Skip to main content

Home/ Dr. Goodyear/ Group items tagged performance

Rss Feed Group items tagged

Filter: All | Bookmarks | Topics Simple Middle
olivehealthcare

DNA Testing - Olive Health & Travel Clinic, Ilford, London - 0 views

www.olivehealthandtravel.co.uk/dna-testing

DNA Testing BCG NHS BCG vaccination BCG Injection Pregnancy Tests Travel clinic Travel vaccinations Travel jabs Travel clinic ilford

shared by olivehealthcare on 26 Jun 18 - No Cached
  • olivehealthcare on 26 Jun 18
     
    In legal cases, DNA Testing performed by only registered nurses, doctors or accredited individuals. At Olive Health & Travel Clinic We offer pregnancy tests by a choice of blood test and urine test. Blood tests are more sensitive than urine tests so we prefer urine test for assurance.
Nathan Goodyear

How We Read Oncologic FDG PET/CT | Cancer Imaging | Full Text - 0 views

cancerimagingjournal.biomedcentral.com/...s40644-016-0091-3

PET_CT PET scan CT cancer

shared by Nathan Goodyear on 20 Feb 18 - No Cached
  • In early PET literature focusing on analysis of solitary pulmonary nodules, some researchers defined malignancy based on a SUVmax threshold of greater than 2.5
  • We contend that SUV analysis has virtually no role in this setting.
  • tumours grow as spheres, whereas inflammatory processes are typically linear
  • ...35 more annotations...
  • Far more important than the SUVmax is the pattern rather than intensity of metabolic abnormality and the correlative CT findings
  • Descriptively, we define SUV < 5 as “low intensity”, 5–10 as “moderate”, 10–15 as “intense” and >15 as “very intense”
  • Evolving literature suggests that intensity of uptake is an independent prognostic factor and in some tumour subtypes superior to histopathologic characterisation.
  • aerobic glycolysis
  • Our practice of thresholding the grey and colour scale to liver as detailed above results in similar image intensity to a fixed upper SUV threshold of 8 to 10
  • The advantage of using the liver as a reference tissue is also aided by this organ having rather low variability in metabolic activity
  • When the liver is abnormal and cannot be used as a reference organ, we use the default SUV setting of an upper SUV threshold of 8
  • One of the most challenging aspects of oncologic FDG PET/CT review, however, is to recognise all the patterns of metabolic activity that are not malignant and which consequently confound interpretation
  • Many benign and inflammatory processes are also associated with high glycolytic activity
  • Future articles in the “How I Read” series will address the specific details of reading PET/CT in various cancers
  • The intensity of uptake in metastases usually parallels that in the primary site of disease
  • For example, discordant low-grade activity in an enlarged lymph node in the setting of intense uptake in the primary tumour suggests it is unlikely malignant and more likely inflammatory or reactive
  • By CT criteria the enlarged node is ‘pathologic’ but the discordantly low metabolic signature further characterises this is as non-malignant since such a node is not subject to partial volume effects and therefore the intensity of uptake should be similar to the primary site
