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Lottie Peppers

Campus Outbreak! - National Center for Case Study Teaching in Science - 0 views

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    This PowerPoint-driven case study follows the progress of three undergraduate students as they attempt to model the rapid spread of an influenza outbreak to determine whether their local newspaper's claim that "40% of the campus has the flu" is accurate. The case introduces epidemiological modeling using a base model for a seasonal influenza outbreak written in the NetLogo programmable modeling environment. In class, students develop tests for the various parameters of the model, run simulations, and evaluate the output. The students then explore the impact of influenza control strategies (vaccination, isolation, and antiviral medications), and finish with the question of whether the continuing outbreak on campus could be a pandemic. The case is written at a basic level for a lower-level undergraduate lecture-style class, but can be adapted to upper-level courses as well. The case was piloted in four different microbiology courses. The simulations stimulated active discussion and the content worked well, whether it was used in a pre-nursing microbiology or upper-level immunology class.
Lottie Peppers

Genomic responses in mouse models poorly mimic human inflammatory diseases - 0 views

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    A cornerstone of modern biomedical research is the use of mouse models to explore basic pathophysiological mechanisms, evaluate new therapeutic approaches, and make go or no-go decisions to carry new drug candidates forward into clinical trials. Systematic studies evaluating how well murine models mimic human inflammatory diseases are nonexistent. Here, we show that, although acute inflammatory stresses from different etiologies result in highly similar genomic responses in humans, the responses in corresponding mouse models correlate poorly with the human conditions and also, one another.
Lottie Peppers

How Animal Testing and Research is Advancing Treatments for Type 2 Diabetes | Foundatio... - 0 views

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    Scientists work with animal models to better understand type 2 diabetes to treat the disease. They have developed specialized animal models that mimic the condition.  One line of mice, known as KK mice, develop obesity and glucose intolerance that lead to type 2 diabetes. Another rodent model, the Zucker diabetic fatty rat, is bred to be a precise model of human type 2 diabetes.
Lottie Peppers

Mad Dogs and Chicken Heads - National Center for Case Study Teaching in Science (NCCSTS) - 0 views

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    Although rabies still causes thousands of deaths globally every year, it has essentially been eradicated from most industrialized countries. Part of the success story is due to an unusual project undertaken by the Swiss prompted by a series of large outbreaks in the 1970s: the large-scale vaccination of wild foxes to stop the epidemic. In this directed case study, students use an easily accessible MS Excel-based model to understand key epidemiological parameters of rabies outbreaks in wild foxes. The simple model allows students also to predict what proportion of foxes needs to be vaccinated to eradicate the virus from the population. The case fits into both ecological and microbiological (epidemiological) courses and offers opportunities to explore zoonotic diseases and "One Health" questions. The mathematical basis of the differential equations in the models is explained, although prior knowledge of calculus is not essential. A key learning outcome is the critical understanding of both the power and limitations of simple epidemiological models. This case was written for an online course but could also be used as a face-to-face activity if students have access to computers in class.
Lottie Peppers

Activities Preview | RI-ITEST Project Portal - 2 views

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    The goal of RI-ITEST is to prepare diverse students for careers in information technologies by engaging them in exciting, inquiry- based learning activities that use sophisticated computational models in support of a revolutionary science curriculum. Teachers will incorporate interactive computer models developed under the Science of Atoms and Molecules (SAM) project at the Concord Consortium. These materials were specifically designed to support a deeper understanding of science made possible through interactive computer simulations and the new physics-chemistry-biology sequence. Connections will be made between the models students use to learn science and possible careers in research and industry where computer modeling is used.
Lottie Peppers

Nobel Prize | FB Research - 0 views

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    Research leading to almost every Nobel Prize in Medicine awarded since 1901 was dependent on data from animal models.  This fact dramatically demonstrates the important contribution animal models in biomedical research make to both international and American medical progress. In fact, since 1979, every Nobel Prize in Medicine awarded was dependent on data from animal models with the exception of the 1983 Prize awarded to Dr. Barbara McClintock for her work in plant genetics.
Lottie Peppers

Modeling the Structure of DNA - 0 views

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    In this activity, students build a paper model of DNA and use their model to explore key structural features of the DNA double helix. This activity can be used to complement the short film The Double Helix.
Lottie Peppers

Should the Mouse Model be Used to Study Human Diseases? : Health & Medicine : Nature Wo... - 0 views

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    The mouse is a common model used in research as a way of studying human biology and diseases, but a new study questions whether this is an accurate approach considering some stark differences - aside from many similarities - between the two species.
Lottie Peppers

SDCOE Science Resource Center > CA NGSS Course Models > High School (9-12) > Four-Cours... - 0 views

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    The life science/biology course is divided into 12 instructional segments grouped into four sections. In the first section, From Molecules to Organisms: Structures and Processes, students develop models of how molecules combine to build cells and organisms (IS1 [Structure and Function]; IS2 [Growth and Development of Organisms]; IS3 [Organization for Matter and Energy Flow in Organisms]). In the second section, Ecosystems: Interactions, Energy, and Dynamics, students zoom out to the macroscopic scale to show how organisms interact (IS4 [Interdependent Relationships in Ecosystems]; IS5 [Cycles of Matter and Energy Transfer in Ecosystems]; IS6 [Ecosystem Dynamics, Functioning, and Resilience]; IS7 [Social Interactions and Group Behavior]). Students return to the role that DNA plays in inheritance during the third section, Heredity: Inheritance and Variation of Traits (IS8 [Inheritance of Traits]; IS9 [Variation of Traits]). The class ends tying together interactions at all these scales by explaining evolution and natural selection in Biological Evolution: Unity and Diversity (IS10 [Evidence of Common Ancestry and Diversity]; IS11 [Natural Selection]; IS12 [Adaptation and Biodiversity]). A vignette in IS12 illustrates the level of three-dimensional understanding students are expected to exhibit as a capstone of the course.
Lottie Peppers

