ScienceDaily (Apr. 5, 2009) - Docosahexanoic acid (DHA), an omega-3 fatty acid found in fish oils, has been shown to reduce the size of tumours and enhance the positive effects of the chemotherapy drug cisplatin, while limiting its harmful side effects. The rat experiments provide some support for the plethora of health benefits often ascribed to omega-3 acids.
Nutritional intervention with omega-3 Fatty acids in a case of
malignant fibrous histiocytoma of the lungs.
Pardini RS, Wilson D, Schiff S, Bajo SA, Pierce R.
Nutr Cancer. 2005;52(2):121-9.
PMID: 16201843
CONCLUSION: Our results indicate that n-3 PUFA from seal oils is safe and efficacious for patients with NAFLD associated with hyperlipidemia and can improve their total symptom scores, ALT, serum lipid levels and normalization of ultrasonographic evidence. Further study is needed to confirm these results.
Effects of n-3 polyunsaturated fatty acids from seal oils on nonalcoholic fatty liver disease associated with hyperlipidemia.
Zhu FS, Liu S, Chen XM, Huang ZG, Zhang DW.
World J Gastroenterol. 2008 Nov 7;14(41):6395-400.
PMID: 19009658
These data indicate that fish oil feeding downregulated the endogenous PPAR-activation system and increased antioxidant gene expressions to protect against ROS excess
Fish oil feeding alters liver gene expressions to defend against PPARalpha activation and ROS production.
Takahashi M, Tsuboyama-Kasaoka N, Nakatani T, Ishii M, Tsutsumi S, Aburatani H, Ezaki O.
Am J Physiol Gastrointest Liver Physiol. 2002 Feb;282(2):G338-48.
PMID: 11804856
Here we propose that the beneficial effect of (n-3) PUFA diet is related to down-regulation of the mutually positive interactions of platelet activation and coagulation. In addition, we consider the possibility that the dietary effect on hemostatic and lipid factors involves transcription regulation of multiple genes, perhaps in a subject-dependent manner.
Fish oil consumption and reduction of arterial disease.
Vanschoonbeek K, de Maat MP, Heemskerk JW.
J Nutr. 2003 Mar;133(3):657-60. Review.
PMID: 12612132
"Results indicated that mice on diets supplemented with flaxseed meal and flaxseed oil had, on average, 45 percent fewer tumors in the small intestine and the colon compared to the control group."
The scientists published their research findings in February in the academic peer-reviewed international journal Nutrition and Cancer.