Teenage girls and elderly women living in northern Europe have low winter vitamin D status.
Andersen R, Mølgaard C, Skovgaard LT, Brot C, Cashman KD, Chabros E, Charzewska J, Flynn A, Jakobsen J, Kärkkäinen M, Kiely M, Lamberg-Allardt C, Moreiras O, Natri AM, O'brien M, Rogalska-Niedzwiedz M, Ovesen L.
Eur J Clin Nutr. 2005 Apr;59(4):533-41.
PMID: 15714215
doi:10.1038/sj.ejcn.1602108
CONCLUSION: Vitamin D status is low in northern Europe during winter. More than one-third of the adolescent girls have vitamin D status below 25 nmol/l and almost all are below 50 nmol/l. Two-thirds of the elderly community-dwelling women have vitamin D status below 50 nmol/l. Use of vitamin D supplements is a significant positive determinant for S-25OHD for both girls and women (P = 0.001). SPONSORSHIP: The European Fifth Framework Programme (Contract No. QLK1-CT-2000-00623)
25-Hydroxyvitamin D levels in serum at the onset of multiple sclerosis.
Soilu-Hänninen M, Airas L, Mononen I, Heikkilä A, Viljanen M, Hänninen A.
Mult Scler. 2005 Jun;11(3):266-71.
PMID: 15957505
DOI: 10.1191/1352458505ms1157oa
Relationship between serum 25-hydroxyvitamin d and pulmonary function in the third national health and nutrition examination survey.
Black PN, Scragg R.
Chest. 2005 Dec;128(6):3792-8.
PMID: 16354847
Using these functional indicators, several studies have more accurately defined vitamin D deficiency as circulating levels of 25(OH)D ≤ 80 nmol or 32 µg/L. Recent studies reveal that current dietary recommendations for adults are not sufficient to maintain circulating 25(OH)D levels at or above this level, especially in pregnancy and lactation.
Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D.
Hollis BW.
J Nutr. 2005 Feb;135(2):317-22. Review.
PMID: 15671234 [
Vitamin D is associated with improved survival in early-stage non-small cell lung cancer patients.
Zhou W, Suk R, Liu G, Park S, Neuberg DS, Wain JC, Lynch TJ, Giovannucci E, Christiani DC.
Cancer Epidemiol Biomarkers Prev. 2005 Oct;14(10):2303-9.
PMID: 16214909
In conclusion, the joint effects of surgery season and recent vitamin D intake seem to be associated with the survival of early-stage non-small cell lung cancer patients.
Effects of calcium, dairy product, and vitamin D supplementation on bone mass accrual and body composition in 10-12-y-old girls: a 2-y randomized trial.
Cheng S, Lyytikäinen A, Kröger H, Lamberg-Allardt C, Alén M, Koistinen A, Wang QJ, Suuriniemi M, Suominen H, Mahonen A, Nicholson PH, Ivaska KK, Korpela R, Ohlsson C, Väänänen KH, Tylavsky F.
Am J Clin Nutr. 2005 Nov;82(5):1115-26; quiz 1147-8.
PMID: 16280447
25(OH)D Serum levels decline with age earlier in women than in men and less efficiently prevent compensatory hyperparathyroidism in older adults.
Maggio D, Cherubini A, Lauretani F, Russo RC, Bartali B, Pierandrei M, Ruggiero C, Macchiarulo MC, Giorgino R, Minisola S, Ferrucci L.
J Gerontol A Biol Sci Med Sci. 2005 Nov;60(11):1414-9.
PMID: 16339327
Conclusions. These findings suggest that the age-associated fall of serum 25(OH)D starts earlier in women than in men and that higher levels of 25(OH)D are required in older compared to younger persons to avoid the age-associated compensatory hyperparathyroidism.
Acute vitamin D intoxication in a child.
Barrueto F Jr, Wang-Flores HH, Howland MA, Hoffman RS, Nelson LS.
Pediatrics. 2005 Sep;116(3):e453-6.
