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All of comparative biology depends on knowledge of the evolutionary relationships (phylogeny) of living and extinct organisms. In addition, understanding biodiversity and how it changes over time is only possible when Earth's diversity is organized into a phylogenetic framework. The goals of the Genealogy of Life (GoLife) program are to resolve the phylogenetic history of life and to integrate this genealogical architecture with underlying organismal data. The ultimate vision of this program is an open access, universal Genealogy of Life that will provide the comparative framework necessary for testing questions in systematics, evolutionary biology, ecology, and other fields. A further strategic integration of this genealogy of life with data layers from genomic, phenotypic, spatial, ecological and temporal data will produce a grand synthesis of biodiversity and evolutionary sciences. The resulting knowledge infrastructure will enable synthetic research on biological dynamics throughout the history of life on Earth, within current ecosystems, and for predictive modeling of the future evolution of life.Projects submitted to this program should emphasize increased efficiency in contributing to a complete Genealogy of Life and integration of various types of organismal data with phylogenies.This program also seeks to broadly train next generation, integrative phylogenetic biologists, creating the human resource infrastructure and workforce needed to tackle emerging research questions in comparative biology. Projects should train students for diverse careers by exposing them to the multidisciplinary areas of research within the proposal.

Comprehensive understanding of life and how and why it changes over time depends on knowledge of the phylogeny (evolutionary relationships) of living and extinct organisms. The goals of the Genealogy of Life (GoLife) program are to resolve the phylogenetic history of all life’s diverse forms and to integrate this genealogical architecture with underlying organismal and environmental data. The ultimate vision of this program is an open access, comprehensive Genealogy of Life that will provide the comparative framework necessary for testing questions in systematics, evolutionary biology, ecology, and other fields. Strategic integration of this genealogy of life with data layers from genomic, phenotypic, spatial, ecological and temporal data will produce an extensive synthesis of biodiversity and evolutionary sciences. The resulting knowledge infrastructure will enable synthetic research on biological dynamics throughout the history of life on Earth, within current ecosystems, and for predictive modeling of the future evolution of life. Projects submitted to this program should emphasize increased efficiency in contributing to a complete Genealogy of Life and strategic integration of various types of organismal and environmental data with phylogenies. This program also seeks to broadly train next generation, integrative phylogenetic biologists, creating the human resource infrastructure and workforce needed to tackle emerging research questions in comparative biology. Projects should train students for diverse careers by exposing them to the multidisciplinary areas of research within the proposal.

The purpose of this Funding Opportunity Announcement (FOA) in Malawi is to strengthen the laboratory systems by training human resources, improving laboratory infrastructure, building capacity in data management and use, and improving quality management systems. The objectives are to provide pre-service and in-service training for various cadre or laboratory staff, and to equip and perform alterations and refurbishments to at least 10 laboratories to perform essential microbiology, mycobacteriology, parasitology, hematology and chemistry. The FOA will also develop laboratory information management systems (LIMS) and improve the use of generated data in decision making, increase quality by supporting laboratories to develop and adhere to quality management systems (QMS), and strengthen quality control and quality assurance. The activities of the program will include health systems strengthening by increasing human resources, implementing necessary alterations and refurbishment to physical infrastructure, improving the specimen referral system, and improving data generation and handling capabilities through an electronic information system.

This Funding Opportunity Announcement (FOA) invites grant applications from institutions/organizations that propose to build research infrastructure to promote external collaboration with the medical rehabilitation community. The aim of this FOA is to create a national network of research cores that provide access to collateral expertise in biomedical, behavioral, engineering, and/or psychosocial fields that is particularly relevant to medical rehabilitation research. We are particularly interested in supporting infrastructure programs in clinical trial design, engineering and the environment, individualized medical rehabilitation and dynamic reassessment, and applied behavioral supports for rehabilitation research and healthy outcomes. However, other areas of expertise may be proposed provided they offer unique research opportunities and have potential for promoting medical rehabilitation research and improving outcomes for people with disabilities. In response to this FOA, applicants should propose a program of research resources and collaborative opportunities in a specific research domain. This may be accomplished through a workshops, written material, and websites, consultations, collaborations, and pilot funding. In addition, the research core may support activities within the grantee institution related to technique development, adaptation, and validation. To accomplish the aims of the FOA, applicants may propose collaborations to other institutional sites, provided that they cover the appropriate administrative and logistical issues.

