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MiamiOH OARS

Administrative Supplements to Promote Collaborative Activities in Basic Cancer Research... - 0 views

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    The purpose of this Funding Opportunity Announcement (FOA) is to incentivize collaborative, multidisciplinary research across a broad area of challenging topics in basic cancer biology. These supplement applications must propose a collaboration between at least two researchers, one being the PI of the parent NCI grant. Awarded supplements will leverage and extend currently funded cancer research in the parent grant.
MiamiOH OARS

Oncology Co-Clinical Imaging Research Resources to Encourage Consensus on Quantitative ... - 0 views

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    The purpose of this Funding Opportunity Announcement (FOA) is to invite Cooperative Agreement applications to develop research resources that will encourage a consensus on how Quantitative Imaging (QI) methods are optimized to improve the quality of imaging results for co-clinical trials. The scientific goals of this FOA are to: (a) perform the appropriate optimization of the pre-clinical quantitative imaging methods, (b) implement the optimized methods in the co-clinical trial, and finally (c) populate a web-accessible research resource with all the data, methods, workflow documentation, and results collected from the co-clinical investigations. Co-clinical trials are defined in this FOA as investigations in patients and in parallel (or sequentially) in mouse or human-in-mouse models of cancer that mirror the genetics and biology of the patients malignancies or pre-cancerous lesions. The co-clinical trial should include either (a) a therapeutic goal, such as the prediction, staging, and/or measurement of tumor response to therapies, or (b) a screening and early detection or a cancer risk stratification goal for lethal cancer versus non-lethal disease. Applicants are encouraged to organize multi-disciplinary teams with experience in mouse models research, human investigations, imaging platforms, QI methods, decision support software and informatics to populate the research resource.
MiamiOH OARS

RFA-CA-18-025: Collaborative Human Tissue Network (CHTN) (UM1 Clinical Trials Not Allowed) - 0 views

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     The purpose of this Funding Opportunity Announcement (FOA), issued by the National Cancer Institute (NCI), is to support the Cooperative Human Tissue Network (CHTN). The goal for CHTN is to collect and distribute to investigators high quality human tissue specimens to facilitate basic and early translational cancer research. For example, such specimens may be needed for scientific discovery and the development of various molecular diagnostic tests, prognostic or predictive assays. The CHTN is designed as a unique biospecimen resource in that it is based on prospective collection and distribution of samples upon specific investigators' requests. Samples to be collected from patients include pre-cancerous, cancerous, and benign neoplastic tissues, as well as specimens corresponding to non-neoplastic diseases and uninvolved tissues.

MiamiOH OARS

LARGE-SCALE T CELL IMMUNE EPITOPE DISCOVERY - Federal Business Opportunities: Opportuni... - 0 views

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    The primary purpose of this solicitation is to support highly interactive, multi-disciplinary teams, whose research efforts are focused on large-scale discovery of T cell immune epitopes associated with infectious or autoimmune diseases, and rejection of, or tolerance to, transplanted cells/organs/tissues. The discovery of epitopes associated with T cell responses to commensals and how they may be altered by the inflammatory state will also be supported by this solicitation. Validation of these epitopes and defining their role in immune protection or immune-mediated pathogenesis in humans is required. Investigators may include development/refinement of T cell epitope prediction tools as part of their research plan. It is anticipated that the multi-disciplinary teams will minimally include immunologists with the appropriate expertise in epitope identification and validation, and either microbiologists and/or virologists with expertise in the target pathogen(s), clinicians with expertise in the target autoimmune diseases, or clinicians with expertise in transplantation, as appropriate. This program will not support studies related to HIV/AIDS, or allergen epitopes, including those which are infection-related.
MiamiOH OARS

PREVENT Cancer Preclinical Drug Development Program - Federal Business Opportunities: O... - 0 views

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    The purpose of this solicitation is to procure Research & Development services to support the PREVENT Program in the areas of
    (1) in vivo development/animal efficacy/biomarker development,
    (2) preclinical product development and CGMP manufacturing of biopharmaceutical agents, and
    (3) toxicology/pharmacology testing.
MiamiOH OARS

