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MiamiOH OARS

PAR-18-427: First in Human and Early Stage Clinical Trials of Novel Investigational Dru... - 0 views

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    The purpose of this Funding Opportunity Announcement (FOA) is to encourage cooperative agreement applications to support early stage clinical trials of novel mechanism of action, investigational drugs or drug candidates for the treatment of psychiatric disorders in areas of unmet medical need. The FOA will support milestone-driven early stage trials in pediatric and adult populations. First in human (FIH) and Phase Ib studies of novel Agents must assess target engagement (brain exposure), pharmacological effects, safety, and tolerability to assess feasibility for Phase II/proof of concept (PoC) studies in psychiatric disorders. Phase II/PoC studies must evaluate the drug's impact on clinically relevant physiological systems (functional measures) and clinical indicators of effect. The FOA also supports FIH and early feasibility studies (EFS) of novel devices to evaluate target engagement, safety, tolerability, and efficacy. The overall objective is to facilitate rapid collection of data to "de-risk" novel mechanism of action investigational drugs, novel drugs for use in pediatric populations with psychiatric disorders, and devices or combination treatments in order to attract private funding for further clinical development as FDA-approved treatments.
MiamiOH OARS

The Esther A. & and Joseph Klingenstein Fund, Inc. - 0 views

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    The Esther A. & Joseph Klingenstein Fund, in partnership with the Simons Foundation, has announced the opening of its 2018 competition for research fellowships in the neurosciences.
    Previously known as the Klingenstein Fellowship Awards in the Neurosciences, this year's awards are the second from this joint initiative. The awards are presented to highly promising early-career scientists. At a critical juncture in young investigators' careers when funding can be a challenge, the awards are intended to promote higher-risk, and potentially higher-reward, projects.
    Payable over three years, the $225,000 award may be used for salary support, research assistants, equipment, or any other purpose that promotes the scientific activities of the fellow.
    To be eligible, investigators must hold a PhD and/or MD degree and have completed all their research training, including postdoctoral training. In addition, the applicant must be an independent investigator within four years (between July 1, 2014, and July 1, 2018) of receiving his/her first tenure-track appointment at a university or medical institution.
MiamiOH OARS

NIMH Exploratory/Developmental Research Grant (R21 - Clinical Trial Not Allowed) - 0 views

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    The NIMH Exploratory/Developmental Grant program supports exploratory and high-risk research projects that fall within the NIMH mission by providing support for the early and conceptual stages of these projects. These studies may involve considerable risk but may lead to a breakthrough or to the development of novel techniques, agents, methods, measures, models, or strategies, or to the generation of pilot or feasibility data. The preliminary work from these studies could lead to a major impact on biomedical, behavioral, or clinical mental health research, or on the delivery of mental health care.
MiamiOH OARS

Promoting Caregiver Health Using Self-Management (R01 Clinical Trial Optional) - 0 views

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    The purpose of this initiative is to stimulate research in promoting caregiver health using self-management. Caregiving is an important science area since the number of people living longer with chronic conditions is growing. Informal caregivers (lay caregivers) are defined as unpaid individuals (spouses, partners, family members, friends, or neighbors) involved in assisting others with activities of daily living and/or medical tasks. Formal caregivers are paid, delivering care in one's home or care settings (daycare, residential care facility). This concept focuses on informal caregivers.
MiamiOH OARS

Prescription Drug Abuse (R21 Clinical Trial Optional) - 0 views

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    This Funding Opportunity Announcement (FOA) encourages applicants to develop innovative research applications on prescription drug abuse, including research to examine the factors contributing to prescription drug abuse; to characterize the adverse medical, mental health and social consequences associated with prescription drug abuse; and to develop effective prevention and service delivery approaches and behavioral and pharmacological treatments. Applications to address these issues are encouraged across a broad range of methodological approaches including basic science, clinical, epidemiological, and health services research to define the extent of the problem of prescription drug abuse, to characterize this problem in terms of classes of drugs abused and combinations of drug types, etiology of abuse, and populations most affected (including analyses by age group, race/ethnicity, gender, and psychiatric symptomatology). Studies on individual- and patient-level factors, prescriber factors, and/or health system factors are encouraged, as are studies on all classes of prescription drugs with high abuse liability, including analgesics, stimulants, sedative/hypnotics and anxiolytics. Researchers are further encouraged to study the relationship between the prescription medication, the indication for which the medication was prescribed (e.g., pain, sleep disorder, anxiety disorder, obesity), and the environmental and individual factors contributing to abuse.
MiamiOH OARS

