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Nathan Goodyear

Effect of hyperthermia on epididymal cyclic AMP levels in diabetic non-diabetic and hyp... - 0 views

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    Hyperthermia increases cAMP
Nathan Goodyear

Cyclic AMP regulates the migration and invasion potential of human pancreatic cancer cells - 0 views

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    An increase in cAMP inhibits pancreatic cell invasions and migration in cell study.
Nathan Goodyear

Chemoresistant KM12C Colon Cancer Cells Are Addicted to Low Cyclic AMP Levels in a Phos... - 0 views

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    Cancer loves low cAMP.
Nathan Goodyear

Cells | Free Full-Text | Targeting Cyclic AMP Signalling in Hepatocellular Carcinoma | ... - 0 views

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    Telling quote from this article, "...confirm that cAMP suppression may be a critical mediator of tumorigenic mechanisms."
Nathan Goodyear

Beyond the male sex hormone: deciphering the metabolic and vascular actions of testoste... - 0 views

  • androgen deprivation therapy results in unfavorable changes in body composition, insulin resistance, and dyslipidemia and predisposes men to develop atherosclerosis and an increased risk of cardiovascular mortality
  • The hypogonadal–obesity cycle hypothesis was originally proposed by Cohen in 1999 to explain the relationship between low testosterone levels and metabolic disease. It was based on the finding that obesity impairs testosterone levels by increasing the aromatization of testosterone to estradiol, while low testosterone levels promote increased fat deposition
  • adipocytokines contribute to low testosterone levels as well as to the processes underlying metabolic syndromes and type 2 diabetes
  • ...15 more annotations...
  • hypogonadal–obesity–adipocytokine hypothesis
  • The presence of estradiol and the adipocytokines TNF-α, IL6, and leptin (as a result of leptin resistance in obesity) inhibits the hypothalamic–pituitary–testicular axis response to decreasing androgen levels
  • An increasing number of studies have illustrated the potential for applying metabolomics to the field of androgen research
  • As early as the 1940s, the therapeutic use of testosterone was reported to improve angina pectoris in men with coronary artery disease
  • most of the epidemiological studies reported increased cardiovascular risk and mortality in men with low testosterone levels
  • long-term testosterone replacement appears to be a safe and effective means of treating hypogonadal elderly men
  • a recent interventional trial showed that testosterone treatment was associated with decreased mortality when compared with no testosterone treatment in an observational cohort of men with low testosterone levels
  • a number of short-term studies conducted support the notion that testosterone therapy reduces the cardiovascular risk
  • The majority of animal studies support the hypothesis that the actions of testosterone on vascular relaxation are both endothelium-dependent and -independent vasodilatory effects
  • Endothelial-dependent actions of testosterone increase the expression or activity of endothelial nitric oxide synthase and enhance nitric oxide production, which in turn activates cyclic guanosine monophosphate to induce vasorelaxation in smooth muscle cells
  • Endothelial-independent mechanisms of testosterone are believed to occur primarily via inhibition of voltage-operated Ca2+ channels and/or activation of K+ channels in smooth muscle cells
  • Testosterone may also inhibit intracellular Ca2+ influx via store-operated Ca2+ channels by blocking the response to prostaglandin F2α
  • testosterone has demonstrated anti-inflammatory effects to protect against atherogenesis in animal studies
  • both genomic AR activation to modulate gene transcription and non-genomic activation to modulate the rapid intracellular signaling pathways of ion channels may mediate testosterone effects on vascular function and inflammation.
  • Butenandt & Ruzicka first showed how testosterone is synthesized and responsible for masculine characteristics in the early 1930s
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    Awesome review on the current understanding of Testosterone and Diabetes, metabolic syndrome, and CVD.  This article even goes into the literature on androgen receptors.
Nathan Goodyear

Inhibition of breast cancer cell migration by activation of cAMP signaling - PubMed - 0 views

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    Increase in cAMP found to inhibit breast cancer motility and migration. Here, they used cAMP analogs, forskolin and PDE inhibitors.
Nathan Goodyear

Phosphodiesterase 4D Inhibitors Limit Prostate Cancer Growth Potential - 0 views

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    PDE inhibitors increase cAMP and useful to inhibit invasion and mobility of prostate cancer.
Nathan Goodyear

Effect of hyperthemia in combination with vitamin E and cyclic amp on neuroblastoma cel... - 0 views

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    Study finds that the additions of vitamin E and cAMP increases the efficacy of hyperthermia.
Nathan Goodyear

Heat treatment induces an increase in intracellular cyclic AMP content in human epiderm... - 0 views

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    Hyperthermia increases cAMP.
Nathan Goodyear

Phosphodiesterase-5 inhibitors in the management of cancer - 0 views

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    Phosphodiesterase 5 inhibitors shown to have numerous effects against cancer, including restoring treatment sensitivity to chemotherapy.
Nathan Goodyear

Chemoresistant KM12C Colon Cancer Cells Are Addicted to Low Cyclic AMP Levels in a Phos... - 0 views

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    PDE inhibition increases cAMP to restore chemosensitivity in this cell study.
Nathan Goodyear

Phosphodiesterase, cAMP, and cGMP - 0 views

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    Not a study, but just a nice descriptive slide.
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