Aniara Grant - 0 views

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    Aniara Diagnostica's Coagulation Research Grant provides $20,000 for established investigators (eg - faculty at an academic institution) and for students/trainees to do innovative coagulation / hematology research. Deadline for receipt of application is November 1, 2018.
    The Aniara Research Panel awards one yearly $20,000 grant for specialized in hematology and coagulation research. All proposed projects must in the coagulation / hematology scientific field.
MiamiOH OARS

Bone Marrow Failure Idea Development Award - 0 views

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    The BMFRP Idea Development Award is intended to support innovative ideas and high-impact approaches based on scientifically sound evidence to move toward the BMFRP vision of understanding and curing BMF diseases. This award mechanism is designed to support new ideas. Proposed research studies should have a high probability of revealing new avenues of investigation. The research project should include a well-formulated, testable hypothesis based on strong scientific rationale and a well-developed and articulated research approach. Personnel on the proposed team should have a strong background in BMF disease research.
MiamiOH OARS

DoD Ovarian Cancer Investigator-Initiated Research Award - 0 views

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    The OCRP Investigator-Initiated Research Award is intended to support high-impact research that has the potential to make an important contribution to ovarian cancer or patient/survivor care. Research projects may focus on any phase of research, from basic laboratory research through translational research, excluding clinical trials. The application must demonstrate logical reasoning and a sound scientific rationale established through a critical review and analysis of the literature for the application to be competitive. Applications must include preliminary data that are relevant to ovarian cancer and support the proposed research project. The proposed research must be relevant to active duty Service members, Veterans, military beneficiaries, and/or the American public. The anticipated direct costs budgeted for the entire period of performance for an FY18 OCRP Investigator-Initiated Research Award will not exceed $450,000. Refer to Section II.D.5, Funding Restrictions, for detailed funding information. All projects should adhere to a core set of standards for rigorous study design and reporting to maximize the reproducibility and translational potential of preclinical research. The standards are described in Landis, S.C., et al., A call for transparent reporting to optimize the predictive value of preclinical research, Nature 2012, 490:187-191.
MiamiOH OARS

Research Supplements to Promote Data Sharing in Cancer Epidemiology Studies (Admin Supp... - 0 views

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    The purpose of the administrative supplement is to provide support for NIH-funded investigators to prepare and deposit individual-level data from cancer epidemiology studies into NIH/NCI-supported, controlled-access databases including the Cancer Epidemiology Data Repository (CEDR) and the database of Genotypes and Phenotypes (dbGaP). Sharing of research data will accelerate scientific discovery and increase opportunities for collaboration to provide new clues to cancer etiology, determine risk factors, and improve cancer survivorship.
MiamiOH OARS

DoD Breast Cancer, Breakthrough Fellowship Award - 0 views

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    Breakthrough Fellowship Award supports recent doctoral or medical graduates in pursuit of innovative, high-impact breast cancer research during their postdoctoral fellowship and allows them to obtain the necessary experience for an independent career at the forefront of breast cancer research. Those individuals should be exceptionally talented researchers who have demonstrated that they are the "best and brightest" of their peers. Applicants for this award must exhibit a strong desire to pursue a career in breast cancer research, with clear evidence for a researcher development plan that will lead to a successful independent career in breast cancer. Applicants must also demonstrate that the proposed research has high potential to lead to or make breakthroughs in breast cancer.
MiamiOH OARS

RFA-FD-18-017: Characterize skin physiology parameters utilized in dermal physiological... - 0 views

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     The purpose of this project is to identify skin physiology characteristics that differ between healthy and skin disease population groups and incorporate them into dermal physiologically-based pharmacokinetic models to improve their predictability. The models developed will be utilized to perform virtual bioequivalence assessments between brand name and generic drug products to inform regulatory decisions relating to the development of generic topical dermatological drug products and transdermal delivery systems.       

