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Alan Rann

Get Affordable Funds As Per Your Financial Requirement With Simple Repay Option - 0 views

www.cosmeticsurgeryloans.net.au/privacy_policy.html

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shared by Alan Rann on 01 Feb 16 - No Cached
  • Alan Rann on 01 Feb 16
     
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www.cosmeticsurgeryloans.net.au/bad_credit_surgery_loans.html

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  • Alan Rann on 02 Dec 15
     
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Nathan Goodyear

Circulating 2-hydroxy and 16-α hydroxy estrone levels and risk of breast canc... - 1 views

www.ncbi.nlm.nih.gov/...PMC2562592

estrogen metabolism menopause post-menopause post menopause estrogen metabolite 2-OH-estrone 16-alpha-OH-estrone 2:16alpha-OH estrone breast cancer risk hormone hormones

shared by Nathan Goodyear on 21 Aug 14 - No Cached
  • 2-OH estrogens bind to the estrogen receptor (ER) with affinity equivalent to or greater than estradiol
  • previous prospective studies have not observed any significant associations with either 2-OH or 16α-OH estrone or the ratio of the two metabolites and breast cancer risk overall.
    • Nathan Goodyear
      Nathan Goodyear on 08 Oct 15
       
      whether that risk is increased or decreased
  • it has been hypothesized that metabolism favoring the 2-OH over the 16α-OH pathway may be inversely associated with breast cancer risk (28).
  • ...24 more annotations...
  • they may act as only weak mitogens (14, 15), or as inhibitors of proliferation
  • No significant associations have been observed between 2-OH estrone and breast cancer risk
  • While 16α-OH estrone binds to the ER with lower affinity than estradiol, it binds covalently (18-20) and once bound, fails to down-regulate the receptor (21). Thus, 16α-OH estrone stimulates cell proliferation in a manner comparable to estradiol in ER+ breast cancer cell lines
  • In this large prospective study of 2-OH and 16α-OH estrone metabolites and breast cancer risk, we did not observe any significant associations overall with either individual metabolite or with the ratio of the two metabolites
  • we observed positive associations with 2-OH estrone and the 2:16α-OH estrone ratio among women with lower BMI and women with ER-/PR-tumors,
  • To date, several epidemiologic studies have examined the association between the 2-OH and 16α-OH estrogen metabolites and breast cancer risk with inconclusive results.
  • circulating estrogen levels have been associated more strongly with ER+/PR+ tumors than with ER-/PR- tumors
  • our results do not support the hypothesis that metabolism favoring the 2-OH estrone pathway is more beneficial to breast cancer risk than that favoring the 16α-OH estrone pathway
  • we observed significant positive associations of both 2-OH estrone and the 2:16α-OH estrone ratio with ER-/PR-tumors
  • Three (30, 32, 33) of four (30-33) studies observed RRs above 1 for the association between 16α-OH estrone and breast cancer risk (range of RRs=1.23-2.47); none of the point estimates was statistically significant though one trend was suggestive
  • based on animal studies, 2-OH estrone and the 2:16α-OH estrone ratio have been hypothesized to be inversely associated with breast cancer risk
  • No significant associations have been observed between 2-OH estrone, 16α-OH estrone, or the 2:16α-OH estrone ratio and breast cancer risk and the direction of the estimates is not consistent across studies.
    • Nathan Goodyear
      Nathan Goodyear on 08 Oct 15
       
      better worded is no consistent, significant associations.   There are some studies that point to the 16 catecholestrogen and increased cancer risk; limited studies show negative effects of 2 catecholestrogens on cancer risk and prospective studies available pretty much dispel the idea that the 2:16 ratio has an risk predictability.
  • we observed a suggestive inverse association with 16α-OH estrone and a significant positive association with the 2:16α-OH estrone ratio among lean women, suggesting possible associations in a low estrogen environment.
  • 16α-OH estrone increases unscheduled DNA synthesis in mouse mammary cells (27) and hence also may be genotoxic
  • Although 2-OH estrogens are capable of redox cycling, the semiquinones and quinones (i.e., the oxidized forms) form stable DNA adducts that are reversible without DNA destruction
  • In our population of PMH nonusers, we observed no associations with ER+/PR+ tumors, but significant positive associations with 2-OH estrone and the 2:16α-OH estrone ratio among women with ER-/PR- tumors
    • Nathan Goodyear
      Nathan Goodyear on 08 Oct 15
       
