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MiamiOH OARS

RFA-EY-17-003: NEI Audacious Goals Initiative: Translation-Enabling Models to Evaluate ... - 0 views

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    The purpose of this FOA is to stimulate development of translation-enabling models for evaluating survival and integration of regenerated photoreceptors (PRCs) and retinal ganglion cells (RGCs) in model systems that are closer to human visual anatomy, function and/or disease than current models. The development of these models, tools, devices, novel therapies and/or other resources is expected to provide a resource to vision researchers developing cell-replacement therapies for visual system diseases and disorders.

    This FOA seeks to develop models that emulate critical aspects of a human blinding disease that might be amenable to regenerative therapy. The model system might involve specific defects generated by transgenic gene insertion and/or deletion, gene editing, chemical/physical means, and/or other approaches to emulate characteristics of human disease or create defects amenable to cell-replacement therapy. Model systems using non-human primates or other cone-dominant species that are more representative of the anatomy and physiology of the human retina are highly encouraged. Other biological models are acceptable provided they meet the overall objectives of the FOA.
MiamiOH OARS

CURE Epilepsy - 0 views

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    The Taking Flight Award seeks to promote the careers of young epilepsy investigators, enabling them to develop a research focus independent of their mentor(s).
    In 2018, CURE will issue one request for proposals for the Taking Flight Award. Please refer to the LOI guidelines for an overview of CURE's 2018 priority areas, application instructions and FAQs.
    Eligibility
    You must fall into one of the following categories to be eligible for the Taking Flight Award:
    A senior postdoctoral fellow who has a minimum of 3 years postdoctoral experience
    A clinical fellow who is a Neurology Resident in his/her Neurology training and considering Epilepsy Fellowships
    Newly appointed faculty within one year of having completed postdoctoral training
MiamiOH OARS

Medical Research Fellows Program | HHMI.org - 0 views

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    The Medical Research Fellows Program enables students to be immersed in a high-impact, intensive research experience at a critical time in their professional education, before they make plans for residency or postdoctoral training. Unique aspects of the program include national and regional professional development activities, mentorship by physician-scientists, interaction with HHMI investigators, and integration into a community of like-minded peers.

    Each student selects and works with a mentor to develop a basic, translational, or applied biomedical research proposal. Both mentor selection and the research proposal are key components of the fellowship application; working with an HHMI scientist is encouraged but not required. Mentors can be at any academic or nonprofit research institution in the United States (excluding the National Institutes of Health and any other government agency) or at HHMI's Janelia Research Campus in Ashburn, VA. 
MiamiOH OARS

The Esther A. & and Joseph Klingenstein Fund, Inc. - 0 views

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    The Esther A. & Joseph Klingenstein Fund, in partnership with the Simons Foundation, has announced the opening of its 2018 competition for research fellowships in the neurosciences.
    Previously known as the Klingenstein Fellowship Awards in the Neurosciences, this year's awards are the second from this joint initiative. The awards are presented to highly promising early-career scientists. At a critical juncture in young investigators' careers when funding can be a challenge, the awards are intended to promote higher-risk, and potentially higher-reward, projects.
    Payable over three years, the $225,000 award may be used for salary support, research assistants, equipment, or any other purpose that promotes the scientific activities of the fellow.
    To be eligible, investigators must hold a PhD and/or MD degree and have completed all their research training, including postdoctoral training. In addition, the applicant must be an independent investigator within four years (between July 1, 2014, and July 1, 2018) of receiving his/her first tenure-track appointment at a university or medical institution.
MiamiOH OARS

BRAIN Initiative Fellows: Ruth L. Kirschstein National Research Service Award (NRSA) In... - 0 views

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    The purpose of the BRAIN Initiative Fellows (F32) program is to enhance the research training of promising postdoctorates, early in their postdoctoral training period, who have the potential to become productive investigators in research areas that will advance the goals of the BRAIN Initiative. Applications are encouraged in any research area that is aligned with the BRAIN Initiative, including neuroethics. Applicants are expected to propose research training in an area that clearly complements their predoctoral research. Formal training in analytical tools appropriate for the proposed research is expected to be an integral component of the research training plan. In order to maximize the training potential of the F32 award, this program encourages applications from individuals who have not yet completed their terminal doctoral degree and who expect to do so within 12 months of the application due date. On the application due date, candidates may not have completed more than 12 months of postdoctoral training.
MiamiOH OARS

