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This case study provides an overview of the seminal experimental work that led to the discovery of DNA structure and the confirmation of the semi-conservative model of DNA replication. By guiding students through a chronological series of historic experiments and discussing some of the collaborations and controversies involved in the original research, students learn about the history and nature of science in addition to several important biological concepts. A number of recommended videos, including one created by the author, enable instructors to use the "flipped-classroom" mode of instruction according to which students read primary literature and watch videos on their own before group discussions and activities. The case study was developed for use in an introductory undergraduate biology course, and would also be appropriate for use in a high school biology course. Some prior knowledge or instruction may be required, depending on the level and learning objectives of the course.

High quality real time animations of processes

Martin Chalifie and GFP video by DNA Learning Center

Lying dormant in our genomes are millions of jumping genes. Originally discovered by Barbara McClintock, transposons are DNA sequences that can move from one location to another in our DNA. Transposons cause mutations when they jump to new locations, so keeping them from jumping is important. 

Your task is to compare two groups of mice to see how well they have learned the platform location. Two reliable measures of learning in mice are 1) the speed at which they find the platform, and 2) the route which they take to the platform (i.e. do they go straight to the platform or do they get a little lost along the way?).  

Compare model organisms interactive

2 minute video interview

2:51 minute video about mechanics of transcription and translation 

Genes for memory- swimming mice knock out lesson