Lipoxins are a series of anti-inflammatory mediators. Lipoxins are short lived endogenously produced nonclassic eicosanoids whose appearance in inflammation signals the resolution of inflammation. They are abbreviated as LX, an acronym for lipoxygenase (LO) interaction products. At present two lipoxins have been identified; lipoxin A4 (LXA4) and lipoxin B4 (LXB4)
Aspirin triggers antiinflammatory 15-epi-lipoxin A4 and inhibits thromboxane in a randomized human trial.
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PMID: 15471991
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Aging is characterized by a profound reduction in anti-inflammatory lipoxin A4 levels.
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PMID: 15935589
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Native and aspirin-triggered lipoxins control innate immunity by inducing proteasomal degradation of TRAF6.
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J Exp Med. 2008 May 12;205(5):1077-86. Epub 2008 Apr 14.
PMID: 18411340
doi:10.1084/jem.20072416
Lipoxin A4: anti-inflammatory and anti-angiogenic impact on endothelial cells.
Baker N, O'Meara SJ, Scannell M, Maderna P, Godson C.
J Immunol. 2009 Mar 15;182(6):3819-26.
PMID: 19265161
doi:10.4049/jimmunol.0803175
Anti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 dependent.
Machado FS, Johndrow JE, Esper L, Dias A, Bafica A, Serhan CN, Aliberti J.
Nat Med. 2006 Mar;12(3):330-4. Epub 2006 Jan 15.
PMID: 16415877
doi:10.1038/nm1355\n