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Matti Narkia

Reducing the Burden of Disease Through Adequate Intake of Vitamin D3 by William B. Gran... - 1 views

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    Reducing the Burden of Disease Through Adequate Intake of Vitamin D3.
    A presentation at University of California, San Diego,
    April 9, 2008
    by William B. Grant, Ph.D
Matti Narkia

The Vitamin D-Antimicrobial Peptide Pathway and Its Role in Protection Against Infectio... - 0 views

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    The vitamin D-antimicrobial peptide pathway and its role in protection against infection.
    Gombart AF.
    Future Microbiol. 2009 Nov;4:1151-65.
    PMID: 19895218

    Vitamin D deficiency has been correlated with increased rates of infection. Since the early 19th century, both environmental (i.e., sunlight) and dietary sources (cod liver) of vitamin D have been identified as treatments for TB. The recent discovery that vitamin D induces antimicrobial peptide gene expression explains, in part, the 'antibiotic' effect of vitamin D and has greatly renewed interest in the ability of vitamin D to improve immune function. Subsequent work indicates that this regulation is biologically important for the response of the innate immune system to wounds and infection and that deficiency may lead to suboptimal responses toward bacterial and viral infections. The regulation of the cathelicidin antimicrobial peptide gene is a human/primate-specific adaptation and is not conserved in other mammals. The capacity of the vitamin D receptor to act as a high-affinity receptor for vitamin D and a low-affinity receptor for secondary bile acids and potentially other novel nutritional compounds suggests that the evolutionary selection to place the cathelicidin gene under control of the vitamin D receptor allows for its regulation under both endocrine and xenobiotic response systems. Future studies in both humans and humanized mouse models will elucidate the importance of this regulation and lead to the development of potential therapeutic applications
Matti Narkia

Vitamin D can save half million babies each year: study - foodconsumer.org - 0 views

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    "Friday Oct 16, 2009 (foodconsumer.org) -- Results of a new trial presented at an international research conference in Bruges suggest that vitamin D supplementation can reduce the risk of premature births and boost the health of newborn babies, the Times reported Oct 10.

    Vitamin D deficiency, which is common everywhere, has been linked in many previous studies to a variety of illnesses from heart disease, cancers, multiple sclerosis
    and many others.

    In the trial, Dr. Bruce Hollis and Dr. Carol Wagner of the Medical University of South Carolina, Charleston, gave one group of pregnant women 4,000 IUs per day of vitamin D at about three months of pregnancy. They gave a second group 400 IUs per day, amounts recommended by U.S. and UK"
Matti Narkia

Cathelicidin - Wikipedia, the free encyclopedia - 0 views

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    "Cathelicidin antimicrobial peptide is a family of polypeptides found in lysosomes in polymorphonuclear leukocytes (PMNs).[1]

    Members of the cathelicidin family of antimicrobial polypeptides are characterized by a highly conserved region (cathelin domain) and a highly variable cathelicidin peptide domain. Cathelicidin peptides have been isolated from many different species of mammals. Cathelicidins were originally found in neutrophils but have since been found in many other cells including epithelial cells and macrophages activated by bacteria, viruses, fungi, or the hormone 1,25-D"
Matti Narkia

The vitamin D-antimicrobial peptide pathway and its role in protection against infectio... - 0 views

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    The vitamin D-antimicrobial peptide pathway and its role in protection against infection.
    Gombart AF.
    Future Microbiol. 2009 Nov;4:1151-65.
    PMID: 19895218
    doi:10.2217/fmb.09.87
Matti Narkia

More Good News About Vitamin D | Print Article | Newsweek.com - 0 views

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    "For more than 80 years, scientists have known that vitamin D is important for building bones. And for most of those 80 years, people thought this was the only thing it was good for. In the past decade, however, we've learned two important things about vitamin D: it appears to have many other important health effects, and many Americans don't get enough of it. In 2008, new research pointed to a vitamin D deficiency as a possible contributing factor in heart disease. And the suspected link between vitamin D deficiency and cancer grew even stronger. This surely will spur much new research in 2009.

