Androgen deprivation promotes intratumoral synthesis of dihydrotestosterone from androgen metabolites in prostate cancer : Scientific Reports : Nature Publishing Group - 0 views
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PSA levels in media were increased by 3α-diol
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Similarly to 3α-diol, 3β-diol also increased PSA levels in media in a concentration-dependent manner
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intracellular DHT is synthesized from inactive androgen 3α- and 3β-diol via different pathways in prostate cancer cells
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DHT metabolites play an important role of intra-prostate DHT synthesis in those following ADT. This is a proposed mechanism for the failure rate and aggressive nature of prostate cancer that fails ADT. 3-alpha androstanediol is converted via 3 alpha HSD back to DHT. In contrast, 3-beta androstanediol cannot.