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Nathan Goodyear

L-ascorbate Attenuates Methamphetamine Neurotoxicity Through Enhancing the Induction of... - 0 views

pubmed.ncbi.nlm.nih.gov/23022510

heme-oxygenase-1 vitamin C oxidative stress ROS reactive oxygen species

shared by Nathan Goodyear on 24 May 20 - No Cached
  • Nathan Goodyear on 24 May 20
     
    vitamin C reduces methamphetamine induced ROS view upregulation of heme-oxygenase-1 expression.
indian-health

La chirurgie cardiaque en Inde fournit les soins cardiaques les plus avancés ... - 0 views

french-health-trip-2-india.blogspot.com/...ium-cardiac-surgery-india.html

Chirurgie cardiaque Inde Coût de la chirurgie cardiaque en Inde Chirurgie cardiaque abordable en Inde Meilleur prix pour la chirurgie cardiaque en Inde Meilleurs hôpitaux de chirurgie cardiaque en Inde Les 10 meilleurs hôpitaux de chirurgie cardiaque de l

shared by indian-health on 18 Apr 22 - No Cached
  • indian-health on 18 Apr 22
     
    Les meilleurs hôpitaux de chirurgie cardiaque en Inde, des chirurgiens expérimentés et une chirurgie robotique à faible coût en Inde aident le patient à trouver la bonne solution à tous ses problèmes médicaux.
Nathan Goodyear

The effect of N-acetyl-l-cysteine (NAC) on liver toxicity and clinical outcome after he... - 0 views

www.ncbi.nlm.nih.gov/...PMC5974141

NAC liver toxicity

shared by Nathan Goodyear on 25 Apr 23 - No Cached
  • Nathan Goodyear on 25 Apr 23
     
    NAC lowers evidence of liver toxicity.
foxtik

15 Clever Tips for Eating Healthy at Restaurants l How to Eat Healthy at Restaurants? - 0 views

foxtik.com/-eating-healthy-at-restaurants

eatingtips #DiningHealthyatRestaurants restaurant foodrestaurant Tipsforeatingatrestaurant Eatinghealthy

shared by foxtik on 12 Jan 23 - No Cached
  • foxtik on 12 Jan 23
     
    Here are some tips for eating healthy when you dine out. Take advantage of these 15 Clever Tips for Eating Healthy at Restaurants.
Nathan Goodyear

Hormetic dose response to L-ascorbic acid as an anti-cancer drug in colorectal cancer c... - 0 views

www.nature.com/...s41598-018-29386-7

hermetic dose response prooxidative low dose vitamin C vitamin sodium dependent vitamin C transporter High dose IV vitamin C SVCT C high dose vitamin C

shared by Nathan Goodyear on 11 Aug 22 - No Cached
  • Nathan Goodyear on 11 Aug 22
     
    Low dose vitamin C, via SVCT, increases tumor proliferation; whereas high dose decreases tumor proliferation.
indian-health

La chirurgie cardiaque en Inde offre une option viable aux patients cardiaques - 0 views

frenchtoindiamedicatourisml.blogspot.com/...for-cardiac-surgery-india.html

Chirurgie cardiaque Chirurgie cardiaque Inde « Patients cardiaques » Les 10 meilleurs hôpitaux de chirurgie cardiaque de l'Inde meilleur prix pour la chirurgie cardiaque en Inde Top 10 des hôpitaux de chirurgie cardiaque opérations cardiaques Maladie de l

shared by indian-health on 26 Dec 22 - No Cached
  • indian-health on 26 Dec 22
     
    De nombreux patients dans le monde cherchant à subir des interventions chirurgicales cardiaques et un traitement choisissent l'Inde en raison des services cliniques de premier ordre à des tarifs modérément bon marché.
Nathan Goodyear

We're Not "DON" Yet: Optimal Dosing and Prodrug Delivery of 6-Diazo-5-oxo-L-norleucine ... - 0 views

www.ncbi.nlm.nih.gov/...PMC6130910

glutamine DON dosing cancer

shared by Nathan Goodyear on 17 Mar 24 - No Cached
  • Glutamine is the most abundant amino acid in blood
  • Rapidly proliferating healthy cells (GI epithelium, lymphocytes) or cells under physiologic stress have increased demand for glutamine
  • Glutamine is transported into cells by one of multiple amino acid transporters (e.g. ASCT2, BOAT2), several of which are thought to be upregulated in cancer cells
  • ...10 more annotations...
  • it is hydrolyzed to glutamate and ammonia by glutaminase (‘glutaminolysis’)
  • Glutamate, produced from glutamine by glutaminase and glutamine amidotransferase activities, may be further metabolized to alpha ketoglutarate and provide a carbon skeleton source for the mitochondrial tricarboxylic acid cycle (TCA cycle)
  • Glutamine-derived glutamate is also involved in the synthesis of the reducing equivalent glutathione, vital to maintaining cellular redox status
  • Many tumors become largely dependent on glutamine to provide carbon and nitrogen building blocks needed for proliferation
  • In cancer model systems, Eagle and colleagues first demonstrated tumor cells in culture require supplementation with exogenous glutamine for efficient proliferation
  • It was subsequently shown that when deprived of glutamine tumor cells undergo apoptosis
  • The most well-characterized oncogene to regulate glutamine metabolism is MYC (9), which enhances glutaminase expression, upregulates glutamine transporters, and enhances glutamine utilization in energy production and biosynthesis
  • Other pro-tumorigenic regulators such as KRAS and mTOR, as well as tumor suppressors (p53, VHL) have also been associated with alterations in glutamine metabolism
  • Tumor cells are highly adaptable and alter nutrient uptake and metabolic networks to resist single agent glutaminase inhibition
  • cells in the microenvironment of several tumor types upregulate glutamine production, thereby enabling tumor cells to escape glutaminase inhibition
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