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Schizophrenia is a very disabling psychiatric illness affecting about 2 to 3 million Americans. Contrary to popular perception, it has nothing to do with a "split personality." Schizophrenia is a chronic brain disorder involving "positive" and "negative" symptoms. Positive symptoms include hallucinations (hearing voices or seeing visions that aren't real), delusions (fixed false beliefs), and disorganized thinking or speech. A recent study in the Archives of General Psychiatry by Paul Grant, Aaron Beck, and their colleagues found that a modified version of cognitive-behavioral therapy (CBT), a specific type of talk therapy, can produce clinically significant improvement in patients with schizophrenia. Importantly, significant improvement was seen in certain negative symptoms-apathy/avolition (lack of drive)-as well as in positive symptoms. These results are impressive, especially considering that the participants had been ill for an average of 18 years and suffered from severe symptoms. In this study, study participants were divided into two groups. One group received CBT in addition to "standard treatment," which included treatment with antipsychotic medications. The other group received standard treatment alone. CBT has been shown to be effective in a variety of psychiatric illnesses. It uses pragmatic techniques to help a person correct inaccurate or dysfunctional thoughts and emotions by promoting critical comparison of those thoughts with observable facts. For example, if a person believes that he/she is "doing absolutely nothing," one CBT technique would be to encourage the person to keep a detailed diary of daily activities. The therapist would later review this diary with the patient and facts would be compared to perceptions. Homework assignments would include strategies to increase productive activities. In the study mentioned above, the researchers focused CBT "on identifying and promoting concrete goals for improving quality of life and

Brain-imaging studies have shown that music activates many diverse parts of the brain, including an overlap in where the brain processes music and language. Brains of people exposed to even casual musical training have an enhanced ability to generate the brain wave patterns associated with specific sounds, be they musical or spoken, said study leader Nina Kraus, director of the Auditory Neuroscience Laboratory at Northwestern University in Illinois. Musicians have subconsciously trained their brains to better recognize selective sound patterns, even as background noise goes up. In contrast, people with certain developmental disorders, such as dyslexia, have a harder time hearing sounds amid the din. Musical experience could therefore be a key therapy for children with dyslexia and similar language-related disorders. Harvard Medical School neuroscientist Gottfried Schlaug has found that stroke patients who have lost the ability to speak can be trained to say hundreds of phrases by singing them first. Schlaug demonstrated the results of intensive musical therapy on patients with lesions on the left sides of their brains, those areas most associated with language. Before the therapy, these stroke patients responded to questions with largely incoherent sounds and phrases. But after just a few minutes with therapists, who asked them to sing phrases and tap their hands to the rhythm, the patients could sing "Happy Birthday," recite their addresses, and communicate if they were thirsty. "The underdeveloped systems on the right side of the brain that respond to music became enhanced and changed structures," Schlaug said at the press briefing.

This article talks about the complexities of language in dementia patients, specifically the fact that they are most likely to revert to their primary language as their condition progresses. The study that was done for this article also expands on the possibility that speaking two or more languages can delay the onset of dementia for an average of five years.

An article about researchers recording results after a patient regained his sight after being blind his whole life and how he reacts to the "new world"

An article about researchers recording results after a patient regained his sight after being blind his whole life and how he reacts to the "new world"

Doctors at Beth Israel Deaconess Medical Center in Boston, Massachusetts, are treating stroke patients who have little or no spontaneous speech by associating melodies with words and phrases. "Music, and music-making, is really a very special form of a tool or an intervention that can be used to treat neurological disorders, said Dr. Gottfried Schlaug, associate professor of neurology at Beth Israel and Harvard University.

According to research led by V. S. Ramachandran, director of the Center for Brain and Cognition at the University of California, San Diego, a region of the brain known as the angular gyrus is probably at least partly responsible for the human ability to understand metaphor. Ramachandran and colleagues tested four right-handed patients with damage to the left angular gyrus. Fluent in English and otherwise intelligent and mentally lucid, the patients showed gross deficits in comprehending such common proverbs as "the grass is always greener on the other side" and "an empty vessel makes more noise." Asked to explain the sayings, the patients tended give responses that were literal. The metaphorical meaning escaped them almost entirely.

The largest study so far to ask whether speaking two languages might delay the onset of dementia symptoms in bilingual patients as compared to monolingual patients has reported a robust result. Bilingual patients suffer dementia onset an average of 4.5 years later than those who speak only a single language.