The NIEHS and partnering Institutes and Centers are establishing an infrastructure, the Human Health Exposure Analysis Resource (HHEAR) as a continuation of the Children's Health Exposure Analysis Resource (CHEAR). The goal of this consortium is to provide the research community access to laboratory and statistical analyses to add or expand the inclusion of environmental exposures in their research and to make that data publicly available as a means to improve our knowledge of the comprehensive effects of environmental exposures on human health throughout the life course. This FOA solicits the Data Center. The Data Center will provide intellectual and logistical support for the maintenance, integration, analysis, interpretation, curation, and reuse of data generated by HHEAR in support of extramural research projects. The Data Center will build and manage an exposure data repository and associated data science resources, including a public access Data Portal, a Data Submission and Review Portal, and an ontology and associated standardized data structure. In addition, the Data Center will provide statistical, analytical, and informatic support for HHEAR components and studies using the HHEAR infrastructure. The ultimate goal is maximizing potential use and impact of exposure data in human health studies.

The National Institute of Dental and Craniofacial Research (NIDCR) intends to continue support for research conducted within a national Dental Practice-Based Research Network (DPBRN). The NIDCR will fund one national DPBRN Administrative and Resource Center (RFA-DE-19-001) and one national DPBRN Coordinating Center (RFA-DE-19-002) as companion awards to support the infrastructure for and implementation of multiple observational studies and clinical trials. This Funding Opportunity Announcement (FOA) is soliciting applications for investigator-initiated clinical observational studies and clinical trials to be conducted in the DPBRN through a milestone-driven UG3/UH3 cooperative agreement mechanism. Each UG3/UH3 award will support an individual project which will utilize the DPBRN infrastructure and resources for study planning and implementation. This FOA supports a UG3 clinical study planning phase and potential transition to a UH3 implementation phase, with a combined total funding period of up to six years. Progression to the UH3 phase is based on an administrative review and is dependent on success in meeting UG3 milestones, consideration of the DPBRN as an appropriate venue for conduct of the research, NIDCR program priorities, and availability of funds. The main goals of the national DPBRN are to streamline the implementation of national oral health research studies in dental practices on topics of importance to practitioners and their patients, to provide evidence useful in daily patient care, and to facilitate the translation of research findings into clinical practice.

During the last nine years, the U.S. Centers of Disease Control and Prevention (CDC) has worked with nations around the world to build capacity to prepare, detect, and respond to pandemics. Through previous funding opportunity announcements (FOA) and subsequent cooperative agreements, CDC and its international partners and national ministries of health focused on three pillars: 1) preparedness and communication; 2) surveillance and detection; 3) response and containment. The success of this developed capacity is evident across the globe. Through these cooperative agreements, CDC and partners have: Developed national government public-health pandemic preparedness plans Developed pandemic communication plans Improved laboratory capacity and infrastructure for influenza virologic surveillance Enhanced epidemiology capacity and infrastructure for disease surveillance Developed sentinel, hospital-based surveillance for severe acute respiratory illness (SARI) Enhanced integration of laboratory and epidemiologic surveillance for influenza Developed surveillance for cases and clusters of respiratory and febrile illnesses that could represent emerging new pandemics. Trained local rapid-response and containment teams. Developed infection control guidelines in public health-care settings for the prevention of avian and pandemic flu. It is critical that these new capacities be sustained and strengthened over time to ensure global capacity to detect and respond to pandemic influenza effectively.

The scope of this FOA is to establish the NHGRI Genomic Data Science Analysis, Visualization, Informatics Lab-space ("AnVIL") in support of genomic research. The AnVIL aims to create an interoperable resource for the research community by co-locating data, storage and computing infrastructure with commonly used services and tools for analyzing and sharing data. The AnVIL will further advance research by leveraging a cloud-based infrastructure to facilitate genomic data access by the broad scientific community, integration and computing on and across large datasets generated by NHGRI programs, or programs funded by others in support of human genomics research. In particular, the AnVIL resource will provide genomic researchers with the following:

The scope of this FOA is to establish the NHGRI Genomic Data Science Analysis, Visualization, Informatics Lab-space ("AnVIL") in support of genomic research. The AnVIL aims to create an interoperable resource for the research community by co-locating data, storage and computing infrastructure with commonly used services and tools for analyzing and sharing data. The AnVIL will further advance research by leveraging a cloud-based infrastructure to facilitate genomic data access by the broad scientific community, integration and computing on and across large datasets generated by NHGRI programs, or programs funded by others in support of human genomics research.

