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in title, tags, annotations or urlNeoadjuvant chemotherapy induces breast cancer metastasis through a TMEM-mediated mechanism | Science Translational Medicine - 0 views
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We found about a twofold increase in circulating tumor cells (CTCs) (P < 0.05) after paclitaxel treatment in all experimental models examined
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We found an increase in both the metastatic incidence (at least one micrometastatic focus of more than five tumor cells) (Fig. 3I) and the number of cancer cell micrometastases in the lungs of paclitaxel-treated mice
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in early-stage breast cancers, chemotherapy increases vascular permeability at TMEM sites, which is accompanied by increased cancer cell dissemination.
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