MiamiOH OARS

Research Grants - 0 views

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    In celebrating its 350th anniversary, Merck KGaA, Darmstadt, Germany offers a series of research grants to stimulate innovative research in challenging areas of future importance. Merck KGaA, Darmstadt, Germany intends to provide several research grants of up to EUR 350,000 per year for 3 years in various research areas with the option of extension or expansion.
    Grants are offered for research in the following areas:
    Healthy Lives / Drug Discovery:
    Challenge 1: What is the next game-changing molecule or technology to help cure cancer or autoimmune disease?
    Life Reimagined / Synthetic Biology:
    Challenge 1: What is the next generation production technology for biologics?
    Challenge 2: Can you revolutionize microbiome research?
    Materials & Solutions:
    Challenge 1: Can you develop a new generation of intelligent materials?
    Challenge 2: Can you develop advances in characterization, control and surface chemistry?
    Challenge 3: Can you develop better atomic layer processes - from modelling to materials?
    Digitalization / Computing:
    Challenge 1: How can in-silico research benefit from deep learning or quantum computing?
MiamiOH OARS

RFA-CA-18-019: Research Answers to National Cancer Institute's (NCI) Provocative Questi... - 0 views

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    The purpose of this Funding Opportunity Announcement (FOA) is to support research projects designed to solve specific problems and paradoxes in cancer research identified by the National Cancer Institute (NCI) Provocative Questions initiative. These problems and paradoxes phrased as questions are not intended to represent the full range of NCI's priorities in cancer research. Rather, they are meant to challenge cancer researchers to think about and elucidate specific problems in key areas of cancer research that are deemed important but have not received sufficient attention.
    Some of these "Provocative Questions" (PQs) stem from intriguing but older, neglected observations that have never been adequately explored. Other PQs are built on more recent findings that are perplexing or paradoxical, revealing important gaps in current knowledge. Finally, some PQs reflect problems that traditionally have been thought to be intractable but that now may be open to investigations using new strategies and recent technical advances.
    The current issuance of the PQ Initiative includes an updated set of 12 PQs. Each research project proposed in response to this FOA must be focused on addressing one particular research problem defined by one specific PQ selected from the list. Projects proposed to address specific PQs may use strategies that incorporate ideas and approaches from multiple disciplines, as appropriate. Transdisciplinary projects are encouraged as long as they serve the scientific focus of the specific PQ chosen. Also listed under R21
MiamiOH OARS

Autoimmunity Centers of Excellence, Basic Research Program (U19 Clinical Trial Not Allo... - 0 views

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    The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications to participate in the NIAID Autoimmunity Centers of Excellence (ACE), a cooperative network intended to improve the understanding, prevention, and treatment of autoimmune diseases (www.autoimmunitycenters.org). The ACE was founded on the premise that collaborations among basic and clinical scientists can accelerate both fundamental and applied research. The ACE combines Basic and Clinical research programs. This FOA solicits applications for the Basic research program; a companion FOA solicits applications for the Clinical research program. Members of the Basic research program will conduct innovative studies of human autoimmunity within Principal, Pilot, and Collaborative Projects. Members of the Basic and Clinical ACE will work together to design and conduct studies of autoimmune disease pathogenesis and mechanisms of action of immune-modulating agents being tested in ACE clinical trials.
MiamiOH OARS

ASH Bridge Grant - 0 views

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    The mission of the American Society for Hematology, the world's largest professional organization dedicated to the causes and treatment of blood disorders, is to further the understanding, diagnosis, treatment, and prevention of disorders affecting the blood, bone marrow, and immunologic, hemostatic and vascular systems through the promotion of research, clinical care, education, training, and advocacy in hematology.
    To that end, ASH is accepting proposals from hematologists whose research would not otherwise be accomplished due to cuts in NIH funding. Established in January 2013, the long-term goal of the program is to help sustain recipients' research and contribute to their retention in hematology investigation.
    The Bridge Grants program will provide at least thirty one-year awards annually, in the amount of $150,000 each, to ASH members who applied for an NIH R01 grant or equivalent but were denied funding due to budget cuts. Grants will support projects in basic, translational, patient-oriented, or outcomes-based research.
MiamiOH OARS

