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pharmacybiz

Dr Nik Kotecha OBE - Distinguished Alumni Award Winner 2022 - 0 views

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    Dr Nik Kotecha OBE, chairman of Morningside Pharmaceuticals and the Randal Charitable Foundation, has won the Distinguished Alumni Award at Imperial College London's Alumni Awards 2022. The annual awards honour outstanding alumni who have demonstrated sustained excellence in their personal and professional achievements and have made a substantial impact on society. Dr Kotecha, who founded Morningside in 1991, which manufactures and supplies generic and branded medicines to the UK and globally, said: "I'm thrilled to be honoured by the university in this way. "As a child growing up in Leicester my family had very little, but I was fortunate to be given opportunities to gain a good education. After finishing my degree in Newcastle; Professor Steve Ley FRS at Imperial College took a chance in accepting me into his eminent group and this really was the opportunity I needed to forge a career.
Alan Rann

Plastic Surgery Loans- Get Implausible Look with Simple Financial Assistance! - 0 views

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    Plastic Surgery Loans are provided an opportunity to obtain sufficient cash support for your health conscious problems. This cash advance is very helpful to all as they give you a new life and a new meaning to live for so without any second thought apply with us.
Nathan Goodyear

Investigations on oxidativ... [Eur Arch Psychiatry Clin Neurosci. 1999] - PubMed - NCBI - 0 views

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    This study finds that AGE, advanced glycation end products, play a significant role in free radical generation and neurodegenerative disease. Quote: "... pharmacologoical approaches which break the vicious cycle of oxidative stress and neurodegeneration offer new opportunities for the treatment of AD. These approaches include AGE- inhibitors, antioxidants, and anti-inflammatory substances which prevent radical production." They focus on the pharmacological, how about the natural first?
Richard  Joseph

5 Questions to ask your Eye Doctor | Overland Optical Family Eyecare - 0 views

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    Your vision is likely to be one of your most valuable senses, you want to consider your visit to the eye doctor as important an opportunity to review your health status as your regular checkup with your physician.
wheelchairindia9

A Friendly Tricycle For The Disabled Users - 0 views

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    Those of all ages whose physical disabilities restrict their movement, affect their ability to earn a living or become valued members of society. Specially designed tricycles provide a mode of transport for the physically disabled allowing them much sought after independence and an opportunity for self support. The tricycles will enable freedom of movement and less dependency on others. Most of the people who depend on these tricycles are daily wage workers who have to travel long distances every day. The regular tricycles have no suspension and the riders are prone to spinal injuries. Most of them also cannot afford good medical care, and driving these tricycles for a long time affects. To deal with the problem, come up with a model tricycle that can be very useful to people who have a disability in their lower limbs, but a strong torso. The Handy tricycle to provide the ideal cycling experience for users advancement of upper body strength and toning for athletic events. Especially valuable to triathletes and challenged, it provides the perfect way to get in shape and stay that way. The tricycle achieves the true convenience of transportation while providing easy-to-use pedaling, steering and breaking controls. These are amongst the top selling handcycles on the market today. Handy is available in upright and recumbent versions. Hand powered front wheel drive. An internal hub-based gear shifting system is built into the front wheel.This provides ultra smooth shifting and is virtually maintenance-free. The entire front frame section is removable and connects easily, quickly and securely using a bolt-on system. The seat can be repositioned quickly and easily to allow the rider to achieve an optimally efficient distance between seat and handlebars.The rear wheels are removed using a single finger push system, allowing the bike to be broken down very quickly. Defined by two ways: Fork steer: It represent the majority of handcycles. They work well for both low
KELLY147

How to use Artificial Intelligence in Fintech for decisive experience - 0 views

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    As the FinTech industry has a widespread reach globally, AI is allowed to upsurge several new opportunities. Thus, the benefits of using AI in the financial sector are wide-ranging and recurring. From bank service marketing to handling customer queries, FinTech companies are introducing AI-enabled services.
spineneuro

Top VBT Surgeons of India in 2021 Using FDA-Approved Spinal Tethering Device - 0 views

