Group items tagged

Chemotherapy causes EMT.

Full dose chemotherapy induces cytokine storm to induce metastasis.

Case study of long-term survival in angiosarcoma with metronomic chemotherapy.

Chemotherapy increases TAMs in the primary tumors. These TAMs suppresses the anti-cancer cytotoxicity of T cells. The authors here describe both TAMs and TIMs. TAMs are the M1/M2 most often discussed. M2 TAMs increase Tumor Infiltrating Macrophages (TIMs) which increase local immunosuppression and chemotherapy resistance.

Animal study finds synergistic effects of hyperthermia, whole body, and metronomic chemotherapy after tumor removal to prevent metastasis.

Awesome read on the review of the effects of metronomic chemotherapy.

Great review of metronomic chemotherapy

Boom!

higher glutathione S-transferase activity associated with improved survival and response with chemotherapy.

glutathione counters toxicity of chemotherapy ifosfamide and mesna

Androgen deprivation therapy is associated with increased diabetes, metabolic syndrome, insulin resistance, and cardiovascular mortality.  The longer the duration of therapy, the more the progression of metabolic dysfunction.  This process seems similar to chemotherapy i.e. secondary cancer due to chemotherapy.  The treatment of one disease, prostate cancer in this case, leads to an increase in the risk of the #1 killer in men--logic seems severely flawed there.

Chemotherapy is associated with a decline in lean body mass.  This could play a role in increase weight, especially in pre menopause women.

study suggests chemotherapy slows basic metabolic rate (BMR) in breast cancer treatment.

Older study, but adjuvant chemotherapy and age associated with weight gain after diagnosis.

Gut microbiome effected by chemotherapy and the result is GI mucositis.  A decrease in Firmicutes and Actinobacteria was found.

Omega-3 supplementation reduces chemotherapy toxicity and may increase survival

Study reviews the studies of IV vitamin C and cancer.  The authors discuss the mechanism of action of the high dose vitamin C.  The authors are correct in their conclusion that a large body of evidence is lacking and that the majority are case study.  However, to even discount these in the face of the safety and the reduction in side effects associated with chemotherapy by IV vitamin C would be unacceptable. To delay recommendation due to a full lack of understanding would be unacceptable as well.   No deaths have been reported due to IV vitamin C.  Contrast this with chemotherapy.  However, case studies have pointed to IV vitamin C as a positive tool to attach cancer.  

Study reveals negatively altered brain activity, as visualized by functional MRI, after chemotherapy.  This is a small study, but it appears to be the first to prove that "chemo brain" is not just in a patients head--in fact, it is in their brain.

Article points to potential chemosensitizing effect of T3 in cancer treatment.  Chemotherapy with increased metabolic demand with T3 may improve cancer kill rate.