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In this interrupted case study, students meet a pair of fictional newlyweds on their way to Australia for their honeymoon. Initially eager to enjoy the sun, sand, and sights, Tanya and Julien Brahim end up more intimately acquainted with the local wildlife than they had planned. Tanya is bitten by a venomous arachnid and Julien has a run-in with a dangerous cnidarian. This case study was created to help students solidify their knowledge about cardiac myocytes, particularly ion movements associated with action potential generation in autorhythmic and contractile cells. As students work through the case, they will complete fill-in-the-blank paragraphs describing the heart, diagram membrane potentials and ion movements, and compare and contrast action potentials from different cell types. Written for a course in human physiology, the case requires some prior knowledge of membrane potentials, equilibrium potentials, ion gradients, neuronal action potentials, and skeletal muscle action potentials. An optional pre-case assignment (included in the teaching notes) can be used to make sure that students are familiar with the necessary concepts.

In this video Paul Andersen details the action potential in neurons. The resting potential of a neuron (-70mV) is maintained through differences in concentration and permeability of Na, K, and Cl ions. A graded potential is created as neurotransmitters from adjacent cells that are either excitatory or inhibitory. If the neuron reaches the threshold of -55mV an opening of voltage-gated sodium channels triggers an action potential

What do you and a sack of batteries have in common? Today, Hank explains. -- Table of Contents: Ion Channels Regulate Electrochemistry to Create Action Potential 4:51 Resting State 3:22 Depolarization 6:09 Repolarization 7:35 Hyperpolarization 8:00

This interrupted case study introduces basic modeling to investigate a decline in an American marten population on an island in Southeast Alaska. Two summer field technicians working on a long-term field ecology project for one of their professors notice that there are fewer marten captures this year. Through discussions with their professor, conversations with a local fur trapper, and based on their own observations, they develop a plan to model the population and the potential causes of the decline to solve the mystery. Students use Excel or other database software along with life tables and introductory population ecology to investigate three potential causes of the marten population decline. This case was developed for use in an environmental science or wildlife management course but could also be used in an advanced science high school course or general ecology course. It would be beneficial for students to have some background in statistics including how to interpret R-squared values, p-values, and 95% confidence intervals.

Dubilier is hardly alone in her plight. A heaping teaspoon of soil or a shot of ocean water may contain as many as one million bacterial species. Many of them are potential gold mines of chemicals and metabolites with medicinal, engineering, and energy applications. But when researchers have tried to culture these microbes in the lab, only a minority of cells form colonies. Clearly, nutrients, a carbon source, and time are usually not enough to coax bacteria isolated from the wild to grow in a laboratory setting. So what's the missing ingredient?

In order to improve the surgical outcome of these procedures and enhance patient quality of life, new and better tools are needed for esophageal reconstruction. Biostage is working on a new regenerative technology to address esophageal cancer through their pioneer Cellframe Technology. Two weeks before the surgery, stem cells are harvested from patient abdominal adipose tissue and allowed to incubate with a biocompatible esophageal implant. These cells interact and adhere to the implant and are able to respond to signals for regeneration once inside the patient, potentially restoring both the structural and functional integrity of the esophagus. These new approaches to organ implants could revolutionize resectional surgery by providing patients with functional replacements derived from their own cells.

In this video Paul Andersen explains how the electrochemical gradient is a combination of the chemical and electrical gradient of ions. As ions move across a membrane the potential change creates a hidden force that isn't always apparent.

In the largest study of its kind, a research team has meshed extensive genome data on more than 50,000 people with their electronic health records and identified potential new disease-causing genes. The data further suggest that about one in 250 people may harbor a gene variant that puts them at risk for heart attacks and strokes, yet aren't receiving adequate treatment.

Signaling at the neuromuscular junction (NMJ) is a complex process that is required for many actions that sustain life within humans. Toxins that act upon the NMJ, both natural and synthetic, act in a variety of ways to inhibit this function. This case study examines how a variety of toxins can act to disrupt the normal mechanism of function of the NMJ  by placing a protagonist ("Unlucky Chucky") at an eco-spa in Colombia with his good friend Melody. Unfortunately, during their time at the eco-spa, things don't always turn out well for Chucky. A variety of neuromuscular toxins are discussed including curare (d-tubocurarine), Botox (botulinum toxin A), physostigmine and sarin gas (GB). This case was designed to be used in a variety of classrooms ranging from an undergraduate introduction to biology course in a module focused on neuromuscular functioning, to an introduction to physiology course as an introduction to the NMJ; it could also potentially be used in a nursing course that is examining NMJ physiology.

