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MiamiOH OARS

BRAIN Initiative: Standards to Define Experiments Related to the BRAIN Initiative (R01 ... - 0 views

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    This Funding Opportunity Announcement (FOA) solicits applications to develop standards that describe experimental protocols that are being conducted as part of the BRAIN Initiative.It is expected that applications will solicit community input at all stages of the process. It is recommended that the first step of standard development will involve sharing data between different key groups in the experimental community in order to ensure that the developing standard will cover the way that all of those groups are collecting data. The developed standard is expected to be made widely available.
MiamiOH OARS

BRAIN Initiative: Data Archives for the BRAIN Initiative (R24 Clinical Trial Optional) - 0 views

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    This Funding Opportunity Announcement (FOA) solicits applications to develop web-accessible data archives to capture, store, and curate data related to BRAIN Initiative activities. The data archives will work with the research community to incorporate tools that allow users to analyze and visualize the data, but the creation of such tools is not part of this FOA. The data archives will use appropriate standards to describe the data, but the creation of such standards is not part of this FOA. A goal of this program is to advance research by creating a community resource data archive with appropriate standards and summary information that is broadly available and accessible to the research community for furthering research.
MiamiOH OARS

Encouraging Development of Novel Amelogenesis Models (UG3/UH3 Clinical Trial Not Allowed) - 0 views

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    The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications to develop physiologically relevant models of amelogenesis that are robust and validated so that they can advance studies of healthy and diseased human conditions involving teeth. The objectives of this FOA are two-fold: 1) generate new and improved models that closely mimic physiological enamel development and maturation to empower studies of amelogenesis, and 2) validate those models to ensure they are robust and accurately reflect human physiology and pathology. These tandem objectives will be accomplished with an Exploratory/Developmental Phased Award Cooperative Agreement (UG3/UH3) mechanism, where the UG3 developmental phase is initiated and carried out through a milestone-driven process which will then be assessed to determine if advancement to the UH3 phase providing subsequent support to further advance the UG3 outcomes will be granted . It is expected this FOA will enhance the capability of resources to serve biomedical research and accelerate understanding of multiscale processes of enamel formation to inform strategies to mitigate diseases affecting enamel and associated structures.
MiamiOH OARS

RFA-AG-19-011: Integrative Omics to Enhance Therapeutics Development for Healthy Aging ... - 0 views

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    This Funding Opportunity Announcement (FOA) is a phased innovation initiative to facilitate multi-omics/integrative approaches to identify omics profiles associated with protection against multiple aging conditions, with exceptional health span, and to refine strategies for utilizing these profiles for therapeutics development. Specifically, a phased innovation cooperative agreement mechanism (UH2/UH3) involving an interdisciplinary research team will be used to support a single project that will conduct integrative analysis of person-specific multiple omics measurements (e.g., transcriptomics, proteomics, metabolomics) generated across multiple tissues; the multi-omic profiling should be conducted on individuals from extensively phenotyped cohorts with substantial numbers of long-lived individuals with characteristics of exceptionally healthy aging and appropriate controls.
MiamiOH OARS

AIDS Research Center on Mental Health and HIV/AIDS (P30 Clinical Trial Optional) - 0 views

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    The National Institute of Mental Health (NIMH) Division of AIDS Research (DAR) encourages applications for Center Core grants (P30) to support an HIV/AIDS Research Center (ARC). The ARC is intended to provide infrastructural support that facilitates the development of high impact science in HIV/AIDS and mental health that is relevant to the NIMH mission. This FOA intends to support innovative, interdisciplinary research in several areas, including basic, neurological (i.e., neuro-HIV), behavioral and social, integrated biobehavioral, applied, clinical, translational, and implementation science.
MiamiOH OARS

RFA-AI-18-026: Modeling and Simulation to Optimize HIV Prevention Research (MS OPR) (R0... - 0 views

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    The purpose of this Funding Opportunity Announcement (FOA) is to support the development and validation of modeling and simulation methods and related tools to examine HIV transmission dynamics, make epidemic projections, and estimate the impact of HIV treatment and prevention. Investigators are expected to share these resources with other researchers. Funding for the final fourth year is dependent upon achieving applicant-proposed and pre-award negotiated "Go/No-Go criteria". 