Clarifying the Relationship between Delirium and Alzheimers Disease and Related Dementi... - 0 views

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    This Funding Opportunity Announcement (FOA) invites applications that focus on clarifying the relationship between delirium and Alzheimer's disease and related dementias (ADRD). Specifically sought is research focusing on understanding why persons with ADRD are at increased risk to develop delirium, often with a worse prognosis compared to those without antecedent ADRD, and why patients who experience delirium are at higher risk to develop subsequent short- and/or long-term mild cognitive impairment or ADRD, often with an accelerated rate of cognitive decline compared to those without preceding delirium. Relevant research projects may focus on, but are not limited to, those that A) provide insight into possible common, sequential, causative, contributory and/or synergistic pathways underlying both ADRD and delirium, B) elucidate mechanisms that lead to the development of delirium against the background of aging and/or neurodegeneration, with particular emphasis on use of appropriate animal models, C) identify risk factors for the onset and/or progression of delirium in those with ADRD and vice versa, D) diagnose and assess one condition in the setting of the other, E) identify putative phenotypes of patients with co-existing ADRD and delirium, or F) test pharmacologic and/or non-pharmacologic strategies to prevent, treat, or reduce the impact of delirium in patients with ADRD and vice versa. Research supported by this FOA is intended to provide mechanistic insight to improve risk assessment, diagnosis, phenotyping, prevention, and management approaches for both delirium and ADRD.
MiamiOH OARS

Direct Services for Survivors of Torture - 0 views

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    The Office of Refugee Resettlement (ORR) within the Administration for Children and Families (ACF) announces the availability of funds for the fiscal year 2018 Direct Services for Survivors of Torture (DS SOT) grant program. The purpose of the DS SOT program is to increase access to strengths-based, trauma-informed services that assist survivors of torture and their families in the healing and recovery process. Under this grant program, direct services are provided to persons who have been tortured on foreign soil under the color of law. The program offers holistic and integrated services including medical, psychological, legal, and social work. All of these services are provided either directly by the grantee or indirectly through partner organizations or affiliates.
MiamiOH OARS

RWJF Health Policy Fellows Program Issues Call for Applications | RFPs | PND - 0 views

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    The Robert Wood Johnson Foundation Health Policy Fellows program is designed to provide a comprehensive fellowship experience at the nexus of health science, policy, and politics in Washington, D.C.
    The program provides an opportunity for exceptional mid-career health professionals and behavioral and social scientists with an interest in health and healthcare policy. Fellows participate in the policy process at the federal level and use that leadership experience to improve health, health care, and health policy.
    Exceptional candidates from academic faculties and nonprofit healthcare organizations are encouraged to apply. Applicants may have backgrounds in the disciplines of allied health professions, biomedical sciences, dentistry, economics or other social sciences, health services organization and administration, medicine, nursing, public health, social and behavioral health, or health law. Applicants must be U.S. citizens or permanent residents.
    Up to six grants of a maximum of $165,000 will be made in 2018. Each fellow will receive up to $104,000 for their stay in Washington (September 1, 2018, through August 31, 2019) in salary, plus fringe benefits or a fellowship stipend.
MiamiOH OARS

