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Casey Finnerty

Really? The Claim: Hand Sanitizer Stops Norovirus Spread - NYTimes.com - 0 views

  • Some viruses, like influenza, are coated in lipids, “envelopes” that alcohol can rupture.
    • Casey Finnerty
       
      Which are more resistant to dessication, enveloped or naked viruses?
Casey Finnerty

Reassessing Flu Shots as the Season Draws Near - NYTimes.com - 0 views

  • “It does not protect as promoted. It’s all a sales job: it’s all public relations.”
  • “I say, ‘Use this vaccine,’ ” he said. “The safety profile is actually quite good. But we have oversold it. Use it — but just know it’s not going to work nearly as well as everyone says.”
  • “Does it work as well as the measles vaccine? No, and it’s not likely to. But the vaccine works,” Dr. Joseph Bresee, chief of epidemiology and prevention in the C.D.C.’s influenza division, said. And research is advancing to improve the effectiveness of the vaccine.
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  • “Not having evidence doesn’t prove it doesn’t work; we just don’t know,” said Dr. Roger Thomas, a Cochrane Collaboration coordinator for the University of Calgary in Alberta, who was an author of both of the reviews. “The intelligent decision would be to have large, publicly funded independent trials.”
  • Another option for those who want to reduce their risk of influenza and flulike infections may be simply this: Wash your hands more often. There is good evidence this works.
Casey Finnerty

Reassessing Flu Shots as the Season Draws Near - NYTimes.com - 0 views

  • “We have overpromoted and overhyped this vaccine,” said Michael T. Osterholm, director of the Center for Infectious Disease Research and Policy, as well as its Center of Excellence for Influenza Research and Surveillance. “It does not protect as promoted. It’s all a sales job: it’s all public relations.”
  • He still considers himself a “a pro-vaccine guy,” Dr. Osterholm said.
  • “I say, ‘Use this vaccine,’ ” he said. “The safety profile is actually quite good. But we have oversold it. Use it — but just know it’s not going to work nearly as well as everyone says.”
Richard Herron

Braconidae - Wikipedia, the free encyclopedia - 1 views

  • Endoparasitoid species often display elaborate physiological adaptations to enhance larval survival within the host, such as the co-option of endosymbiotic viruses for compromising host immune defenses.
  • he DNA of the wasp actually contains portions that are the templates for the components of the viral particles and they are assembled in an organ in the female's abdomen known as the calyx.
  • Because of this highly modified system of host immunosuppression it is not surprising that there is a high level of parasitoid-host specificity. It is this specificity that makes Braconids a very powerful and important biological control agent.
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    My husband was telling me about this yesterday. He heard about it on reddit but he couldn't remember which kind of bug it was.
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    That's actually where I found it the other night. It was a very interesting read to say the least.
Richard Herron

Escherichia coli O157:H7 - Wikipedia, the free encyclopedia - 1 views

  • Escherichia coli O157:H7 is an enterohemorrhagic strain of the bacterium Escherichia coli and a cause of illness through food.[1] Infection may lead to hemorrhagic diarrhea, and to kidney failure.
  • E. coli serotype O157:H7 is a Gram-negative, rod-shaped bacterium. The "O" in the name refers to the cell wall (somatic) antigen number, whereas the "H" refers to the flagella antigen.
Casey Finnerty

How Scientists Stopped Klebsiella Pneumoniae: Deadly Superbug Killed 6 At NIH Clinical ... - 1 views

  • 18 people harbored the dangerous germ, and six died of bloodstream infections from it. Another five made it through the outbreak only to die from the diseases that brought them to NIH's world-famous campus in the first place.
  • Infections at health care facilities are one of the nation's leading causes of preventable death, claiming an estimated 99,000 lives a year.
  • KPC has emerged over the past decade to become a fast-growing threat in intensive care units, spreading easily between very ill people and killing half of those it sickens.
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  • KPC was transmitted three separate times from Patient No. 1, and then spread more widely.
  • Test after test never found the bug on hospital workers' hands.
  • "There's better technology becoming available for your hospital to prevent these bacteria from spreading, and this is what you should expect from your hospital," he said.
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    I agree that it is wise to broaden the scope of infection control to custodial workers, since they would often be in contact with several of the inanimate objects in the room. This is really shown when they were unable to find the superbug on the "hospital workers' hands." Did they test everyone?
Casey Finnerty

Antiseptics Used to Prevent Health Care Infections Might Cause Them. Oops. | Wired Scie... - 0 views

