.
Nathan Goodyear

Growth hormone treatment in adults with Prader-Wil... [Endocrine. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22081257

growth hormone growth hormone hormones Prader-Willi Syndrome fat

shared by Nathan Goodyear on 03 Aug 14 - No Cached
  • Nathan Goodyear on 03 Aug 14
     
    Thought GH in those with Prader-Willi Syndrome did not see an improvement in lipid and glucose metabolism, lean body mass increased and fat mass decreased.
Nathan Goodyear

Regulation of production and secretion of sex hormone-binding globulin in HepG2 cell cu... - 0 views

jcem.endojournals.org/...160.abstract

SHBG hormones insulin IGF-1 EGF estradiol testosterone T3 cortisol

shared by Nathan Goodyear on 11 Dec 12 - No Cached
  • Nathan Goodyear on 11 Dec 12
     
    SHBG and hormones.  Insulin, IGF-1, and EGF decrease SHBG levels.  Contrast that with estradiol, testosterone, T3, and cortisol that increase SHBG
Nathan Goodyear

Breast Cancer Research | Full text | The combined influence of multiple sex and growth ... - 0 views

breast-cancer-research.com/...R99

breast cancer estrogen estradiol estrone Testosterone women hormone hormones

shared by Nathan Goodyear on 16 Dec 13 - No Cached
  • Nathan Goodyear on 16 Dec 13
     
    Elevated estradiol, estrone, and Testosterone increases breast cancer risk by 50 to 200% depending on the hormone(s) elevated.
Nathan Goodyear

The Growth Hormone/Insulin-Like Growth Factor-I Axis in Exercise and Sport - 0 views

edrv.endojournals.org/...603.long

growth hormone GH IGF-1 exercise health sport growth hormone

shared by Nathan Goodyear on 21 Jan 13 - No Cached
  • Nathan Goodyear on 21 Jan 13
     
    Review of the physiological roles of GH and IGF-1 during exercise.  The focus is on maximizing the normal physiologic response, not supra physiologic.
Nathan Goodyear

Regulation of muscle mass by growth hormone and IGF-I - 0 views

www.ncbi.nlm.nih.gov/...PMC2439518

muscle hormones muscle mass GH growth hormone IGF-1

shared by Nathan Goodyear on 14 Apr 15 - No Cached
  • Nathan Goodyear on 14 Apr 15
     
    good review of GH and IGF-1 impact on muscle growth/muscle loss.
Nathan Goodyear

Letrozole Significantly Improves Growth Potential in a Pubertal Boy With Growth Hormone... - 0 views

pediatrics.aappublications.org/...e245.full

Letrozole HGH deficiency growth plate aromatase inhibition stature

shared by Nathan Goodyear on 13 Sep 11 - No Cached
  • Nathan Goodyear on 13 Sep 11
     
    Letrazole improves growth potential in boys with HGH deficiency through aromatase inhibition and delayed closure of the growth plates
Nathan Goodyear

