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Casey Finnerty

Antiseptics Used to Prevent Health Care Infections Might Cause Them. Oops. | Wired Scie... - 0 views

  • pre-operative antiseptics have never been examined for infection risk. They were grandfathered into FDA approval because they were on the market long before the FDA began assessing such products, as a result of expert testimony that they would kill any microbes that contaminated them.  That assumption turns out to have been incorrect.
Casey Finnerty

How Much Is a Drug-Resistance Death Worth? Less Than $600 | Wired Science | Wired.com - 0 views

  • For every death from AIDS, the US federal research establishment awards approximately $69,000 in grant funds. And for every death from MRSA, it awards $570.
  • MRSA, let’s remember, kills an estimated 19,000 Americans a year: more than HIV, and more than pneumococcal disease, meningococcal disease, H. influenzae and group A Streptococcus combined. 
  • because HIV has been a research priority for most of the 30 years of its existence, research has brought forth thousands of  antiviral compounds and drug combinations for treatment.
Katelyn Madigan

Research may lead to new strategies against sepsis - 0 views

    • Katelyn Madigan
       
      I have read other articles where the fatality for sepsis has ranged between 25-50%, so it seems like an improvement to have antibiotics currently at 25%. This is still way too high to be acceptable.
  • This cell migration further stimulates the immune system, increasing the release of other signaling molecules and factors. But how this occurs hasn't been completely understood."
  • Eliminating STIM1 or blocking the channel both reduced the permeability of the lungs' blood vessels and lessened lung edema
    • Katelyn Madigan
       
      Huge issue - especially in older population
  • ...1 more annotation...
  • design new molecules that target the activation of the STIM protein.
Nate Scheibe

Video - Breaking News Videos from CNN.com - 1 views

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    If you get the "stomach flu", you don't actually have the flu! :-)
Katelyn Madigan

Novel approaches needed to end growing scourge of 'superbugs' - 1 views

    • Katelyn Madigan
       
      How common are intestinal infections compared to the more well-known UTIs?
  • development of new antibiotics to treat these infections is plummeting
    • Katelyn Madigan
       
      Unable to keep up with the rapidly mutating strains?
  • ...6 more annotations...
  • greater disinfection and less usage of invasive materials than can transmit antibiotic-resistant bacteria into the body
  • moderate the inflammatory response to infection or that limit microbial growth by blocking access to host resources without attempting to kill microbes.
    • Katelyn Madigan
       
      Are there multiple ways to provide resistance to the host cell? Would this be done only after an infection, so as to just limit the damage done?
  • If we want a long-term solution, the answer is not incremental tweaking of these policies and processes. Novel approaches, based on a reconceptualization of the nature of resistance, disease, and prevention, are needed.
    • Katelyn Madigan
       
      Well stated.
  • infect more than 2 million Americans every year and kill more than 100,000 annually,
Katelyn Madigan

Viral reactivation a likely link between stress and heart disease - 1 views

    • Katelyn Madigan
       
      It is important not to exaggerate your findings, so I think it is good that they are honest with areas of the research that are still not definitive.
  • enhanced levels of proinflammatory proteins in the blood of patients with acute coronary events and detectable levels of the EBV-related protein
  • having more of one of these proteins in the blood was linked to the presence of antibodies that signal a latent Epstein-Barr virus
  • ...4 more annotations...
  • looked for antibodies against a protein that can be produced even when only partial or incomplete reactivation of Epstein-Barr EBV occurs
  • EBV, a human herpes virus that causes infectious mononucleosis and several different types of tumors
  • Stress is a known predictor of reactivation of EBV, meaning virus reactivation could be a mechanism by which stress leads to chronic inflammation and eventually cardiovascular diseases.
  • viral proteins can induce inflammation, affecting the lining of blood vessels, so that inflammation is in the right place to function as a significant risk factor for heart disease
Alison Prodzinski

Belly Button Biodiversity - 1 views

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    I was thinking of this after culturing my belly button..... 
Richard Herron

A mutant Tat protein provides strong pr - PubMed Mobile - 0 views

  • Nullbasic is a mutant form of the HIV-1 Tat protein that was previously shown to strongly inhibit HIV-1 replication in non-hematopoietic cell lines by targeting three steps of HIV-1 replication: reverse transcription, transport of viral mRNA and transactivation of HIV-1 gene expression.
Richard Herron

Escherichia coli O157:H7 - Wikipedia, the free encyclopedia - 1 views

  • Escherichia coli O157:H7 is an enterohemorrhagic strain of the bacterium Escherichia coli and a cause of illness through food.[1] Infection may lead to hemorrhagic diarrhea, and to kidney failure.
  • E. coli serotype O157:H7 is a Gram-negative, rod-shaped bacterium. The "O" in the name refers to the cell wall (somatic) antigen number, whereas the "H" refers to the flagella antigen.
Richard Herron

Braconidae - Wikipedia, the free encyclopedia - 1 views

  • Endoparasitoid species often display elaborate physiological adaptations to enhance larval survival within the host, such as the co-option of endosymbiotic viruses for compromising host immune defenses.
  • he DNA of the wasp actually contains portions that are the templates for the components of the viral particles and they are assembled in an organ in the female's abdomen known as the calyx.
  • Because of this highly modified system of host immunosuppression it is not surprising that there is a high level of parasitoid-host specificity. It is this specificity that makes Braconids a very powerful and important biological control agent.
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    My husband was telling me about this yesterday. He heard about it on reddit but he couldn't remember which kind of bug it was.
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    That's actually where I found it the other night. It was a very interesting read to say the least.
Casey Finnerty

Fecal Treatment Gains Favor for Some Illnesses - NYTimes.com - 3 views

  • A new study finds that such transplants cured 15 of 16 people who had recurring infections with Clostridium difficile bacteria, whereas antibiotics cured only 3 of 13 and 4 of 13 patients in two comparison groups.
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    I didn't know this was even possible. I wonder how they convinced people to donate. "The donors were tested for an array of diseases to make sure they did not infect the patients." I wonder how extensive that panel was and what they tested for.
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    Isn't this neat? I have met people who are hoping to get this treatment. Re: the screening, I think it is probably just for the absence of pathogens. As the article states, we really don't know what the "good" bacteria are that help these patients.
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    RE: I would hope that they would check for things like HIV and other blood to blood transmitted diseases. If there was a bleed in the GI tract of both the donor and the patient, I could imagine it would be a problem.
Casey Finnerty

How to Get Rid of Bieber Fever: 8 steps - wikiHow - 0 views

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    Good advice for the afflicted.
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