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Nathan Goodyear

Metabolic Treatment of Cancer: Intermediate Results of a Prospective Case Series - 0 views

ar.iiarjournals.org/...973.abstract

IV intravenous alpha lipoic acid ALA cancer LDN low dose naltrexone

shared by Nathan Goodyear on 08 Sep 14 - No Cached
  • Nathan Goodyear on 08 Sep 14
     
    advanced, end-stage cancer treated in few patients with IV alpha lipoic acid, oral LDN, and hydroxycitrate--case study presentation.  The therapies were well tolerated without toxicity.  The authors concluded that the therapy "enhances the efficacy" of the chemotherapy.
Nathan Goodyear

The prognostic role of inflammation and hormones in patients with m... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25638467

Testosterone cancer TNF-alpha hormone hormones CRP

shared by Nathan Goodyear on 02 Feb 15 - No Cached
  • Nathan Goodyear on 02 Feb 15
     
    Study finds that declining Testosterone levels and increasing TNF-alpha and CRP are associated with shorter end-stage cancer survival.  Testosterone is not the same in men and women.  The effects on inflammatory cytokines are different.  This study should be divided into women and men to better differentiate these effects.
Richard Joseph

Eyeglasses & Eyewear Specials in St. Louis | Mobypicture - 0 views

www.mobypicture.com/...17911795

Eyeglasses in O'Fallon

shared by Richard Joseph on 13 Mar 15 - No Cached
  • Richard Joseph on 13 Mar 15
     
    Don't miss out on this great promotion! Enjoy up to 30% off every eyeglasses & Eyewear product in St. Louis, IL area. See office for details. This offer ends March 31, 2015.
Nathan Goodyear

Implications of free radicals and antioxidant levels in carcinoma of the breast: A neve... - 0 views

www.indianjcancer.com/article.asp

SOD superoxide disumutase catalase antioxidants antioxidant breast cancer cancer malondialdehyde MDA lipid peroxides oxidative stress inflammation

shared by Nathan Goodyear on 10 Nov 14 - No Cached
  • Experimental investigations as well as clinical and epidemiological findings have provided evidence supporting the role of reactive oxygen metabolites or free radicals such as singlet oxygen O 2 - , superoxide anions (O 2 ), hydrogen peroxide (H­2 O2 ) and hydroxyl radical in the etiology of cancer.
  • Certain aldehydes such as Malonyldialdehyde (MDA), the end product of lipid peroxidation arising from free radical degeneration of polyunsaturated fatty acids can cause cross linking in lipids, proteins and nucleic acids leading to cellular damage.
  • In this study, patients with cancer exhibited higher levels of MDA, both in tissues and serum (p<0.001) compared to the control group [Table 1]. In tissue, the MDA level in stage IV was significantly higher as compared to stage I indicating increased free radical activity with increasing severity of cancer
  • ...6 more annotations...
  • From these observations, it can be concluded that MDA levels play an important role in assessing the outcome of cancer
  • SOD and CAT are considered primary antioxidant enzymes, since they are involved in direct elimination of reactive oxygen metabolites. [13-16] They also act as anti-carcinogens and inhibitors at initiation and promotion/transformation stage in carcinogenesis
  • In our study, SOD and CAT levels were found to be low in all cancer patients as compared to controls
  • Fridovich and Tayarani have demonstrated in their respective studies that the reduction in SOD activity increases the toxic effects of O2 - and this might lead to severe cellular damage.
  • Mehrotra et al. in their study also observed high levels of MDA and low levels of SOD and CAT in patients of cancer cervix which is in sync with our observations.
  • strong evidence regarding the definitive role of free radicals in breast malignancy.
  • Nathan Goodyear on 10 Nov 14
     
    This study finds a strong correlation between advancing breast cancer, decreased catalase and SOD with increasing MDA.  The authors of this study conclude this is a key factor in carcinogenesis and not a by-product of cancer.  This flies in the face of traditional medicines fear of antioxidant therapy in cancer.
wheelchairindia9