Integrating Biology and Social Science Knowledge (BioSS) | RSF - 0 views

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    The Russell Sage Foundation (RSF) has long had the mission to improve social and living conditions in the United States. It pursues this goal by supporting outstanding research in the social sciences that explores how social, economic, and political factors affect the lives of Americans and their children. Support of such research remains the Foundation's core focus. RSF also has a long history of encouraging new scientific advances to strengthen the methods, data, and theoretical core of the social sciences.
    Two recent intellectual developments have prompted RSF to launch a special research initiative that integrates knowledge from the biological and social sciences. First, there has been a paradigm shift in the life sciences, spurred by the realization that many biological processes, rather than being fixed, immutable mechanisms that consign people to particular life outcomes, are instead fluid, dynamic responses to features of the social and physical environments humans inhabit. Second, this shift led researchers to launch interdisciplinary studies that seek to integrate approaches from the social and biological sciences, recognizing the potential for a deeper understanding of how social inequalities are initiated, maintained, and transmitted from one generation to the next.
MiamiOH OARS

2018 Technology Awards McKnight Endowment Fund for Neuroscience - 0 views

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    The McKnight Endowment Fund for Neuroscience supports innovative research designed to bring science closer to the day when diseases of the brain can be accurately diagnosed, prevented, and treated. To that end, the McKnight Endowment Fund for Neuroscience invites Letters of Intent for its 2018 McKnight Technological Innovations in Neuroscience awards.
    The program encourages and supports scientists working on the development of novel and creative approaches to the understanding of brain function. McKnight is interested in how a new technology may be used to monitor, manipulate, analyze, or model brain function at any level, from the molecular to the entire organism. Technology may take any form, from biochemical tools to instruments to software and mathematical approaches. Because the program seeks to advance and enlarge the range of technologies available to the neurosciences, research based primarily on existing techniques will not be considered.
    A goal of the Technological Innovations awards is to foster collaboration between the neurosciences and other disciplines; therefore, collaborative and cross-disciplinary applications are explicitly invited.
MiamiOH OARS

Continuation of the AMP-AD Target Discovery and Preclinical Validation Consortium (U01 ... - 0 views

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    The goal of this funding opportunity announcement is to continue and expand the open-science, systems-biology enterprise of the AMP-AD Target Discovery and Preclinical Validation Consortium and enable data-driven discovery and validation of novel targets and biomarkers for AD and AD-related dementias through the development of predictive network models of brain health and disease.
MiamiOH OARS

Limited Competition: Data Coordinating Center for the Accelerating Medicines Partnershi... - 0 views

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    The goal of this funding opportunity announcement is to solicit applications focused on 1) providing data enablement for the open-science, systems-biology enterprise of the AMP-AD Target Discovery and Preclinical Validation Consortium supported through the companion FOA (RFA-AG-18-013) and 2) sustaining and expanding the big-data infrastructure of the AMP-AD Knowledge Portal as a collaborative research platform through which members of the Consortium, researchers at large, and citizen scientists can engage in rapid translational learning and contribute to the development of predictive models of AD and AD-related dementias.
MiamiOH OARS

Call for nominations: Scolnick Prize in Neuroscience | McGovern Institute for Brain Res... - 0 views

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    The McGovern Institute for Brain Research at the Massachusetts Institute of Technology was established in 2000 by Patrick J. McGovern and Lore Harp McGovern, with the goal of improving human welfare, communication, and understanding through their support for neuroscience research.
    The institute has announced a call for nominations for its twelfth annual Edward M. Scolnick Prize in Neuroscience.
    Now in its fifteenth year, the Scolnick Prize is designed to recognize outstanding advances in the field of neuroscience. The prize, which is endowed through a gift from Merck to the McGovern Institute, consists of a $150,000 award, plus an inscribed gift. In addition, the recipient will present a public lecture at the McGovern Institute in spring 2018. A gala dinner for the recipient and invited guests follows the prize lecture.
    Candidates for the award must be nominated by individuals affiliated with universities, hospitals, medicals schools, or research institutes, with a background in neuroscience. Self-nomination is not permitted.
MiamiOH OARS