      one of the few studies to find this association between 2 catecholestrogens and the 2:16 ratio and ER-/PR-tumors
  • Animal and in vitro studies have shown that hydroxy estrogens can induce DNA damage either directly, through the formation of quinones and DNA adducts, or indirectly, through redox cycling and the generation of reactive oxygen species
    • Nathan Goodyear
      Nathan Goodyear on 08 Oct 15
       
      genotoxic via directe DNA adducts and indirectly via ROS; this is in addition to the proliferative effect
  • we observed a significant positive association between the 2:16α-OH estrone ratio and breast cancer risk among lean women
  • No significant associations have been observed with the 2:16α-OH estrone ratio
  • In the Danish study, no associations were observed with either ER+ or ER- tumors among PMH nonusers
  • significant positive associations with 2-OH estrone and the 2:16α-OH estrone ratio were observed among PMH users with ER+, but not ER-, tumors
  • it is possible that the genotoxicity of 2-OH estrone plays a role in hormone receptor negative tumors
  • 4-OH estrogens have a greater estrogenic potential than 2-OH estrogens, given the lower dissociation rate from estrogen receptors compared with estradiol (61), and are potentially more genotoxic since the quinones form unstable adducts, leading to depurination and mutation in vitro and in vivo
  • the balance between the catechol (i.e., 2-OH and 4-OH) and methoxy (i.e., 2-Me and 4-Me) estrogens may impact risk
  • Nathan Goodyear on 21 Aug 14
     
    The risks of estrogen metabolism are not clear cut.  Likely never will be due to the complexity of individual metabolism.  This study found no correlation between 2OH-Estrone and 2OH:16alpha-Estrone and breast cancer risk in ER+/PR+ breast cancer.  Translated: no benefit in breast cancer risk in 2OH-Estrone metabolism or increased 2OH:16alpha estrone metabolism.  There was a positive association between 2OH-Estrone and 2:16alpha-Estrone in women with ER-/PR- tumors and low BMI.
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icerailson

4 Japanese Home Remedies for the Common Cold - 0 views

healthytokyo.com/...nese-home-remedies-common-cold

Japan cold home-remedies natural

shared by icerailson on 08 Jan 16 - No Cached
  • icerailson on 08 Jan 16
     
    With the coldest months of this winter ahead of us, let's take a look at how the Japanese tackle the common cold and stay healthy with four Japanese home remedies using natural ingredients.
wheelchairindia9

Weight Cuff - 0 views

www.wheelchairindia.com/...Tynor-Weight-Cuff

The Best Exercise for Strengthening Shoulders improve muscle strength Iron pellets filled cuff multiple sclerosis patients rehab therapy programs allowing sufficient flexibility

shared by wheelchairindia9 on 06 Apr 16 - No Cached
  • wheelchairindia9 on 06 Apr 16
     
    Tynor Weight Cuff Tynor Weight cuffs are used to exercise ailing joints to build strength and aid recovery. Tynor Weight Cuff is flexible and cushion, so it does not injure. Recommended for use to improve muscle tone, muscle mass, strength and stamina. Tynor Weight Cuff Features Offers 1 kg resistance when wrapped around Weight is wrapped in comfortable and soft fabric Used to build muscles, flexibility or to lose weight Can be secured easily around to prevent injuries or accidents Cuff is safe to be used during everyday activities as well Tynor Weight Cuff Measurements Sizes Available: 1/2 Kg / 1Kg / 2 Kg
wheelchairindia9

