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Nathan Goodyear

Lipopolysaccharide (LPS) increases the invasive ability of pancreatic cancer cells thro... - 0 views

onlinelibrary.wiley.com/...full

LPS lipopolysaccharides cancer pancreatic cancer

shared by Nathan Goodyear on 11 Sep 17 - No Cached
  • Nathan Goodyear on 11 Sep 17
     
    only abstract available here.  LPS increased pancreatic cancer cell invasion and progression through TLR4 and MyD88.
Nathan Goodyear

microRNA Expression in Ethnic Specific Early Stage Breast Cancer: an Integration and Co... - 0 views

www.nature.com/...s41598-017-16978-y

genetics cancer epigenetics breast cancer

shared by Nathan Goodyear on 06 Feb 18 - No Cached
mamdouh_hfz liked it
  • dysregulated miRNA could be involved in tumor cell proliferation and growth as well as cell cycle progression
  • under-expression of miR-497, 376c and 1271 in Lebanese breast cancer tissues
  • The upregulated miR-183 in our samples was predicted to be responsible for the decrease in expression of the BTG1 mRNA whose protein is involved in cell cycle arrest and apoptosis in breast cancer cells18.
  • ...9 more annotations...
  • nother molecule related to cell proliferation that was over-expressed in our data and suggested as a target of downregulated miR-376c is AURKA
  • the over-expression of miR-183 and miR-21 in Lebanese breast cancer tissues is consistent with downregulation of two important tumor suppressor predicted targets: AKAP12 whose protein regulates cellular adhesion dynamics by controlling cytoskeletal architecture, cell migration, and mitogenic signaling20; and LATS2 whose protein causes cell cycle arrest
  • dysregulation in cancer particularly in breast cancer highlights their importance in tumor development
  • mRNA-miRNA integration analysis of early breast cancer revealed a potential role of miRNA in increasing cellular proliferation and progression, and decreasing invasion and migration
  • most of the miRNA dysregulated in Lebanese breast cancer patients are similar to those dysregulated in American patients, differences in miRNA expression exist and could be attributed either to the patients’ age at diagnosis or to ethnic variation in miRNA epigenetic regulation and sequence variation of pre-miRNA
  • the number one cancer killer of women worldwide
  • microRNA (miRNA) are small non-coding 18–25 nucleotide RNA molecules currently being studied as potential diagnostic, prognostic and therapeutic biomarkers for cancer and other diseases
  • Extensive research on these post-transcriptional modulators has proven that they are deregulated in breast cancerous tissues and even in biological fluids from breast cancer patients
  • five candidate miRNAs (miR-10b, miR-148b, miR-221, miR-21, and miR-155)
  • Nathan Goodyear on 06 Feb 18
     
    Epigenetics plays a role, via disregulated miRNA, in increased cell growth, progression, and invasion in Lebanese women with breast cancer.  It is not just genetics that play a role, but epigenetics.
Nathan Goodyear

Frontiers | Management of Glioblastoma Multiforme in a Patient Treated With Ketogenic M... - 0 views

www.frontiersin.org/...full

press-pulse therapy hyperbaric ketogenic metabolic therapy cancer ketogenic diet Glioblastoma glioblastoma multiforme HBOT nutrition