Stephen Wilson, an associate professor in the University of Arizona's Department of Speech, Language, and Hearing Sciences, studied the upper and lower white-matter connecting pathways between Broca's region and Wernicke's region: the two areas of the brain that are hubs for language processing. Brain imaging and language tests were used to examine patients suffering from language impairments caused by neurodegeneration. Wilson discovered the pathways have distinct functions. Damage to the lower pathway affects lexicon and semantics: "You forget the name of things, you forget the meaning of words. But surprisingly, you're extremely good at constructing sentences." Conversely, damage to the upper pathway creates problems in syntactic processing and figuring out the relationship between words in a sentence.

Language isn't found in just one part of the brain but rather in separate individual parts that are responsible for different aspects of language. Neurodegentive diseases that target specific areas of the brain affecting language, only have a partial effect on the patients ability to understand and communicate.

An interesting story--my students, you might recall Sheryl Turkle of MIT referencing robot therapists in her TED talk. USC has developed a robot therapist, Ellie, designed to talk to people who are struggling emotionally, and to take their measure in a way no human can. Originally developed to work with military PTSD patients, Ellie's purpose: to gather information and provide real human therapists detailed analysis of patients' movements and vocal features, in order to give new insights into people struggling with emotional issues. The body, face and voice express things that words sometimes obscure. Ellie's makers believe that her ability to do this will ultimately revolutionize American mental health care.

"Researchers have demonstrated a striking method to reconstruct words, based on the brain waves of patients thinking of those words. ... In a 2011 study, participants with electrodes in direct brain contact were able to move a cursor on a screen by simply thinking of vowel sounds. ... With the help of that model, when patients were presented with words to think about, the team was able to guess which word the participants had chosen. They were even able to reconstruct some of the words, turning the brain waves they saw back into sound on the basis of what the computer model suggested those waves meant. ... The authors caution that the thought-translation idea is still to be vastly improved before such prosthetics become a reality." Full study: http://www.plosbiology.org/article/info%3Adoi%2F10.1371%2Fjournal.pbio.1001251

Study examined the medical records of 648 Alzheimer's patients in Hyderabad and found that bilinguals developed dementia four to five years later than monolinguals. 

"What you're seeing here is, we've selected the pathways in the brain of a chronic pain patient. This may shock you, but we're literally reading this person's brain in real time. They're watching their own brain activation, and they're controlling the pathway that produces their pain."

Why does psychotherapy favorably compare to medication in treating depression? One reason may be rooted in the evolutionary origins of depression. Scholars suggest humans may become depressed to help us focus attention on a problem that might cause someone to fall out of step with family, friends, clan or the larger society-an outcast status that, especially in Paleolithic times, would have meant an all-but-certain tragic fate. Depression, by this account, came about as a mood state to make us think long and hard about behaviors that may have caused us to become despondent because some issue in our lives is socially problematic. Steven D. Hollon, a professor of psychology at Vanderbilt University, explores the implications of helping a patient come to grips with the underlying causes of a depression-which is the goal of CBT (cognitive behavioral therapy), and is also in line with an evolutionary explanation. The anodyne effects of an antidepressant, by contrast, may divert a patient from engaging in the reflective process for which depression evolved-a reason perhaps that psychotherapy appears to produce a more enduring effect than antidepressants. Hollon notes that depression has a purpose--it spurs rumination about complex social problems, and that CBT can expedite rumination and make it more effective. He states, "For most people, depression motivates them to think more deliberately about the causes of their problems and the solutions they can apply. In most instances in our ancestral past this worked well enough; most depressions remit spontaneously even in the absence of treatment. Cognitive therapy, at the least, hurries the process along and, at the most, helps unstick that subset of individuals who get stuck making negative ascriptions about themselves, typically about personal competence or lovability."

Over the years, we have found that our words come from different parts of the brain. In addition the part of the brain which we use to formulate thoughts into sentences, we also use the part of the brain that deals with emotion when we swear. Researchers discovered that patients with neurodegenerative diseases like a stroke, were still able to swear. Studying patients with Tourette syndrome have also proved that swearing uses many areas of the brain. Since swearing involves the emotional part of the brain, we know that profanity is used to express intense emotions.