The Mystery of the Missing Martens - National Center for Case Study Teaching in Science - 0 views

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    This interrupted case study introduces basic modeling to investigate a decline in an American marten population on an island in Southeast Alaska. Two summer field technicians working on a long-term field ecology project for one of their professors notice that there are fewer marten captures this year. Through discussions with their professor, conversations with a local fur trapper, and based on their own observations, they develop a plan to model the population and the potential causes of the decline to solve the mystery. Students use Excel or other database software along with life tables and introductory population ecology to investigate three potential causes of the marten population decline. This case was developed for use in an environmental science or wildlife management course but could also be used in an advanced science high school course or general ecology course. It would be beneficial for students to have some background in statistics including how to interpret R-squared values, p-values, and 95% confidence intervals.
Lottie Peppers

Model Center :: DNA Learning Center - 0 views

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    Compare model organisms interactive
Lottie Peppers

Artificial intelligence joins hunt for human-animal diseases : Nature News & Comment - 0 views

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    Lyme disease, Ebola and malaria all developed in animals before making the leap to infect humans. Predicting when such a 'zoonotic' disease will spark an outbreak remains difficult, but a new study suggests that artificial intelligence could give these efforts a boost. A computer model that incorporates machine learning can pinpoint, with 90% accuracy, rodent species that are known to harbour pathogens that can spread to humans, researchers report this week in the Proceedings of the National Academy of Sciences1. The model also identified more than 150 species that are likely to be disease reservoirs but have yet to be confirmed as such.
Lottie Peppers

Technical approaches for mouse models of human disease - 0 views

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    The mouse is the leading organism for disease research. A rich resource of genetic variation occurs naturally in inbred and special strains owing to spontaneous mutations. However, one can also obtain desired gene mutations by using the following processes: targeted mutations that eliminate function in the whole organism or in a specific tissue; forward genetic screens using chemicals or transposons; or the introduction of exogenous transgenes as DNAs, bacterial artificial chromosomes (BACs) or reporter constructs. The mouse is the only mammal that provides such a rich resource of genetic diversity coupled with the potential for extensive genome manipulation, and is therefore a powerful application for modeling human disease.
Lottie Peppers

CAMEL Question: Can Applied Math Extend Life? - National Center for Case Study Teaching... - 0 views

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    This directed case study examines differences between the exponential and logistic growth models in biology and how they are applied to solve real life problems. The narrative follows a student returning to the United States as he tries to assess his possible exposure to Middle East Respiratory Syndrome (MERS). To better understand his risk, James needs to get up to speed on a variety of topics including the difference between infection, transmission, virulence, etc., and how these topics can be mathematically modeled not only in relation to MERS, but also with respect to Ebola and influenza. This case was designed for use in the second semester of a biocalculus course or a course involving ordinary differential equations, which are appropriate for second year undergraduate students majoring in biology, pre-med, and bio-mathematics. These students typically have completed a semester of calculus and one year of general biology. The case provides an opportunity for students to develop their understanding of differential equations and increase their appreciation of mathematics as it applies to solving a problem of biology.
Lottie Peppers

National Centre for Biotechnology Education | DNA50 | Cut-out model - 0 views

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    DNA folding model
Lottie Peppers

The Fluid Mosaic Model - 0 views

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    Animation on fluid mosaic model of plasma membrane
Lottie Peppers

I*MOLD - 0 views

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    Welcome to the interactive model of leaf decomposition (I*MOLD). The goal of this project is to explain leaf decomposition and how it relates to the Earth's carbon cycle and climate. This website contains a series of animated lessons about decomposition, an interactive model that lets you predict how different types of leaves will decompose in different climates, and classroom activities about decomposition for teachers.
Lottie Peppers

Exponential Outbreaks: The Mathematics of Epidemics - NYTimes.com - 0 views

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    In this lesson, students explore the fundamental mathematical concepts underlying the spread of contagious diseases. Using a simple exponential model, students compare and contrast the effects of different transmission rates on a population and develop an understanding of the nature and characteristics of exponential growth. Students can then compare their projections with actual Ebola data from West Africa, to create context for analyzing the strengths and limitations of this simplified model.
Lottie Peppers

About Us - Rare Disease Foundation - 0 views

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    The Rare Disease Foundation is focussed on linking basic science and clinical practice to increase the efficiency of rare disease research. This model is called Translational Care. This model drives patient based, treatment focussed research projects from disease characterization to treatment with greater efficiency. By incorporating research, astute clinician observation and parental knowledge into the various stages of rare disease research we impact the speed of discovery and the way rare conditions are managed.
Lottie Peppers

http://ec.europa.eu/research/health/pdf/summary-report-25082010_en.pdf - 0 views

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    Species like yeast, flies, fish and mice have many genes in common with humans and are therefore considered 'model organisms' and are widely used in research to study human genes and human diseases. Mouse research has lead to major advances in our ability to treat a number of serious diseases and conditions.
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