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Nathan Goodyear

Estriol and Progesterone: A New Role for Sex Hormones - 0 views

www.ncbi.nlm.nih.gov/...PMC3614637

Estriol Progesterone autoimmune disease inflammation hormones

shared by Nathan Goodyear on 09 May 16 - No Cached
  • Pregnancy-associated Th2 shift has been proposed as a mechanism underlying the improvement of Th1-mediated autoimmune diseases (as rheumatoid arthritis, multiple sclerosis (MS), autoimmune thyoriditis, uveitis, and psoriatic arthritis
  • Th2-mediated autoimmune diseases (as systemic lupus erythematosus)
  • During pregnancy PRG serum level increases by a factor of 4, while estrogen estriol (E3) serum concentration increases by a factor of 20
  • ...1 more annotation...
  • In pregnant women at or near term there is a daily production of about 300 μmol (80 mg) of E3 and 1 mmol (300 mg) of PRG
  • Nathan Goodyear on 09 May 16
     
    Estriol and Progesterone associated, as found with pregnancy, associated with decrease in Th1 autoimmune disease.
Nathan Goodyear

Increased frequency of delayed type hypersensitivity to metals in patients with connect... - 0 views

www.ncbi.nlm.nih.gov/...25636536

mercury gold nickel lupus autoimmune disease autoimmune disease RA rheumatoid arthritis arthritis Sjogren's

shared by Nathan Goodyear on 26 Sep 16 - No Cached
  • Nathan Goodyear on 26 Sep 16
     
    increased delayed type hypersensitivity reactions in individuals with certain autoimmune diseases.
Nathan Goodyear

Boswellia Serrata, A Potential Antiinflammatory Agent: An Overview - 0 views

www.ncbi.nlm.nih.gov/...PMC3309643

boswellia Frankincense inflammation NF-kappaB arthritis cancer osteoarthritis rheumatoid arthritis

shared by Nathan Goodyear on 07 Jun 16 - No Cached
  • Nathan Goodyear on 07 Jun 16
     
    review article of anti-inflammatory effects of Boswellia.  Boswellia inhibits 5-LOX and resultant leukotrienes.  3-actyl-11-keto-Beta-boswellic acid is the most potent inhibitor of 5-LOX.  As it relates to disease states and symptoms, Boswellia reduces pain in OA and RA.  Boswellia also shown to inhibit NF-kappa B: a potent nuclear transcription factor for inflammation.  In prostate cancer, Boswellia inhibits prostate tumor growth.
Nathan Goodyear

Interleukin-6 and rheumatic diseases - 0 views

www.ncbi.nlm.nih.gov/...PMC2946778

IL-6 sIL-6Ralpha autoimmune disease Rheumatoid arthritis RA

shared by Nathan Goodyear on 28 Apr 12 - No Cached
  • Nathan Goodyear on 28 Apr 12
     
    IL-6 and sIL-6Ralpha (soluble receptor) associated with autoimmune disease.
Nathan Goodyear

Androgen replacement therapy in male patient... [Arthritis Rheum. 1991] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...1824615

testosterone therapy replacement RA rheumatoid arthritis inflammation inflammatory cytokines male men

shared by Nathan Goodyear on 12 Aug 12 - No Cached
  • Nathan Goodyear on 12 Aug 12
     
    Testosterone replacement reduces inflammation in men with RA
Nathan Goodyear

The antioxidants curcumin and quercetin inhibit ... [Inflamm Res. 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16807698

arthritis RA rheumatoid arthritis curcumin tumeric inflammation antioxidants

shared by Nathan Goodyear on 13 Sep 13 - No Cached
  • Nathan Goodyear on 13 Sep 13
     
    curcumin again found to be beneficial in RA.
Nathan Goodyear

A randomized, pilot study to assess the effica... [Phytother Res. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22407780

curcumin tumeic RA rheumatoid arthritis arthritis inflammation

shared by Nathan Goodyear on 13 Sep 13 - No Cached
  • Nathan Goodyear on 13 Sep 13
     
    Curcumin beneficial in RA.
Nathan Goodyear

Aromatase and regulation of the estrogen-to... [Ann N Y Acad Sci. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24684533

aromatase aromatase activity vitamin D estrone E1 inflammation RA rheumatoid arthritis

shared by Nathan Goodyear on 07 Apr 14 - No Cached
  • Nathan Goodyear on 07 Apr 14
     