This Funding Opportunity Announcement (FOA) invites applications for infrastructure support to advance the development of efficacy and/or effectiveness research on recovery support services for those who were or who are being maintained on medications for the treatment of opioid use disorder. The infrastructure support will facilitate multi-stakeholder (e.g. researchers and students, payors, providers, individuals in recovery) research networks through meetings, conferences, small-scale pilots, data development work, short-term educational opportunities (such as intensive workshops, summer institutes, or visiting scholar programs), and dissemination to encourage growth and development of specified priority areas and to build resources for advancing recovery support services research. Network applications are to support research related to the following priority recovery support services (1) peer-based recovery support, (2) recovery community centers, (3) active recovery communities, (4) recovery residences, (5) education-based recovery support services, and (6) continuing care models, or others proposed by applicants.

The Division of Integrative Organismal Systems (IOS) Core Programs Track supports research aimed at understanding why organisms are structured the way they are and function as they do. Proposals are welcomed in all of the core scientific program areas supported by the Division of Integrative Organismal Systems (IOS). Areas of inquiry include, but are not limited to, developmental biology and the evolution of developmental processes, nervous system development, structure, modification, function, and evolution; biomechanics and functional morphology, physiological processes, symbioses and microbial interactions, interactions of organisms with biotic and abiotic environments,plant and animal genomics, and animal behavior. Proposals should focus on organisms as a fundamental unit of biological organization. Principal Investigators (PIs) are encouraged to apply systems approaches that will lead to conceptual and theoretical insights and predictions about emergent organismal properties. TheRules of Life Tracksupports integrative proposals that span the subcellular and cellular scales normally funded by MCB to the organ, tissue, organismal, and group scale typically funded by IOS, to population, species, community and ecosystem scales typically funded by DEB. Rules of Life proposals may also include enabling infrastructure through joint submission with DBI. Discovery of fundamental principles and enabling infrastructure will advance understanding and further predict how key properties of living systems emerge from the interaction of genomes, phenotypes, and developmental, social and environmental context across space and time.This track provides opportunities to advance understanding of the Rules of Life by new mechanisms for review and funding of proposals that span two or more divisions in the Biological Sciences Directorate.

This FOA encourages applications for exploratory clinical trials of investigational agents (drugs, biologics, surgical therapies or devices) that may contribute to the justification for and provide the data required for designing a future trial, for biomarker validation studies, or for proof of mechanism clinical studies. Diseases chosen for study should be based on the NINDS' strategic plan and clinical research interests (www.ninds.nih.gov/funding/areas/index.htm). Successful applicants will be given access to the NeuroNEXT infrastructure. Following peer review, NINDS will prioritize and order trials that are given access to the NeuroNEXT infrastructure. The NeuroNEXT Clinical Coordinating Center (CCC) will work with the successful applicant to efficiently implement the proposed study. The NeuroNEXT Data Coordinating Center (DCC) will provide statistical and data management support. The NeuroNEXT clinical sites will provide recruitment/retention support as well as on-site implementation of the clinical protocol.

The Division of Integrative Organismal Systems (IOS) continues to support the Enabling Discovery through GEnomic Tools (EDGE) program, previously a component of the IOS Core Programs solicitation (NSF 16-505). EDGE is designed to provide support for research addressing current impediments to research progress in organismal biology. In particular, the ability to directly test gene function is essential to improve understanding of the genomes-to-phenomes relationship, an area relevant to Understanding the Rules of Life, one of 10 Big Ideas for future NSF investment (www.nsf.gov/about/congress/reports/nsf_big_ideas.pdf). EDGE projects should focus on development of functional genomic tools, approaches, and associated infrastructure to enable direct tests of hypotheses about gene function in diverse organisms for which such tools and infrastructure are presently unavailable

The National Institute of General Medical Sciences (NIGMS) invites applications for Centers of Biomedical Research Excellence (COBRE) from investigators at biomedical research institutions that award doctoral degrees in the health sciences or sciences related to health or at independent biomedical research institutes with ongoing biomedical research programs funded by the NIH or other federal agencies within Institutional Development Award (IDeA) eligible states. The objectives of the COBRE initiative is to strengthen an institution's biomedical research infrastructure through the establishment of a thematic multi-disciplinary center and to enhance the ability of investigators to compete independently for complementary National Institutes of Health (NIH) individual research grants or other external peer-reviewed support. COBRE awards are supported through the IDeA Program, which aims to foster health-related research by increasing the competitiveness of investigators at institutions located in states with historically low aggregate success rates for grant awards from the NIH.