    Why is vitamin D deficiency so common? The vitamin is made in our skin when sunlight strikes it. Many Americans-especially those who live in the northern part of the country, are elderly or have dark skin-don't soak up enough sun. And the vitamin isn't found in many foods. The main sources are fatty fish (such as salmon, mackerel, herring and sardines) and milk, cereal and juices that have been fortified with it. Vitamin D deficiency often is unsuspected because it causes no direct symptoms; like high blood pressure, it does its damage silently."
Matti Narkia

Association Between Serum 25-Hydroxyvitamin D Level and Upper Respiratory Tract Infecti... - 0 views

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    Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey.
    Ginde AA, Mansbach JM, Camargo CA Jr.
    Arch Intern Med. 2009 Feb 23;169(4):384-90.
    PMID: 19237723

    Conclusions Serum 25(OH)D levels are inversely associated with recent URTI. This association may be stronger in those with respiratory tract diseases. Randomized controlled trials are warranted to explore the effects of vitamin D supplementation on RTI.
Matti Narkia

Cod liver oil, vitamin A toxicity, frequent respiratory infections, and the vitamin D d... - 0 views

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    Cod liver oil, vitamin A toxicity, frequent respiratory infections, and the vitamin D deficiency epidemic.
    Cannell JJ, Vieth R, Willett W, Zasloff M, Hathcock JN, White JH, Tanumihardjo SA, Larson-Meyer DE, Bischoff-Ferrari HA, Lamberg-Allardt CJ, Lappe JM, Norman AW, Zittermann A, Whiting SJ, Grant WB, Hollis BW, Giovannucci E.
    Ann Otol Rhinol Laryngol. 2008 Nov;117(11):864-70. Review.
    PMID: 19102134

    Until we have better information on doses of vitamin D that will reliably provide adequate blood levels of
    25(OH)D without toxicity, treatment of vitamin D deficiency in otherwise healthy children should be individualized
    according to the numerous factors that affect 25(OH)D levels, such as body weight, percent body fat,
    skin melanin, latitude, season of the year, and sun exposure.2 The doses of sunshine or oral vitamin D3 used
    in healthy children should be designed to maintain 25(OH)D levels above 50 ng/mL. As a rule, in the absence
    of significant sun exposure, we believe that most healthy children need about 1,000 IU of vitamin D3 daily
    per 11 kg (25 lb) of body weight to obtain levels greater than 50 ng/mL. Some will need more, and others less.
    In our opinion, children with chronic illnesses such as autism, diabetes, and/or frequent infections should be
    supplemented with higher doses of sunshine or vitamin D3, doses adequate to maintain their 25(OH)D levels
    in the mid-normal of the reference range (65 ng/mL) - and should be so supplemented year round. Otolaryngologists
    treating children are in a good position to both diagnose and treat vitamin D deficiency.
Matti Narkia

Oral vitamin D may help prevent some skin infections - 0 views

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    October 6th, 2008

    A study led by researchers at the University of California, San Diego School of Medicine suggests that use of oral Vitamin D supplements bolsters production of a protective chemical normally found in the skin, and may help prevent skin infections that are a common result of atopic dermatitis, the most common form of eczema.
Matti Narkia

Vitamin D, respiratory infections, and asthma. [Curr Allergy Asthma Rep. 2009] - PubMed... - 0 views

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    Vitamin D, respiratory infections, and asthma.
    Ginde AA, Mansbach JM, Camargo CA Jr.
    Curr Allergy Asthma Rep. 2009 Jan;9(1):81-7. Review.
    PMID: 19063829
Matti Narkia

Animal Pharm: Hearts of Stone, Arteries of Glass - 0 views

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    A recent Wall Street Journal article "Defending Against Disease -- With Vitamin D New Studies Suggest It Isn't Just Bones That Might Benefit" by the wonderful Melinda Beck highlights benefits of Vitamin D3. In TYP, we've known the benefits for years :) but it's nice to see the rest of the world catching up.