BRAIN Initiative Fellows: Ruth L. Kirschstein National Research Service Award (NRSA) In... - 0 views

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    The purpose of the BRAIN Initiative Fellows (F32) program is to enhance the research training of promising postdoctorates, early in their postdoctoral training period, who have the potential to become productive investigators in research areas that will advance the goals of the BRAIN Initiative. Applications are encouraged in any research area that is aligned with the BRAIN Initiative, including neuroethics. Applicants are expected to propose research training in an area that clearly complements their predoctoral research. Formal training in analytical tools appropriate for the proposed research is expected to be an integral component of the research training plan. In order to maximize the training potential of the F32 award, this program encourages applications from individuals who have not yet completed their terminal doctoral degree and who expect to do so within 12 months of the application due date. On the application due date, candidates may not have completed more than 12 months of postdoctoral training.
MiamiOH OARS

Altered neuronal circuits, receptors and networks in HIV-induced Central Nervous System... - 0 views

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    This Funding Opportunity Announcement (FOA) invites research grant applications to decipher pathways and mechanisms responsible for HIV-1 induced central nervous system (CNS) dysfunction seen in virally suppressed HIV-1 positive patients, by understanding the causal role played by altered neuronal circuits, neuronal receptors and neuronal networks. Basic and translational research in domestic and international settings are of interest. Multidisciplinary research teams and collaborative alliances are encouraged but not required.
    This RFA [RFA-MH-18-610] uses the R01 grant mechanism while the companion RFA [RFA-MH-18-611] uses the R21 mechanism. High risk/high payoff projects that lack preliminary data may be most appropriate for the R21 [RFA-MH-18-611] mechanism, while applicants with preliminary data and a discrete, specified, circumscribed project can apply using the R01 [RFA-MH-18-610] mechanism.
MiamiOH OARS

National MS Society Accepting Applications for Pilot Programs | RFPs | PND - 0 views

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    The National Multiple Sclerosis Society mobilizes people and resources to find a cure for and address challenges faced by those affected by MS.
    To that end, the society is accepting applications for its Pilot Grant Program. The program funds high-risk pilot grants in support of novel ideas that may serve to advance its mission of stopping MS progression, restoring function, and improving quality of life for those with MS. The program supports fundamental as well as applied studies, both non-clinical or clinical in nature, including projects in patient management, care, and rehabilitation.
    One-year grants of up to $44,000 will be awarded to test innovative, cutting-edge ideas or untested methods, and to gather sufficient preliminary data that can be used to apply for longer-term funding.
    Researchers who have completed their postdoctoral training are invited to apply. Individuals who are currently postdoctoral fellows or the equivalent, or who are graduate/medical students are not eligible for support under this program.
    Pre-applications must be received no later than January 8, 2018.
MiamiOH OARS

McKnight Endowment Fund for Neuroscience Seeks Applications for 2018 Technology Awards ... - 0 views

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    The McKnight Endowment Fund for Neuroscience supports innovative research designed to bring science closer to the day when diseases of the brain can be accurately diagnosed, prevented, and treated. To that end, the McKnight Endowment Fund for Neuroscience invites Letters of Intent for its 2018 McKnight Technological Innovations in Neuroscience awards.
    The program encourages and supports scientists working on the development of novel and creative approaches to the understanding of brain function. McKnight is interested in how a new technology may be used to monitor, manipulate, analyze, or model brain function at any level, from the molecular to the entire organism. Technology may take any form, from biochemical tools to instruments to software and mathematical approaches. Because the program seeks to advance and enlarge the range of technologies available to the neurosciences, research based primarily on existing techniques will not be considered.
    A goal of the Technological Innovations awards is to foster collaboration between the neurosciences and other disciplines; therefore, collaborative and cross-disciplinary applications are explicitly invited.
MiamiOH OARS

Systems Biology Approaches using Non-Mammalian Laboratory Animals to Uncover Causes of ... - 0 views