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    "As patients emerge as increasingly interested in non-fusion surgical alternatives for treating scoliosis whilst a back brace has not been effective, vertebral body tethering is an opportunity that preserves movement and flexibility-especially in younger patients as they continue to grow," says top VBT surgeons of India in 2021. For Enquiry Helpline Number: +91-9325887033 Email id: enquiry@spineandneurosurgeryhospitalindia.com
fitspresso

https://www.sightcare-co.com/ - 0 views

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    Sight Care | Official Site sightcare-co.com · by Sight Care Sight Care Only $49/Bottle Limited Time Offer! Sight Care Special Deal + Special 67% Discount Save $600 + 180 Days Money Back Guarantee #1.The Sight Care vision supplement is a dietary supplement for helping you improve your vision and brain health. Sight Care eye supplements are formulated to provide a synergistic blend of vitamins, minerals, antioxidants, and other bioactive compounds that are essential for maintaining healthy vision Regular Price: 147/per bottle Only for: $49/per bottle What Is Sight Care? This powerful vision support supplement is made with a unique blend of natural ingredients and plant extracts that work together synergistically to deliver numerous benefits for your brain and eye health. With Sight Care, you can expect to experience increased energy levels, improved eyesight, and an overall revitalized sense of well-being. Taking care of your vision health is not just about seeing clearly; it's also about maintaining your overall brain health. As we age, our vision deteriorates, and our eyes and brain can experience a decline in function, but there are steps you can take to support your visual and cognitive health. Regular eye exams are crucial for detecting and treating vision problems early on, and making healthy choices such as eating a nutritious diet and exercising regularly can also help. However, with busy schedules, it can be difficult to find the time to devote to a healthy lifestyle. This is where the Sight Care supplement comes in. It's designed to support both vision and brain health with its blend of natural ingredients that have been shown to promote healthy vision and cognitive function You must not compromise your eye health for momentary exhilaration. If you are glued to digital screens day and night, you must take measures to prevent eye diseases like age-related macular degeneration. The SightCare vision supplement has been made using 100% natura
wheelchairindia9

Karma KM 2500 Wheelchair - 0 views

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    Karma KM 2500 Small Wheel Wheelchair: Karma KM 2500 Small Wheel Wheelchair Specifications: Width 18" Front/Rear Wheels 6" to 14" Seat Width 47cm Seat Depth 40cm Overall Width 66cm Overall Collapsed Width 36cm Armrest Height 21cm Overall Length 90cm Seat Height 47cm Backrest Height 38cm Overall Height 86cm Weight 9.2 k.g. Karma KM 2500 Small Wheel Wheelchair Seat and Back: AEGIS Microbe Shield Approved by the FDA, EPA, EU, etc., bonded anti-microbial barrier upholstery protects from odor, staining and deterioration from bacteria, fungus and other microorganisms. It is a shield for your health. Karma KM 2500 Small Wheel Wheelchair Extended Armrest: By simulating the natural position of arms, the extended armrest design is ergonomic and creates bigger seating space. An Ultra lightweight wheelchair (9.2 kg) with a compact design for either attendant assisted or self propelling users. The use of aircraft-grade aluminium alloy and double cross brace provide this model with outstanding strength and durability. Karma Healthcare KM-2500 Premium Wheelchair is amazingly light and compact transit wheelchair which is ideal for outings and travelers. It folds down to take up virtually no space in the boot of a car and weighs just over 9.2 kg making it easy for anyone to lift into a vehicle. Backrest folds-down for easy transportation. Maximum user weight: 100 K.g. Aluminium frame. Fixed armrest/fixed footrest. Foldable frame via double cross bars. Comfortable & durable upholstery. Swing-away foot plates. Puncture proof tyres. Attendant cable brake. 14" flat-free rear wheels. Detachable and washable cushion. One Year Warranty. It folds down to take up virtually no space in the boot of a car. This amazingly light and compact transit wheelchair is ideal for outings and travelling. It comes with detachable and washable cushion. The wheel chair has attendant cable brake. It is made from aircraft-grade aluminium alloy fra
Nathan Goodyear

