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indiacardiacsurg

Child Heart Surgeon in India Will Create a Healthy Tomorrow for Children and Their Families - Statistically, about 1% of all newborns are born with more or less extreme coronary heart defects. - 0 views

ny.biznet-us.com/12244992

Child Heart Surgeon in India Cost of pediatric cardiac surgery in India Pediatric cardiac surgery in India low cost pediatric cardiac surgery

shared by indiacardiacsurg on 01 Dec 21 - No Cached
  • indiacardiacsurg on 01 Dec 21
     
    The cost of pediatric cardiac surgery in India remains low even when additional prices which include boarding, hotel charges, and length of stay at the hospital are taken into account. Since the cost of getting the best price for child heart surgery in India is less, hundreds of people from all around the world travel to India each year with the hope to get treated without any financial burden. Get Fast Track Query Reply just call us at +91-9370586696 or Email us: enquiry@indiacardiacsurgerysite.com
indiacardiacsurg

Dr. Anil Saxena Best ICD Implantation Surgeon Fortis to Get Your Heart Healthy ~ Medical Tourism India - 0 views

medical-tourism-india-magazine.blogspot.com/...plantation-surgeon-fortis.html

Dr. Anil Saxena best ICD implantation surgeon in Fortis ICD implant procedures in India

shared by indiacardiacsurg on 14 Mar 22 - No Cached
  • indiacardiacsurg on 14 Mar 22
     
    India stands as a top destination for ICD implant procedures in India with high success rates from over 150,000 numerous cardiac strategies done each year. Dr. Anil Saxena's best ICD implantation surgeon in Fortis is known worldwide for the expert evaluation and treatment of patients with a variety of heart rhythm disorders. Phone No.: +91-9370586696 Email id: dranilsaxena@indiacardiacsurgery.com
indian-health

Restore Your Healthy Vision With Eye Surgery India - 0 views

medical-tourism-magazine.blogspot.com/...est-eye-surgeons-in-india.html

Eye Surgery India Eye Surgeons In India Best Eye Surgeons of India Top Eye Surgeons In India Top 10 Eye Surgeons of India Best Eye Surgery Hospitals India Top Hospitals for Eye Surgery in India List of Best Eye Surgery Hospitals India Top 10 Hospitals for

shared by indian-health on 19 Apr 22 - No Cached
  • indian-health on 19 Apr 22
     
    Increasing patients stricken by problems, defects, and illnesses of the vision are actually choosing to travel overseas foreign places for eye surgery India.
Nathan Goodyear

NETosis and Neutrophil Extracellular Traps in COVID-19: Immunothrombosis and Beyond - PMC - 0 views

www.ncbi.nlm.nih.gov/...PMC8924116

cancer NETosis SARS-CoV-2 COVID COVID-19 COVID19 platelets

shared by Nathan Goodyear on 18 Apr 23 - No Cached
  • Pneumonia is a typical symptom of COVID-19 infection, while acute respiratory distress syndrome (ARDS) and multiple organ failure are common in severe COVID-19 patients
  • NETs are important for preventing pathogen invasion, their excessive formation can result in a slew of negative consequences, such as autoimmune inflammation and tissue damage
  • SARS-CoV-2 infection has also been linked to increased neutrophil-to-lymphocyte ratios, which is associated with disease severity and clinical prognosis
  • ...40 more annotations...
  • NETosis is a special form of programmed cell death in neutrophils, which is characterized by the extrusion of DNA, histones, and antimicrobial proteins in a web-like structure known as neutrophil extracellular traps (NETs)
    • Nathan Goodyear
      Nathan Goodyear on 23 Apr 23
       
      Definition
  • increased generation of reactive oxygen species (ROS) is a crucial intracellular process that causes NETosis
  • Another indirect route of SARS-CoV-2-induced NET production is platelet activation
  • When NETs are activated in the circulation, they can also induce hypercoagulability and thrombosis
  • In COVID-19, major NET protein cargos of NETs (i.e., NE, MPO, and histones) are significantly elevated.
  • SARS-CoV-2 can also infect host cells through noncanonical receptors such as C-type lectin receptors
  • Immunopathological manifestations, including cytokine storms and impaired adaptive immunity, are the primary drivers behind COVID-19, with neutrophil infiltration being suggested as a significant cause
  • NETosis and NETs are increasingly recognized as causes of vascular injury
  • SARS-CoV-2 and its components (e.g., spike proteins and viral RNA) attach to platelets and increase their activation and aggregation in COVID-19, resulting in vascular injury and thrombosis, both of which are linked to NET formation
    • Nathan Goodyear
      Nathan Goodyear on 23 Apr 23
       