MiamiOH OARS

Service Area Competition (SAC): Round 1 - 0 views

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    This notice solicits applications for the Health Center Program's Service Area Competition (SAC). The Health Center Program supports public and private nonprofit community-based and patient-directed organizations that provide primary health care services to the Nation's medically underserved populations. The purpose of the SAC NOFO is to ensure continued access to affordable, quality primary health care services for communities and vulnerable populations currently served by the Health Center Program. This NOFO details the SAC eligibility requirements, review criteria, and awarding factors for organizations seeking funding for operational support to provide primary health care services to an announced service area. For the purposes of this document, the term "health center" encompasses Health Center Program award recipients funded under the following subsections: Community Health Center (CHC - section 330(e)), Migrant Health Center (MHC - section 330(g)), Health Care for the Homeless (HCH - section 330(h)), and/or Public Housing Primary Care (PHPC - section 330(i)).
MiamiOH OARS

Approaches for Understanding Disease Mechanisms and Improving Outcomes in TB Meningitis... - 0 views

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    The purpose of this Funding Opportunity Announcement (FOA) is to invite applications for support of innovative clinical and preclinical/non-clinical research to improve our understanding of disease mechanisms in tuberculosis meningitis (TBM) and to improve therapy in the presence or absence of human immunodeficiency virus (HIV) co-infection.
MiamiOH OARS

Radiation Protection of the Public as Practiced by the State and Local Radiation Programs - 0 views

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    The purpose of this NOFO is to provide a forum that should make it possible for state and federal agencies to work together and apply their limited resources to address radiological health issues of mutual interest. This project will be accomplished by a multi-faceted approach that includes joint working groups assigned to specific issues, participation at annual meetings for presentations and discussion of issues of mutual interest, new developments in the field, upcoming challenges and recommendations, along with training and workshops for keeping state and federal regulatory personnel informed and educated on new technologies, issues, and regulatory procedures. The goal of the guidance, recommendations, suggested regulations, and exchange of information is to increase the available tools, knowledge, and capabilities for radiological health staff throughout the country. As a result of the increased capability to assure radiation protection, a reduction in the risk of illness and deaths associated with unnecessary radiation exposure will occur.
MiamiOH OARS

PA-18-793: AHRQ Health Services Research Demonstration and Dissemination Grants (R18) - 0 views

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    The Research Demonstration and Dissemination Grant (R18) is an award made by AHRQ to an institution/organization to support a discrete, specified health services research project. The project will be performed by the named investigator and study team. The R18 research plan proposed by the applicant institution/organization must be related to the mission and priority research interests of AHRQ.  

    Also listed under R03 and R01
MiamiOH OARS

Ending the Pandemic Threat: A Grand Challenge for Universal Influenza Vaccine Developme... - 0 views

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    The Bill & Melinda Gates Foundation has issued an Request for Proposals for research that will lead to the development of a universal influenza vaccine
    Part of the foundation's Grand Challenges program, the goal of the foundation's Ending the Pandemic Threat: A Grand Challenge for Universal Influenza Vaccine Development initiative is to identify novel, transformative concepts that will lead to development of universal influenza vaccines offering protection from morbidity and mortality caused by all subtypes of circulating and emerging (drifted and shifted) Influenza A subtype viruses and Influenza B lineage viruses for at least three to five years. It is envisaged that such a universal influenza vaccine would address the threat from both seasonal and pandemic influenza, thus alleviating the need for annual seasonal influenza vaccination campaigns, averting significant global morbidity and mortality, and better preparing the world for the next influenza pandemic.
    While other funders are supporting development of universal Influenza vaccines, three things set this Grand Challenge apart. The Gates Foundation seeks to fund ideas that are bold and innovative, bridging the funding 'valley of death' to translate these novel approaches into products ready for human clinical trials. It also aims to encourage interdisciplinary collaboration and cross-fertilization of ideas from outside the traditional influenza research community. Third, it seeks completely transformative approaches rather than incremental research.
MiamiOH OARS