Regular speech is generated in the left hemisphere, in an area of the brain close to the surface. The cerebral cortex, or "gray matter," is often associated with higher thought processes such as thought and action. "It's sophisticated," says Bergen, "and comports with the idea of what it means to be human." Swearing, on the other hand, is generated much deeper in the brain, in regions that are older and more primitive in evolutionary terms, says Bergen. These regions are often found in the right hemisphere in the brain's emotional center, the limbic system."These are words that express intense emotions-surprise, frustration, anger, happiness, fear," says psychologist and linguist Timothy Jay, who began studying profanity more than 40 years ago."[Swearing] serves my need to vent, and it conveys my emotions to other people very effectively and symbolically," he says. "Where other animals like to bite and scratch each other, I can say 'f*ck you' and you get my contempt-I don't have to do it physically." Profanity serves other purposes, too. Lovers use it as part of enticing sex talk; athletes and soldiers use it to forge camaraderie; and people in positions of power use it to reaffirm their superiority. Profanity is even used as a celebratory expression, says Adams, citing "F*ck yeah!" as an example. The meaning of a profanity, like any other word, changes with time, culture and context. While swear words have been around since Greek and Roman times, and maybe even earlier, the types of things people consider offensive have changed. "People of the Middle Ages had no problems talking about sex or excrement, that was not their hang-up," Adams explains. "Their hang-up was talking about God disrespectfully...so that was what a profanity was."

The left hemisphere of the brain is responsible for emotions like happiness, sadness, and anger. The part of the brain that we use to formulate thoughts into sentences is that part that we also use to deal with emotion when we swear. Different studies done on people found with brain issues/diseases allowed researchers to understand that profanity is used to express the extreme emotions.

A South African scientist who was pregnant wanted to document what sounds actually reached the fetus during pregnancy. She designed a waterproof microphone that was put inside next to the fetus' neck. Outside music was recorded by the microphone proving that music can be heard in the womb. Music also stimulates the brain more than anything else scientist have tested and has been used in some cases to coax parts of the brain to take over the job of other, dead parts of the brain in stroke patients

Register--the degree of formality employed in language--is dependent on audience, topic, purpose and location. A successful language user should be able to employ the correct register for particular audiences and purposes. There are five types: 1. Frozen/Static Register: This register rarely or never changes. Examples of frozen register include the Pledge of Allegiance or the Preamble to the Constitution. 2. Formal/Academic Register: This register includes academic language from speeches, proclamations and formal announcements. 3. Consultative Register: This register is formal and acceptable speech often used in professional settings. Some examples of this register include discourse between teachers and students, judges and lawyers, doctors and patients, and between a superior and a subordinate. 4. Casual Register: This register is used among friends and peers, and includes informal language including slang and colloquialisms. Casual register is often used among friends, teammates, etc. 5. Intimate Register: This register is reserved for close family members such as parents and children and siblings, or intimate people such as spouses.

Theoretical physicist and cosmologist Stephen Hawking, ALS patient, uses an Intel microprocessor which enables him to speak. Hawking irreversibly lost speech function in 1985 as a result of a tracheotomy. Since his hands are too weak to type, Hawking uses a single cheek muscle to control the device. The device uses an adaptive word predictor from London startup SwiftKey which allows Hawking to select a word after typing a letter. Intel worked with SwiftKey, incorporating many of Hawking's documents into the system, so that, in some cases, he no longer needs to type a character before the predictor guesses the word based on context. The new version of Hawking's user interface (now called ACAT, after Assistive Contextually Aware Toolkit) includes contextual menus that provide Hawking with various shortcuts to speak, search or email; and a new lecture manager, which gives him control over the timing of his delivery during talks. It also has a mute button, a curious feature that allows Hawking to turn off his speech synthesizer.

Excellent study. "While it has long been recognized that certain areas in the brain's left hemisphere enable us to understand and produce language, scientists are still figuring out exactly how those areas divvy up the highly complex processes necessary to comprehend and produce language. ... Two brain areas called Broca's region and Wernicke's region serve as the main computing hubs underlying language processing, with dense bundles of nerve fibers linking the two ... Working with patients suffering from language impairments because of a variety of neurodegenerative diseases, Wilsons' team used brain imaging and language tests to disentangle the roles played by the two pathways. ... The study marks the first time it has been shown that upper and lower tracts play distinct functional roles in language processing."

While the left hemisphere of the brain is where the processing and understanding of language is, different sections of the brain control different parts of language. Two separate areas of the brain control the ability to remember and understand specific words, and the other controls how we construct sentences and make sense of them. If one of these sections is damaged, the other can still work properly, so it is possible to be able to remember words and what they mean but not know how to create sentences.