Overexpression of SIRT1 Protects Pancreatic β-Cells Against Cytokine Toxicity by Suppressing the Nuclear Factor-κB Signaling Pathway - 0 views
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SIRT1, a class III histone/protein deacetylase, is known to interfere with the nuclear factor-κB (NF-κB) signaling pathway and thereby has an anti-inflammatory function
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central role of NF-κB in cytokine-mediated pancreatic β-cell damage
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SIRT1 as a possible target to attenuate cytokine-induced β-cell damage.