Tuberous Sclerosis Complex Idea Development Award - 0 views

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    The Idea Development Award promotes ideas that have the potential to yield high-impact findings and new avenues of investigation. This award mechanism supports conceptually innovative research that could ultimately lead to critical discoveries in TSC research and/or improvements in patient care. Research projects should include a well-formulated, testable hypothesis based on strong preliminary data and scientific rationale.
MiamiOH OARS

RFA-CA-18-014: Investigation of the Transmission of Kaposi Sarcoma-Associated Herpesvir... - 0 views

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    The purpose of the funding opportunity announcement (FOA) is to advance our understanding of the modes of transmission of Kaposi sarcoma-associated herpesvirus (KSHV), also called human herpesvirus-8 (HHV-8); the biology of the initial steps of infection; and risk factors for infection to inform efforts to prevent KSHV transmission and thus prevent Kaposi sarcoma (KS), KSHV-associated multicentric Castleman disease (MCD), primary effusion lymphoma (PEL), and other KSHV-induced diseases in populations living with HIV or at high risk of developing HIV.
    This program covers two parallel FOAs of identical scientific scope. This FOA solicits applications for exploratory/developmental projects using the NIH R21 mechanism. The companion FOA, RFA-CA-18-013, is a parallel announcement for well-developed research projects using the NIH R01 funding mechanism.
MiamiOH OARS

Enhance the National Department of Health's coordination and leadership on HIV and TB p... - 0 views

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    South Africa's has been making steady progress towards 90-90-90 targets, but these targets are unlikely to be attained without additional support and resources. The South African Department of Health developed an HIV Treatment and Retention Acceleration Plan (TRAP) in September 2017 to aggressively improve performance in the ART Program. CDC has been partnering with National Department of Health (NDoH) for several years through three consecutive cooperative agreements, 2003 to 2009, 2009 to 2014 and currently 2014 to 2019. This follow-on NOFO will allow CDC South Africa to continue to support and engage with the National Department of Health in developing and reviewing guidance and policy documents on HIV and TB, support surveys and surveillance activities to correctly characterize and describe the epidemic, provide guidance on evidence-based program implementation and coordinate monitoring and evaluation activities and other health systems interventions to assess effectiveness of interventions and program performance and ensure that health delivery systems are functional and structurally conducive to optimal HIV and TB service delivery.
MiamiOH OARS

PA-18-775: Pilot and Feasibility Studies in Preparation for Drug and Alcohol Abuse Prev... - 0 views

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    This Funding Opportunity Announcement (FOA) for R34 applications seeks to support: (a) pilot and/or feasibility testing of innovative new, revised, or adapted prevention intervention approaches to prevent or delay the initiation and onset of drug and alcohol use, the progression to misuse or problem use or alcohol and other substance use disorder, reduce drinking and driving and deaths related to impaired driving, prevent suicide attempts (nonfatal and fatal), and the drug- or alcohol-related acquisition or transmission of HIV infection and viral hepatitis among diverse populations and settings; and, (b) pre-trial feasibility and acceptability testing for prevention services and systems research. It is expected that research conducted via this mechanism will consist of studies that are a pre-requisite for preparing and submitting subsequent applications for larger scale drug or alcohol abuse prevention and/or drug- or alcohol-related HIV prevention intervention studies. This FOA does not support applications for which the sole focus is development of intervention protocols, manuals, or the standardization of protocols. Any intervention development work must be imbedded within a pilot/feasibility study. Of particular interest is prevention research that addresses current public health priorities and priority settings and systems.
MiamiOH OARS

PA-18-773: International Research Collaboration on Drug Abuse and Addiction Research (R... - 0 views

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    This Funding Opportunity Announcement (FOA) encourages collaborative research applications on drug abuse and addiction that:
    1. Take advantage of unusual opportunities that exist outside the United States to access talent, resources, populations, or environmental conditions in other countries that will speed scientific discovery
    2. Describe how the research will significantly advance U.S. health sciences
    3. Demonstrate specific relevance to the NIDA mission and objectives. To determine whether your research plan is relevant to the NIDA mission and objectives, review the NIDA Strategic Plan (https://www.drugabuse.gov/about-nida/2016-2020-nida-strategic-plan). Where feasible, applications should address NIDA's international scientific priority areas (https://www.drugabuse.gov/international/research-priorities)
    4. Include an investigator from a U.S. institution and a non-U.S. citizen partner living and working in another country.
MiamiOH OARS

