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Nathan Goodyear

Prostate-specific antigen flare induced by cabazitaxel-based chemotherapy in patients w... - 0 views

www.ncbi.nlm.nih.gov/...24725337

Chemotherapy taxanes "psa flare" psa "prostate cancer"

shared by Nathan Goodyear on 05 Dec 18 - No Cached
  • Nathan Goodyear on 05 Dec 18
     
    Taxanes associated with PSA flare. The authors concluded that the flar within 12 weeks of therapy was not associated with any change in outcomes and could be ignored. The Taxanes as a whole group appears to be associated with this PSA flare pheonomenon.
Nathan Goodyear

Immunotherapy for Prostate Cancer with Gc Protein-Derived Macrophage-Activating Factor,... - 0 views

europepmc.org/...PMC2510818

GC-MAF Nagalase cancer prostate cancer immunotherapy PSA

shared by Nathan Goodyear on 08 May 18 - No Cached
  • the MAF precursor activity of prostate cancer patient Gc protein is lost or reduced, because their serum Gc protein is deglycosylated by serum α-N-acetylgalactosaminidase (Nagalase) secreted from cancerous cells
  • Administration of 100 ng of GcMAF
  • 100 ng of GcMAF was administered intramuscularly once a week
  • ...11 more annotations...
  • As GcMAF therapy progressed the MAF precursor activity of all five patients increased and their serum Nagalase activity decreased inversely
  • As GcMAF therapy progressed, the MAF precursor activity increased with a concomitant decrease in serum Nagalase activity
  • serum Nagalase is proportional to tumor burden
  • as GcMAF therapy progressed, serum Nagalase activity decreased and, concomitantly, tumor burden decreased
  • the serum Nagalase activities of all 16 patients decreased as GcMAF therapy progressed
  • annual computed tomographic scans of these patients confirmed them being tumor recurrence-free for the 7 years
  • undifferentiated cells were killed rapidly during the first few weeks, and the differentiated cells were killed slowly in the remaining GcMAF therapeutic period
  • PSA levels of prostatectomized patients decreased as serum Nagalase decreased during GcMAF therapy
  • In patients without tumor resection, however, although serum Nagalase activity decreased as GcMAF therapy progressed, their PSA values remained unchanged. The result suggests that the PSA derived from tumor-bearing prostate did not change while tumor burden decreased. Because tumor-induced inflammation in the noncancerous prostate tissues causes secretion of PSA [38], the PSA produced from these inflamed noncancerous prostate tissues cannot be changed by the decrease in tumor burden
  • Advanced cancer patients have high serum Nagalase activities, resulting in no macrophage activation and severe immunosuppression that explain why cancer patients die with overwhelming infection
  • Prognostic utility of serum α-N-acetylgalactosaminidase and immunosuppression resulted from deglycosylation of serum Gc protein in oral cancer patients
  • Nathan Goodyear on 08 May 18
     
    GC-MAF levels exist in inverse relationship to nagalase.  In this study of men with prostate cancer, weekly GCMAF injections reduced Nagalase activity to levels found in healthy controls suggesting tumor free. The dose was 100 ng/week. Nagalase is a protein that suppresses GC-MAF production and thus is immunosuppressive.
rajeshsharma10

What Key Features must you look for in a Hospital Management System? - 0 views

prathimahospitals.blogspot.com/...ures-must-you-look-for-in.html

best hospital in hyderabad best neuro hospital in hyderabad best multi specialty hospital in Hyderabad

shared by rajeshsharma10 on 31 Jul 18 - No Cached
  • rajeshsharma10 on 31 Jul 18
     
    Social insurance industry ought to be changed and update with the time, Hms365cloud Systems is giving driving administrations development in this part of human services as Hospital Management System.
Nathan Goodyear

Metabolic dysregulation in monogenic disorders and cancer - finding method in madness |... - 0 views

www.nature.com/nrc3949

cancer metabolism

shared by Nathan Goodyear on 27 Sep 18 - No Cached
  • Nathan Goodyear on 27 Sep 18
     
    only abstract available here, but nice discussion of cancer's aberrant metabolism inducing epigenetic changes to increase cancer potential.
therapy1on1