N-acetylcysteine (NAC) in neurological disorders: mechanisms of action and therapeutic opportunities - 0 views

  • There is a marked increase in expression of TNF in active multiple sclerosis (MS)
  • a correlation exists between cerebrospinal fluid levels of TNF and the severity and progression of disease
  • With cytokine activation, free-radical production increases and this has been demonstrated in MS
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  • NAC inhibits the toxicity of TNF and in an animal model of MS
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    Good discussion of NAC and neurodegenerative diseases.
wheelchairindia9

Tricycle For Disabled Children - 0 views

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    The tricycles are individually designed to meet the needs of each disabled child and help provide physiotherapy, build muscle tone and promote play. Italso help benefit growth and development in children with disabilities, enabling them to keep active and retain their independence. Disabled children get huge physical and emotional benefits from having the specially tricycles, which are each custom made to suit the individual child's needs. Riding a tricycle provides both fun and fitness, and is a therapeutic activity that allows children to exercise their lower extremities. As the muscles move through cycling motions, they are flexed, extended and stretched. This range of motion is crucial for children with disabilities, because muscles are incapable of keeping up with bone growth unless fully extended. Tricycles are provided to severely disabled children and adults and come in two sizes, 20 inch and 24 inch models. These trikes are grant funded and to qualify for one of these, an individual must suffer from a condition such as, but not limited to, Cerebral Palsy, Down Syndrome, Traumatic Brain Injury or Autism. Trunk support system is ideal for riders who have trouble remaining upright while seated. An optional headrest is available. A headrest can be purchased with either a flat or contoured headpiece, and adjusts both horizontally and vertically for optimum positioning. The Front Pulley System maintains a level pedal position for children whose extreme tone forces the front of the pedal downward. Turn the oval knob to raise and lower the handlebar. A handbrake for the conventional handlebar will arrive installed on Large tricycle. Open access combined with a low transfer step makes it easy to get on and off trikes. Tricycle Deluxe Double Hand Drive: Frame : Made by E.R.W. Tubes 38.0 mm-16 G. 25.4 mm & 22.22 mm- 18 G. Seat & Back : M S, C.R.C. Sheet. Seat Size 18"x 16" Wheel Size : Wheel Diameter 24"x 1 1/2" Tyre and Tube Standard Company. Pa
Nathan Goodyear

Urinary Estrogens and Estrogen Metabolites and Subsequent Risk of Breast Cancer among Premenopausal Women - 0 views