Tick-Borne Disease, Career Development Award - 0 views

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    The FY18 TBDRP Career Development Award (CDA) supports independent, early-career
    investigators to conduct impactful research with the mentorship of an experienced tick-borne
    diseases researcher (i.e., the Mentor) as an opportunity to obtain the funding, guidance, and
    experience necessary for productive, independent careers at the forefront of tick-borne diseases
    research. This award supports impactful research projects with an emphasis on discovery.
    Under this award mechanism, the early-career investigator is considered the Principal Investigator
    (PI), and the application should focus on the PI's research and career development. It should be
    clear that the proposed research is intellectually designed by the PI and not a product of the
    Mentor. Preliminary data are not required. However, logical reasoning and a sound
    scientific rationale for the proposed research must be demonstrated.
MiamiOH OARS

LARGE-SCALE T CELL IMMUNE EPITOPE DISCOVERY - Federal Business Opportunities: Opportuni... - 0 views

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    The primary purpose of this solicitation is to support highly interactive, multi-disciplinary teams, whose research efforts are focused on large-scale discovery of T cell immune epitopes associated with infectious or autoimmune diseases, and rejection of, or tolerance to, transplanted cells/organs/tissues. The discovery of epitopes associated with T cell responses to commensals and how they may be altered by the inflammatory state will also be supported by this solicitation. Validation of these epitopes and defining their role in immune protection or immune-mediated pathogenesis in humans is required. Investigators may include development/refinement of T cell epitope prediction tools as part of their research plan. It is anticipated that the multi-disciplinary teams will minimally include immunologists with the appropriate expertise in epitope identification and validation, and either microbiologists and/or virologists with expertise in the target pathogen(s), clinicians with expertise in the target autoimmune diseases, or clinicians with expertise in transplantation, as appropriate. This program will not support studies related to HIV/AIDS, or allergen epitopes, including those which are infection-related.
MiamiOH OARS

International Research Collaboration on Drug Abuse and Addiction Research (R01 Clinical... - 0 views

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    This Funding Opportunity Announcement (FOA) encourages collaborative research applications on drug abuse and addiction that: 1. Take advantage of unusual opportunities that exist outside the United States to access talent, resources, populations, or environmental conditions in other countries that will speed scientific discovery 2. Describe how the research will significantly advance U.S. health sciences 3. Demonstrate specific relevance to the NIDA mission and objectives. To determine whether your research plan is relevant to the NIDA mission and objectives, review the NIDA Strategic Plan (https://www.drugabuse.gov/about-nida/2016-2020-nida-strategic-plan). Where feasible, applications should address NIDAs international scientific priority areas (https://www.drugabuse.gov/international/research-priorities) 4. Include an investigator from a U.S. institution and a non-U.S. citizen partner living and working in another country.
MiamiOH OARS

Medication Assisted Treatment - Prescription and Opioid Addiction - 0 views

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    The Substance Abuse and Mental Health Services Administration (SAMHSA), Center for Substance Abuse Treatment (CSAT), is accepting applications for fiscal year (FY) 2018 Targeted Capacity Expansion: Medication Assisted Treatment - Prescription Drug and Opioid Addiction (Short Title: MAT-PDOA) grants. The purpose of this program is to expand/enhance access to medication-assisted treatment (MAT) services for persons with an opioid use disorder (OUD) seeking or receiving MAT. This program's focus is on funding organizations and tribes/tribal organizations within states identified as having the highest rates of primary treatment admissions for heroin and opioids per capita and includes those states with the most dramatic increases for heroin and opioids, based on SAMHSA's 2015 Treatment Episode Data Set (TEDS). The desired outcomes include: 1) an increase in the number of individuals with OUD receiving MAT 3) a decrease in illicit opioid drug use and prescription opioid misuse at six-month follow-up.
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