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Nathan Goodyear

Boswellia ovalifoliolata abrogates ROS mediated NF-κB activation, causes apoptosis and chemosensitization in Triple Negative Breast Cancer cells - PubMed - 0 views

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    Boswellia shows chemosensitizing effects with doxorubicin and cisplatin with TNBC.
Nathan Goodyear

Quercetin Inhibits the Proliferation and Metastasis of Human Non-Small Cell Lung Cancer Cell Line: The Key Role of Src-Mediated Fibroblast Growth Factor-Inducible 14 (Fn14)/Nuclear Factor kappa B (NF-κB) pathway - 0 views

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    Quercetin inhibits NF-kappaB through src suppression.
Nathan Goodyear

Abscopal antitumor immune effects of magnet-mediated hyperthermia at a high therapeutic temperature on Walker-256 carcinosarcomas in rats - 0 views

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    Local hyperthermia stimulates distal tumor death via abscopal effects.
Nathan Goodyear

Neoadjuvant chemotherapy induces breast cancer metastasis through a TMEM-mediated mechanism | Science Translational Medicine - 0 views

  • We found about a twofold increase in circulating tumor cells (CTCs) (P < 0.05) after paclitaxel treatment in all experimental models examined
  • We found an increase in both the metastatic incidence (at least one micrometastatic focus of more than five tumor cells) (Fig. 3I) and the number of cancer cell micrometastases in the lungs of paclitaxel-treated mice
  • in early-stage breast cancers, chemotherapy increases vascular permeability at TMEM sites, which is accompanied by increased cancer cell dissemination.
  • ...1 more annotation...
  • significant ~1.3-fold (P = 0.027) increase in the number of CTCs
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    New study suggests chemotherapy may increase metastasis  via increase in TMEM.  I wonder if this increases recurrence as well.  Could the very corner stone of Cancer therapy actually increase metastatic risk potential?
Nathan Goodyear

Premetastatic milieu explained by TLR4 agonist-mediated homeostatic inflammation - 0 views

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    To be read
Nathan Goodyear

Artemisinin sensitizes tumor cells to NK cell-mediated cytolysis - ScienceDirect - 0 views

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    Artemisinin increases tumor cell sensitivity to NK cell killing activity.
Nathan Goodyear

Ferritin induction protects cortical astrocytes from heme-mediated oxidative injury - ScienceDirect - 0 views

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    HO-1 induces increase in ferritin to reduce ROS
Nathan Goodyear

Molecular mechanism and functional consequences of lansoprazole-mediated heme oxygenase-1 induction - 0 views

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    HO-1 and thus increase in ferritin induction by lansoprozole reduces ROS.
Nathan Goodyear

Editorial: Cytokine-Mediated Organ Dysfunction and Tissue Damage Induced by Viruses - 1 views

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    Influenza and other virus' induce cytokine production i.e. cytokine storm via TLR
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