Based on a comprehensive analysis of the scientific evidence, as required by the Federal Food, Drug and Cosmetic Act (FD&C Act), the FDA has determined that AquAdvantage Salmon meets the statutory requirements for safety and effectiveness under the FD&C Act. The salmon are safe to eat, the introduced DNA is safe for the fish itself, and the salmon meet the sponsor's claim about faster growth. Because the sponsor has met these requirements, the FDA must approve the application. The FDA has also analyzed the potential environmental impact that an approval of the AquAdvantage Salmon application would have on the quality of the human environment in the United States and has issued its final Environmental Assessment and Finding of No Significant Impact.

CRISPR still has a long way to go before it can be used safely and effectively to repair-not just disrupt-genes in people. That is particularly true for most diseases, such as muscular dystrophy and cystic fibrosis, which require correcting genes in a living person because if the cells were first removed and repaired then put back, too few would survive. And the need to treat cells inside the body means gene editing faces many of the same delivery challenges as gene transfer-researchers must devise efficient ways to get a working CRISPR into specific tissues in a person, for example. CRISPR also poses its own safety risks. Most often mentioned is that the Cas9 enzyme that CRISPR uses to cleave DNA at a specific location could also make cuts where it's not intended to, potentially causing cancer.

Girls are less likely than boys to think that women have genius potential, a new study finds. And that stereotype can show up in kids as young as six.

In this interactive activity adapted from the HHMI Outreach Program at Harvard University, learn about the ways in which stem cells can be used to treat and help cure diseases in humans. The activity explains what stem cells are and how they're produced, and provides details on their existing or potential therapeutic role in diseases related to the pancreas, liver, lungs, and bone marrow.

Another case is ready for you: "East Meets West: An Infectious Disease Case" by Harry M. Zollars, Catherine D. Santanello, and Marcelo J. Nieto, Department of Pharmaceutical Sciences, Southern IL University Edwardsville.   Ying is sick and is progressively getting worse. His parents' clashing views on Eastern and Western medicine prevent them from agreeing on a course of treatment. As the case unfolds, students follow the progression of their son's illness. After a physician is finally seen and the results of tests are evident, students should be able to narrow the list of possible etiological agents and suggest a potential treatment. In addition, the students should integrate the different health beliefs into the final treatment as well as the aspects of patient counseling. The case works well as an interrupted case that can be assigned to individual students or student teams. This case is appropriate for graduate courses with a component in health care, therapeutics, medicinal chemistry, medicinal plants, microbiology, epidemiology, or cultural competency. Instructors can choose to focus only on the medical components of the case or incorporate the cultural and ethical aspects, depending on course goals and subject area.

The UK's leading cancer charity yesterday welcomed work by British scientists who created a breed of genetically modified hens that can produce cancer-fighting medicines in their eggs. The research could slash the cost of producing drugs and potentially save the NHS millions of pounds.

Possibly the most exciting use of stem cells rests on their ability to differentiate into an enormous range of healthy functioning adult cells, thereby providing a replacement source of cells to treat serious diseases. This ultimately means that virtually any disease that results in cellular and tissue destruction can potentially be treated by stem cells. Some of the conditions are particularly debilitating and these include diabetes, spinal cord injuries, retinal disease, Parkinson's disease, heart disease and cancer.

If you are finding it difficult to understand stem cells, you should know that many other people share your struggle. To make it easier for everyone, we have created a website that covers all you need to know about the topic. With regular updates and a language that speaks clearly, we hope that you will understand the potential of stem cells and how they might play a role in your life or that of someone you know.

China is engulfed in an extreme amount of pollution, and it's causing health problems for people living in this area! How can we help fight some of these diseases? Laci explains how broccoli could incredibly helpful when it comes to ridding the body of deadly toxins! Follow DNews on Twitter: http://www.twitter.com/dnews Follow Laci on Twitter: http://www.twitter.com/gogreen18  Read More: China's toxic air pollution resembles nuclear winter, say scientists http://www.theguardian.com/world/2014... "Air pollution now impeding photosynthesis and potentially wreaking havoc on country's food supply, experts warn."

In a retrospective cohort study investigating the role of epigenetic control in the onset of allergic diseases, it was shown that mothers who suffered from allergic symptoms very early in pregnancy were more likely to have offspring with allergies. This was compared to mothers who did not suffer from allergies in early pregnancy, taking into account family history of allergies and total allergic response during pregnancy (10). These results indicate that gene-environment interactions during embryonic development may modify the epigenetic code in ways that may potentially lead to allergic disease.

Chinese scientists say they've genetically modified human embryos for the very first time. The team attempted to modify the gene responsible for beta-thalassaemia, a potentially fatal blood disorder, using a gene-editing technique known as CRISPR/Cas9. Gene editing is a recently developed type of genetic engineering in which DNA is inserted, replaced, or removed. Here, experts weigh-in with ethical questions and considerations.