Does Relations Counseling Really Work? - Therapy 1 on 1 - Medium - 0 views

medium.com/...eling-really-work-87afcfeb75ce

online counselling services relationship

shared by therapy1on1 on 31 Mar 19 - No Cached
  • therapy1on1 on 31 Mar 19
     
    Taking a step forward towards a healthy relationship and eliminating the toxic dynamics. Statistics say that married couple counselling, pre-marital counselling, breakup counselling has helped people a lot in regaining trust and take a step forward towards a healthy and happy life and when you take a conscious effort things do change.
Nathan Goodyear

How We Read Oncologic FDG PET/CT | Cancer Imaging | Full Text - 0 views

cancerimagingjournal.biomedcentral.com/...s40644-016-0091-3

PET_CT PET scan CT cancer

shared by Nathan Goodyear on 20 Feb 18 - No Cached
  • In early PET literature focusing on analysis of solitary pulmonary nodules, some researchers defined malignancy based on a SUVmax threshold of greater than 2.5
  • We contend that SUV analysis has virtually no role in this setting.
  • tumours grow as spheres, whereas inflammatory processes are typically linear
  • ...35 more annotations...
  • Far more important than the SUVmax is the pattern rather than intensity of metabolic abnormality and the correlative CT findings
  • Descriptively, we define SUV < 5 as “low intensity”, 5–10 as “moderate”, 10–15 as “intense” and >15 as “very intense”
  • Evolving literature suggests that intensity of uptake is an independent prognostic factor and in some tumour subtypes superior to histopathologic characterisation.
  • aerobic glycolysis
  • Our practice of thresholding the grey and colour scale to liver as detailed above results in similar image intensity to a fixed upper SUV threshold of 8 to 10
  • The advantage of using the liver as a reference tissue is also aided by this organ having rather low variability in metabolic activity
  • When the liver is abnormal and cannot be used as a reference organ, we use the default SUV setting of an upper SUV threshold of 8
  • One of the most challenging aspects of oncologic FDG PET/CT review, however, is to recognise all the patterns of metabolic activity that are not malignant and which consequently confound interpretation
  • Many benign and inflammatory processes are also associated with high glycolytic activity
  • Future articles in the “How I Read” series will address the specific details of reading PET/CT in various cancers
  • The intensity of uptake in metastases usually parallels that in the primary site of disease
  • For example, discordant low-grade activity in an enlarged lymph node in the setting of intense uptake in the primary tumour suggests it is unlikely malignant and more likely inflammatory or reactive
  • By CT criteria the enlarged node is ‘pathologic’ but the discordantly low metabolic signature further characterises this is as non-malignant since such a node is not subject to partial volume effects and therefore the intensity of uptake should be similar to the primary site
  • The exception is when the lymph node is centrally necrotic as a small rim of viable tumour is subject to partial volume effects with expectant lower intensity of uptake; integrating the CT morphology is therefore critical to reaching an accurate interpretation
  • Small nodes that are visualised on PET are conversely much more likely to be metastatic as such nodes are subject to partial volume effects.
  • The exception to this rule is tumours with a propensity for tumour heterogeneity at different sites
  • The combination of FDG and a more specific tracer, which visualises the well-differentiated disease can be very useful to characterise this phenomenon
  • “metabolic signature”
  • For the majority of malignant processes, the intensity of metabolic abnormality correlates with degree of aggressiveness or proliferative rate.
  • a negative PET/CT study in a patient with biopsy proven malignancy would be considered false-negative
  • Warburg effect
  • There, however, are a significant minority of tumours that utilise substrates other glucose such as glutamine or fatty acids as a source of the carbon atoms required for growth and proliferation
  • This includes a subset of diffuse gastric adenocarcinomas, signet cell colonic adenocarcinomas and some sarcomas, particularly liposarcoma
  • There may be a role for other radiotracers such as fluorothymidine (FLT) or amino acid substrates in this setting.
  • Some tumours harbour mutations that result in defective aerobic mitochondrial energy metabolism, effectively simulating the Warburg effect
  • patients with hereditary paraganglioma and pheochromocytoma highlight this phenomenon
  • These have intense uptake on FDG PET/CT despite often having low proliferative rate.
  • Uterine fibroids, hepatic adenomas, fibroadenomas of the breast and desmoid tumours are benign or relatively benign lesions that can have quite high FDG-avidity.
  • Metabolic activity switches off rapidly following initiation of therapy
  • Common examples where patients have commenced active therapy but the referrer is requesting “staging” includes hormonal therapy (eg. tamoxifen) in breast cancer, oral capecitabine in colorectal cancer or high dose steroids in Hodgkin’s lymphoma
  • It is therefore critical to perform PET staging before commencement of anti-tumour therapy
  • The potential advantage of routine diagnostic CT is improved anatomic localisation and definition
  • Without intravenous contrast, additional identification of typical oncologic complications such as pulmonary embolism or venous thrombosis cannot be identified
  • If the study is performed as an “interim” restaging study after commencement of therapy but before completion, in order to reach a valid or clinically useful conclusion findings must be interpreted in the context of known changes that occur at a specific timing and type of therapy
  • The most well studied use of interim PET is in Hodgkin’s lymphoma where repeat PET after two cycles of ABVD-chemotherapy provides powerful prognostic information and may improve outcomes by enabling early change of management
  • Nathan Goodyear on 20 Feb 18
     