shared by Nathan Goodyear on 01 Apr 18 - No Cached
  • The SOC for GBM was modified in this patient to initiate KMT prior to surgical resection, to eliminate steroid medication, and to include HBOT as part of the therapy
  • the greatest therapeutic benefit for patients (near 1.0)
  • The observed reduction in blood glucose in our patient would reduce lactic acid fermentation in the tumor cells, while the elevation of ketone bodies would fuel normal cells thus protecting them from hypoglycemia and oxidative stress
  • ...30 more annotations...
  • Previous studies showed that GBM survival and tumor growth was correlated with blood glucose levels
  • Evidence indicates that glioma cells cannot effectively use ketone bodies for energy due to defects in the number, structure, and function of their mitochondria
  • The accuracy of the GKI as a predictor for therapeutic efficacy, however, is better when ketone bodies are measured from the blood than when measured from the urine
  • A reduction of glucose-driven lactic acid fermentation would not only increase tumor cell apoptosis, but would also reduce inflammation and edema in the tumor microenvironment thus reducing tumor cell angiogenesis and invasion
  • Besides serving as a metabolic fuel for GBM, glutamine is also an essential metabolite for normal immune cells
  • therapies that inhibit glutamine availability and utilization must be strategically employed to avoid inadvertent impairment of immune cell functions
  • we used the non-toxic green tea extract, EGCG, and chloroquine in an attempt to limit glutamine availability to the tumor cells
  • EGCG is thought to target the glutamate dehydrogenase activity that facilitates glutamine metabolism in GBM cells
  • Chloroquine, on the other hand, will inhibit lysosomal digestion thus restricting fermentable amino acids and carbohydrates from phagocytosed materials in the tumor microenvironment
  • HBOT to increase oxidative stress in the tumor cells
  • As glucose and glutamine fermentation protect tumor cells from oxidative stress, reduced availability of these metabolites under ketosis could enhance the therapeutic action of HBOT, as we recently described
  • Prior to subtotal tumor resection and standard of care (SOC), the patient conducted a 72-h water-only fast
  • Following the fast, the patient initiated a vitamin/mineral-supplemented ketogenic diet (KD) for 21 days that delivered 900 kcal/day
  • KD (increased to 1,500 kcal/day at day 22
  • the patient received metformin (1,000 mg/day), methylfolate (1,000 mg/day), chloroquine phosphate (150 mg/day), epigallocatechin gallate (400 mg/day), and hyperbaric oxygen therapy (HBOT) (60 min/session, 5 sessions/week at 2.5 ATA)
  • Biomarkers showed reduced blood glucose and elevated levels of urinary ketones with evidence of reduced metabolic activity (choline/N-acetylaspartate ratio) and normalized levels of insulin, triglycerides, and vitamin D
  • This is the first report of confirmed GBM treated with a modified SOC together with KMT and HBOT, and other targeted metabolic therapies
  • Glioblastoma multiforme (GBM) is the most common and malignant of the primary adult brain cancers
  • less than 20% of younger adults generally survive beyond 24 months
  • glucose and glutamine are the primary fuels that drive the rapid growth of most tumors including GBM
  • Glucose drives tumor growth through aerobic fermentation (Warburg effect), while glutamine drives tumor growth through glutaminolysis
  • The fermentation waste products of these molecules, i.e., lactic acid and succinic acid, respectively, acidify the tumor microenvironment thus contributing further to tumor progression
  • Glucose and glutamine metabolism is also responsible for the high antioxidant capacity of the tumor cells thus making them resistant to chemo- and radiotherapies
  • The reliance on glucose and glutamine for tumor cell malignancy comes largely from the documented defects in the number, structure, and function of mitochondria and mitochondrial-associated membranes
  • These abnormalities cause the neoplastic GBM cells to rely more heavily on substrate level phosphorylation than on oxidative phosphorylation for energy
  • dexamethasone not only increases blood glucose levels but also increases glutamine levels through its induction of glutamine synthetase activity
    • Nathan Goodyear
      Nathan Goodyear on 21 May 18
       
      use mannitol instead
  • Calorie restriction and restricted KD are anti-angiogenic, anti-inflammatory, anti-invasive, and also kill tumor cells through a proapoptotic mechanism
  • Evidence also shows that therapeutic ketosis can act synergistically with several drugs and procedures to enhance cancer management improving both progression free and overall survival
  • hyperbaric oxygen therapy (HBOT) increases oxidative stress on tumor cells especially when used alongside therapies that reduce blood glucose and raise blood ketones
  • The glutamine dehydrogenase inhibitor, epigallocatechin gallate (EGCG) is also proposed to target glutamine metabolism
  • Nathan Goodyear on 01 Apr 18
     
    Case study of Glioblastoma treated with ketogenic metabolic therapy as an adjuct to modified standard therapy.
Nathan Goodyear

Lipopolysaccharide (LPS) increases the invasive ability of pancreatic cancer cells thro... - 0 views

onlinelibrary.wiley.com/...jso.21392

LPS cancer pancreatic cancer NF-kappaB

shared by Nathan Goodyear on 10 Jan 21 - No Cached
  • Nathan Goodyear on 10 Jan 21
     
    Lipopolysaccharide (LPS) activates Toll-like 4 receptors (TLR-4) to increase cancer invasion, growth, and metastasis.
Nathan Goodyear

Radiation-enhanced cell migration/invasion process: A review - ScienceDirect - 0 views

www.sciencedirect.com/...S1040842814000857

cancer metastasis radiation

shared by Nathan Goodyear on 09 Feb 21 - No Cached
  • Nathan Goodyear on 09 Feb 21
     
    Radiation induces invasion and metastasis.
Nathan Goodyear

Cyclic AMP regulates the migration and invasion potential of human pancreatic cancer cells - 0 views

www.ncbi.nlm.nih.gov/...PMC4087083

cyclic AMP cAMP cancer

shared by Nathan Goodyear on 14 Feb 21 - No Cached
  • Nathan Goodyear on 14 Feb 21
     