  • pre-operative antiseptics have never been examined for infection risk. They were grandfathered into FDA approval because they were on the market long before the FDA began assessing such products, as a result of expert testimony that they would kill any microbes that contaminated them.  That assumption turns out to have been incorrect.
Casey Finnerty

How Much Is a Drug-Resistance Death Worth? Less Than $600 | Wired Science | Wired.com - 0 views

  • For every death from AIDS, the US federal research establishment awards approximately $69,000 in grant funds. And for every death from MRSA, it awards $570.
  • MRSA, let’s remember, kills an estimated 19,000 Americans a year: more than HIV, and more than pneumococcal disease, meningococcal disease, H. influenzae and group A Streptococcus combined. 
  • because HIV has been a research priority for most of the 30 years of its existence, research has brought forth thousands of  antiviral compounds and drug combinations for treatment.
Katelyn Madigan

Research may lead to new strategies against sepsis - 0 views

    • Katelyn Madigan
       
      I have read other articles where the fatality for sepsis has ranged between 25-50%, so it seems like an improvement to have antibiotics currently at 25%. This is still way too high to be acceptable.
  • This cell migration further stimulates the immune system, increasing the release of other signaling molecules and factors. But how this occurs hasn't been completely understood."
  • Eliminating STIM1 or blocking the channel both reduced the permeability of the lungs' blood vessels and lessened lung edema
    • Katelyn Madigan
       
      Huge issue - especially in older population
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  • design new molecules that target the activation of the STIM protein.
Nate Scheibe

Video - Breaking News Videos from CNN.com - 1 views

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    If you get the "stomach flu", you don't actually have the flu! :-)
Katelyn Madigan

Novel approaches needed to end growing scourge of 'superbugs' - 1 views

    • Katelyn Madigan
       
      How common are intestinal infections compared to the more well-known UTIs?
  • development of new antibiotics to treat these infections is plummeting
    • Katelyn Madigan
       
      Unable to keep up with the rapidly mutating strains?
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  • greater disinfection and less usage of invasive materials than can transmit antibiotic-resistant bacteria into the body
  • moderate the inflammatory response to infection or that limit microbial growth by blocking access to host resources without attempting to kill microbes.
    • Katelyn Madigan
       
      Are there multiple ways to provide resistance to the host cell? Would this be done only after an infection, so as to just limit the damage done?
  • If we want a long-term solution, the answer is not incremental tweaking of these policies and processes. Novel approaches, based on a reconceptualization of the nature of resistance, disease, and prevention, are needed.
    • Katelyn Madigan
       
      Well stated.
  • infect more than 2 million Americans every year and kill more than 100,000 annually,
Katelyn Madigan

Viral reactivation a likely link between stress and heart disease - 1 views

    • Katelyn Madigan
       
      It is important not to exaggerate your findings, so I think it is good that they are honest with areas of the research that are still not definitive.
  • enhanced levels of proinflammatory proteins in the blood of patients with acute coronary events and detectable levels of the EBV-related protein
  • having more of one of these proteins in the blood was linked to the presence of antibodies that signal a latent Epstein-Barr virus
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  • looked for antibodies against a protein that can be produced even when only partial or incomplete reactivation of Epstein-Barr EBV occurs
  • EBV, a human herpes virus that causes infectious mononucleosis and several different types of tumors
  • Stress is a known predictor of reactivation of EBV, meaning virus reactivation could be a mechanism by which stress leads to chronic inflammation and eventually cardiovascular diseases.
  • viral proteins can induce inflammation, affecting the lining of blood vessels, so that inflammation is in the right place to function as a significant risk factor for heart disease
Casey Finnerty

BBC News - Antibiotic 'apocalypse' warning - 1 views

  • The rise in drug resistant infections is comparable to the threat of global warming, according to the chief medical officer for England.
  • MRSA rapidly became one of the most feared words in hospitals wards and there are growing reports of resistance in strains of E. coli, tuberculosis and gonorrhoea.
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    Some UK perspective on the antibiotic resistance problem.
Alison Prodzinski

Belly Button Biodiversity - 1 views

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    I was thinking of this after culturing my belly button..... 
Richard Herron

A mutant Tat protein provides strong pr - PubMed Mobile - 0 views

  • Nullbasic is a mutant form of the HIV-1 Tat protein that was previously shown to strongly inhibit HIV-1 replication in non-hematopoietic cell lines by targeting three steps of HIV-1 replication: reverse transcription, transport of viral mRNA and transactivation of HIV-1 gene expression.
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