Ultra Lightweight Folding Wheelchair - 0 views

onlywheelchair.blogspot.in/...weight-folding-wheelchair.html

Ultra Lightweight Folding Wheelchair Ultra Light Wheelchair Transport Wheelchair Karma KM 2500 Lightweight Wheelchair Ultra Lightweight Wheelchair KM 2500 Wheelchair Portable Wheelchair

shared by wheelchairindia9 on 09 Dec 15 - No Cached
  • wheelchairindia9 on 09 Dec 15
     
    Ultra light wheelchairs are part of the manual wheelchair series that offer a light durable frame and great features. Ultra light wheelchairs that are considered folding wheelchairs, meaning that the frame can be folded and stored into a small space, such as a vehicle trunk, car garage or storage space. Ultra light wheelchairs offer performance and durability in a manual wheelchair that can't be beat. These wheelchairs come in three frame options: rigid wheelchairs, titanium wheelchairs and folding wheelchairs. Folding Ultralight Wheelchair is ideal for both outdoor and indoor usage, and mostly used while travelling. With the available locking footrests to hold the front end rigid and receivers mounted on the side frames to hold the folding mechanism firmly, these chairs deliver rigid ride characteristics with the convenience of an ultra lightweight folding wheelchair. Karma KM 2500 Small Wheel Wheelchair: Karma KM 2500 Small Wheel Wheelchair Specifications: Width 18" Front/Rear Wheels 6" to 14" Seat Width 47cm Seat Depth 40cm Overall Width 66cm Overall Collapsed Width 36cm Armrest Height 21cm Overall Length 90cm Seat Height 47cm Backrest Height 38cm Overall Height 86cm Weight 9.2 k.g. Karma KM 2500 Small Wheel Wheelchair Seat and Back: AEGIS Microbe Shield Approved by the FDA, EPA, EU, etc., bonded anti-microbial barrier upholstery protects from odor, staining and deterioration from bacteria, fungus and other microorganisms. It is a shield for your health. Karma KM 2500 Small Wheel Wheelchair Extended Armrest: By simulating the natural position of arms, the extended armrest design is ergonomic and creates bigger seating space. An Ultra lightweight wheelchair (9.2 kg) with a compact design for either attendant assisted or self propelling users. The use of aircraft-grade aluminium alloy and double cross brace provide this model with outstanding strength and durability. Karma Healthcare KM-2500 Premium Wheelchair i
Nathan Goodyear

Study of Artesunate in Metastatic Breast Cancer - Full Text View - ClinicalTrials.gov - 0 views

clinicaltrials.gov/...NCT00764036

artemisinin artesunate cancer

shared by Nathan Goodyear on 14 May 19 - No Cached
  • Nathan Goodyear on 14 May 19
     
    The purpose here is for the list of studies at end that were published as a result of this 1 phase 1 study.
Nathan Goodyear

Cellular and molecular basis for endometriosis-associated infertility - 0 views

www.ncbi.nlm.nih.gov/...PMC3429772

endometriosis epigenetics infertility

shared by Nathan Goodyear on 13 Sep 17 - No Cached
  • Retrospective studies have shown that women with a first-degree relative with endometriosis are 5%–8% more likely to have endometriosis
  • Having a sister with endometriosis increases the risk of developing endometriosis by 5.2-fold
  • epigenetic reprogramming during embryonic or fetal development
  • ...1 more annotation...
  • DNMT1, DNMT3A and DNMT3B are over-expressed
  • Nathan Goodyear on 13 Sep 17
     
    good review of the cellular physiology of endometriosis and associated increased infertility.  At the end of the article, they discuss possible epigenetic causes.  Is endometriosis the result of epigenetics?
Nathan Goodyear