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    The National Institute on Aging is seeking applications on systems biology approaches using non-mammalian laboratory animal models to increase our understanding of the basic biology underpinning neurodegeneration. It is expected that research supported under this FOA will provide new insights into molecular networks that might be involved in causing, amplifying or protecting against neurodegeneration, and that, in turn, might ultimately contribute to Alzheimer's disease or related dementias. Importantly, a major goal of this FOA is to use interaction and regulatory networks produced and analyzed using systems biology to gain these new insights. Because this FOA is directed toward discovery, currently employed genetically modified laboratory animals used to study AD are not required, although they may be used. Because this FOA requires systems biology approaches, data used to build interaction or regulatory networks may also come from humans or other mammals in which AD, related dementias, or aging-related cognitive decline have been observed. This FOA will only support studies using non-mammalian laboratory animal models; studies involving humans or experiments with mammals will not be allowed under this FOA.
MiamiOH OARS

Parkinson's Foundation: Better Lives. Together. - 0 views

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    The Parkinson's Foundation is inviting applications from new investigators for its PDF-PSG Mentored Clinical Research Award.
    One $50,000 grant will be awarded for a one-year project in patient-oriented research in Parkinson's disease or other Parkinsonian disorders under the mentorship of an experienced investigator. The goal of the award is to provide funding for an investigator who has the potential to become an independent researcher.
    To be eligible, applicants should be clinicians and scientists who are within five years of having completed formal training. Fellows may apply.
MiamiOH OARS

Accelerating the Pace of Drug Abuse Research Using Existing Data (R01 Clinical Trial Op... - 0 views

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    The purpose of this Funding Opportunity Announcement (FOA) is to invite applications proposing the innovative analysis of existing social science, behavioral, administrative, and neuroimaging data to study the etiology and epidemiology of drug using behaviors (defined as alcohol, tobacco, prescription and other drug) and related disorders, prevention of drug use and HIV, and health service utilization. This FOA encourages the analyses of public use and other extant community-based or clinical datasets to their full potential in order to increase our knowledge of etiology, trajectories of drug using behaviors and their consequences including morbidity and mortality, risk and resilience in the development of psychopathology, strategies to guide the development, testing, implementation, and delivery of high quality, effective and efficient services for the prevention and treatment of drug abuse and HIV.
MiamiOH OARS

Marijuana, Prescription Opioid, or Prescription Benzodiazepine Drug Use Among Older Adu... - 0 views

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    Despite significant scientific advancements made in substance use disorder research over the last century, the causes and consequences of drug use in later life remain poorly understood. The intent of this funding opportunity announcement is to support innovative research that examines aspects of marijuana and prescription opioid and benzodiazepine use in adults aged 50 and older. This FOA encourages research that examines the determinants of these types of drug use and/or characterizes the resulting neurobiological alterations, associated behaviors, and public health consequences. This initiative will focus on two distinct populations of older adults: individuals with earlier onset of drug use who are now entering this stage of adult development or individuals who initiate drug use after the age of 50. Applications are encouraged to utilize broad methodologies ranging from basic science, clinical, and epidemiological approaches. The insights gleaned from this initiative are critical to our understanding of the determinants of drug use in later life, as well as its consequences in the aging brain and on behavior. This knowledge may have the potential to identify risk factors and to guide clinical practices in older populations.
MiamiOH OARS

Neuroscience Research on Drug Abuse (R01 Clinical Trial Optional) - 0 views

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    Long-term misuse and chronic exposure to abused substances can produce widespread changes in brain structure and function. Although much progress has been made, additional research is still needed to identify the neurobiological changes that result from substance use, and how these changes contribute to substance use disorders. The overarching goals of the research areas described in this FOA are to understand the neurobiological mechanisms underlying substance use disorders, with special emphasis on identifying changes and neuroadaptations that occur during dependence, withdrawal, and relapse to chronic substance use. An understanding of the basic mechanisms underlying substance use disorders can help to identify targets for prevention and treatment interventions. Research utilizing basic, translational, or clinical approaches is appropriate.
MiamiOH OARS

Clarifying the Relationship between Delirium and Alzheimers Disease and Related Dementi... - 0 views