Chest Binder - 0 views

www.wheelchairindia.com/...Tynor-Chest-Binder

The Best Exercise for Strengthening Shoulders improve muscle strength Iron pellets filled cuff multiple sclerosis patients rehab therapy programs allowing sufficient flexibility

shared by wheelchairindia9 on 06 Apr 16 - No Cached
  • wheelchairindia9 on 06 Apr 16
     
    Tynor Chest Binder Chest Binder is applied to the thoracic region to compress and bind the rib cage and provide splinting to the sternum while allowing sufficient flexibility for comfortable breathing. Anatomic chest pad. Controlled compression. Optimum chest splinting. Soft feel. Tynor Chest Binder Features 50 mm thick PUF pad hold and binds the fractured sternum without compromising on patient comfort. Strong elastic band gives good grip and helps in equidistribution of pressure. Reduces post operative pain and discomfiture. Facilitates phlegm expulsion after cardio thoracic surgery. Tynor Chest Binder Measurements Measure circumference around the chest.
Nathan Goodyear

The anti-malarial artesunate is also active against cancer - 0 views

www.spandidos-publications.com/...767

Artesunate Cancer

shared by Nathan Goodyear on 18 Oct 18 - No Cached
  • Nathan Goodyear on 18 Oct 18
     
    Artesunate induces apoptosis in esophageal cell lines.
Nathan Goodyear

Clinical review: Specific aspects of acute renal failure in cancer patients - 0 views

www.ncbi.nlm.nih.gov/...PMC1550893

cancer renal failure

shared by Nathan Goodyear on 13 Aug 18 - No Cached
  • uric acid crystal formation in the renal tubules secondary to hyperuricaemia
  • calcium phosphate deposition related to hyperphosphataemia
  • usually develops shortly after the initiation of cytotoxic chemotherapy
  • ...18 more annotations...
  • Non-recombinant urate oxidase (Uricozyme®)
  • recombinant urate oxidase (Rasburicase®)
  • urine alkalisation may induce calcium phosphate deposition
  • renal replacement therapy should be started on an emergency basis when hydration fails to produce a prompt metabolic improvement or when ARF develops
  • Up to 50% of patients with newly diagnosed multiple myeloma have renal failure and up to 10% require dialysis
  • renal ultrasonography remains the method of choice for investigating extra-renal obstruction
  • The relief of the obstruction, either by percutaneous nephrostomy or through a ureteral stent, is the cornerstone of treatment
  • TMA may be associated with the cancer itself, with cancer chemotherapy, or with allogeneic BMT
  • thrombotic microangiopathy (TMA)
  • it may be as high as 5%
  • Most of the cases occur in patients with solid tumours, the most common type being adenocarcinoma (stomach, breast and lung)
  • The pathophysiology of the TMA-malignancy association remains controversial, although many studies suggest an insult to the vascular endothelium
  • mitomycin C. Subsequently, TMA has been reported with many anti-cancer agents, including gemcita-bine, bleomycin, cisplatin, CCNU, cytosine arabinoside, daunorubicin, deoxycoformycin, 5-FU, azathioprine and interferon α
  • Plasma exchanges have been shown to improve prognosis in the general population of patients with TMA
  • Causative factors should be looked for and antihypertensive treatment given. Lastly, in the absence of guidelines, we believe that plasma exchange should be proposed in patients with severe cancer treatment-associated TMA
  • The most widely used protective measure is saline infusion to induce solute diuresis
  • During methotrexate infusion and elimination, fluids should be given to maintain a high urinary output and urinary alkalisation should be performed to keep the urinary pH above 7.5. Rescue with folinic acid (50 mg four times a day) should be started 24 hours after each high-dose metho-trexate infusion and serum methotrexate concentrations should be measured every day
  • cyclophosphamide and ifosfamide
  • Nathan Goodyear on 13 Aug 18
     
    cancer and renal failure
beautybycagla

healthy skin | Get Beauty Tips On - 0 views

beautybycagla.com/...healthy-skin

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shared by beautybycagla on 24 Mar 19 - No Cached
  • beautybycagla on 24 Mar 19
     
