Telomerase at the intersection of cancer and aging - 0 views
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The anti-aging role of telomerase has been demonstrated to be largely mediated by its canonical role in elongating telomeres, which prevents the accumulation of critically short telomeres and loss of tissue homeostasis
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Short telomeres, and subsequent DDR activation, could occur both in cancer and aging
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increased abundance of short telomeres correlates with higher genomic instability and decreased longevity in various organisms, including mice, zebrafish, and yeast
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Telomerase activity and longer telomere length is shown to correlated inversely with many chronic diseases of aging. In contrast, telomerase activity is found to be involved in carcinogenesis. Increased carcinogenic potential of telomerase activity has not borne out in studies. In addition, increased CD8 cell activity as a result of telomerase activation will actually decrease carcinogenic potential via NK activation.