PMID: 16140692
EPIDEMICS' TIMING DETERMINED BY LATITUDEGoing back to 1945, Hope-Simpson discovered that influenza epidemics above 30 degrees latitude in both hemispheres occurred during the six months of least solar radiation and that outbreaks in the tropics almost always occured during the rainy season. He thus concluded, "Latitude alone broadly determines the timing of the epidemics in the annual cycle, a relationship that suggests a rather direct effect of some component of solar radiation acting positively or negatively upon the virus, the human host, or their interaction." That is, something may be regularly reducing our immunity every fall and winter. In 2003 researchers confirmed that influenza epidemics in the tropics occur, with few exceptions, during the rainy season, when vitamin D levels should be falling
A Lecture by Reinhold Vieth, Professor, Departments of Nutritional Sciences and Laboratory Medicine and Pathobiology, Mount Sinai Hospital.
Presentation Date: Friday, October 21, 2005
(works in Internet Explorer, but not properly in Firefox (slides don't change in Firefox)).
Pilot study: potential role of vitamin D (Cholecalciferol) in patients with PSA relapse after definitive therapy.
Woo TC, Choo R, Jamieson M, Chander S, Vieth R.
Nutr Cancer. 2005;51(1):32-6.
PMID: 15749627
The role of vitamin D in cancer prevention.
Garland CF, Garland FC, Gorham ED, Lipkin M, Newmark H, Mohr SB, Holick MF.
Am J Public Health. 2006 Feb;96(2):252-61. Epub 2005 Dec 27. Review.
PMID: 16380576
DOI: 10.2105/AJPH.2004.045260
Vitamin D status differs by latitude and race, with residents of the northeastern United States and individuals with more skin pigmentation being at increased risk of deficiency. A PubMed database search yielded 63 observational studies of vitamin D status in relation to cancer risk, including 30 of colon, 13 of breast, 26 of prostate, and 7 of ovarian cancer, and several that assessed the association of vitamin D receptor genotype with cancer risk.
The majority of studies found a protective relationship between sufficient vitamin D status and lower risk of cancer. The evidence suggests that efforts to improve vitamin D status, for example by vitamin D supplementation, could reduce cancer incidence and mortality at low cost, with few or no adverse effects
The role of vitamin D in cancer prevention.
Garland CF, Garland FC, Gorham ED, Lipkin M, Newmark H, Mohr SB, Holick MF.
Am J Public Health. 2006 Feb;96(2):252-61. Epub 2005 Dec 27. Review.
PMID: 16380576
DOI: 10.2105/AJPH.2004.045260
Vitamin D status differs by latitude and race, with residents of the northeastern United States and individuals with more skin pigmentation being at increased risk of deficiency. A PubMed database search yielded 63 observational studies of vitamin D status in relation to cancer risk, including 30 of colon, 13 of breast, 26 of prostate, and 7 of ovarian cancer, and several that assessed the association of vitamin D receptor genotype with cancer risk.
The majority of studies found a protective relationship between sufficient vitamin D status and lower risk of cancer. The evidence suggests that efforts to improve vitamin D status, for example by vitamin D supplementation, could reduce cancer incidence and mortality at low cost, with few or no adverse effects.
Upper levels of vitamin D intake were set at 50 microg/d (2000 IU/d) for all ages. Some individuals would require higher levels than these to achieve serum 25-hydroxyvitamin D concentrations for optimal calcium absorption. So much new information on vitamin D and health has been collected since the requirements were set in 1997 that this nutrient is likely the most in need of revised requirements.
Vitamin D requirements: current and future.
Weaver CM, Fleet JC.
Am J Clin Nutr. 2004 Dec;80(6 Suppl):1735S-9S. Review. Erratum in: Am J Clin Nutr. 2005 Mar;81(3):729.
PMID: 15585797
In the July 2005 FASEB Journal, Adrian F. Gombart of the University of California, Los Angeles (UCLA) and his colleagues reported that vitamin D boosts production in white blood cells of one of the antimicrobial compounds that defends the body against germs.\n\nImmediately, Cannell says, the proverbial lightbulb went on in his head: Maybe the high doses of vitamin D that he had been prescribing to virtually all the men on his ward had boosted their natural arsenal of the antimicrobial, called cathelicidin, and protected them from flu. Cannell had been administering the vitamin D because his patients, like many other people in the industrial world, had shown a deficiency:
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