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there are many studies showing that consumption of fructose in comparison to other monosaccharides results in increased de novo lipogenesis, dyslipidemia, insulin resistance, BW6, 7 and, most recently, impaired cognitive function

in the present study, the intake of fructose by mice was more similar to that of typical human consumption in comparison to previous studies

prolonged consumption of diets containing fructose (11 weeks) increased BW and body fat deposition

studies in humans confirm that fructose, but not glucose (when provided as 25% of energy requirements), in the context of an energy-balanced diet increases de novo lipogenesis and visceral adiposity along with dyslipidemia, decreases insulin sensitivity10, 12 and decreases in fat oxidation

we hypothesize that fructose may reduce voluntary energy expenditure in terms of physical activity.

significant reduction (~20%) in physical activity in the fructose-fed animals in comparison to glucose

a recent study reported that ingestion of fructose (25% energy intake, 10 weeks) in human volunteers also resulted in reduced energy expenditure in relation to a diet with the same glucose dose

There is certainly evidence to suggest that, for example, exercise is able to prevent dyslipidemia in healthy subjects fed a weight-maintenance high-fructose diet (30%)54, which strongly suggests a protective role of physical activity in metabolic regulation.

the potential negative effects of fructose in brain and cognitive function have been investigated, with a series of studies showing cognitive deficits in spatial memory and learning in adolescent and adult animals following access to a high fructose diet

access to both fructose and sucrose, but not glucose, results in a 40% reduction in hippocampal neurogenesis

Collectively these studies seem to suggest that fructose consumption can have a considerable impact on hippocampal function and learning, which is in direct contrast with what we observed.

the impact of fructose is apparent only in BW, liver mass and body fat, but not in cognitive measures or rates of neurogenesis