    good read on the PET/CT scan reading.  They mention that tumors are spheres and inflammation is linear, yet inflammation coexists with cancer; hard to simply delineate these on simple terms. I do agree aon the metabolic signature of the PET/CT scan
Nathan Goodyear

PET/CT Standardized Uptake Values (SUVs) in Clinical Practice and Assessing Response to... - 0 views

www.ncbi.nlm.nih.gov/...PMC3026294

cancer PET scan PET_CT CT PET_CT scan

shared by Nathan Goodyear on 20 Feb 18 - No Cached
  • use of PET in clinical research, clinical trials, and drug discovery
  • use of PET/CT in assessing response to therapy
  • In some cases, such as Hodgkins lymphoma, quantitative PET/CT imaging may not actually be needed, as success can be defined by the complete absence of tracer uptake in the PET image following a course of standardized therapy
  • ...9 more annotations...
  • The utilization of PET/CT to assess response to therapy is increasing in the US related, in part, to the creation and subsequent favorable results of the National Oncologic PET Registry (NOPR)
  • Changes in size as a result of therapy may take many months to develop and any opportunity to make early decisions about therapy success or failure is often unduly delayed or lost altogether
  • measures of changes in metabolic activity via FDG PET/CT can provide an alternate approach to assess response to therapy -- often very early in the course of treatment
  • Current recommendations are that tumor SUVs should be reported
  • The true tracer uptake in a patient is composed of two components: the first being the amount of tracer uptake (e.g. FDG) associated with the disease status (the signal of interest), which can be modified by the biophysiological status of the patient. One of the more important patient parameters is the blood glucose level, which has been shown to inversely-linearly affect SUVs
  • A prospective study by Crippa et al.30 in eight patients showed that as blood glucose levels were increased from 92.4 ±10.2 to 158 ± 13.8 mg/100 ml by glucose loading, the average SUV of 20 liver metastases decreased from 9.4 ± 5.7 to 4.3 ± 8.3
  • chemotherapy can result in impaired renal function, significantly reducing the clearance of plasma FDG through the kidney and thus increasing tumor SUV relative to an initial PET scan
  • The second component of the true tracer uptake is biological variability
  • The biological variability has been estimated in several test-retest studies7,32–35 at approximately 10% for scans repeated within a few days
  • Nathan Goodyear on 20 Feb 18
     