    An increase in cAMP inhibits pancreatic cell invasions and migration in cell study.
spineneuro

French to India Medical Travel: Meilleur chirurgien de la colonne vertébrale ... - 0 views

frenchtoindiamedicaltravel.blogspot.com/...-india-new-hospital-india.html

Meilleur chirurgien de la colonne vertébrale mini-invasive Mumbai Inde Coût de la chirurgie robotique de la colonne vertébrale en Inde Les meilleurs chirurgiens robotiques de la colonne vertébrale en Inde Dr. Mihir Bapat India

shared by spineneuro on 11 Sep 21 - No Cached
  • spineneuro on 11 Sep 21
     
    Coût de la chirurgie robotique de la colonne vertébrale L'Inde est le facteur le plus influent pour les patients, ce qui signifie que les personnes souffrant de troubles de la colonne vertébrale sont attirées par un coût aussi raisonnable. Le meilleur chirurgien de la colonne vertébrale minimalement invasif, Mumbai en Inde, est prêt à vous fournir la meilleure assistance médicale pour vous aider à soulager vos maux de dos chroniques.
spineneuro

Best Robotic Spine Surgery Raising Spine Surgery Care in India to A Bold New Level ~ Ne... - 0 views

neuro-and-spine-surgery-in-india.blogspot.com/...india-to-a-bold-new-level.html

Best robotic spine surgery hospitals in India Dr. Mihir Bapat top minimally invasive spine surgeon in Mumbai India

shared by spineneuro on 26 Apr 22 - No Cached
  • spineneuro on 26 Apr 22
     
    Best robotic spine surgery hospitals in India are being run by world-famous doctors with the knowledge of every guideline of the medical world. Dr. Mihir Bapat is one of the top spine surgeons for minimally invasive surgery in India.
indiacardiacsurg

Robotic Cardiac Surgery in India A Boon In The World of Cardiac Surgery by Rachel Smith - 0 views

www.apsense.com/...-world-of-cardiac-surgery.html

robotic cardiac surgery minimally invasive cardiac surgeons top hospitals for robotic cardiac surgery robotic cardiac surgical treatment in india

shared by indiacardiacsurg on 14 Jan 22 - No Cached
  • indiacardiacsurg on 14 Jan 22
     
    The success rates of robotic cardiac surgery in India are paramount; the success rate provided by a list of top 10 minimally invasive cardiac surgeons in India is close to 98%, which is unquestionably top-notch. Call for appointment +91-9370586696 or you may write to the doctor enquiry@indiacardiacsurgerysite.com
spineneuro

Unveiling Excellence in Spine Care: Dr. Mihir Bapat, Mumbai's Leading Minimally Invasiv... - 0 views

www.briefingwire.com/...ing-minimally-invasive-surgeon

Dr. Mihir Bapat Minimally Invasive Surgeon Spine Surgeon in Nanavati Mumbai

shared by spineneuro on 24 Jun 23 - No Cached
  • spineneuro on 24 Jun 23
     
    Spine issues bring hundreds of people to their doctors every year. Dr. Mihir Bapat is a highly renowned spine surgeon in Mumbai, India strives to provide the most advanced medical spinal treatments possible based on practices by utilizing the latest in surgical technology.
spineneuro

French to India Medical Travel: Gardien de la vie : récit de survie d'un pati... - 0 views

frenchtoindiamedicaltravel.blogspot.com/...der-dr-mihir-bapat-s-care.html

Dr Mihir Bapat chirurgien mini-invasif de la colonne vertébrale colonne vertébrale mini-invasive

shared by spineneuro on 30 Nov 23 - No Cached
  • spineneuro on 30 Nov 23
     
    En chirurgie de la colonne vertébrale, le Dr Mihir Bapat est une lueur d'espoir. Réputé pour son expertise dans les techniques mini-invasives, le Dr Bapat a acquis la réputation de s'attaquer aux cas les plus difficiles avec précision et succès. Zuva Nkomo a trouvé du réconfort entre les mains d'un chirurgien dont les compétences transcendent les frontières.
spineneuro

