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Role of Polymorphic Human Cytochrome P450 Enzymes in Estrone Oxidation - 0 views

cebp.aacrjournals.org/...551.long estrogen metabolism estrogen metabolites cytochrome P450 estrogen estrone hormones detoxification metabolites
shared by Nathan Goodyear on 11 Sep 15 - No Cached
  • CYP1A1 and CYP1B1 are not expressed in any significant quantity in the liver. Therefore, they would not be expected to contribute to the overall systemic metabolism of estrone. However, both enzymes have been identified in breast tissue
  • CYP1A1 displayed relatively high activity for all three hydroxylations, suggesting that it may play an important role in extrahepatic tissues where it is expressed
  • CYP1A1 was more active with regard to 2-hydroxylation and 4-hydroxylation, it also displayed one of the greatest 16α-hydroxylating activities of the CYP enzymes tested.
  • ...4 more annotations...
  • CYP1B1 displayed a high affinity for estrone and preferentially catalyzed 4-hydroxylation over 2-hydroxylation
  • CYP1B1 did not seem to contribute to 16α-hydroxylation.
  • CYP1B1 was shown to preferentially catalyze 4-hydroxylation, whereas CYP1A1 was shown to preferentially catalyze 2-hydroxylation
  • Among the CYP enzymes expressed in the liver, CYP1A2 was the most active with regard to 2-hydroxylation
  • Nathan Goodyear on 11 Sep 15
     
    good discussion of estrogen metabolism and the P450 enzymes.
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Product Information > Lipstick and Lead: Questions and Answers - 0 views

www.fda.gov/...ucm137224.htm lead lipstick
shared by Nathan Goodyear on 19 Feb 11 - No Cached
  • FDA Analyses of Lead in Lipsticks
  • Nathan Goodyear on 19 Feb 11
     
    FDA finds lead in all lipsticks

Proven Very Effective Anti-Snoring Products - 1 views

started by Meredith Blige on 25 Oct 11 no follow-up yet
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Questions and answers on the role of faecal calprotectin as a biological marker in infl... - 0 views

www.sciencedirect.com/...S1590865808001916 Calprotectin inflammation IBD colorectal cancer infection disease
shared by Nathan Goodyear on 21 May 14 - No Cached
  • Nathan Goodyear on 21 May 14
     
    Calprotectin is a useful biomarker in IBD.  Colorectal cancer and GI infection can also increase fecal Calprotectin. 
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If offered a picture of an unknown woman in front of a man, and asked him if he liked it? - 0 views

www.weightloss24.tk/...arousal-vary-according-to.html hormones hormone Testosterone cancer men disease inflammation male obesity low weight loss Nutrition Beauty Fitness Health tips
shared by laabidi1987 on 28 Feb 15 - No Cached
  • laabidi1987 on 28 Feb 15
     
    His answer would be probably after a little thinking: "Yes" or "No", he will know the answer clearly and completely. But if our offer image unknown man and we raised the same question on the mirror, it will be assumed her answer: "I'm still not sure, it comes to how I would feel after in-depth knowledge and deal with it, and maybe then you will know." Difference in libido between the sexes! Differences in approach in the expression of feelings is not a coincidence, it is a clear and distinct. Is it possible that women are more reluctant than men? Or maybe the point of view based on the components did not know the men? Studies suggest that women need more information to see her passion and expression of feelings toward the man standing front of them, including. http://www.weightloss24.tk/2015/02/is-sexual-arousal-vary-according-to.html

Relieve your pain with TENs devices. Is it the best choice? - 0 views

started by mdcurebyaerotel on 29 Dec 15 no follow-up yet
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Update on Medical Practices That Should Be Questioned in 2015. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...26551354 evidence-based medicine medicine
shared by Nathan Goodyear on 24 Nov 15 - No Cached
  • Nathan Goodyear on 24 Nov 15
     
    Some of evidence-based medicine is found to be not so evidence-based.  Only abstract available.  
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Get Free Medicare Guide | Heaven Offers - 0 views

newheavenoffers.com/get-free-medicare-guide medicare guide guidelines advantage eligibility online apply for questions usa
shared by aileenoleary on 02 Sep 18 - No Cached
  • aileenoleary on 02 Sep 18
     
    This guide will help you construct a solid plan for understanding Medicare Navigating the World of Medicare can be tricky. This is why Medicare World's "2018 Guide To Medicare" is a must have for anyone with Medicare. In this guid we will breakdown the complexities of Medicare to help you make informed decisions.
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Treatment of Men for "Low Testosterone": A Systematic Review - 0 views

journals.plos.org/...article low t low Testosterone Testosterone Testosterone therapy
shared by Nathan Goodyear on 11 Jan 17 - No Cached
  • Of 47 studies that assessed sexual function or satisfaction, 23 studies reported beneficial effects of testosterone treatment for at least 1 measure of sexual function or satisfaction,[6, 26, 35, 37, 40, 43–60] and 24 studies did not show testosterone-associated improvements in any sexual function endpoint
  • Of 31 studies that evaluated erectile function, 15 found no improvement with testosterone therapy
  • Twelve studies included men with ED; 8 found no benefit of testosterone over placebo
  • ...2 more annotations...
  • Of 23 studies that specifically reported changes in libido, 13 found that testosterone treatment increased libido,[26, 35, 37, 45, 46, 54, 56, 60, 63, 65, 70, 77, 79] eight found no effect,
  • Eleven studies used the Aging Males’ Symptoms scale, which includes 3 questions on libido and sexual function. Five studies found no difference between testosterone and placebo on total scores,[26, 54, 57, 72, 76] and 4 studies found a benefit of testosterone
  • Nathan Goodyear on 11 Jan 17
     
    A systemic review of Testosterone benefit in men stirs the pot.  I can't say that I agree with the majority of their conclusions.  What I do agree with them on is that the majority of men on Testosterone therapy likely don't need it and are simply using Testosterone as a drug.
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