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Nathan Goodyear

Drug-induced lupus erythematosus. [Autoimmunity. 2005] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...16373256

Lupus drug-induced

shared by Nathan Goodyear on 19 Feb 11 - No Cached
  • More than 80 drugs have been associated with DILE.
  • Nathan Goodyear on 19 Feb 11
     
    Drug induced Lupus
Nathan Goodyear

Atypical antipsychotic drugs and the risk of sudde... [N Engl J Med. 2009] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...19144938

atypical antipsychotic drugs risk

shared by Nathan Goodyear on 06 Apr 11 - No Cached
  • Current users of typical and of atypical antipsychotic drugs had a similar, dose-related increased risk of sudden cardiac death.
  • Nathan Goodyear on 06 Apr 11
     
    antipsychotic drugs increase risk of sudden cardiac death
Nathan Goodyear

Multiple Myeloma Tumor Cells are Selectively Killed by Pharmacologically-dosed Ascorbic... - 0 views

www.ebiomedicine.com/...fulltext

multiple myeloma vitamin C IV vitamin C smoldering myeloma cancer

shared by Nathan Goodyear on 25 Sep 17 - No Cached
  • Recent reports indicate that a certain ROS concentration is required for high-dose vitamin C to induce cytotoxicity in cancer cells.
  • The generation of ascorbyl- and H2O2 radicals by PAA increases ROS stress in cancer cells
  • In this study, we report that PAA is efficacious in killing MM cells in vitro and in vivo models, which generated levels of 20–40 mM ascorbate and 500 nM ascorbyl radicals after intraperitoneal administration of 4 g ascorbate per kilogram of body weight (Chen et al., 2008Chen et al., 2008), in xenograft MM mice
  • ...33 more annotations...
  • These data suggest that PAA may show a therapeutic advantage to blood cancers vs solid tumors because of the communication between tumor cells and blood plasma
  • These results strongly suggest that the mechanism of PAA killing of MM cells is indeed iron-dependent
  • These results suggest that PAA administration in SMM may be able to prevent progression to symtomatic MM
  • A recent study by Yun and colleagues demonstrated that vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH, but spares normal cells
  • RAS family genes show the most frequent mutations in MM. KRAS, NRAS and BRAF are mutated in 22%, 20% and 7% of MM samples
  • the disease stage rather than the mutation of RAS and/or BRAF is the major predictive factor for PAA sensitivity in MM treatment
  • Other molecular mechanisms including ATP depletion and ATM-AMPK signaling have been reported to explain PAA-induced cell death
  • our pilot study also suggested that PAA could overcome drug resistance to bortezomib in MM cells
  • Our findings complement reported studies and further address the mechanism of action using clinical samples in which we observed that PAA killed tumor cells with high iron content, suggesting that iron might be the initiator of PAA cytotoxicity
  • combination of PAA with standard therapeutic drugs, such as melphalan, may significantly reduce the dose of melphalan needed
  • Combined treatment of reduced dose melphalan with PAA achieved a significantly longer progression-free survival than the same dose of melphalan alone.
  • These data also suggest that the bone marrow suppression induced by high-dose melphalan can be ameliorated by the combination of PAA with lower dose of melphalan because of the lack of toxicity of PAA on normal cells with low iron content.
  • if creatinine clearance is <30 mL/min, high dose ascorbic acid should be not administrated.
  • In MM preclinical and clinical studies, ascorbate was used as an adjunct drug and showed controversial results (Harvey et al., 2009, Perrone et al., 2009, Held et al., 2013, Sharma et al., 2012, Nakano et al., 2011, Takahashi, 2010, Sharma et al., 2009, Qazilbash et al., 2008). However, none of these tests used pharmacological doses of ascorbate and intravenous administration
  • Multiple myeloma (MM) is a plasma cell neoplasm.
  • Cameron and Pauling reported that high doses of vitamin C increased survival of patients with cancer
  • pharmacologically dosed ascorbic acid (PAA) 50–100 g (Chen et al., 2008, Padayatty et al., 2004, Hoffer et al., 2008, Padayatty et al., 2006, Welsh et al., 2013), administered intravenously, has potent anti-cancer activity and its role as anti-cancer therapy is being studied at the University of Iowa and in other centers
  • In the presence of catalytic metal ions like iron, PAA administered intravenously exerts pro-oxidant effects leading to the formation of highly reactive oxygen species (ROS), resulting in cell death
  • the labile iron pool (LIP) is significantly elevated in MM cells
  • The survival of CD138+ cells in vitro was significantly decreased following PAA treatment in all 9 MM
  • In contrast, no significant change of cell viability was observed in CD138− BM cells from the same patients
  • The same effect of PAA was also observed in the SMM patients
  • no response to PAA was detected in CD138+ cells from the 2 MGUS patients
  • the combination of melphalan plus PAA showed greater tumor burden reduction than each drug alone, suggesting a synergistic activity between these two drugs
  • Both catalase and NAC protect cells from oxidative damage
  • cells pretreated with NAC and catalase became resistant to PAA even at high doses
  • adding deferoxamine (DFO), an iron chelator, to OCI-MY5 cells before PAA treatment was also sufficient to prevent PAA-induced cellular death
  • iron is essential for PAA to achieve its anti-cancer activity
  • PAA induced early necrosis (Fig. 3Fig. 3A, 60 min) followed by late apoptosis
  • results further indicated that PAA induced mitochondria-mediated apoptosis
  • PAA by reacting with LIP and generating ROS induces mitochondria-mediated apoptosis in which AIF1 cleavage is important for cell death.
  • ROS and H2O2 are well known factors mediating PAA-induced cancer cell death
  • PAA was sensitive to all 9 MMs and 2 SMMs
  • Nathan Goodyear on 25 Sep 17
     