The National Institute of General Medical Sciences (NIGMS) invites applications for Centers of Biomedical Research Excellence (COBRE) from investigators at biomedical research institutions that award doctoral degrees in the health sciences or sciences related to health or at independent biomedical research institutes with ongoing biomedical research programs funded by the NIH or other federal agencies within Institutional Development Award (IDeA) eligible states. The objectives of the COBRE initiative is to strengthen an institution's biomedical research infrastructure through the establishment of a thematic multi-disciplinary center and to enhance the ability of investigators to compete independently for complementary National Institutes of Health (NIH) individual research grants or other external peer-reviewed support. COBRE awards are supported through the IDeA Program, which aims to foster health-related research by increasing the competitiveness of investigators at institutions located in states with historically low aggregate success rates for grant awards from the NIH. 

The NIH encourages institutions that seek to engage undergraduate students in innovative mentored research training programs to submit applications for cooperative agreement awards through the NIH Building Infrastructure Leading to Diversity (BUILD) initiative, one of three new Common Fund initiatives that together aim to enhance diversity in the biomedical, behavioral, clinical, and social sciences research workforce. Addressing a major leakage point in the research workforce pipeline, BUILD awards are intended to support the design and implementation of innovative programs, strategies and approaches to transform undergraduate research training and mentorship. BUILD awards will also support institutional and faculty development to further strengthen undergraduate research training environments.

The Established Program to Stimulate Competitive Research (EPSCoR) is designed to fulfill the mandate of the National Science Foundation (NSF) to promote scientific progress nationwide. A jurisdiction is eligible to participate in EPSCoR programs if its level of NSF research support is equal to or less than 0.75 percent of the total NSF research and related activities budget for the most recent three-year period. Through this program, NSF establishes partnerships with government, higher education, and industry that are designed to effect sustainable improvements in a jurisdiction's research infrastructure, Research and Development (R&D) capacity, and hence, its R&D competitiveness. RII Track-2 FEC builds interjurisdictional collaborative teams of EPSCoR investigators in scientific focus areas consistent with NSF priorities.

The RCMI Research Coordination Network (RRCN), formerly known as the RCMI Translational Research Network (RTRN), was established in 2007 to enhance collaboration across RCMI institutions. The network is designed to engage all stakeholders in the RCMI institutions, increase the quality and efficiency of basic biomedical, behavioral, and clinical research, facilitate study participant recruitment and retention, and increase the efficiency of the implementation and dissemination of research advances to improved health outcomes among minority and health disparity populations. Maintaining the longstanding networking and collaboration with the RCMI grantee community is key to the continued success of this program. The purpose of this funding opportunity announcement (FOA) is to provide infrastructure and research funding to support overall network coordination and collaboration, and to expand the Research Coordinating Center (RCC) and Data Coordinating Center (DCC) functions of the RRCN.

This Funding Opportunity Announcement (FOA) invites applications from the Program Directors/Principal Investigators of the current Building Infrastructure Leading to Diversity (BUILD) awards. BUILD is part of the Enhancing the Diversity of the NIH-Funded Workforce Program, also known as the Diversity Program Consortium (DPC), consists of three integrated initiatives: BUILD, the National Research Mentoring Network (NRMN) and the Coordination and Evaluation Center (CEC). The purpose of the funding is to allow BUILD sites to continue to implement and evaluate the multi-pronged student, faculty, and institutional interventions to enhance diversity in the NIH biomedical research workforce. In preparation for the second phase of the BUILD initiative, the applicants are expected to provide plans to transition into sustainable models for enhancing diversity in the biomedical research fields at their institutions. Applicants are also expected to develop an effective training, mentoring, or research capacity building intervention that will be disseminated to other institutions to increase the national impact of the initiative.

The Physics Frontiers Centers (PFC) program supports university-based centers and institutes where the collective efforts of a larger group of individuals can enable transformational advances in the most promising research areas. The program is designed to foster major breakthroughs at the intellectual frontiers of physics by providing needed resources such as combinations of talents, skills, disciplines, and/or specialized infrastructure, not usually available to individual investigators or small groups, in an environment in which the collective efforts of the larger group can be shown to be seminal to promoting significant progress in the science and the education of students. Activities supported through the program are in all sub-fields of physics within the purview of the Division of Physics: atomic, molecular, optical, plasma, elementary particle, nuclear, astro-, gravitational, and biological physics.

The purpose of this FOA is to support an initial series of activities over a 3-year period to build the foundation for enhanced collaborations across NIA's 6 centers programs. These collaborations are intended to leverage NIA's substantial investments by fostering the development of novel interdisciplinary efforts in aging research. This opportunity will provide resources to build additional infrastructure and establish specific collaborative activities that could include, but are not limited to, information and data exchange, meetings and conferences, pilot studies, research opportunities for beginning investigators, visiting scholar programs, dissemination, and other collaborative efforts. The successful awardee will involve all 6 centers programs.