  • The exception is when the lymph node is centrally necrotic as a small rim of viable tumour is subject to partial volume effects with expectant lower intensity of uptake; integrating the CT morphology is therefore critical to reaching an accurate interpretation
  • Small nodes that are visualised on PET are conversely much more likely to be metastatic as such nodes are subject to partial volume effects.
  • The exception to this rule is tumours with a propensity for tumour heterogeneity at different sites
  • The combination of FDG and a more specific tracer, which visualises the well-differentiated disease can be very useful to characterise this phenomenon
  • “metabolic signature”
  • For the majority of malignant processes, the intensity of metabolic abnormality correlates with degree of aggressiveness or proliferative rate.
  • a negative PET/CT study in a patient with biopsy proven malignancy would be considered false-negative
  • Warburg effect
  • There, however, are a significant minority of tumours that utilise substrates other glucose such as glutamine or fatty acids as a source of the carbon atoms required for growth and proliferation
  • This includes a subset of diffuse gastric adenocarcinomas, signet cell colonic adenocarcinomas and some sarcomas, particularly liposarcoma
  • There may be a role for other radiotracers such as fluorothymidine (FLT) or amino acid substrates in this setting.
  • Some tumours harbour mutations that result in defective aerobic mitochondrial energy metabolism, effectively simulating the Warburg effect
  • patients with hereditary paraganglioma and pheochromocytoma highlight this phenomenon
  • These have intense uptake on FDG PET/CT despite often having low proliferative rate.
  • Uterine fibroids, hepatic adenomas, fibroadenomas of the breast and desmoid tumours are benign or relatively benign lesions that can have quite high FDG-avidity.
  • Metabolic activity switches off rapidly following initiation of therapy
  • Common examples where patients have commenced active therapy but the referrer is requesting “staging” includes hormonal therapy (eg. tamoxifen) in breast cancer, oral capecitabine in colorectal cancer or high dose steroids in Hodgkin’s lymphoma
  • It is therefore critical to perform PET staging before commencement of anti-tumour therapy
  • The potential advantage of routine diagnostic CT is improved anatomic localisation and definition
  • Without intravenous contrast, additional identification of typical oncologic complications such as pulmonary embolism or venous thrombosis cannot be identified
  • If the study is performed as an “interim” restaging study after commencement of therapy but before completion, in order to reach a valid or clinically useful conclusion findings must be interpreted in the context of known changes that occur at a specific timing and type of therapy
  • The most well studied use of interim PET is in Hodgkin’s lymphoma where repeat PET after two cycles of ABVD-chemotherapy provides powerful prognostic information and may improve outcomes by enabling early change of management
  • Nathan Goodyear on 20 Feb 18
     