    animal study finds high-dose, pharmacologic vitamin C found to kill multiple myeloma cells via pro-oxidant effect found in similar studies in dealing with different cancers.
Nathan Goodyear

The Pharmacokinetics and Interactions of Ivermectin in Humans-A Mini-review - 0 views

www.ncbi.nlm.nih.gov/...PMC2751445

Ivermectin

shared by Nathan Goodyear on 19 Mar 18 - No Cached
  • This drug is extensively metabolized by human liver microsomes by cytochrome P450
  • cytochrome P-4503A4, converting the drug to at least 10 metabolites
  • its elimination half-life is around a day
  • ...12 more annotations...
  • second rise in plasma levels (mostly occurring between 6 and 12 h after the dose) suggesting an enterohepatic recycling of the drug
  • Ivermectin is exceptionally potent, with effective dosages levels that are unusually low.
  • the optimal dose of ivermectin is 150 μg/kg, but the frequency of administration is still controversial, ranging from 150 μg/kg once to three times yearly.
  • high lipid solubility of ivermectin, this compound is widely distributed within the body.
  • To interrupt the transmission of onchocerciasis in humans, the combination of ivermectin and doxycycline is highly effective as, in infested patients, the ingestion of the anthelmintic (200 μg/kg, single dose) and the antibacterial (100 mg/kg, daily for 6 weeks)
  • ivermectin interactions with another concurrently administered drugs can occur.
  • This issue becames important, as combination chemotherapy is being used with increasing frequency as resistance to antiparasitic agents is becoming more widespread.
  • haematomatous swellings
  • prothrombin times were significantly above baseline by one week to one month after drug ingestion, suggesting an antagonist effect against vitamin K
  • bleeding disorders were not found in 15,000 patients treated with ivermectin (150 μg/kg)
  • prolonged prothrombin ratios were observed in 148 subjects given ivermectin orally. Although no patients suffered bleeding complications, factor II and VII levels were reduced in most of them, suggesting interference with vitamin K metabolism
  • Ivermectin has a minimal effect on coagulation and concern about mass treatment for this reason appears to be unjustified
  • Nathan Goodyear on 19 Mar 18
     
    Review of Ivermectin as an anti-parasitic.
Nathan Goodyear

Cancer Drugs - National Cancer Institute - 0 views

www.cancer.gov/...drugs

cancer chemotherapy cancer drugs

shared by Nathan Goodyear on 09 May 18 - No Cached
  • Nathan Goodyear on 09 May 18
     
    NIH resource of cancer drugs
Nathan Goodyear

ScienceDirect.com - Biochemical Pharmacology - CARBOXYLESTERASE-2 IS A HIGHLY SENSITIVE... - 0 views

www.sciencedirect.com/...S0006295212007678

Alli xenical toxicity orlistat weight loss drugs weight loss drugs

shared by Nathan Goodyear on 11 Dec 12 - No Cached
  • Nathan Goodyear on 11 Dec 12
     
    popular weight loss drug Alli linked to liver, pancreatic, and kidney toxicity.
Nathan Goodyear

Stanford scientists discover multitude of drug side effects, interactions using new com... - 0 views

med.stanford.edu/...offsides.html

stanford side effects medicine prescription drugs

shared by Nathan Goodyear on 05 Apr 12 - No Cached
  • Nathan Goodyear on 05 Apr 12
     