FedConnect: Opportunity Summary - 0 views

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    The National Heart, Lung, and Blood Institute (NHLBI) is seeking a Data Coordinating Center (DCC) for biospecimen and consent related activities for the Sudden Death in the Young (SDY) Case Registry. SDY is a tragic event with longstanding impact on families and communities. Although the causes of SDY are myriad, sudden unexpected infant death (SUID), sudden cardiac death and sudden unexpected death in epilepsy (SUDEP) are three examples that have inspired public health efforts at prevention. Yet fundamental gaps in knowledge about incidence, mechanisms, and risk factors for SDY limit the identification of effective prevention efforts.
    This acquisition is for one contract for a SDY Data Coordinating Center with subcontracts and/or other mechanisms as needed to accomplish all necessary work described in the Statement of Work.
MiamiOH OARS

Innovative Basic Research on Adducts in Cancer Risk Identification and Prevention (R21 ... - 0 views

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    This Funding Opportunity Announcement (FOA) encourages research projects focused on adducts to cellular macromolecules as indicators of exposures to cancer risk factors relevant to human populations. The priority is on projects that will focus on adductomic approaches, i.e., address some aspects of the totality of adducts. These projects should explore the basic aspects of adducts/adductomics that may have a potential utility in cancer detection, cancer prevention, and/or assessing cancer risks. The projects should be relevant to adducts in humans and human populations but may be conducted using various model systems (e.g., cultured cells, animals, etc.). The use of human biospecimens is encouraged and expected if appropriate but not required. In well-justified cases, innovative studies using the adductomic approaches in the context of cancer etiology and/or gene-environment interaction research may also be appropriate. For projects intended for NIEHS support, the focus may be on innovative technology and method development.
MiamiOH OARS

Innovative Therapies and Tools for Screenable Disorders (R21 Clinical Trial Optional) - 0 views

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    This FOA encourages research relevant to the development of therapeutic interventions for potentially fatal or disabling conditions that have been identified through newborn screening, as well as "high priority" genetic conditions where screening may be possible in the near future. Demonstrating the benefits of treatment is often a primary criterion for including a condition on a newborn screening panel; therefore, this FOA, a "high priority" condition is one where screening is not currently recommended but would significantly benefit from early identification and treatment. Also listed under R03
MiamiOH OARS

ACS Seeks Proposals on Role of Health Care and Insurance in Improving Cancer Prevention... - 0 views

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    The American Cancer Society is accepting proposals for research projects with the potential to generate new knowledge of the effects of the United States healthcare system structure and the role of insurance in both access to and the outcomes of cancer screening, early detection, and treatment services.

    ACS is keenly interested in supporting rapid learning research on the effects of health policy changes on patients, providers, and health systems. This includes but is not limited to facilitators and barriers to care; unintended consequences; differential experiences and outcomes of patients seeking or receiving care; best practice models for quality care; and economic impact.

    Awards will not exceed $200,000 per year (direct costs) for up to four years.

    To be eligible, applicants must be affiliated with a nonprofit institution in the United States, one of its territories, or the Commonwealth of Puerto Rico; and be a U.S. citizen, non-citizen national, or permanent resident of the United States. Independent investigators at all stages of their career are encouraged to apply.
MiamiOH OARS

Epidemiologic Research on Emerging Risk Factors and Liver Cancer Susceptibility (R21 - Cl - 0 views

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    The purpose of this concept initiative is to promote etiologic research investigating novel and innovative hypotheses on emerging risk factors (biological, environmental, and social) and their interplay with established risk factors (e.g., viral hepatitis) associated with the development of liver cancer (hepatocellular carcinoma and other histological subtypes) in the United States.
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