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Nathan Goodyear

5-Methyltetrahydrofolate Rapidly Improves Endothelial Function and Decreases Superoxide Production in Human Vessels | Circulation - 0 views

circ.ahajournals.org/...1193.long

BH4 5-methyltetrahydrofolate tetrahydrobiopterine MTHFR MTHFR A1298C eNOS NO nitric oxide atherosclerosis cardiovascular disease CVD

shared by Nathan Goodyear on 14 Sep 17 - No Cached
  • Nathan Goodyear on 14 Sep 17
     
    5-MTHF increases BH4 which increases eNOS activity and NO production providing improved endothelial function and thereby providing a mechanism to reduce atherosclerosis.  Interesting that the MTHFR A1298C decreases BH4 in contrast to the 677T.
Nathan Goodyear

Hyperbaric Oxygen Therapy Can Improve Post Concussion Syndrome Years after Mild Traumatic Brain Injury - Randomized Prospective Trial - 0 views

www.ncbi.nlm.nih.gov/...PMC3829860

hbot hyperbaric therapy hyperbaric brain concussion post concussion syndrome TBI traumatic brain injury

shared by Nathan Goodyear on 17 May 17 - No Cached
  • The changes in SPECT images after treatment indicate that HBOT led to reactivation of neuronal activity in stunned areas that seemed normal under CT and MRI imaging. While SPECT imaging has a limited spatial resolution (compared, for example, to fMRI), the changes in activity were sufficiently robust to be clearly detected by the SPECT images.
  • HBOT might initiate a cellular and vascular repair mechanism and improve cerebral vascular flow
  • HBOT induces regeneration of axonal white matter [61], [62], [63], [64], has positive effect upon the myelinization and maturation of injured neural fibers [65], and can stimulate axonal growth and increase the ability of neurons to function and communicate with each other
  • ...6 more annotations...
  • HBOT was found to have a role in initiation and/or facilitation of angiogenesis and cell proliferation processes needed for axonal regeneration [67].
  • The observed reactivation of neuronal activity in the stunned areas found here, along with similar results in post-stroke patients
  • At the cellular level, HBOT can improve cellular metabolism, reduce apoptosis, alleviate oxidative stress and increase levels of neurotrophins and nitric oxide through enhancement of mitochondrial function (in both neurons and glial cells)
  • HBOT may promote the neurogenesis of endogenous neural stem cells
  • With regard to secondary injury mechanisms in mTBI, HBOT can initiate vascular repair mechanism and improve cerebral vascular flow [58], [59], [68], [69], promote blood brain barrier integrity and reduce inflammatory reactions [28] as well as brain edema
  • It might be possible that HBOT enables the metabolic change simply by supplying the missing energy/oxygen needed for those regeneration processes.
  • Nathan Goodyear on 17 May 17
     
    Hbot therapy, according to study, induces neuroplasticity and improves brain function in post concussion syndrome and those with mTBI.  The important point about this study was that the study was done years after the injury; what if the therapy was employed immediately after...
Nathan Goodyear

Chronic stress impacts the cardiovascular system: animal models and clinical outcomes | Heart and Circulatory Physiology - 0 views

ajpheart.physiology.org/...H1476

chronic stress stress inflammation cardiovascular disease atherosclerosis NO nitric oxide oxidative stress cardiovascular heart

shared by Nathan Goodyear on 03 Sep 17 - No Cached
  • Nathan Goodyear on 03 Sep 17
     
    Chronic stress increases cardiovascular disease.  Of note, chronic stress reduces eNOS activity and NO bioavailability, increased lipid oxidation (oxLDL) via a reduction in antioxidant protection, increased pro-inflammatory cytokines, increased thrombosis and clotting risk, increased blood pressure and reduced HRV.
Nathan Goodyear

Quercetin Reduces Inflammatory Responses in LPS-Stimulated Cardiomyoblasts - 0 views

www.hindawi.com/...837104

quercetin bioflavonoids LPS lipopolysaccharide iNOS inflammation nitric oxide

shared by Nathan Goodyear on 20 Jun 17 - No Cached
  • Nathan Goodyear on 20 Jun 17
     