    A proper title would have been, "are the drugs your are taking killing you?"
Nathan Goodyear

Colonization-Induced Host-Gut Microbial Metabolic Interaction - 0 views

mbio.asm.org/...e00271-10.full

gut flora gut microbiome gut microbiota CYP450 metabolism

shared by Nathan Goodyear on 06 May 15 - No Cached
  • he gut microbiota enhances the host’s metabolic capacity for processing nutrients and drugs and modulate the activities of multiple pathways in a variety of organ systems.
  • Acquisition of the gut microbiota was associated with rapid increase in body weight (4%) over the first 5 days of colonization
  • The colonization process stimulated glycogenesis in the liver prior to triggering increases in hepatic triglyceride synthesis
  • ...11 more annotations...
  • modifications of hepatic Cyp8b1 expression and the subsequent alteration of bile acid metabolites
  • Expression and activity of major drug-metabolizing enzymes (Cyp3a11 and Cyp2c29) were also significantly stimulated
  • The gut microbiota (GM) exhibits a relatively low level of diversity compared to those of most soil ecosystems and in humans it is comprised of usually no more than nine phyla of microorganisms, of which only two are dominant: the Firmicutes and the Bacteroidetes
  • colonization of a germfree gut was rapid and remarkably stable, establishing within only a week after first exposure
  • a study conducted on germfree rats by Nicholls et al. showed that 3 weeks were necessary to obtain a stabilization and “normalization”
  • the microbiota status affects the systemic metabolism of the host, modulating the metabolic fingerprint of topographically remote organs such as the liver and the kidney
  • Gut colonization induces a rapid weight gain associated with stimulation of hepatic glycogenesis and triglyceride synthesis
  • Gut colonization alters bile acid metabolite profiles via modulation of hepatic Cyp8b1 expression
  • Bile acids are well-known contributors to glucose and lipid metabolism in the liver
  • GM is known to alter bile metabolism
  • GM is also known to exert a strong influence on the metabolism of xenobiotics
  • Nathan Goodyear on 06 May 15
     
    The effects of gut microbiome are not confined to the gut.  They alter bile acid metabolism and thus lipid/glucose metabolism.  They alter CYP450 activity.  They effect metabolism.  They effect the metabolism, and thus effects, of other drugs. 
Nathan Goodyear

[Drug-induced lupus erythematosus and systemic lup... [Przegl Lek. 2007] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...18409355

drug induced lupus

shared by Nathan Goodyear on 19 Feb 11 - No Cached
  • Since that time over 80 medications are known to be responsible for development of the disease.
  • Nathan Goodyear on 19 Feb 11
     
    Drug-induced Lupus
Sonny Cher

Get a Fulfilling and Explosive Sex Life - 1 views

My friend's wife told me that she cannot cope up with her husband's stamina when they are together. And she was worried that he might try to find another woman because she cannot satisfy him. So I...

legal drugs

started by Sonny Cher on 20 Apr 11 no follow-up yet
Nathan Goodyear

Evaluation of gabapentin in management of hot flushes in postmenopausal women - 0 views

min.sagepub.com/...36.short

gabapentin GABA neurontin hot flashes post menopause women vasomotor symptoms menopause

shared by Nathan Goodyear on 25 Mar 14 - No Cached
  • Nathan Goodyear on 25 Mar 14
     
    Study finds non-hormonal therapy to manage hot flashes in postmenopausal women--drug them.  The authors of this study, looked to gabapentin, also known as neurontin to treat hot flashes.  Instead of looking at the causes: hormone imbalance, stress... these authors looked to a sedating drug.  The dosing of neurontin was 900 mg.   Most can't stand at this dose.  This study points to the lunacy in the research today.  Very soon, there will be the walking dead among us.  They will be the walking doped instead of dead.
Willow O'Donnell

Refurbished B. Braun Outlook 100 Infusion IV Pump - 0 views

willowmed.tumblr.com/...n-outlook-100-infusion-iv-pump

Purchase IV pumps Buy Sell your

shared by Willow O'Donnell on 04 Nov 14 - No Cached
  • Willow O'Donnell on 04 Nov 14
     
    Refurbished B. Braun Outlook 100 Infusion IV Pump equipped with a color-coded key pad and audible key clicks, the safe, reliable and easy to use Outlook 100 infusion pump provides comprehensive "at-a-glance" viewing of infusion status on a large color display. Designed to help prevent IV medication administration errors, the Outlook 100 Safety Infusion Pump System's extensive customizable DoseGuard™ drug library allows you to configure the pump to match your clinical practice. Hospitals confidently rely on the Outlook 100 Safety Infusion Pump System's: Real-time display of dose limit values during infusion for titration safety Active alphabetic matrix for quick and easy drug selection Proven delivery mechanism provides reliable and accurate operation Air trapping cassette eliminates nuisance alarms Enhanced battery life *Refurbished *1-Year Warranty
Willow O'Donnell