    good read on the PET/CT scan reading.  They mention that tumors are spheres and inflammation is linear, yet inflammation coexists with cancer; hard to simply delineate these on simple terms. I do agree aon the metabolic signature of the PET/CT scan
Nathan Goodyear

Intravenous Ascorbate as a Tumor Cytotoxic Chemotherapeutic Agent - 0 views

www.seanet.com/...d_hypotheses_1995-v44-p207.htm

vitamin C cancer IV vitamin C ascorbic acid

shared by Nathan Goodyear on 05 Mar 18 - No Cached
  • There is a 10 — 100-fold greater content of catalase in normal cells than in tumor cells
  • induce hydrogen peroxide generation
  • Ascorbic acid and its salts (AA) are preferentially toxic to tumor cells in vitro (6 — 13) and in vivo
  • ...36 more annotations...
  • related to intracellular hydrogen peroxide generation
  • only be obtained by intravenous administration of AA
  • Preferentially kills neoplastic cells
  • Is virtually non-toxic at any dosage
  • Does not suppress the immune system, unlike most chemotherapy agents
  • Increases animal and human resistance to infectious agents by enhancing lymphocyte blastogenesis, enhancing cellular immunity, strengthening the extracellular matrix, and enhancing bactericidal activity of neutrophils and modulation of complement protein
  • Strengthens the structural integrity of the extracellular matrix which is responsible for stromal resistance to malignant invasiveness
  • 1969, researchers at the NCI reported AA was highly toxic to Ehrlich ascites cells in vitro
  • In 1977, Bram et al reported preferential AA toxicity for several malignant melanoma cell lines, including four human-derived lines
  • Noto et al reported that AA plus vitamin K3 had growth inhibiting action against three human tumor cell lines at non-toxic levels
  • Metabolites of AA have also shown antitumor activity in vitro
  • The AA begins to reduce cell proliferation in the tumor cell line at the lowest concentration, 1.76 mg/dl, and is completely cytotoxic to the cells at 7.04 mg/dl
  • the normal cells grew at an enhanced rate at the low dosages (1.76 and 3.52 mg/dl)
  • preferential toxicity of AA for tumor cells. >95% toxicity to human endometrial adenocarcinoma and pancreatic tumor cells (ATCC AN3-CA and MIA PaCa-2) occurred at 20 and 30 mg/dl, respectively.
  • No toxicity or inhibition was demonstrated in the normal, human skin fibroblasts (ATCC CCD 25SK) even at the highest concentration of 50 mg/dl.
  • the use of very high-dose intravenous AA for the treatment of cancer was proposed as early as 1971
  • Cameron and Pauling have published extensive suggestive evidence for prolonged life in terminal cancer patients orally supplemented (with and without initial intravenous AA therapy) with 10 g/day of AA
  • AA, plasma levels during infusion were not monitored,
  • the long-term, oral dosage used in those experiments (10 g/day), while substantial and capable of producing immunostimulatory and extracellular matrix modulation effects, was not high enough to achieve plasma concentrations that are generally cytotoxic to tumor cells in culture
  • This low cytotoxic level of AA is exceedingly rare
  • 5 — 40 mg/dl of AA is required in vitro to kill 100% of tumor cells within 3 days. The 100% kill levels of 30 mg/dl for the endometrial carcinoma cells and 40 mg/dl for the pancreatic carcinoma cells in Figure 2 are typical
  • normal range (95% range) of 0.39-1.13 mg/dl
  • 1 h after beginning his first 8-h infusion of 115 g AA (Merit Pharmaceuticals, Los Angeles, CA), the plasma AA was 3.7 mg/dl and at 5 h was 19 mg/dl. During his fourth 8-h infusion, 8 days later, the 1 h plasma level was 158 mg/dl and 5 h was 185 mg/dl
  • plasma levels of over 100 mg/dl have been maintained in 3 patients for more than 5 h using continuous intravenous infusion
  • In rare instances of patients with widely disseminated and rapidly proliferating tumors, intravenous AA administration (10 — 45 g/day) precipitated widespread tumor hemorrhage and necrosis, resulting in death
  • Although the outcomes were disastrous in these cases, they are similar to the description of tumor-necrosis-factor-induced hemorrhage and necrosis in mice (52) and seem to demonstrate the ability of AA to kill tumor cells in vivo.
  • toxic effects of AA on one normal cell line were observed at 58.36 mg/dl and the lack of side effects in patients maintaining >100 mg/dl plasma levels
  • Although it is very rare, tumor necrosis, hemorrhage, and subsequent death should be the highest priority concern for the safety of intravenous AA for cancer patients.
  • Klenner, who reported no ill effects of dosages as high as 150 g intravenously over a 24-h period
  • Cathcart (55) who describes no ill effects with doses of up to 200 g/d in patients with various pathological conditions
  • following circumstances: renal insufficiency, chronic hemodialysis patients, unusual forms of iron overload, and oxalate stone formers
  • Screening for red cell glucose-6-phosphate dehydrogenase deficiency, which can give rise to hemolysis of red blood cells under oxidative stress (57), should also be performed
  • any cancer therapy should be started at a low dosage to ensure that tumor hemorrhage does not occur.
  • patient is orally supplementing between infusions
  • a scorbutic rebound effect can be avoided with oral supplementation. Because of the possibility of a rebound effect, measurement of plasma levels during the periods between infusions should be performed to ensure that no such effect takes place
  • Every effort should be made to monitor plasma AA levels when a patient discontinues intravenous AA therapy.
  • Nathan Goodyear on 05 Mar 18
     
    Older study, 1995, but shows the long-standing evidence that IVC preferentially is cytotoxic to cancer cells.`
sofiawalker171