    Good review of the SUVs of a PET/CT scan.
Nathan Goodyear

The role of progesterone metabolites in breast cancer: Potential for new diagnostics an... - 0 views

www.sciencedirect.com/...S0960076004004224

progesterone progesterone metabolites cancer breast cancer hormones

shared by Nathan Goodyear on 07 Oct 16 - No Cached
  • Nathan Goodyear on 07 Oct 16
     
    changes in progesterone metabolism associated with breast cancer i.e. 5alpha-pregnanes are associated with proliferation in breast cancer and the 4-pregnenes inhibit proliferation and cellular detachment.
Nathan Goodyear

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflamm... - 0 views

www.cell.com/...S0092-8674(16)31162-X

inflammation LPS macrophages lipopolysaccharide mitochondria energy ATP ROS

shared by Nathan Goodyear on 12 Oct 16 - No Cached
  • Nathan Goodyear on 12 Oct 16
     
    Fascinating study: inflammation via LPS induces pro-inflammatory move by macrophages that induces a change in mitochondria to increase inflammation and decrease ATP production.
Nathan Goodyear

Young Adult Cancer: Influence of the Obesity Pandemic - Berger - 2018 - Obesity - Wiley... - 0 views

onlinelibrary.wiley.com/...oby.22137

obesity cancer

shared by Nathan Goodyear on 14 Sep 19 - No Cached
  • Nathan Goodyear on 14 Sep 19
     
    The obesity epidemic is increasing cancer risk and changing the cancer aggressiveness in younger and younger adults. The cancer of today is different than the cancer of yesterday. It behaves differently.
Nathan Goodyear

Targeting matrix metalloproteinases in cancer: Bringing new life to old ideas - Science... - 0 views

www.sciencedirect.com/...S2352304215000021

cancer MMP MMP2 MMP9 matrix metalloproteinase

shared by Nathan Goodyear on 01 May 20 - No Cached
  • Nathan Goodyear on 01 May 20
     
    Matrix Metalloproteinase expression is critical in changing the TME and promoting tumor growth, progression, and metastasis.
Nathan Goodyear

Striatal H3K27 Acetylation Linked to Glutamatergic Gene Dysregulation in Human Heroin A... - 0 views

www.ncbi.nlm.nih.gov/...27863698

opiates heroin brain brain health

shared by Nathan Goodyear on 20 Apr 17 - No Cached
  • Nathan Goodyear on 20 Apr 17
     
    Heroin use, and yes prescription opiate use, alters glutamate pathways.  Opiates change the brain.  
Nathan Goodyear

A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice: Cell Metabolism - 0 views

www.cell.com/...S1550-4131(17)30490-4

epigenitics diet nutrition ketogenic diet low carbohydrate diet low carb diet brain longevity

shared by Nathan Goodyear on 08 Sep 17 - No Cached
  • Nathan Goodyear on 08 Sep 17
     
    study of mice finds that high fat diet changes genetic expression, epigenetics, to increase lifespan of mice by 13%.
Nathan Goodyear

Reduction in the Incidence of Type 2 Diabetes With the Mediterranean Diet - 0 views

www.ncbi.nlm.nih.gov/...PMC3005482

cardiovascular disease Mediterranean diet diabetes nutrition insulin resistance inflammation

shared by Nathan Goodyear on 29 Aug 17 - No Cached
  • Nathan Goodyear on 29 Aug 17
     
    Mediterranean diet + EVOO or + nuts reduced diabetes risk those in high risk by 52%.  This was a 4 year f/u study.  A reduction of circulating inflammatory biomarkers was also noted.  Insulin resistance was noted to be improved as early as 3 months, but weight was not changed statistically throughout this study
Nathan Goodyear

Acute Sleep Loss Induces Tissue-Specific Epigenetic and Transcriptional Alterations to ... - 0 views

academic.oup.com/...JC.2015-2284

sleep epigenetics BMAL1 CLOCK CRY1 PER1 sleep deprivation

shared by Nathan Goodyear on 30 Aug 17 - No Cached
  • Nathan Goodyear on 30 Aug 17
     
    Sleep deprivation, defined as 1 night of no sleep, changed epigenetic expression of BMAL via increased methylation. Other findings: decreased cortisol, increased glucose...
Nathan Goodyear