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde... - 0 views

www.hindawi.com/...360438

MDA malondialdehyde peroxidation oxidative stress free radicals

shared by Nathan Goodyear on 05 Dec 17 - No Cached
  • Hydroxyl radicals cause oxidative damage to cells because they unspecifically attack biomolecules [22] located less than a few nanometres from its site of generation and are involved in cellular disorders such as neurodegeneration [23, 24], cardiovascular disease [25], and cancer [26, 27].
  • It is generally assumed that in biological systems is formed through redox cycling by Fenton reaction, where free iron (Fe2+) reacts with hydrogen peroxide (H2O2) and the Haber-Weiss reaction that results in the production of Fe2+ when superoxide reacts with ferric iron (Fe3+)
  • other transition-metal including Cu, Ni, Co, and V can be responsible for formation in living cells
  • ...20 more annotations...
  • The hydroperoxyl radical () plays an important role in the chemistry of lipid peroxidation
  • The is a much stronger oxidant than superoxide anion-radical
  • Lipid peroxidation can be described generally as a process under which oxidants such as free radicals or nonradical species attack lipids containing carbon-carbon double bond(s), especially polyunsaturated fatty acids (PUFAs) that involve hydrogen abstraction from a carbon, with oxygen insertion resulting in lipid peroxyl radicals and hydroperoxides as described previously
  • under medium or high lipid peroxidation rates (toxic conditions) the extent of oxidative damage overwhelms repair capacity, and the cells induce apoptosis or necrosis programmed cell death
  • The overall process of lipid peroxidation consists of three steps: initiation, propagation, and termination
  • Once lipid peroxidation is initiated, a propagation of chain reactions will take place until termination products are produced.
  • The main primary products of lipid peroxidation are lipid hydroperoxides (LOOH)
  • Among the many different aldehydes which can be formed as secondary products during lipid peroxidation, malondialdehyde (MDA), propanal, hexanal, and 4-hydroxynonenal (4-HNE) have been extensively studied
  • MDA has been widely used for many years as a convenient biomarker for lipid peroxidation of omega-3 and omega-6 fatty acids because of its facile reaction with thiobarbituric acid (TBA)
  • MDA is one of the most popular and reliable markers that determine oxidative stress in clinical situations [53], and due to MDA’s high reactivity and toxicity underlying the fact that this molecule is very relevant to biomedical research community
  • 4-HNE is considered as “second toxic messengers of free radicals,” and also as “one of the most physiologically active lipid peroxides,” “one of major generators of oxidative stress,” “a chemotactic aldehydic end-product of lipid peroxidation,” and a “major lipid peroxidation product”
  • MDA is an end-product generated by decomposition of arachidonic acid and larger PUFAs
  • Identifying in vivo MDA production and its role in biology is important as indicated by the extensive literature on the compound (over 15 800 articles in the PubMed database using the keyword “malondialdehyde lipid peroxidation” in December 2013)
  • MDA reactivity is pH-dependent
  • When pH decreases MDA exists as beta-hydroxyacrolein and its reactivity increases
  • MAA adducts are shown to be highly immunogenic [177–181]. MDA adducts are biologically important because they can participate in secondary deleterious reactions (e.g., crosslinking) by promoting intramolecular or intermolecular protein/DNA crosslinking that may induce profound alteration in the biochemical properties of biomolecules and accumulate during aging and in chronic diseases
  • MDA is an important contributor to DNA damage and mutation
  • This MDA-induced DNA alteration may contribute significantly to cancer and other genetic diseases.
  • Dietary intake of certain antioxidants such as vitamins was associated with reduced levels of markers of DNA oxidation (M1dG and 8-oxodG) measured in peripheral white blood cells of healthy subjects, which could contribute to the protective role of vitamins on cancer risk
  • 4-HNE is an extraordinarily reactive compound
  • Nathan Goodyear on 05 Dec 17
     
    Great review of lipid peroxidation
Nathan Goodyear

[Malondialdehyde (MDA) as a lipid peroxidation marker]. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15765761

MDA malondialdehyde oxidative stress peroxidation free radicals

shared by Nathan Goodyear on 05 Dec 17 - No Cached
  • Nathan Goodyear on 05 Dec 17
     
    Only abstract her and it is an older article.  Malondialdehyde (MDA) is a great marker of oxidative stress.  Specifically, MDA is an end product of polyunsaturated fat peroxidation.
Nathan Goodyear

The emerging role of nutrition in Parkinson's disease - 0 views

www.ncbi.nlm.nih.gov/...PMC3945400

nutrition disease Parkinson's disease Parkinson's

shared by Nathan Goodyear on 18 Oct 17 - No Cached
  • Nathan Goodyear on 18 Oct 17
     
