Skip to main content

Home/ Vitamin D/ Group items tagged bacterial

Rss Feed Group items tagged

Matti Narkia

Maternal Vitamin D Deficiency Is Associated with Bacterial Vaginosis in the First Trime... - 0 views

  •  
    Vitamin D deficiency is associated with BV and may contribute to the strong racial disparity in the prevalence of BV. Maternal vitamin D deficiency is associated with bacterial vaginosis in the first trimester of pregnancy. Bodnar LM, Krohn MA, Simhan HN. J Nutr. 2009 Jun;139(6):1157-61. Epub 2009 Apr 8. PMID: 19357214 doi:10.3945/jn.108.103168
Matti Narkia

One dose of vitamin D boosts TB immunity - New Zealand's source for health news on Stuf... - 0 views

  •  
    In healthy people who have been exposed to tuberculosis, a single oral dose of vitamin D enhances their immunity against this bacterial infection.
Matti Narkia

JNNP -- eLetters for Soilu-Hänninen et al., 79 (2) 152-157 - 0 views

  •  
    Vitamin D may suppress infections which lead to development of Multiple Sclerosis Steven R Brenner, None (16 August 2007) J Neurol Neurosurg Psychiatry 2008 I read the article with reference to the inverse relationship between multiple sclerosis clinical activity and deficiency of vitamin D by Soilu-Hannienen (1) with interest, and was considering what mechanism could be in play to cause such a relationship. 25-hydroxylated metabolites of vitamin D act as intracellular regulators of the synthesis and action of defensin (2) molecules against bacterial antigens, defensin being an endogenously synthesized antimicrobial substance (2). Human cathelicidin antimicrobial peptide gene is a target of vitamin D receptor and is strongly up-regulated by 1,25-dihydroxyvitamin D3, indicating vitamin D receptor and the 1,25-dihydroxyvitaminD3 regulate primate innate immunity (3)
Matti Narkia

Animal Pharm: Hearts of Stone, Arteries of Glass - 0 views

  •  
    A recent Wall Street Journal article "Defending Against Disease -- With Vitamin D New Studies Suggest It Isn't Just Bones That Might Benefit" by the wonderful Melinda Beck highlights benefits of Vitamin D3. In TYP, we've known the benefits for years :) but it's nice to see the rest of the world catching up. The benefits of Vitamin D3 are potent, powerful immunomodulation -- to the point where autoimmune diseases, viral and bacterial infections and cancer are effectively reduced. What is the value for heart disease and diabetes prevention? In hemodialysis patients, great lessons are can be learned. Nephrologists often describe patients with severe (stage 5) chronic kidney disease (CKD) patients on hemodialysis as having 'hearts of stone, blood vessels of glass.' Unfortunately over 70% of chronic hemodialysis patients have coronary artery disease (and Lp(a)). What medical science shows is that Agatston coronary calcification scores can be dramatically reduced when vitamin D is replenished and calcium is restricted. Sevelamer (Renagel) is a calcium-free, metal-free polymer phosphate binder. In 52-weeks, calcium restriction, a phosphate-binder and vitamin D resulted in one individual in a 21% reduction in Agatston CAC score (from 968 to 756; see Figure 2).
Matti Narkia

Vitamin D: the alternative hypothesis. - Autoimmun Rev. 2009 Jul;8(8):639-44. (full tex... - 0 views

  •  
    Vitamin D: the alternative hypothesis. Albert PJ, Proal AD, Marshall TG. Autoimmun Rev. 2009 Jul;8(8):639-44. Epub 2009 Feb 12. Review. PMID: 19393200 Emerging molecular evidence suggests that symptomatic improvements among those administered vitamin D is the result of 25-D's ability to temper bacterial-induced inflammation by slowing VDR activity. While this results in short-term palliation, persistent pathogens that may influence disease progression, proliferate over the long-term.
Matti Narkia

The Vitamin D-Antimicrobial Peptide Pathway and Its Role in Protection Against Infectio... - 0 views

  •  
    The vitamin D-antimicrobial peptide pathway and its role in protection against infection. Gombart AF. Future Microbiol. 2009 Nov;4:1151-65. PMID: 19895218 Vitamin D deficiency has been correlated with increased rates of infection. Since the early 19th century, both environmental (i.e., sunlight) and dietary sources (cod liver) of vitamin D have been identified as treatments for TB. The recent discovery that vitamin D induces antimicrobial peptide gene expression explains, in part, the 'antibiotic' effect of vitamin D and has greatly renewed interest in the ability of vitamin D to improve immune function. Subsequent work indicates that this regulation is biologically important for the response of the innate immune system to wounds and infection and that deficiency may lead to suboptimal responses toward bacterial and viral infections. The regulation of the cathelicidin antimicrobial peptide gene is a human/primate-specific adaptation and is not conserved in other mammals. The capacity of the vitamin D receptor to act as a high-affinity receptor for vitamin D and a low-affinity receptor for secondary bile acids and potentially other novel nutritional compounds suggests that the evolutionary selection to place the cathelicidin gene under control of the vitamin D receptor allows for its regulation under both endocrine and xenobiotic response systems. Future studies in both humans and humanized mouse models will elucidate the importance of this regulation and lead to the development of potential therapeutic applications
Matti Narkia