      Connects SARS-CoV-2 to TLR on Platelets to NETosis to metastasis.
  • NET formation may be caused by activated platelets rather than SARS-CoV-2 itself
  • NETosis, leading to aberrant immunity such as cytokine storms, autoimmune disorders, and immunosuppression.
  • early bacterial coinfections were more prevalent in COVID-19 patients than those infected with other viruses
  • NETosis and NETs may also have a role in the development of post COVID-19 syndromes, including lung fibrosis, neurological disorders, tumor growth, and worsening of concomitant disease
    • Nathan Goodyear
      Nathan Goodyear on 23 Apr 23
       
      NETosis-> tumor growth
  • NETs and other by-products of NETosis have been shown to act as direct inflammation amplifiers. Hyperinflammation
  • “cytokine storm”
  • SARS-CoV-2 drives NETosis and NET formation to allow for the release of free DNA and by-products (e.g., elastases and histones). This may trigger surrounding macrophages and endothelial cells to secrete excessive proinflammatory cytokines and chemokines, which, in turn, enhance NET formation and form a positive feedback of cytokine storms in COVID-19
    • Nathan Goodyear
      Nathan Goodyear on 23 Apr 23
       
      Cycle of hyperinflammation
  • NET release enables self-antigen exposure and autoantibody production, thereby increasing the autoinflammatory response
  • patients with COVID-19 who have higher anti-NET antibodies are more likely to be detected with positive autoantibodies [e.g., antinuclear antibodies (ANA) and anti-neutrophil cytoplasmic antibodies (ANCA)]
  • COVID-19 NETs may act as potential inducers for autoimmune responses
  • have weakened adaptive immunity as well as a high level of inflammation
    • Nathan Goodyear
      Nathan Goodyear on 23 Apr 23
       
      Immunomodulation
  • tumor-associated NETosis and NETs promote an immunosuppressive environment in which anti-tumor immunity is compromised
  • NETs have also been shown to enhance macrophage pyroptosis in sepsis
  • facilitating an immunosuppressive microenvironment
  • persistent immunosuppression may result in bacterial co-infection or secondary infection
  • can enhance this process by interacting with neutrophils through toll-like receptor 4 (TLR4), platelet factor 4 (PF4), and extracellular vesicle-dependent processes
  • NET-induced immunosuppression in COVID-19 in the context of co-existing bacterial infection
  • Following initial onset of COVID-19, an estimated 50% or more of COVID-19 survivors may develop multi-organ problems (e.g., pulmonary dysfunction and neurologic impairment) or have worsening concomitant chronic illness
  • NETs in the bronchoalveolar lavage fluid of severe COVID-19 patients cause EMT in lung epithelial cells
  • decreased E-cadherin (an epithelial marker) expression
    • Nathan Goodyear
      Nathan Goodyear on 23 Apr 23
       
      Leads to emt
  • COVID-19 also has a long-term influence on tumor progression
  • Patients with tumors have been shown to be more vulnerable to SARS-CoV-2 infection and subsequent development of severe COVID-19
  • patients who have recovered from COVID-19 may have an increased risk of developing cancer or of cancer progression and metastasis
  • awaken cancer cells
  • NETs have been shown to change the tumor microenvironment
  • enhance tumor progression and metastasis
  • vitamin C has been tested in phase 2 clinical trials aimed at reducing COVID-19-associated mortality by reducing excessive activation of the inflammatory response
  • vitamin C is an antioxidant that significantly attenuates PMA-induced NETosis in healthy neutrophils by scavenging ROS
  • vitamin C may also inhibit NETosis and NET production in COVID-19
  • Metformin
  • Vitamin C
  • Nathan Goodyear on 18 Apr 23
     
    NETosis intimately involved in progressive COVID, long COVID, autoimmunity, and cancer
indiacardiacsurg

বাংলাদেশ স্বাস্থ্য নিউজ আপডেট - সংবাদ মাধ্যম: ভারতের শীর্ষ হার্ট ভালভ সার্জনরা আপনার হৃদপিণ্ডকে চিরকাল সুস্থ রাখবে - 0 views

bangladeshhealthnews.blogspot.com/...our-heart-healthy-forever.html

হার্টের ভালভ প্রতিস্থাপন সার্জারির কম খরচে ভারত হার্টের ভালভ প্রতিস্থাপন হার্ট ভালভ প্রতিস্থাপন খরচ

shared by indiacardiacsurg on 02 Apr 22 - No Cached
  • indiacardiacsurg on 02 Apr 22
     