Trina Blum, Atwell - Cylex® profile - 0 views

www.cylex.com.au/...trina-blum-23811062.html

Hypnosis therapy for women's work life enrichment

shared by sofiawalker171 on 06 Feb 18 - No Cached
  • sofiawalker171 on 06 Feb 18
     
    extremely passionate about enriching the lives of other women and enhancing their performance in sports, at work or life in general to help them create a life of greater happiness and fulfillment as being a professional clinical hypnotherapist in Atwell Australia.
Nathan Goodyear

Germline BRCA mutation and outcome in young-onset breast cancer (POSH): a prospective c... - 0 views

www.thelancet.com/...fulltext

breast cancer cancer BRCA 1 BRCA BRCA 2 mastectomy

shared by Nathan Goodyear on 17 Jan 18 - No Cached
  • Nathan Goodyear on 17 Jan 18
     
    New study casts doubt on survival benefit from bilateral mastectomy in women with BRCA1 or BRCA 2 breast cancer.   Of concern also, only 14% of women had genetic testing done with most occurring at the time of diagnosis.  It is very likely that these women had significant family history that could have been identified if genetic testing was performed earlier.  
olivehealthcare

Ear Irrigation | Ear Wax Removal | Ear Cleaning | Ear Wax - 0 views

www.olivehealthandtravel.co.uk/ear-irrigation

Ear Wax Removal Ear Irrigation Ear Cleaning

shared by olivehealthcare on 23 Jun 18 - No Cached
  • olivehealthcare on 23 Jun 18
     
    Ear wax removal by irrigation replaces the old fashioned technique of ear syringing. Now Ear irrigation is performed by using an electronic ear irrigation machine to remove ear wax. It is an exceptionally safe, effective and comfortable method of ear cleaning.
Nathan Goodyear

The Effect of a Vegetarian vs Conventional Hypocaloric Diabetic Diet on Thigh Adipose T... - 0 views

www.tandfonline.com/...07315724.2017.1302367

vegetarian diabetes fat nutrition

shared by Nathan Goodyear on 26 Jun 17 - No Cached
  • Nathan Goodyear on 26 Jun 17
     
    Vegetarian diet out performs low calorie diet by reducing more muscle fat.
Nathan Goodyear

Effects of zinc supplementation on sexual behavior of male rats - 0 views

www.ncbi.nlm.nih.gov/...PMC2800928

zinc Zn Testosterone hormones male hormones libido sexual dysfunction prolactin

shared by Nathan Goodyear on 09 Mar 17 - No Cached
  • Nathan Goodyear on 09 Mar 17
     
    rat study finds that zinc supplementation increases Testosterone and prolactin levels, which increase sexual performance.
vishal Parasrampuria

How to Perform Testing of Glass and PET bottles? - 0 views

vishalpet.blogspot.in/...-testing-of-glass-and-pet.html

PET bottle preform price 28 mm pco preforms Pet preform PET bottle preforms PET bottle preform

shared by vishal Parasrampuria on 22 Aug 17 - No Cached
  • vishal Parasrampuria on 22 Aug 17
     
    Some of the testing procedures are as same as Pet bottle testing. However, glass bottles don't undergo bursting tests etc. If the quality manager wants to do the same, there are specially designed machines with closed cavities, to avoid any mishap when bottle bursts.
Nathan Goodyear

Alzheimer's Disease Clinical and Research Update for Health Care Practitioners - 0 views

www.ncbi.nlm.nih.gov/...PMC3776389

Alzheimer's disease cognition memory Alzheimers brain brain health alpha-GPC phosphatidyl serine Huperzine A choline