    Good review of the current data on the role of nutrition in Parkinson's disease.  Take home, a lot of data is conflicting.  But the figure at the end does well to summarize: diet rich in polyphenols in fruits/veggies, carotenoids, resveratrol, Vitamin C, D, E, and MUFA and PUFA are neuroprotective compared to dairy being neurodegenerative.
snfilms

New Music Releases Of Katy Perry - 0 views

sdtunes NewReleases katyperry

shared by snfilms on 12 May 21 - No Cached
  • snfilms on 12 May 21
     
    Latest releases from #KatyPerry | Check out I'll cry about it later, Not the End of the World and more on #sdtunes http://www.sdtunes.com/.../katy-perry-huge-hit-music...
Nathan Goodyear

Positive feedback loop between cancer stem cells and angiogenesis in hepatocellular car... - 0 views

www.sciencedirect.com/...S0304383516301628

CSC angiogenesis cancer stem cells

shared by Nathan Goodyear on 27 Apr 21 - No Cached
  • Nathan Goodyear on 27 Apr 21
     
    Closed end, feed-back look of CSC and angiogenesis.
Nathan Goodyear

ALIVE AND WELL by Philip E. Binzel, Jr., M.D. - 1 views

whale.to/binzel.html

cancer amygdalin vitamin B17 laetrile Dr. Binzel

shared by Nathan Goodyear on 16 Apr 18 - No Cached
  • Nathan Goodyear on 16 Apr 18
     
    The end report of Dr. Binzel's experience with the use of Laetril in cancer.
Nathan Goodyear

Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis - 1 views

www.ncbi.nlm.nih.gov/...PMC3937164

sepsis IV vitamin C vitamin C CRP

shared by Nathan Goodyear on 11 Oct 17 - No Cached
  • Padayatty and colleagues showed that high-level ascorbic acid plasma concentrations could only be achieved by intravenous administration
  • No patient in the low or high dose ascorbic acid treatment arms of this study suffered any identifiable adverse event
  • a pharmacologic ascorbic acid treatment strategy in critically ill patients with severe sepsis appears to be safe
  • ...7 more annotations...
  • subnormal plasma ascorbic acid levels are a predictable feature in patients with severe sepsis
  • Ascorbic acid depletion in sepsis results from ascorbic acid consumption by the reduction of plasma free iron, ascorbic acid consumption by the scavenging of aqueous free radicals (peroxyl radicals), and by the destruction of the oxidized form of ascorbic acid dehydroascorbic acid
  • Sepsis further inhibits intracellular reduction of dehydroascorbic acid, producing acute intracellular ascorbic acid depletion
  • Ascorbic acid treated patients in this study exhibited rapid and sustained increases in plasma ascorbic acid levels using an intermittent every six hours administration protocol
  • Septic ascorbic acid-deficient neutrophils fail to undergo normal apoptosis. Rather, they undergo necrosis thereby releasing hydrolytic enzymes in tissue beds, thus contributing to organ injury
  • We speculate that intravenous ascorbic acid acts to restore neutrophil ascorbic acid levels
  • Repletion of ascorbic acid in this way allows for normal apoptosis, thus, preventing the release of organ damaging hydrolytic enzymes.
  • Nathan Goodyear on 11 Oct 17
     
    Study finds IV vitamin C in patients with sepsis is very safe and blunts the effects (endothelial damage, end organ damage...) of sepsis.  Of note, the IV vitamin C group reached serum levels of ascorbic acid of 1,592 to 5,722 micromol/L.  The IV groups maintained elevated serum C levels for up to 96 hours post infusion.  
digitalorainfo

Blog - Best Wordpress Developer / Digital Marketing Agency in Atlanta, GA - 0 views

www.webagencyatlanta.com/blog

Wordpress SEO Experts in Atlanta GA

shared by digitalorainfo on 21 May 20 - No Cached
  • digitalorainfo on 21 May 20
     
    We don't just build a boat, we make it sail too. Our team of expert developers is adept in both front-end and back-end programming and are delivering innovative web solutions everyday.
digitalorainfo

Blog - Ora Infotech - 0 views

orainfotech.com/blog

Android App and Web Development Company in USA

shared by digitalorainfo on 21 May 20 - No Cached
  • digitalorainfo on 21 May 20
     
