March 7, 2005
Boston, MA - The anti-inflammatory effect of fish oils appears to be due to a powerful anti-inflammatory compound called resolvin (resolution-phase interaction product) E1, which is produced from eicosapentaenoic acid (EPA), Dr Makoto Arita (Brigham and Women's Hospital and Harvard Medical School, Boston, MA) and colleagues report in the March 7, 2005 issue of the Journal of Experimental Medicine [1]. Arita writes, "At nanomolar levels, resolvin E1 dramatically reduced dermal inflammation, peritonitis, dendritic cell migration, and interleukin (IL)-12 production.
Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and
ChemR23 to regulate inflammation.
Arita M, Ohira T, Sun YP, Elangovan S, Chiang N, Serhan CN.
J Immunol. 2007 Mar 15;178(6):3912-7.
PMID: 17339491
Identification of endogenous resolvin E1 and other lipid mediators
derived from eicosapentaenoic acid via electrospray low-energy tandem
mass spectrometry: spectra and fragmentation mechanisms.
Lu Y, Hong S, Yang R, Uddin J, Gotlinger KH, Petasis NA, Serhan CN.
Rapid Commun Mass Spectrom. 2007;21(1):7-22.
PMID: 17131464
Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1.
Arita M, Bianchini F, Aliberti J, Sher A, Chiang N, Hong S, Yang R, Petasis NA, Serhan CN.
J Exp Med. 2005 Mar 7;201(5):713-22.
PMID: 15753205
oi:10.1084/jem.20042031
The contributions of aspirin and microbial oxygenase to the biosynthesis of anti-inflammatory resolvins: novel oxygenase products from omega-3 polyunsaturated fatty acids.
Arita M, Clish CB, Serhan CN.
Biochem Biophys Res Commun. 2005 Dec 9;338(1):149-57. Epub 2005 Aug 10. Review.
PMID: 16112645
doi:10.1016/j.bbrc.2005.07.181
RvE1 protects from local inflammation and osteoclast- mediated bone destruction in periodontitis.
Hasturk H, Kantarci A, Ohira T, Arita M, Ebrahimi N, Chiang N, Petasis NA, Levy BD, Serhan CN, Van Dyke TE.
FASEB J. 2006 Feb;20(2):401-3. Epub 2005 Dec 22.
PMID: 16373400
doi:10.1096/fj.05-4724fje