shared by Nathan Goodyear on 26 Sep 17 - No Cached
  • Alpha GPC, phosphatidylserine, Huperzine A, and choline show promise as nutraceutical agents for enhancing cognitive performance and slowing cognitive decline
  • Alpha GPC, also known as L-Alpha Glycerylphosphorylcholine, a naturally occurring form of choline, acts as a parasympathomimetic acetylcholine precursor and has shown promise in improving cognitive symptoms related to AD, vascular dementia, and multi-infarct dementia
  • Phosphatidylserine is a widely abundant anionic phospholipid in the human body and has been shown to improve age-related cognitive changes
  • ...2 more annotations...
  • Huperzine A (a natural cholinesterase inhibitor) has been linked to improved memory performance in elderly people with benign forgetfulness, as well as patients with AD and vascular dementia
  • Cholinesterase inhibitors have been shown to have neuroprotective properties in patients with mild [37] as well as moderate-to-advanced AD
  • Nathan Goodyear on 26 Sep 17
     
    good review of treatment for Alzheimer's, both prescription and natural.
Nathan Goodyear

Effect of Distinct Lifestyle Interventions on Mobilization of Fat Storage Pools: The CE... - 0 views

circ.ahajournals.org/...CIRCULATIONAHA.117.030501

Mediterranean diet diet nutrition lifestyle obesity lifestyle intervention weight loss

shared by Nathan Goodyear on 19 Dec 17 - No Cached
  • Nathan Goodyear on 19 Dec 17
     
    low carb mediterranean nutrition out performs low fat diet; but both are not served by following weight number.  MRI shows that fat mobilization of the superior low carb mediterranean nutrition plan is not adequately reflected in weight measurement. 
sofiawalker171

A Professional Hypnotherapist Providing Medical Hypnosis for Anxiety - 0 views

www.trinablum.com/about-me

professional hypnotherapist

shared by sofiawalker171 on 08 Jan 18 - No Cached
  • sofiawalker171 on 08 Jan 18
     
    How to overcome fear and anxiety? Get in contact with Trina Blum providing sports performance hypnosis, hypnosis to cure anxiety, Life enrichment to Women
snfilms

Music Video Shooting for Upcoming Film - 0 views

snfilms Snfpa Shortfilms

shared by snfilms on 03 May 21 - No Cached
  • snfilms on 03 May 21
     
    #MusicVideo shooting pic for our upcoming #shortFilm | Performed by Debasmita Chattopadhyay Created by Sanjib Nath Subscribe us on https://www.youtube.com/c/snfilms to stay tuned on #snfilms youtube releases.
snfilms

Upcoming music video shoot - SN Films - 0 views

Snfilms Snfpa BengaliMusicVideos SnfilmsMusicSong SingingSchoolHooghly OchinPakhi

shared by snfilms on 25 Mar 21 - No Cached
  • snfilms on 25 Mar 21
     
    Shooting still of #snfpa upcoming #musicVideos performed by Debasmita Chattopadhyay directed by Sanjib Nath https://youtu.be/7JuRXedc_ks Contact us at 9051355050 for #singingCourse admission and #musicVideo shoot or edit.
snfilms

Upcoming Music Video Shoot - SNFPA - 0 views

Snfilms Snfpa BengaliMusicVideos HindiMusicVideos SnfimsMusicSong SingingSchoolHooghly khacherBhitorOchinPakhi

shared by snfilms on 09 Apr 21 - No Cached
  • snfilms on 09 Apr 21
     
    Shooting still of #snfpa upcoming #musicVideos performed by Debasmita Chattopadhyay directed by Sanjib Nath https://youtu.be/7JuRXedc_ks Contact us at 9051355050 for #singingClass admission and #musicVideo shoot.
krsnaphysio1

