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Nathan Goodyear

Effect of hyperthermia on epididymal cyclic AMP levels in diabetic non-diabetic and hyp... - 0 views

pubmed.ncbi.nlm.nih.gov/196989

hyperthermia cAMP cyclic AMP

shared by Nathan Goodyear on 14 Feb 21 - No Cached
  • Nathan Goodyear on 14 Feb 21
     
    Hyperthermia increases cAMP
Nathan Goodyear

Cyclic AMP regulates the migration and invasion potential of human pancreatic cancer cells - 0 views

www.ncbi.nlm.nih.gov/...PMC4087083

cyclic AMP cAMP cancer

shared by Nathan Goodyear on 14 Feb 21 - No Cached
  • Nathan Goodyear on 14 Feb 21
     
    An increase in cAMP inhibits pancreatic cell invasions and migration in cell study.
Nathan Goodyear

Chemoresistant KM12C Colon Cancer Cells Are Addicted to Low Cyclic AMP Levels in a Phos... - 0 views

cancerres.aacrjournals.org/...5248.long

cancer cyclic AMP cAMP

shared by Nathan Goodyear on 14 Feb 21 - No Cached
  • Nathan Goodyear on 14 Feb 21
     
    Cancer loves low cAMP.
Nathan Goodyear

Cells | Free Full-Text | Targeting Cyclic AMP Signalling in Hepatocellular Carcinoma | ... - 0 views

www.mdpi.com/...htm

cancer cyclic AMP cAMP

shared by Nathan Goodyear on 14 Feb 21 - No Cached
  • Nathan Goodyear on 14 Feb 21
     
    Telling quote from this article, "...confirm that cAMP suppression may be a critical mediator of tumorigenic mechanisms."
Nathan Goodyear

Beyond the male sex hormone: deciphering the metabolic and vascular actions of testoste... - 0 views

joe.endocrinology-journals.org/...C1.full

AR androgen receptors androgen receptor testosterone androgen receptors Diabetes metabolic syndrome MetS CVD cardiovascular disease men hormone hormones male

shared by Nathan Goodyear on 08 May 13 - No Cached
  • androgen deprivation therapy results in unfavorable changes in body composition, insulin resistance, and dyslipidemia and predisposes men to develop atherosclerosis and an increased risk of cardiovascular mortality
  • The hypogonadal–obesity cycle hypothesis was originally proposed by Cohen in 1999 to explain the relationship between low testosterone levels and metabolic disease. It was based on the finding that obesity impairs testosterone levels by increasing the aromatization of testosterone to estradiol, while low testosterone levels promote increased fat deposition
  • adipocytokines contribute to low testosterone levels as well as to the processes underlying metabolic syndromes and type 2 diabetes
  • ...15 more annotations...
  • hypogonadal–obesity–adipocytokine hypothesis
  • The presence of estradiol and the adipocytokines TNF-α, IL6, and leptin (as a result of leptin resistance in obesity) inhibits the hypothalamic–pituitary–testicular axis response to decreasing androgen levels
  • An increasing number of studies have illustrated the potential for applying metabolomics to the field of androgen research
  • As early as the 1940s, the therapeutic use of testosterone was reported to improve angina pectoris in men with coronary artery disease
  • most of the epidemiological studies reported increased cardiovascular risk and mortality in men with low testosterone levels
  • long-term testosterone replacement appears to be a safe and effective means of treating hypogonadal elderly men
  • a recent interventional trial showed that testosterone treatment was associated with decreased mortality when compared with no testosterone treatment in an observational cohort of men with low testosterone levels
  • a number of short-term studies conducted support the notion that testosterone therapy reduces the cardiovascular risk
  • The majority of animal studies support the hypothesis that the actions of testosterone on vascular relaxation are both endothelium-dependent and -independent vasodilatory effects
  • Endothelial-dependent actions of testosterone increase the expression or activity of endothelial nitric oxide synthase and enhance nitric oxide production, which in turn activates cyclic guanosine monophosphate to induce vasorelaxation in smooth muscle cells
  • Endothelial-independent mechanisms of testosterone are believed to occur primarily via inhibition of voltage-operated Ca2+ channels and/or activation of K+ channels in smooth muscle cells
  • Testosterone may also inhibit intracellular Ca2+ influx via store-operated Ca2+ channels by blocking the response to prostaglandin F2α
  • testosterone has demonstrated anti-inflammatory effects to protect against atherogenesis in animal studies
  • both genomic AR activation to modulate gene transcription and non-genomic activation to modulate the rapid intracellular signaling pathways of ion channels may mediate testosterone effects on vascular function and inflammation.
  • Butenandt & Ruzicka first showed how testosterone is synthesized and responsible for masculine characteristics in the early 1930s
  • Nathan Goodyear on 08 May 13
     