    Quercetin lowers LPS levels
Nathan Goodyear

Inhibition of nitric oxide and inflammatory cytokines in LPS-stimulated murine macrophages by resveratrol, a potent proteasome inhibitor. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22698256

quercetin resveratrol pterostilbene iNOS LPS lipopolysaccharides inflammation

shared by Nathan Goodyear on 04 Oct 17 - No Cached
  • Nathan Goodyear on 04 Oct 17
     
    In addition to quercetin, resveratrol and pterostilbene inhibit LPS stimulated cytokine production.
Nathan Goodyear

Vitamin C Pharmacokinetics: Implications for Oral and Intravenous Use | Annals of Internal Medicine | American College of Physicians - 0 views

annals.org/...lications-oral-intravenous-use

vitamin C IV vitamin C cancer hypertension blood pressure NO nitric oxide

shared by Nathan Goodyear on 20 Dec 17 - No Cached
  • Nathan Goodyear on 20 Dec 17
     
    IV vitamin C found to significantly increased serum levels beyond that of oral.  IV vitamin C is the only route that should be administered for patients with cancer.  IVC at 50 grams showed peak C concentration at 13,400 micromol/L.  Levels of at least 400-600 are required for tumorcidal effects.  In addition, IV vitamin C increased NO release and decreases b/p
Nathan Goodyear

Endothelium and control of vascular function. State of the Art lecture. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...2661425

vitamin C NO nitric oxide blood pressure CV cardiovascular disease hypertension endothelium

shared by Nathan Goodyear on 20 Dec 17 - No Cached
  • Nathan Goodyear on 20 Dec 17
     
    vitamin C, absorbed via the endothelium, increases NO.  This will have a positive effect in lowering the blood pressure.
Nathan Goodyear

Vitamin C inhibits NO-induced stabilization of HIF-1alpha in HUVECs | Request PDF - 0 views

www.researchgate.net/...zation_of_HIF-1alpha_in_HUVECs

Hypoxia-inducible Factor 1 HIF-1alpha vitamin C nitric oxide HIF-1 NO

shared by Nathan Goodyear on 01 Apr 21 - No Cached
  • Nathan Goodyear on 01 Apr 21
     
    Only abstract available. NO increases accumulation of HIF-1alpha and Loading of the cells with vitamin C counteracted NO-induced HIF-1alpha accumulation. It is the HIF-1alpha and HIF-1beta combination that will change genetic expression (epigenetics)
Nathan Goodyear

Immunotherapy of C3H/HeJ mammary adenocarcinoma with interleukin-2, mistletoe lectin or their combination: effects on tumour growth, capillary leakage and nitric oxide (NO) production - 0 views

www.sciencedirect.com/...S0959804901001563

immunotherapy IL-2 mistletoe cancer

shared by Nathan Goodyear on 01 Jun 19 - No Cached
  • Nathan Goodyear on 01 Jun 19
     
    Study finds IL-2 reduces cancer proliferation and metastasis; however, mistletoe alone found to stimulate proliferation, though at very low doses i.e. 1 ng/kg, in mouse model.
Nathan Goodyear

Antitumor effect of pretreatment for colon cancer cells with hyperthermia plus geranylgeranylacetone in experimental metastasis models and a subcutaneous tumor model of colon cancer in mice - PubMed - 0 views

pubmed.ncbi.nlm.nih.gov/19337914

nitric oxide colon cancer NO metastasis COX2 matrix metalloproteinase hyperthermia NF-KappaB heat shock proteins MMP HSP HSP70

shared by Nathan Goodyear on 25 Feb 21 - No Cached
  • Nathan Goodyear on 25 Feb 21
     
    Hyperthermia via HSP70 blocks NF-kappaB and all associated downstream signaling that favor metastasis.
Nathan Goodyear

Anti-angiogenic effect of high doses of ascorbic acid - 0 views

www.ncbi.nlm.nih.gov/...PMC2562367

vitamin C angiogenesis nitric oxide NO

shared by Nathan Goodyear on 26 Aug 20 - No Cached
  • Nathan Goodyear on 26 Aug 20
     
    Vitamin C inhibits angiogenesis via suppression of NO levels.
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