  • both 2- and 4-catechol estrogen metabolites bind to the ER with affinities comparable with estradiol, 4-catechol estrogen metabolites have lower dissociation rates than estradiol and an enhanced ability to upregulate ER-dependent processes
  • 2-catechol estrogen metabolites act as either weak mitogens (39) or weak inhibitors of cell proliferation
  • While 16α-hydroxyestrone binds to the ER with lower affinity than estradiol, it binds covalently (41) and leads to a constitutively activated ER
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  • 4-hydroxyestradiol and 16α-hydroxyestrone increasing proliferation and decreasing apoptosis in a manner similar to estradiol; however, these effects were achieved only at concentrations 10-fold higher than estradiol (39). In contrast, 2-hydroxyestradiol did not have substantial proliferative or antiapoptotic effects
  • In our study, the associations with both 2-hydroxyestrone and 16α-hydroxyestrone were nonsignificantly inverse and we did not observe a consistent trend or significant associations between the 2-hydroxyestrone:16α-hydroxyestrone ratio and breast cancer risk
  • Ratios of the 3 hydroxylation pathways were not significantly associated with risk although the 2:16-pathway and 4:16-pathway ratios were suggestively inversely associated
  • a significant inverse association with the ratio of parent estrogens to estrogen metabolites
  • several potentially estrogenic and genotoxic mechanisms
  • Estrogen metabolites also can be genotoxic
  • Catechol estrogens can be oxidized into quinones and induce DNA damage directly through the formation of DNA adducts, or indirectly via redox cycling and generation of reactive oxygen species
  • the oxidized forms of the catechol estrogens differ in their ability to damage DNA through adducts, with oxidized 2-catechols forming stable and reversible DNA adducts and oxidized 4-catechols forming unstable adducts, which lead to depurination and mutations
  • 2- and 4-catechols have been shown to produce reactive oxygen species and induce oxidative DNA damage
  • act independently from the ER
  • 16α-Hydroxyestrone also may be genotoxic
  • While the catechol estrogens have estrogenic and genotoxic potential, the methylated catechol estrogens, which are catechol estrogens with one hydroxyl group methylated, have been hypothesized to lower the risk of breast cancer
  • The suggested mechanisms are indirect, by decreasing circulating levels of catechol estrogens and thereby the opportunity for catechols to exert genotoxic or proliferative effects, or direct, by inhibiting tumor growth and inducing apoptosis
  • the balance between phase I (oxidation) and phase II (methylation) metabolism of estrogen may be important in hormonally related cancer development.
  • Despite the estrogenic and genotoxic potential of many of the estrogen metabolites, we only observed a significantly increased breast cancer risk with one estrogen metabolite, 17-epiestriol, which has particularly strong estrogenic activity and binds to both ERα and ERβ with an affinity comparable with estradiol
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    review of estrogen metabolites and breast cancer risk in premenopausal women.
srujal shah

George Brown's Google Sniper 2.0 - 0 views

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    Give Me The System Now (Just $47 For Instant Access) Dear Friend:OK, I hope you're ready for this... ... Because I'm about to speak to you very, very frankly.I'm about to show you EXACTLY how I made $530,354.00 last year on Clickbank... And that's with ZERO traffic generation... ...
Nathan Goodyear

ScienceDirect - The Journal of Nutritional Biochemistry : Analytical metabolomics: nutritional opportunities for personalized health - 0 views

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    metabolomics?  the future of medicine is customized medicine
Syed Amjad Ali

Soft-skills training for employees via E-learning - 0 views

Soft-skills training use full for employee what good looks like and giving the some introductory practice opportunities. Soft-skills are important port in a company culture. Please have a look at f...

E-Learning

started by Syed Amjad Ali on 06 Feb 15 no follow-up yet
Nathan Goodyear

Nutrients | Free Full-Text | Myths, Artifacts, and Fatal Flaws: Identifying Limitations and Opportunities in Vitamin C Research | HTML - 0 views

  • l-gulonolactone oxidase, an enzyme with the synthesis of l-ascorbic acid as its only known function
  • prolonged fasting causes ascorbate synthesis to decline
  • agents that stimulate glycogenolysis also stimulate ascorbate synthesis when an animal is in a fed state
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    Great review on the science of vitamin C.
Nathan Goodyear

Niclosamide Suppresses Cancer Cell Growth By Inducing Wnt Co-Receptor LRP6 Degradation and Inhibiting the Wnt/β-Catenin Pathway - 0 views

  • Wnt/β-catenin signaling plays an important role in embryonic development and can lead to tumor formation when aberrantly activated.
  • Compelling evidence has indicated that there is an abnormal up-regulation of this pathway in tumorigenesis of many types of cancer
  • disruption of Wnt/β-catenin signaling represents a great opportunity to develop novel drugs for cancer chemoprevention and therapy
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  • Niclosamide (trade name Niclocide) is a teniacide in the antihelmintic family that is especially effective against cestodes, which infects humans. Niclosamide has been FDA approved for such indications and has been used in humans for nearly 50 years
  • We demonstrated for the first time that niclosamide can inhibit Wnt/β-catenin signaling by inducing LRP6 degradation, and that this activity is closely associated with its antiproliferative and apoptosis inducing activity.
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    Niclosamide, an old anti-parasitic drug, found to inhibit the Wnt/B-catenin pathways so critical to cancer growth.  This triggers apoptosis of the cancer cell.
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