Take or avoid vitamin D supplements? - ImmInst.org Forums - 0 views

  •  
    My plans to take vitamin D seemed well funded (lots of positive research these days about high vitamin D levels) and then I stumbled upon this article that promotes the views of Trevor Marshall. "The Truth About Vitamin D: Fourteen Reasons Why Misunderstanding Endures", by Amy Proal (a biologist), 15/09/2007 http://bacteriality.com/2007/09/15/vitamind/
Matti Narkia

Voices of reason in the vitamin D debate - 0 views

  •  
    "Maybe vitamin D isn't the answer after all. Not only does the above statement ring true, it's also the title of a recent post on "Dr. Len's Cancer Blog" - a website written by Dr. Len Lichtenfeld, Deputy Chief Medical Officer for the national office of the American Cancer Society, in order to facilitate communication with the public on important issues related to cancer. "
Matti Narkia

Vitamin D Deficiency Lead to Disease - Dr. Weil's Weekly Bulletin - 0 views

  •  
    "If you're running low on vitamin D - as an estimated 70 percent of the U.S. population is - your immune system may not be functioning as well as it should. As a result, you may be more vulnerable to infectious diseases than you would if your vitamin D levels were optimal. Worse, you could be at higher than normal risk of a long list of diseases including heart disease and several kinds of cancer. A report recently published journal, Future Microbiology, highlighted research at the Linus Pauling Institute at Oregon State University, which has shown that vitamin D induces expression of an antimicrobial peptide gene called cathelicidin that is the "first line of defense" in the immune system's response to minor wounds, cuts and bacterial and viral infections. The regulation of cathelicidin by vitamin D could help explain its vital role in immune function. The report noted that vitamin D is a key cofactor in reducing inflammation, in blood pressure control and helping to protect against heart disease. Author Adrian Gombart explains that there is still much to explore about D's mechanisms of action, the potential use of synthetic analogs of it in new treatments, and its duty in fighting infection."
Matti Narkia

Second-guessing the consensus on vitamin D - 0 views

  •  
    This article discusses our experience at the one-day Institute of Medicine workshop on vitamin D and calcium. Both of us had an opportunity to make comments before the committee. Here are Paul's comments and slides and here are Amy's comments and slides. Note that our 2009 paper in Autoimmunity Reviews[1] discusses some of the science we allude to in further detail.
Matti Narkia

A Single Dose of Vitamin D Enhances Immunity to Mycobacteria -- Martineau et al. 176 (2... - 0 views

  •  
    Martineau AR, Wilkinson RJ, Wilkinson KA, Newton SM, Kampmann B, Hall BM, Packe GE, Davidson RN, Eldridge SM, Maunsell ZJ, Rainbow SJ, Berry JL, Griffiths CJ. A single dose of vitamin D enhances immunity to mycobacteria. Am J Respir Crit Care Med. 2007
Matti Narkia

Cutting Edge: Vitamin D-Mediated Human Antimicrobial Activity against Mycobacterium tub... - 0 views

  •  
    Liu PT, Stenger S, Tang DH, Modlin RL. Cutting Edge: Vitamin D-Mediated Human Antimicrobial Activity against Mycobacterium tuberculosis Is Dependent on the Induction of Cathelicidin. J Immunol. 2007 Aug 15;179(4):2060-3. PMID: 17675463 [PubMed - in pr
Matti Narkia

What is new in vitamin D: 2006-2007. - Current Opinion in Rheumatology - Abstract: Volu... - 0 views

  •  
    Bikle DD. What is new in vitamin D: 2006-2007. Curr Opin Rheumatol. 2007 Jul;19(4):383-8. PMID: 17551371 [PubMed - in process]
Matti Narkia

Vitamin D in the treatment of pulmonary tuberculosis...[J Steroid Biochem Mol Biol. 200... - 0 views

  •  
    Martineau AR, Honecker FU, Wilkinson RJ, Griffiths CJ. Vitamin D in the treatment of pulmonary tuberculosis. J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):793-8. Epub 2007 Jan 12. Review. PMID: 17223549 [PubMed - indexed for MEDLINE]
Matti Narkia

The Truth About Vitamin D: Fourteen Reasons Why Misunderstanding Endures - 0 views

  •  
    The Truth About Vitamin D: Fourteen Reasons Why Misunderstanding Endures Author: Amy Proal
1 - 15 of 15
Showing 20 items per page