Nonantibiotic Effects of Fluoroquinolones in Mammalian Cells - 0 views

www.jbc.org/...22287.long

flouroquinolones cipro levaquin epigenetics HIF-1alpha tendinopathy

shared by Nathan Goodyear on 16 Nov 17 - No Cached
  • Nathan Goodyear on 16 Nov 17
     
    New study suggests global epigenetics is the cause behind fluoroquinolone mechanism of the Tendinopathies.  Specifically, they suggest that Iron chelation by the fluoroquinolones supresses the expression of P4HA1 and LH1 to lead to weakend collagen.  They also described decreased epigenetic changes in collagen hydroxylation and suppression of HIF-1alpha as mechanisms contributing to the tendinopathies as well.
Nathan Goodyear

Thieme E-Journals - International Journal of Sports Medicine / Abstract - 0 views

www.thieme-connect.de/...DOI

exercise training sports sports medicine resistance training weight lifting

shared by Nathan Goodyear on 30 Nov 17 - No Cached
  • Nathan Goodyear on 30 Nov 17
     
    Only abstract available here: compound resistance treaining in highly trained young men found to increase GH and Testosterone over isolation exercises. Those that trained > 2 years had significnt increase in Testosterone pre/post exercise compared to no statistical change in those traing < 2 years.
Nathan Goodyear

Epigenetic correlates of neonatal contact in humans | Development and Psychopathology |... - 0 views

www.cambridge.org/...D9799A7C6E0859B93E092EA0727A4B

epigenetics genetics

shared by Nathan Goodyear on 30 Nov 17 - No Cached
  • Nathan Goodyear on 30 Nov 17
     
    physical contact with infants effects changes in genetic expression--epigenetics.  In this study, methylation patters were altered in the evaluation of 4 genes by "maternal contact" with infants 4-5 years later indicating a lasting and possible life-long effect of genetic expression from a mother's hug.
Nathan Goodyear

A Six Months Exercise Intervention Influences the Genome-wide DNA Methylation Pattern i... - 0 views

journals.plos.org/...article

exercise epigenetics methylation obesity diabetes type 2 diabetes type II diabetes

shared by Nathan Goodyear on 03 Oct 17 - No Cached
  • In skeletal muscle, HDAC4 has been found to be exported from the nucleus during exercise, suggesting that removal of the transcriptional repressive function could be a mechanism for exercise adaptation [50]. For HDAC4, we observed increased levels of DNA methylation and a simultaneous decrease in mRNA expression in adipose tissue in response to the exercise intervention. Additionally, the functional experiments in cultured adipocytes suggested increased lipogenesis when Hdac4 expression was reduced
  • NCOR2 also exhibited increased levels of DNA methylation and a simultaneous decrease in mRNA expression in adipose tissue in response to the exercise intervention, and furthermore we observed increased lipogenesis when Ncor2 expression was down regulated in the 3T3-L1 cell line. NCOR2 is a nuclear co-repressor, involved in the regulation of genes important for adipogenesis and lipid metabolism, and with the ability to recruit different histone deacetylase enzymes, including HDAC4
  • Nathan Goodyear on 03 Oct 17
     
    Study finds 6 month exercise program in men induced epigenetic change via DNA methylation of CPG islands in adipose cells effecting metabolism and altering obesity and type II diabetes risk.  The study looked at 2 genes: HDAC4 and NCOR2 and found that exercise decreased expression via methylation altering adipogenesis and lipid metabolism.
Nathan Goodyear

Curcumin Attenuation of Lipopolysaccharide Induced Cardiac Hypertrophy in Rodents - 0 views

www.hindawi.com/...539305

curcumin LPS lipopolysaccharides epigenetics inflammation heart disease heart health

shared by Nathan Goodyear on 04 Oct 17 - No Cached
  • Nathan Goodyear on 04 Oct 17
     
    This is just to cool. Curcumin found to inhibit LPS mediated cardiac hypertrophy. The how is fascinating. No only does LPS induce inflammatory cytokine production, but he inflammation induces disease--cardiac hypertrophy. LPS induces epigenetic changes that lead to the hypertrophy. Curcumin blocked the histone acetylation induced by LPS.
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