Physiotherapist in Gurgaon - 0 views

krsnaphysioplus.com/...physiotherapist-in-gurgaon

physiotherapist physiotherapy

shared by krsnaphysio1 on 26 Nov 19 - No Cached
  • krsnaphysio1 on 26 Nov 19
     
    Since its establishment in the year 2011, Krshna Physio Plus is aimed to provide patients with comprehensive, high quality and professional physiotherapy treatments and rehabilitation to people in need. The efficient team of three, Dr. Ravi Sahauta - A very well-known complex trauma surgeon and Orthopaedician, Dr. Dharm Pal Sharma - an ex-Air force Physio trainer and Dr. Parmila Sharma - an experienced and talented physio expert, Krshna Physio Plus is counted among the well-known Physiotherapy clinic in Gurgaon and Delhi/NCR regions.  This clinic is one of the oldest organizations which was started with a vision to help people suffering from diverse dysfunctionalities with proper guidance and treatment which encompasses mainly physical, psychological, emotional, and social well being. With 8 centers in Delhi/NCR and Bihar, we are aimed at setting over 300 centers across Asia by 2020 and become the Physiotherapy clinic in Gurgaon.  Moreover, KRSNA Physio Plus is well equipped with various advanced facilities and equipment used to treat people to assure patient satisfaction and fast recovery. We have with us Top Physiotherapist in Gurgaon and Delhi/NCR regions with us who are specialized in offering treatment in physiotherapy dealing with Orthopedic, Neurological, Pediatric, Cardio-pulmonary, and Sports Injury, etc. All the experts here put their best for providing the best results.  Our experienced team of doctors and physiotherapists in Gurgaon who would be better able to diagnose what might be making it impossible for you to crane your neck, or pick articles off the floor, or simply kneel before your deity. Sports-Related Injuries Could Happen to Anyone It could be just that badminton match on a winter evening, or an office football match. Before you realize what is happening you've pulled a back muscle or your hamstring. Playing tug-of-war in colleges and office parties is fraught with the risk of a rotator cuff injury. Cricketers diving to save
snfilms

SNFPA - Admission Open for Acting, Singing, Film Making, Spoken English, Share Trading ... - 0 views

ShareMarket intradayTrading shareTradingClass #actingInstituteHooghly singing school hooghly spokenEngilshClassesHooghly

shared by snfilms on 07 Jan 21 - No Cached
  • snfilms on 07 Jan 21
     
    Let's dream together, Let's fly high. Join SN Films Performing Arts to live your dreams. Check out our Bengali and Hindi music videos, movies, short films and web series. Contact us at 9051355050 for acting classes, singing classes, film making, spoken English classes and share trading training courses at Chandannagar (Hooghly).
snfilms

Upcoming Bengali Music Video Recording Clip. - 0 views

snfilms #BengaliMusicVideo snfilmsMusicSongs singing school hooghly tumiJabekinaBalo

shared by snfilms on 09 Jan 21 - No Cached
  • snfilms on 09 Jan 21
     
    Tumi Jabe Kina Balo | Upcoming Bengali Music Videos from SN FILMS Check out the recording glimpse of Debasmita Chattopadhyay performing with music director Soumyadip Halder. Directed by Sanjib Nath. https://youtu.be/6cPYRYFn-cc #snfilms #BengaliMusicVideos #snfilmsMusicSongs #singingSchoolHooghly #tumiJabeKinaBalo
snfilms

Haunting Memories with Loneliness - 0 views

Sn films snfpa Hindi music videos singinginstituteHooghly #yaadSatayeDinaRaina hindustaniclassical

shared by snfilms on 08 Nov 20 - No Cached
  • snfilms on 08 Nov 20
     
    Loneliness haunts memories | याद सताये Full song: https://youtu.be/GAovmDYkWJ0 Performing Debasmita Chattopadhyay Created by Sanjib Nath
snfilms

Debasmita Chattopadhyay - Khachar vitor ochin pakhi - kemne ase jay - snfilms - 0 views

#BengaliMusicVideos #snfilms #snfpa #KhacharBhitorOchinPakhi

shared by snfilms on 13 Sep 20 - No Cached
  • snfilms on 13 Sep 20
     
    খাঁচার ভিতর অচিন পাখি Performed by Debasmita Chattopadhyay Created by Sanjib Nath Music Robin Ganguli Full song: https://youtu.be/7JuRXedc_ks
« First ‹ Previous 101 - 120 of 249 Next › Last »
Showing 20▼ items per page