    The benefits of Vitamin D3 are potent, powerful immunomodulation -- to the point where autoimmune diseases, viral and bacterial infections and cancer are effectively reduced. What is the value for heart disease and diabetes prevention? In hemodialysis patients, great lessons are can be learned. Nephrologists often describe patients with severe (stage 5) chronic kidney disease (CKD) patients on hemodialysis as having 'hearts of stone, blood vessels of glass.' Unfortunately over 70% of chronic hemodialysis patients have coronary artery disease (and Lp(a)). What medical science shows is that Agatston coronary calcification scores can be dramatically reduced when vitamin D is replenished and calcium is restricted. Sevelamer (Renagel) is a calcium-free, metal-free polymer phosphate binder. In 52-weeks, calcium restriction, a phosphate-binder and vitamin D resulted in one individual in a 21% reduction in Agatston CAC score (from 968 to 756; see Figure 2).
Matti Narkia

Vitamin D supplementation to prevent infections: a sub-study of a randomised placebo-co... - 0 views

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    Vitamin D supplementation to prevent infections: a sub-study of a randomised placebo-controlled trial in older people (RECORD trial, ISRCTN 51647438).\nAvenell A, Cook JA, Maclennan GS, Macpherson GC.\nAge Ageing. 2007 Sep;36(5):574-7. Epub 2007 Aug 15. No abstract available.\nPMID: 17702768 \ndoi:10.1093/ageing/afm091
Matti Narkia

Vitamin D signaling, infectious diseases, and regulation of innate immunity. - Infect I... - 0 views

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    Vitamin D signaling, infectious diseases, and regulation of innate immunity.
    White JH.
    Infect Immun. 2008 Sep;76(9):3837-43. Epub 2008 May 27. Review.
    PMID: 18505808
    doi:10.1128/IAI.00353-08
Matti Narkia

Four times current vitamin D doses needed for winter levels: Study - 0 views

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    Maintaining adequate levels of vitamin D during winter months requires a daily dose of 20 micrograms, four times the current recommended dose, says a new study.
    The study, led by Susan Sullivan from the University of Maine, has important implications for ongoing consultations on vitamin D recommendations, with the current level of five micrograms (200 International Units) seen by many as insufficient.
Matti Narkia

One dose of vitamin D boosts TB immunity - New Zealand's source for health news on Stuf... - 0 views

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    In healthy people who have been exposed to tuberculosis, a single oral dose of vitamin D enhances their immunity against this bacterial infection.
Matti Narkia

A Single Dose of Vitamin D Enhances Immunity to Mycobacteria -- Martineau et al. 176 (2... - 0 views

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    Martineau AR, Wilkinson RJ, Wilkinson KA, Newton SM, Kampmann B, Hall BM, Packe GE, Davidson RN, Eldridge SM, Maunsell ZJ, Rainbow SJ, Berry JL, Griffiths CJ.
    A single dose of vitamin D enhances immunity to mycobacteria.
    Am J Respir Crit Care Med. 2007
Matti Narkia

Cutting Edge: Vitamin D-Mediated Human Antimicrobial Activity against Mycobacterium tub... - 0 views

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    Liu PT, Stenger S, Tang DH, Modlin RL.
    Cutting Edge: Vitamin D-Mediated Human Antimicrobial Activity against Mycobacterium tuberculosis Is Dependent on the Induction of Cathelicidin.
    J Immunol. 2007 Aug 15;179(4):2060-3.
    PMID: 17675463 [PubMed - in pr
Matti Narkia

What is new in vitamin D: 2006-2007. - Current Opinion in Rheumatology - Abstract: Volu... - 0 views

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    Bikle DD.
    What is new in vitamin D: 2006-2007.
    Curr Opin Rheumatol. 2007 Jul;19(4):383-8.
    PMID: 17551371 [PubMed - in process]
Matti Narkia

Vitamin D in the treatment of pulmonary tuberculosis...[J Steroid Biochem Mol Biol. 200... - 0 views

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    Martineau AR, Honecker FU, Wilkinson RJ, Griffiths CJ.
    Vitamin D in the treatment of pulmonary tuberculosis.
    J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):793-8. Epub 2007 Jan 12. Review.
    PMID: 17223549 [PubMed - indexed for MEDLINE]
Matti Narkia

The Heart Scan Blog: Unique vitamin D observations - 0 views

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    It seems not a single day passes that I don't learn something new about this unique hormone (mis)named "vitamin D." \nFrom its humble beginnings recognized only as the factor responsible for bone maturation (with deficiency leading to childhood rickets), vitamin D now commands a recognized role in almost every conceivable aspect of health and disease. \n
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