    Awesome review on the current understanding of Testosterone and Diabetes, metabolic syndrome, and CVD.  This article even goes into the literature on androgen receptors.
Nathan Goodyear

Inhibition of breast cancer cell migration by activation of cAMP signaling - PubMed - 0 views

pubmed.ncbi.nlm.nih.gov/26022351

phosphodiesterase inhibitors breast cancer phosphodiesterase 5 inhibitors cyclic AMP PDE5 inhibitors cAMP

shared by Nathan Goodyear on 08 Mar 21 - No Cached
  • Nathan Goodyear on 08 Mar 21
     
    Increase in cAMP found to inhibit breast cancer motility and migration. Here, they used cAMP analogs, forskolin and PDE inhibitors.
Nathan Goodyear

Phosphodiesterase 4D Inhibitors Limit Prostate Cancer Growth Potential - 0 views

www.ncbi.nlm.nih.gov/...PMC4312503

cyclic AMP prostate cancer cAMP phosphodiesterase inhibitors

shared by Nathan Goodyear on 08 Mar 21 - No Cached
  • Nathan Goodyear on 08 Mar 21
     
    PDE inhibitors increase cAMP and useful to inhibit invasion and mobility of prostate cancer.
Nathan Goodyear

Effect of hyperthemia in combination with vitamin E and cyclic amp on neuroblastoma cel... - 0 views

www.sciencedirect.com/...0024320584903746

cAMP cancer vitamin E hyperthermia

shared by Nathan Goodyear on 14 Feb 21 - No Cached
  • Nathan Goodyear on 14 Feb 21
     
    Study finds that the additions of vitamin E and cAMP increases the efficacy of hyperthermia.
Nathan Goodyear

Heat treatment induces an increase in intracellular cyclic AMP content in human epiderm... - 0 views

www.ncbi.nlm.nih.gov/...PMC1151059

cAMP hyperthermia

shared by Nathan Goodyear on 14 Feb 21 - No Cached
  • Nathan Goodyear on 14 Feb 21
     
    Hyperthermia increases cAMP.
Nathan Goodyear

Phosphodiesterase-5 inhibitors in the management of cancer - 0 views

cAMP PDE5 inhibitors phosphodiesterase inhibitors PDE chemotherapy phosphodiesterase 5 inhibitors cancer cyclic AMP

shared by Nathan Goodyear on 16 Feb 21 - No Cached
  • Nathan Goodyear on 16 Feb 21
     
    Phosphodiesterase 5 inhibitors shown to have numerous effects against cancer, including restoring treatment sensitivity to chemotherapy.
Nathan Goodyear

Chemoresistant KM12C Colon Cancer Cells Are Addicted to Low Cyclic AMP Levels in a Phos... - 0 views

cancerres.aacrjournals.org/...5248

phosphodiesterase colorectal cancer chemoresistance PDE phosphodiesterase inhibitors

shared by Nathan Goodyear on 16 Feb 21 - No Cached
  • Nathan Goodyear on 16 Feb 21
     
    PDE inhibition increases cAMP to restore chemosensitivity in this cell study.
Nathan Goodyear

Phosphodiesterase, cAMP, and cGMP - 0 views

ars.els-cdn.com/...-S0024320519303996-ga1_lrg.jpg

angiogenesis PDE phosphodiesterase cancer proliferation cGMP apoptosis cAMP cyclic AMP

shared by Nathan Goodyear on 16 Feb 21 - No Cached
  • Nathan Goodyear on 16 Feb 21
     
    Not a study, but just a nice descriptive slide.
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