Anticancer mechanisms of cannabinoids - 0 views

www.ncbi.nlm.nih.gov/...PMC4791144

THC cannabinoids cancer

shared by Nathan Goodyear on 18 Sep 18 - No Cached
  • modulating key cell signalling pathways involved in the control of cancer cell proliferation and survival
  • cannabinoids inhibit angiogenesis and decrease metastasis in various tumour types in laboratory animals
  • Cannabis sativa L. (marijuana)
  • ...41 more annotations...
  • of the approximately 108 cannabinoids produced by C. sativa, Δ9-tetrahydrocannabinol (thc) is the most relevant because of its high potency and abundance in plant preparations
  • Tetrahydrocannabinol exerts a wide variety of biologic effects by mimicking endogenous substances—the endocannabinoids anandamide3 and 2-arachidonoylglycerol4,5—that engage specific cell-surface cannabinoid receptors
  • the cb2 receptor was initially described to be present in the immune system6, but was more recently shown to also be expressed in cells from other origins
  • transient receptor potential cation channel subfamily V, member 1
  • orphan G protein–coupled receptor 55
  • Most of the effects produced by cannabinoids in the nervous system and in non-neural tissues rely on cb1 receptor activation
  • two major cannabinoid-specific receptors—cb1 and cb2
  • cardiovascular tone, energy metabolism, immunity, and reproduction
  • cannabinoids are well known to exert palliative effects in cancer patients
  • best-established use is the inhibition of chemotherapy-induced nausea and vomiting
  • thc and other cannabinoids exhibit antitumour effects in a wide array of animal models of cancer
  • cannabinoid receptors and their endogenous ligands are both generally upregulated in tumour tissue compared with non-tumour tissue
  • cb2 promotes her2 (human epidermal growth factor receptor 2) pro-oncogenic signalling in breast cancer
  • pharmacologic activation of cannabinoid receptors decreases tumour growth
  • endocannabinoid signalling can also have a tumour-suppressive role
  • pharmacologic stimulation of cb receptors is, in most cases, antitumourigenic. Nonetheless, a few reports have proposed a tumour-promoting effect of cannabinoids
  • most prevalent effect is the induction of cancer cell death by apoptosis and the inhibition of cancer cell proliferation
  • impair tumour angiogenesis and block invasion and metastasis
  • thc and other cannabinoids induce the apoptotic death of glioma cells by cb1- and cb2-dependent stimulation
  • Autophagy is primarily a cytoprotective mechanism, although its activation can also lead to cell death
  • autophagy is important for cannabinoid antineoplastic activity
  • autophagy is upstream of apoptosis in the mechanism of cannabinoid-induced cell death
  • the effect of cannabinoids in hormone- dependent tumours might rely, at least in part, on the ability to interfere with the activation of growth factor receptors
  • glioma cells), pharmacologic blockade of either cb1 or cb2 prevents cannabinoid-induced cell death with similar efficacy
  • other types of cancer cells (pancreatic48, breast24, or hepatic43 carcinoma cells, for example), antagonists of cb2 but not of cb1 inhibit cannabinoid antitumour actions
  • thc promotes cancer cell death in a cb1- or cb2-dependent manner (or both) at lower concentrations
  • cannabidiol (cbd), a phytocannabinoid with a low affinity for cannabinoid receptors15, and other marijuana-derived cannabinoids57 have also been proposed to promote the apoptotic death of cancer cells acting independently of the cb1 and cb2 receptors
  • In cancer cells, cannabinoids block the activation of the vascular endothelial growth factor (vegf) pathway, an inducer of angiogenesi
  • In vascular endothelial cells, cannabinoid receptor activation inhibits proliferation and migration, and induces apoptosis
  • cb1 or cb2 receptor agonists (or both) reduce the formation of distant tumour masses in animal models of both induced and spontaneous metastasis, and inhibit adhesion, migration, and invasiveness of glioma64, breast65,66, lung67,68, and cervical68 cancer cells in culture
  • the ceramide/p8–regulated pathway plays a general role in the antitumour activity of cannabinoids targeting cb1 and cb2
  • cbd, by acting independently of the cb1 and cb2 receptors, produces a remarkable anti-tumour effect—including reduction of invasiveness and metastasis
  • cannabinoids can also enhance immune system–mediated tumour surveillance in some contexts
  • ability of thc to reduce inflammation75,76, an effect that might prevent certain types of cancer
  • recent observations suggest that the combined administration of cannabinoids with other anticancer drugs acts synergistically to reduce tumour growth
  • combined administration of gemcitabine (the benchmark agent for the treatment of pancreatic cancer) and various cannabinoid agonists synergistically reduced the viability of pancreatic cancer cells
  • Other reports indicated that anandamide and HU-210 might also enhance the anticancer activity of paclitaxel89 and 5-fluorouracil90 respectively
  • Combined administration of thc and cbd enhances the anticancer activity of thc and reduces the dose of thc needed to induce its tumour growth-inhibiting activity
  • Preclinical animal models have yielded data indicating that systemic (oral or intraperitoneal) administration of cannabinoids effectively decreases tumour growth
  • Combinations of cannabinoids with classical chemotherapeutic drugs such as the alkylating agent temozolomide (the benchmark agent for the management of glioblastoma80,84) have been shown to produce a strong anticancer action in animal models
  • pharmacologic inhibition of egfr, erk83, or akt enhances the cell-death-promoting action of thc in glioma cultures (unpublished observations by the authors), which suggests that targeting egfr and the akt and erk pathways could enhance the antitumour effect of cannabinoids
  • Nathan Goodyear on 18 Sep 18
     