    We don't just build a boat, we make it sail too. Our team of expert developers is adept in both front-end and back-end programming and are delivering innovative web solutions everyday.
ashleyobama

Nembutal Liquid | pills nembutal |Nembutal Liquid | - 0 views

www.roidsmeds.com/...nembutal-liquid

shared by ashleyobama on 28 May 20 - No Cached
  • ashleyobama on 28 May 20
     
    Nembutal Liquid is best quality and prices at First Trust Chemicals. Visit our website and place your order online. Nembutal Liquid Pentobarbital (trade name: Nembutal) is a drug from the barbiturate class. It was widely used during the 1940s and 1950s as a sleeping pill (i.e. hypnotic) or anti-anxiety drug (i.e. sedative). Unlike modern sleeping pills, Nembutal is highly lethal in overdose. Because it is very reliable and brings about peaceful death, it is one of drugs of choice for assisted suicide. Nembutal is used by euthanasia organizations in the United States (Oregon Death With Dignity Act), Switzerland (Dignitas) and The Netherlands. Nembutal Liquid Since it was so easy to overdose on Nembutal (whether accidentally or intentionally), it was almost universally taken off the market and replaced by safer sleeping pills. Nembutal was removed from the Australian prescribing schedule in 1998. However, Nembutal remains in use by veterinary surgeons in order to euthanase bigger animals. Many people were successful in obtaining veterinary Nembutal for their suicide. The famous American actress Marilyn Monroe supposedly used Nembutal to end her life. The brand name "Nembutal" was coined by Dr. John S. Lundy, who started using it in 1930, from the structural formula of the sodium salt-Na (sodium) + ethyl + methyl + butyl + al (common suffix for barbiturates). Nembutal is trademarked and manufactured by the Danish pharmaceutical company Lundbeck
snfilms

Share Trading Course Admission - 0 views

shareMarket intraday shareTradingClass sharetradingCrouse

shared by snfilms on 03 Dec 20 - No Cached
  • snfilms on 03 Dec 20
     
    শেয়ার ট্রেডিং কোর্স | Join #snfpa to learn #shareTrading and start making regular income. Diwali discount ends on 30-Nov. Contact 9051355050 for admission and inquiries. #Trainer Sanjib Nath
indiacardiacsurg

New Heart Transplant Program Launched by Dr. Naresh Trehan India - 0 views

www.briefingwire.com/...ched-by-dr-naresh-trehan-india

Dr. Naresh Trehan Best Cardiac Surgeon in Gurgaon Heart Transplant Surgery in India Top hospital for heart transplant surgery India Best heart transplant surgeon of India Best Cardiac Surgeon in Medanta Gurgaon

shared by indiacardiacsurg on 13 Oct 21 - No Cached
  • indiacardiacsurg on 13 Oct 21
     
    Under the best cardiac surgeon in Gurgaon's leadership, the heart transplant program will provide low-cost hospitals for heart transplant surgery in India with individualized treatment for patients with advanced heart failure in India. Dr. Naresh Trehan India will see patients alongside cardiologists, as well as nurse practitioners, social workers, and other specialists to provide comprehensive care and support patients with end-stage heart disease. For Appointment- +91-9370586696 Email id: nareshtrehan@indiacardiacsurgerysite.com
indiacardiacsurg

Quality of Life With High Heart Transplant Surgery Survival Rate in India - 101 Press R... - 0 views

www.101pressrelease.com/surgery-survival-rate-in-india

heart transplant surgery heart transplant surgery survival rate in India Top hospital for heart transplant surgery india affordable low cost hospital for heart transplant in india Low Cost Heart Transplant Surgery India

shared by indiacardiacsurg on 06 Oct 21 - No Cached
  • indiacardiacsurg on 06 Oct 21
     
    The heart transplant surgery survival rate in India for patients is as high as 95 to 100 percent. As a result, traveling to India for heart surgery might be a boon for end-degree heart patients. India Cardiac Surgery Hospital International Helpline Number : +91-9370586696 Email id: enquiry@indiacardiacsurgerysite.com
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