Hearing Health Foundation - 0 views

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    The mission of the Hearing Health Foundation is to prevent and cure hearing loss and tinnitus through groundbreaking research and promote hearing health. HHF envisions a world where people can enjoy life without hearing loss and tinnitus.
    To advance this mission, the foundation has issued a Call for Applications for its 2018 Emerging Research Grants program for projects designed to explore new avenues in specified topic areas of hearing and balance science.
    For the 2018 ERG cycle, grants of up to $30,000 will be awarded for research in seven priority areas, including general hearing health, central auditory processing disorders, hearing loss in children, hyperacusis, Ménière's disease, tinnitus, and Usher's syndrome.
MiamiOH OARS

BRAIN Initiative: Tools to target, identify and characterize non-neuronal cells in the ... - 0 views

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    The purpose of this Funding Opportunity Announcement [FOA] submitted through the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is to stimulate the development and validation of novel tools and analytical methods to target, identify and characterize non-neuronal cells in the brain. This FOA complements previous and ongoing cell-census and tool development efforts initiated under BRAIN, RFA-MH-14-215 and RFA-MH-14-216, that have focused almost exclusively on neuronal cells. The cutting-edge tools and methods developed under this opportunity should focus specifically on providing improved points of entry into non-neuronal cell-types (glial and vascular) to enable their inventory and characterization within the CNS and help define how these cells interact among each other and with neuronal cells to impact functional circuitries. Plans for validating the utility of the tool/technology/method and demonstrating its advantage over currently available approaches will be an essential feature of a successful application. Tools that can be used in several species or model organisms rather than in a single species are especially desirable.
MiamiOH OARS

Service Area Competition - 0 views

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    This announcement solicits applications for the Health Center Program's Service Area Competition (SAC). The Health Center Program supports patient-directed public and private nonprofit organizations that provide primary and preventive health care services to the Nation's medically underserved. The purpose of the SAC funding opportunity is to ensure continued access to comprehensive, culturally competent, quality primary health care services for communities and vulnerable populations currently served by the Health Center Program.
MiamiOH OARS

Biology Of Aging Dental, Oral And Craniofacial Tissues (R21 - Clinical Trial Not Allowed) - 0 views

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    The purpose of this Funding Opportunity Announcement (FOA) is to stimulate collaborative research to understand the biological mechanisms of aging in dental, oral, and craniofacial (DOC) tissues, as they relate to parallel processes in other tissues and organs. The areas of emphasis under this FOA include inflammation, tissue healing and regeneration, and epigenetic regulation. The overarching long-term goal of this effort is to improve oral health in older adults by addressing knowledge gaps in our understanding of the basic biology of age-associated changes in health and disease states of DOC tissues. Also listed under R01
MiamiOH OARS

New Onset Depressive Symptoms in Acute Illness (R01 Clinical Trial Not Allowed) - 0 views

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    The purpose of the funding opportunity announcement (FOA) is to encourage research on the etiology of depressive symptoms that occur in the context of a sudden onset acute illness. Although it is known that depressive symptoms may linger and affect functional recovery long after physical recovery from an acute insult, there is a gap in knowledge about the pathobiology that may underlie these incident depressive symptoms. A greater understanding of the etiological factors that contribute to and/or mitigate a trajectory of depressive symptoms may inform a personalized, holistic approach to managing recovery from acute illness.
MiamiOH OARS

Human Heredity and Health in Africa (H3Africa): Ethical, Legal, and Societal Issues (EL... - 0 views

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    This Funding Opportunity Announcement (FOA) encourages applications to study the ethical, legal and societal issues (ELSI) of human genome research in African populations. Of particular interest are projects that propose focused bioethical, legal, and social science analyses of new or emerging issues.
MiamiOH OARS

Research to Evaluate Medication Management of Opioids and Benzodiazepines to Reduce Old... - 0 views

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    The purpose of this research is to identify, implement, and evaluate the use of effective strategies and tools for provider and patient use to taper and/or discontinue opioids, benzodiazepines, and other medications in which risk outweighs benefits to prevent falls, overdose, and other injuries among community dwelling older adults.
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