Cirq Robotic Arm By Dr Mihir Bapat Nanavati Enhances Spine Surgeries and Increases Prec... - 0 views

www.briefingwire.com/...geries-and-increases-precision

Dr. Mihir Bapat Nanavati minimally invasive spine surgery Nanavati Hospital Mumbai

shared by spineneuro on 05 Feb 22 - No Cached
  • spineneuro on 05 Feb 22
     
    Dr. Mihir Bapat Nanavati was the first healthcare professional in India to perform minimally invasive spine surgery using the Cirq® arm. Cirq is a medical professional-controlled robotic arm, designed to increase the precision in navigating complex spinal surgeries. Phone No.: +91 9325887033 Email: dr.mihirbapat@neurospinehospital.com
Nathan Goodyear

Assessment of adrenal function by measurement of sa... [Steroids. 2007] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17257634

cortisol hormone hormones salivary hormone salivary hormones' testing steroids

shared by Nathan Goodyear on 02 Mar 13 - No Cached
  • Nathan Goodyear on 02 Mar 13
     
    Saliva shown to be "simple, safe, well-accepted and non-invasive" technique to evaluate cortisol levels.
Nathan Goodyear

Less Invasive Treatment is Associated with Improved Survival in Early Stage Breast Canc... - 0 views

www.dukehealth.org/...l-in-early-stage-breast-cancer

breast cancer breast cancer CA lumpectomy mastectomy

shared by Nathan Goodyear on 30 Jan 13 - No Cached
  • Nathan Goodyear on 30 Jan 13
     
    better survival with lumpectomy and radiation versus mastectomy for early stage breast cancer.
Nathan Goodyear

Vitamin D status and breast cancer in Saudi Arabian women: case-control study - 0 views

ajcn.nutrition.org/...105.abstract

vitamin d cancer breast breast cancer

shared by Nathan Goodyear on 26 Jun 13 - No Cached
  • Nathan Goodyear on 26 Jun 13
     
    Breast cancer inversely associated with vitamin D levels in Saudi Arabian women.  Invasive cancer also correlated with lower vitamin D levels.
Nathan Goodyear

Association of Preoperative Testosterone Levels with Biochemical Failure in Men Undergo... - 0 views

online.liebertpub.com/...jomh.2013.0016

Testosterone low T prostate cancer male men hormone hormones

shared by Nathan Goodyear on 25 Jan 14 - No Cached
  • Nathan Goodyear on 25 Jan 14
     
    Low Testosterone as defined via serum levels found to correlate with poor outcome in prostate cancer: positive margins, seminal vesicle invasion, and biochemical failure (ADR).
Nathan Goodyear

SMW - Swiss Medical Weekly - 22481443 - 0 views

www.smw.ch/...smw-2012-13557

Calprotectin inflammation

shared by Nathan Goodyear on 06 Jan 14 - No Cached
  • Nathan Goodyear on 06 Jan 14
     
    Calprotectin is useful marker to follow inflammation in those with IBD.  Less invasive and can be used as a marker to follow recurrence.  Calprotectin is a neutrophil protein.
Nathan Goodyear

http://download.springer.com/static/pdf/242/art%253A10.1007%252Fs10549-010-1177-4.pdf?a... - 0 views

download.springer.com/...1007%252Fs10549-010-1177-4.pdf

CBD cancer cannabidiol breast cancer

shared by Nathan Goodyear on 15 Dec 14 - No Cached
  • Nathan Goodyear on 15 Dec 14
     
    CBD reduces breast cancer proliferation, invasion, and metastasis.  Analysis was via human cell cultures.
Shelia Morales

Skincare & Skinmedica Laser Treatments St. louis | O'Fallon - 0 views

www.kristenjacobs.com/...laser-treatments

Anti-aging O'fallon Skinmedica O'fallon Skincare Fairview heights Skincare Swansea Skincare O'fallon botox Shiloh fillers Swansea Anti-aging Belleville Anti-aging St. louis

shared by Shelia Morales on 01 Jan 15 - No Cached
  • Shelia Morales on 01 Jan 15
     
    Cutera was founded in 1998 and has quickly become a leader in the laser and light-based aesthetic market. Their lasers are used widely by primary care physicians, dermatologists, plastic surgeons and gynecologists for safe, effective and non-invasive aesthetic treatments for their patients.
Nathan Goodyear

Expression of estrogen receptors-α and -β in bladder cancer cell lines and hu... - 0 views

onlinelibrary.wiley.com/...full

ER ER beta ER-beta bladder cancer bladder cancer

shared by Nathan Goodyear on 04 Jan 15 - No Cached
  • Nathan Goodyear on 04 Jan 15
     
    ER-beta is commonly expressed versus ER-alpha in bladder cancer.  There was a positive correlation between ER-beta expression and invasion and grade of cancer.  This study also found that blockade of the ER resulted in a decrease in growth.
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