    হার্টের ভালভ প্রতিস্থাপনের অস্ত্রোপচারের জন্য কম খরচে ভারতে আসা বাংলাদেশী রোগীরা উন্নত পশ্চিমা দেশে ভ্রমণ করলে ভারত যে খরচ করতে পারে তার 50% পর্যন্ত বাঁচাতে পারে।
spineneuro

ভারতে বাংলা রিয়েল মেডিকেল অভিজ্ঞতা: মুম্বাইয়ের সেরা স্কোলিওসিস সার্জনের সাথে আপনার স্বাস্থ্যকর মেরুদণ্ড ফিরে পান - 0 views

banglarealmedicalexperiences.blogspot.com/...oliosis-surgeon-in-mumbai.html

মুম্বাইয়ের সেরা স্কোলিওসিস সার্জন ডঃ অরবিন্দ কুলকার্নি স্কোলিওসিস ট্রিটমেন্ট ইন্ডিয়া

shared by spineneuro on 11 Mar 23 - No Cached
  • spineneuro on 11 Mar 23
     
    এক দশকেরও বেশি আগে মুম্বাইয়ের সেরা স্কোলিওসিস সার্জন স্কোলিওসিসের চিকিত্সার জন্য "একটি ভাল উপায়" আবিষ্কার করার জন্য একটি যাত্রা শুরু করেছিলেন, এমন একটি উপায় যা এই অবস্থার নিজেই চিকিত্সার উপর কেন্দ্রীভূত ছিল, মেরুদণ্ডের ব্যাধিযুক্ত রোগীদের যত্ন গত দশকে তাড়াহুড়ো করে মোকাবেলা করা অব্যাহত রয়েছে। .
indian-health

Start Journey to a Healthy Heart With Ventricular Septal Defect Surgery India - 0 views

indianhealthguruconsultant.blogspot.com/...ect-surgery-cost-in-india.html

ventricular septal sickness Ventricular Septal Defect Surgery India VSD surgeons in India ventricular septal defect surgery cost in India ventricular septal defect surgery cost Affordable ventricular septal defect surgery best heart surgeons Top heart hos

shared by indian-health on 27 Dec 22 - No Cached
  • indian-health on 27 Dec 22
     
    The average ventricular septal defect surgery cost in India is 40% lesser as compared to other developing countries.
Nathan Goodyear

We're Not "DON" Yet: Optimal Dosing and Prodrug Delivery of 6-Diazo-5-oxo-L-norleucine - PMC - 0 views

www.ncbi.nlm.nih.gov/...PMC6130910

glutamine DON dosing cancer

shared by Nathan Goodyear on 17 Mar 24 - No Cached
  • Glutamine is the most abundant amino acid in blood
  • Rapidly proliferating healthy cells (GI epithelium, lymphocytes) or cells under physiologic stress have increased demand for glutamine
  • Glutamine is transported into cells by one of multiple amino acid transporters (e.g. ASCT2, BOAT2), several of which are thought to be upregulated in cancer cells
  • ...10 more annotations...
  • it is hydrolyzed to glutamate and ammonia by glutaminase (‘glutaminolysis’)
  • Glutamate, produced from glutamine by glutaminase and glutamine amidotransferase activities, may be further metabolized to alpha ketoglutarate and provide a carbon skeleton source for the mitochondrial tricarboxylic acid cycle (TCA cycle)
  • Glutamine-derived glutamate is also involved in the synthesis of the reducing equivalent glutathione, vital to maintaining cellular redox status
  • Many tumors become largely dependent on glutamine to provide carbon and nitrogen building blocks needed for proliferation
  • In cancer model systems, Eagle and colleagues first demonstrated tumor cells in culture require supplementation with exogenous glutamine for efficient proliferation
  • It was subsequently shown that when deprived of glutamine tumor cells undergo apoptosis
  • The most well-characterized oncogene to regulate glutamine metabolism is MYC (9), which enhances glutaminase expression, upregulates glutamine transporters, and enhances glutamine utilization in energy production and biosynthesis
  • Other pro-tumorigenic regulators such as KRAS and mTOR, as well as tumor suppressors (p53, VHL) have also been associated with alterations in glutamine metabolism
  • Tumor cells are highly adaptable and alter nutrient uptake and metabolic networks to resist single agent glutaminase inhibition
  • cells in the microenvironment of several tumor types upregulate glutamine production, thereby enabling tumor cells to escape glutaminase inhibition
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