    Good review of the anticancer effects of cananbinoids.
Nathan Goodyear

The Role of Estrogens in Prostate Carcinogenesis: A Rationale for Chemoprevention - 0 views

www.ncbi.nlm.nih.gov/...PMC1477605

prostate cancer hormone hormones estrogen estrogen receptors aromatase men

shared by Nathan Goodyear on 16 Sep 13 - No Cached
  • Nathan Goodyear on 16 Sep 13
     
    Good review of the mixed pathway of hormones in cancer development--prostate.  Estrogens, through estrogen receptors, promote prostate cancer development and growth.
Nathan Goodyear

Growth hormone responses to 3 differ... [Appl Physiol Nutr Metab. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18641713

growth hormone GH hormone hormones men male exercise endurance

shared by Nathan Goodyear on 03 Aug 14 - No Cached
  • Nathan Goodyear on 03 Aug 14
     
    Endurance training increases GH more than resistance and sprints/short interval training.  This increase in GH, though seen in all age groups, decreased in older aged men.
Nathan Goodyear

Growth hormone release during acute and chronic a... [Sports Med. 2002] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12457419

growth hormone exercise GH hormone hormones

shared by Nathan Goodyear on 03 Aug 14 - No Cached
  • Nathan Goodyear on 03 Aug 14
     
    Exercise is an easy way to increase GH production endogenously.
Nathan Goodyear

Non-genomic Actions of Thyroid Hormones Regulate the Growth and Angiogenesis of T Cell ... - 0 views

www.ncbi.nlm.nih.gov/...PMC6381017

VEGF thyroid hormones non-genomic signaling angiogenesis cancer vascular endothelial growth factor

shared by Nathan Goodyear on 07 Aug 21 - No Cached
  • Nathan Goodyear on 07 Aug 21
     
    Non-genomic signaling of thyroid hormone signals angiogenesis.
Nathan Goodyear

Idiopathic Adult Growth Hormone Deficiency - 0 views

jcem.endojournals.org/...2187.abstract

growth hormone deficiency GH growth hormone

shared by Nathan Goodyear on 10 Jun 13 - No Cached
  • Nathan Goodyear on 10 Jun 13
     
    This study estimates that true adult GH deficiency is < 10%.
Nathan Goodyear

Effect of Body Mass Index on Peak Growth Hormone Response to Provocative Testing in Chi... - 0 views

www.ncbi.nlm.nih.gov/...PMC2795667

HGH human growth hormone provocative testing growth hormone L-Dopa

shared by Nathan Goodyear on 17 Jul 12 - No Cached
  • Nathan Goodyear on 17 Jul 12
     
    HGH evaluation using provocative testing.
Nathan Goodyear

Increased adiposity and insulin correlates with the progressive suppression of pulsatil... - 0 views

joe.endocrinology-journals.org/...233.abstract

growth hormone GH insulin obesity overweight

shared by Nathan Goodyear on 24 Jul 13 - No Cached
  • Nathan Goodyear on 24 Jul 13
     
    Growth hormone inversely associated with weight and insulin levels.
‹ Previous 21 - 40 of 151 Next › Last »
Showing 20▼ items per page