    Study looked at inflammatory markers in RA.  The authors point to high aromatase activity, low androgens, and elevated estrone in synovial fluid as an indicator of a link between aromatase activity and inflammation production through E1 production.  The authors also point to the 16 alpha metabolite pathway as pro-inflammatory as well.  One very interesting point made by the authors is that vitamin D down regulates aromatase activity.  In addition to NK-kappaB inhibition, this may be another mechanism by which vitamin D reduces inflammation.
Nathan Goodyear

Medical ozone increases methotrexate clinical response and improves cellular redox bala... - 0 views

www.sciencedirect.com/...S001429991630471X

ozone

shared by Nathan Goodyear on 31 Jul 18 - No Cached
  • Nathan Goodyear on 31 Jul 18
     
    ozone
Nathan Goodyear

Medical ozone increases methotrexate clinical response and improves cellular redox bala... - 0 views

www.researchgate.net/...ents_with_rheumatoid_arthritis

Ozone

shared by Nathan Goodyear on 31 Jul 18 - No Cached
  • Nathan Goodyear on 31 Jul 18
     
    Ozone
Nathan Goodyear

Alkaline phosphatase isoenzyme activities in rheumatoid arthritis: hepatobiliary enzyme... - 0 views

www.ncbi.nlm.nih.gov/...PMC1005089

alkaline phosphatase ALP ALP fractionation

shared by Nathan Goodyear on 01 Apr 19 - No Cached
hoangkimchi liked it
  • Nathan Goodyear on 01 Apr 19
     
    ALP fractionation isoenzyme study can provide deeper understanding of disease involvement.
Nathan Goodyear

Inhibition of in vitro vascular endothelial cell proliferation and in vivo ne... - 0 views

onlinelibrary.wiley.com/...anr.1780320903

low-dose chemotherapy RA rheumatoid arthritis angiogenesis

shared by Nathan Goodyear on 24 Aug 20 - No Cached
  • Nathan Goodyear on 24 Aug 20
     
    Low-dose methotrexate is anti-angiogenic.
Nathan Goodyear

Low-dose Interleukin-2 in the Treatment of Autoimmune Disease | touchONCOLOGY - 0 views

www.touchoncology.com/...2-treatment-autoimmune-disease

cancer autoimmune disease Tregs Treg cells Treg immune system disease IL-2

shared by Nathan Goodyear on 04 Apr 18 - No Cached
Amol kashikar liked it
  • affect approximately 5 to 8 % of the US population
  • the incidence and prevalence of autoimmune diseases are rising
  • Type 1 diabetes (T1D), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and inflammatory bowel disease (IBD) account for the majority of the patients with autoimmune diseases
  • ...9 more annotations...
  • Autoimmune diseases are characterized by a breakdown of mechanisms that allow the immune system to distinguish between self and nonself and maintain immunologic self-tolerance
  • Tregs, which are important in the maintenance of peripheral immune tolerance.
  • Several subtypes of Tregs exist, the most well studied being CD4+ cells that express high-level CD25 and the transcription factor forkhead box P3 (FOXP3)
  • Treg deficiency or dysfunction is associated with autoimmune disease
  • In clinical studies, decreased levels of circulating CD25+CD4+ T cells have been reported in patients with autoimmune disease
  • These data have led to the hypothesis that augmentation of Tregs may be a useful therapeutic strategy in autoimmune disease
  • Treg augmentation has resulted in clinical improvements in numerous animal models of autoimmune diseases
  • the administration of in vitro expanded CD4+CD25highCD127-Tregs has been found to be safe and may help to preserve β-cell function in children with T1D
  • ability of IL-2 to augment the numbers and function of CD4+ Tregs.
  • Nathan Goodyear on 04 Apr 18
     
    Great article.  Immune dysfunction plays role in autoimmune disease and cancer.  Treg cells sit at the center of autoimmunity.  This artice highlights the different uses: low dose IL2 therapy to augment Tregs and reduce autoinflammation and high dose IL2 to augment Treg cells in the fight against cancer.
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