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medikaur

Specialist Advanced Skin Care Treatments London - 2 views

www.medikaur.com

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shared by medikaur on 17 Jul 17 - No Cached
  • medikaur on 17 Jul 17
     
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  • medikaur on 28 Jul 17
     
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Nathan Goodyear

Effects of short-term high-fat overfeeding on genome-wide DNA methylation in the skelet... - 0 views

link.springer.com/...10.1007%2Fs00125-012-2717-8

epigenetics methylation nutrition high fat diet

shared by Nathan Goodyear on 03 Oct 17 - No Cached
  • short-term HFO introduces DNA methylation changes on a genome-wide scale in human skeletal muscle
  • These changes were only partly reversed after 6–8 weeks
  • The induction of DNA methylation changes after 5 days of HFO supports the growing awareness of DNA methylation as a dynamic signal that is possibly relevant to short-term day-to-day metabolic adaptations, including acute exercise
  • ...4 more annotations...
  • Diverging DNA methylation levels between elderly, but not young, genetically identical twins indicate that environmental exposures throughout life may permanently influence DNA methylation, suggesting some preservation of de novo DNA methylation in adults
  • our finding of a slow reversibility rate indicates the demethylation process may be somewhat impeded compared with the induction of methylation changes by diet, which could have implications for the preservation or build-up of CpG methylation over time
  • A slow reversibility of DNA methylation induced by carcinogenic agents has likewise been observed due to ingestion of high-fat diets in rodents
  • the relationship between DNA methylation and gene expression is not always straightforward
  • Nathan Goodyear on 03 Oct 17
     
    Study finds variability of methylation and some genetic expression alteration with high fat diet.  Restated, what you eat interacts with your DNA to alter genetic expression.  This has implications on initiation of therapy as well as response to therapy.
in-sync

Best Child Development Center in Hyderabad | Speech therapy in Hyderabad | In-Sync - 0 views

in-sync.in

Child psychologist in Hyderabad

shared by in-sync on 07 Nov 19 - No Cached
  • in-sync on 07 Nov 19
     
    Are you looking for child speech therapy sessions in Hyderabad? The therapeutic intervention is what your kids need. Click here to know more!
Nathan Goodyear

Mechanisms of Immunosuppression in the Tumor Microenvironment - 0 views

www.rndsystems.com/...on-and-immunosuppression-tumor

TME cancer tumor microenvironment immunotherapy

shared by Nathan Goodyear on 17 Feb 21 - No Cached
  • Nathan Goodyear on 17 Feb 21
     
    Not a study, but a good short read on the immune system in the TME, i.e., immunosuppression, Treg, TGF-beta...
snfilms

Take a good look, See if you can Recognize... - 0 views

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shared by snfilms on 09 Aug 20 - No Cached
  • snfilms on 09 Aug 20
     
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catherine2345

Best Vitamins Enriched Face oils to give your skin an everlasting Look. - 0 views

livingshe.com/best-face-oil

shared by catherine2345 on 13 May 20 - No Cached
  • catherine2345 on 13 May 20
     
    Which face oils are best for your skin and why.
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Révolution du couteau gamma : un examen plus approfondi des taux de réussite ... - 0 views

frenchtoindiamedicaltravel.blogspot.com/...ccess-rate-hospital-india.html

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shared by spineneuro on 30 Jan 24 - No Cached
  • spineneuro on 30 Jan 24
     
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indiacardiacsurg

ভারতে বাংলা রিয়েল মেডিকেল অভিজ্ঞতা: ভারতের শীর্ষস্থানীয় ন্যূনতম আক্রমণাত্মক... - 0 views

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shared by indiacardiacsurg on 04 Jul 24 - No Cached
  • indiacardiacsurg on 04 Jul 24
     
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