Refurbished B. Braun Outlook 100 Infusion IV Pump - 0 views

www.tuugo.us/...031999453896

Purchase IV pumps Buy IV pumps Sell your IV pumps

shared by Willow O'Donnell on 31 Oct 14 - No Cached
  • Willow O'Donnell on 31 Oct 14
     
    Refurbished B. Braun Outlook 100 Infusion IV Pump equipped with a color-coded key pad and audible key clicks, the safe, reliable and easy to use Outlook 100 infusion pump provides comprehensive "at-a-glance" viewing of infusion status on a large color display. Designed to help prevent IV medication administration errors, the Outlook 100 Safety Infusion Pump System's extensive customizable DoseGuard™ drug library allows you to configure the pump to match your clinical practice. Hospitals confidently rely on the Outlook 100 Safety Infusion Pump System's: Real-time display of dose limit values during infusion for titration safety Active alphabetic matrix for quick and easy drug selection Proven delivery mechanism provides reliable and accurate operation Air trapping cassette eliminates nuisance alarms Enhanced battery life *Refurbished *1-Year Warranty
Nathan Goodyear

In vivo loss-of-function screens identify KPNB1 as a new druggable oncogene in epitheli... - 0 views

www.pnas.org/E7301

Ivermectin cancer ovarian cancer oncogene oncogenes

shared by Nathan Goodyear on 20 Mar 18 - No Cached
  • we functionally validated a potent EOC oncogene, KPNB1, and showed its clinical relevance to human EOC
  • a well-established antiparasitic drug, ivermectin, has antitumor effects on EOC through its inhibition of KPNB1
  • EOC has high intertumor and intratumor heterogeneity at the molecular and epigenetic levels
  • ...22 more annotations...
  • the mortality rate of EOC has not been significantly changed for several decades
  • Sequencing revealed that almost all tumors (96%) had mutations in TP53, which serves as a major driver of this cancer
  • Low-prevalence but statistically significant mutations in nine other genes including NF1, BRCA1, BRCA2, RB1, and CDK12 were also identified, but the majority of genes were mutated at low frequency, making it difficult to distinguish between driver and passenger mutations
  • KPNB1 inhibition via any of three KPNB1 siRNAs or importazole treatment induced apoptosis in human EOC cell lines (Fig. 3 A–F and Fig. S4), and was accompanied by an increase in the expression levels of the proapoptotic proteins BAX and cleaved caspase-3
  • Stable overexpression of KPNB1 in SKOV3 and OVCAR3 (Fig. S6) significantly accelerated cell proliferation/survival (Fig. 5 A–C), confirming that KPNB1 functions as an oncogene in EOC
  • KPNB1 overexpression significantly decreased caspase-3/7 activity (Fig. 5D), in addition to the expression levels of cleaved caspase-3 and BAX proteins (Fig. 5E). KPNB1 overexpression also decreased p21 and p27 protein levels (Fig. 5E), as opposed to their increase by KPNB1 inhibition
  • KPNB1 functions as an antiapoptotic and proproliferative oncogene in EOC.
  • Patients with higher expression levels of KPNB1 showed earlier recurrence and worse prognosis than those with lower expression levels of KPNB1
  • KPNB1 acts as an oncogene in human EOC and represents a promising therapeutic target.
  • ivermectin treatment suppressed cell proliferation/viability in a dose-dependent manner (Fig. 7A), indicating that it exerts an antitumor effect on EOC
  • ivermectin also induced apoptosis
  • ivermectin increased the expression levels of BAX, and cleaved PARP, as well as p21 and p27
  • KPNB1 inhibition is responsible for the antitumor effect of ivermectin
  • we found that ivermectin synergistically reduced cell proliferation/viability in combination with paclitaxel in human EOC cells
  • Single treatment of ivermectin or paclitaxel reduced tumor growth in nude mice, but, notably, combination treatment of ivermectin and paclitaxel almost completely suppressed tumor growth
  • ERBB2, is amplified and overexpressed in many cancers, including breast (31), ovary (31), colon (32), bladder (33), non-small-cell lung (34), and gastric cancer (35), and is a poor prognostic factor in certain cancer types
  • KPNB1 was the second-highest-ranked gene identified in our screen
  • Increased KPNB1 protein levels have been reported in several cancers, including cervical cancer (42), hepatocellular carcinoma (43), and glioma (44), suggesting KPNB1’s oncogenic potential in these tumor types
  • our findings suggest that KPNB1 might serve as a master regulator of cell cycle by regulating several cell cycle-related proteins, including p21, p27, and APC/C family members
  • higher and/or more-frequent doses of ivermectin than currently approved for humans are well tolerated in humans
  • none of the mice in this study treated with the effective dosage of ivermectin for in vivo anticancer therapy showed severe adverse event
  • we found that the combination of ivermectin and paclitaxel produces a stronger antitumor effect on EOC cell lines than either drug alone
  • Nathan Goodyear on 20 Mar 18
     