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    This Funding Opportunity Announcement (FOA) invites applications that focus on clarifying the relationship between delirium and Alzheimer's disease and related dementias (ADRD). Specifically sought is research focusing on understanding why persons with ADRD are at increased risk to develop delirium, often with a worse prognosis compared to those without antecedent ADRD, and why patients who experience delirium are at higher risk to develop subsequent short- and/or long-term mild cognitive impairment or ADRD, often with an accelerated rate of cognitive decline compared to those without preceding delirium. Relevant research projects may focus on, but are not limited to, those that A) provide insight into possible common, sequential, causative, contributory and/or synergistic pathways underlying both ADRD and delirium, B) elucidate mechanisms that lead to the development of delirium against the background of aging and/or neurodegeneration, with particular emphasis on use of appropriate animal models, C) identify risk factors for the onset and/or progression of delirium in those with ADRD and vice versa, D) diagnose and assess one condition in the setting of the other, E) identify putative phenotypes of patients with co-existing ADRD and delirium, or F) test pharmacologic and/or non-pharmacologic strategies to prevent, treat, or reduce the impact of delirium in patients with ADRD and vice versa. Research supported by this FOA is intended to provide mechanistic insight to improve risk assessment, diagnosis, phenotyping, prevention, and management approaches for both delirium and ADRD.
MiamiOH OARS

Alzheimer's Research | The CART Fund - 0 views

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    Rotary International is accepting applications for its CART Fund, a program designed to encourage exploratory and developmental Alzheimer's disease research projects within the United States.
    To that end, the fund will award grants of up to $250,000 to support for early and conceptual plans of those projects that may not yet be supported by extensive preliminary data but have the potential to substantially advance biomedical research. These projects should be new and distinct from those designed to increase knowledge in a well-established area unless they intend to extend previous discoveries toward new directions or applications.
    Eligible applications may come from full time faculty (or equivalent status) at U.S.-based public and private institutions, such as universities, colleges, hospitals, and laboratories.
MiamiOH OARS

Enhancing Central Neural Control of Mobility in Aging - 0 views

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    The overall goal of this funding announcement is to solicit applications to investigate the central neural control of mobility in older adults without overt neurological diseases using innovative and cutting-edge methods that are emerging in neuroscience, geriatrics and mobility-related fields in aging research communities. This announcement also seeks information on the degree of plasticity in the aging brain and how this may be harnessed to maintain or improve mobility. Applicants are highly encouraged to adapt a multidisciplinary and collaborative approach that includes basic, clinical, and translational scientists. Mobility impairments are common in aging and are associated with a host of adverse events including disability and mortality. Identifying novel modifiable predictors of mobility decline will lead to mechanistic insights and the development of novel therapeutic interventions to enhance mobility as a person ages.
MiamiOH OARS

Role of Peripheral Proteostasis on Brain Aging and Alzheimer's Disease - 0 views

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    The National Institute on Aging (NIA) solicits research projects that would advance our understanding of how protein homeostasis (proteostasis) in peripheral tissues affects brain aging, leading to the development of Alzheimers Disease (AD). Much research on AD has focused on the accumulation of aberrant protein aggregates in the brain, and in particular amyloid and Tau. Formation of aggregates due to mutations encoded in the APP gene or due to hyperphosphorylation, respectively, have been linked to familial AD. The etiology of the more common, sporadic form of AD, is less certain, although aging is considered a major risk for development of the disease. It is known that proteostasis is less efficiently maintained in all tissues with aging, and this may indicate a link between proteostasis in the periphery and the appearance of aging-related diseases and conditions, including the decline in cognitive function, as well as dementia and AD. Therefore, testing for a role of aging-related loss of peripheral proteostasis in the development of AD is the focus of this FOA.
MiamiOH OARS

Understanding the Early Development of the Immune System - 0 views

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    The purpose of this funding opportunity announcement (FOA) is to support studies on the very early development of the immune system and the humoral and cellular communication that exists between the mother and fetus that may shape or impact immune system development and maturation.
MiamiOH OARS

Fay/Frank Seed Grant Program - The Brain Research Foundation - 0 views

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    Brain Research Foundation is inviting eligible US institutions to nominate one (1) faculty member to submit a Letter of Intent (LOI) for the Fay/Frank Seed Grant Program by January 8, 2018. To be eligible, the PI must be a full-time Assistant or Associate Professor working in the field of neuroscience.

    Brain Research Foundation's Fay/Frank Seed Grant Program was founded in 1981 with the goal of providing start-up money for new and innovative research projects that have the potential to become competitive for an NIH grant or other external funding sources. Our goal is to have this grant succeed in opening future opportunities for research, collaboration and scientific advancement.
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