    Ivermectin found to be pro-apoptotic for the epithelial ovarian cancer oncogene, KPNB1 in in Vivo study.  This effective anti-parasitic drug inhibits the KPNB1 oncogene.
Rahul Sharma

Hydrophobic Edge CN Membrane Filters - Axiva - 0 views

www.axivafilters.com/...drophobic-c-n-membrane-filters

Hydrophobic Edge CN Membrane Filters CN membrane filters

shared by Rahul Sharma on 21 Jan 19 - No Cached
  • Rahul Sharma on 21 Jan 19
     
    Axiva Hydrophobic Edge CN Membrane Filters are used for sterility testing of antibiotics and drugs containing bacteria-stats. The hydrophobic edge does not allow the drug to seep under the rim of filter holder.
fnfdoc

Cancer Chemotherapy Via Drugs | Your Health Our Priority - 0 views

www.fnfdoc.com/...cancer-chemotherapy-via-drugs

Cancer Chemotherapy Treatment

shared by fnfdoc on 29 Apr 18 - No Cached
  • fnfdoc on 29 Apr 18
     
    How chemotherapy takes place? Depending on type of cancer and period of cancer, it stops cancer cells ability of damage and more to divide. Oftenly drugs are used and different for different person. This is systematic therapy also affect your entire body.
Nathan Goodyear

The Repurposing Drugs in Oncology (ReDO) Project - 0 views

www.ncbi.nlm.nih.gov/...PMC4096030

ReDO project cancer oncology drugs

shared by Nathan Goodyear on 19 May 18 - No Cached
  • Nathan Goodyear on 19 May 18
     
    Repurposing old drugs for the new fight in cancer.
Nathan Goodyear

Overcoming cancer therapeutic bottleneck by drug repurposing | Signal Transduction and ... - 0 views

www.nature.com/...s41392-020-00213-8

cancer repurposed drugs

shared by Nathan Goodyear on 05 Jul 20 - No Cached
  • Nathan Goodyear on 05 Jul 20
     
    Great review article on the the repurpose of old drugs for modern cancer treatment.
pharmacybiz

Reverse Decision Declining Romosozumab Use For Osteoporosis - 0 views

www.pharmacy.biz/mosozumab-use-for-osteoporosis

Romosozumab-Use-For-Osteoporosis Pharmacy-Business news-UK New-treatment-for-osteoporosis-2021 Romosozumab-osteoporosis Romosozumab-NICE

shared by pharmacybiz on 07 Jan 22 - No Cached
  • pharmacybiz on 07 Jan 22
     
    More than 100 NHS clinicians have urged the National Institute for Health and Care Excellence (NICE) to change its decision - declining recommendation of romosozumab, the first new osteoporosis medication for over a decade. In a joint letter published on January 2, the clinicians warned of the consequences of barring access to the drug to those who suffer the bone-weakening disease. The joint letter, led by the Royal Osteoporosis Society (ROS), raised concern over the scarcity of the drug pipeline for osteoporosis and lack of public funding for new research. It quoted recent government research that showed the National Institute for Health Research (NIHR) invested less than £1 million in osteoporosis research in 2020-21, against the £4.6 billion per year cost to the NHS of fractures. Craig Jones, chief executive of the Royal Osteoporosis Society said: "We're calling on NICE and the applicant company to get back round the table and work with us to ensure equal access to this important new treatment.
Nathan Goodyear

Age and Sex Patterns of Drug Prescribing in a Defined American Population - 0 views

www.mayoclinicproceedings.org/...abstract

prescription medications prescriptions medications medication

shared by Nathan Goodyear on 08 Jul 13 - No Cached
  • Nathan Goodyear on 08 Jul 13
     
    Startling statistics on the heavy use of prescription drugs by Americans.
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