Piles, also known as ‘Hemorrhoids’, are small, bluish swellings, comprising of enlarged blood vessels situated either just inside or just outside the anus commonly called internal piles and external piles. In case of bleeding, they ...
Piles, also known as ‘Hemorrhoids’, are small, bluish swellings, comprising of enlarged blood vessels situated either just inside or just outside the anus commonly called internal piles and external piles. In case of bleeding, they ...
Vitamin E supplementation in individuals >65 for 4 months on dosing up to 800 IU not found to have adverse events as described as decreased platelets, prolonged bleeding time, lower hemoglobin/hematocrit...
Tynor Hot and Cold Pack is a convenient device to provide hot fomentation or cold compress.
Hot fomentation of the injured or inflamed area enhances the threshold of pain and thus reduces the perception of pain. It has a synergistic effect along with pain relieving drugs. Raising temperature of the injured tissue also enhances the blood profusion and the healing process. Hot fomentation has a relaxing effect.
Cold compress helps in reduction of inflammation in injuries, protects by slowing the metabolic rate around the tissue, reduce oedema and bleeding. Cold compress helps in immediately lowering fever, in very high fever conditions. It can be used after an acute injury or surgical procedure.
No heat or cryo burns.
Requires no holding.
Reusable.
Easy application.
Appealing aesthetics.
Tynor Hot and Cold Pack Features
Multi functionality
Reduce swelling and odema at the site of injury.
Muscles spasm and pain.
Headache and minor injuries.
Versatile design
Can be used as either cold or hot pack.
Reusable in either hot & cold condition.
Temperature range - Can be used from 0 Cº to 75Cº.
Longer temperature retention time.
Fabric cover ensures no cryo burns or hot skin burns.
Physical features
Non-toxic, and biodegradable.
Gel remains soft and flexible upto 0 degree.
Durable, and puncture resistant.
Soft, "frost free" PVC cover.
Flexible conforms to the body contours.
Easy to clean and maintain.
Excellent workmanship.
Good aesthetics.
Elastic belt
Holds the pack against the body, No need to hold by hand.
Enhances convenience.
Tynor Hot and Cold Pack Measurements
Tynor Hot and Cold Pack is a convenient device to provide hot fomentation or cold compress. Tynor Hot and Cold Pack is of multipurpose advantage. It is a convenient and effective approach for both hot as well as a cold therapy. Hot pack can be used for body ache, joint pain, etc., whereas a cold pack can be used for fever, sprains, fever, bleeding, etc. It is easy to use and maintains the temperature for a long period of time. It is available in 11.22 x 7.67 inch universal sizes.
Hot fomentation of the injured or inflamed area enhances the threshold of pain and thus reduces the perception of pain. It has a synergistic effect along with pain relieving drugs. Raising temperature of the injured tissue also enhances the blood profusion and the healing process. Hot fomentation has a relaxing effect.
Cold compress helps in reduction of inflammation in injuries, protects by slowing the metabolic rate around the tissue, reduce oedema and bleeding. Cold compress helps in immediately lowering fever, in very high fever conditions. It can be used after an acute injury or surgical procedure.
No heat or cryo burns.
Requires no holding.
Reusable.
Easy application.
Appealing aesthetics.
Tynor Hot and Cold Pack Features
Multi functionality
Reduce swelling and odema at the site of injury.
Muscles spasm and pain.
Headache and minor injuries.
Versatile design
Can be used as either cold or hot pack.
Reusable in either hot & cold condition.
Temperature range - Can be used from 0 Cº to 75Cº.
Longer temperature retention time.
Fabric cover ensures no cryo burns or hot skin burns.
Physical features
Non-toxic, and biodegradable.
Gel remains soft and flexible upto 0 degree.
Durable, and puncture resistant.
Soft, "frost free" PVC cover.
Flexible conforms to the body contours.
Easy to clean and maintain.
Excellent workmanship.
Good aesthetics.
Elastic belt
Holds the pack against the body, No need to hold by hand.
Enhances convenience.
Tynor
optimal weight associated with higher testicular volume and Testosterone levels in men. Maternal smoking and higher cord bleed estrogens associated with lower sperm output. This would with the other literature on EDCs.
second rise in plasma levels (mostly occurring between 6 and 12 h after the dose) suggesting an enterohepatic recycling of the drug
Ivermectin is exceptionally potent, with effective dosages levels that are unusually low.
the optimal dose of ivermectin is 150 μg/kg, but the frequency of administration is still controversial, ranging from 150 μg/kg once to three times yearly.
high lipid solubility of ivermectin, this compound is widely distributed within the body.
To interrupt the transmission of onchocerciasis in humans, the combination of ivermectin and doxycycline is highly effective as, in infested patients, the ingestion of the anthelmintic (200 μg/kg, single dose) and the antibacterial (100 mg/kg, daily for 6 weeks)
ivermectin interactions with another concurrently administered drugs can occur.
This issue becames important, as combination chemotherapy is being used with increasing frequency as resistance to antiparasitic agents is becoming more widespread.
haematomatous swellings
prothrombin times were significantly above baseline by one week to one month after drug ingestion, suggesting an antagonist effect against vitamin K
bleeding disorders were not found in 15,000 patients treated with ivermectin (150 μg/kg)
prolonged prothrombin ratios were observed in 148 subjects given ivermectin orally. Although no patients suffered bleeding complications, factor II and VII levels were reduced in most of them, suggesting interference with vitamin K metabolism
Ivermectin has a minimal effect on coagulation and concern about mass treatment for this reason appears to be unjustified
Bleeding in semen caused by medical procedures, also known as hematospermia. Blood in semen caused by infections, tumors, and stones in organs as well as anatomical problems. The most common cause is a prostate biopsy.
"Since 2011 gamma knife radiosurgery hospitals in India have treated more than 1,400 patients with gamma knife," stated Dr. Sandeep Vaishya best gamma knife neurosurgeon in India. Often known as "surgical operation without a knife," gamma knife exactly grants radiation to the focused affected place, maintaining healthy brain tissue and casting off some of the risks of a traditional craniotomy, like bleeding or brain damage.
For Consultation
Email: dr.sandeepvaishya@neurospinehospital.com
Phone No:- +91-9325887033
low level of BCAAs in patients with cirrhosis is hypothesized to be one of multiple factors responsible for development of hepatic encephalopathy
supplementation of BCAAs is thought to facilitate ammonia detoxification by supporting synthesis of glutamine, one of the non-branched chain amino acids, in skeletal muscle and in the brain as well as diminishing the influx of AAAs across the blood-brain barrier
oral BCAA supplementation is more useful in chronic encephalopathic patients than is parenteral BCAA supplementation in patients with acute encephalopathy
malnutrition progressing to cachexia is another common manifestation of cirrhosis
Malnutrition can be mitigated with BCAA supplementation
Studies show that administration of amino acid formulas enriched with BCAAs can reduce protein loss, support protein synthesis, and improve nutritional status of patients with chronic liver disease
Leucine has been shown to be the most effective of the BCAAs because it acts via multiple pathways to stimulate protein synthesis
BCAAs metabolites inhibit proteolysis
Patients with cirrhosis have both insulin deficiency and insulin resistance
BCAAs (particularly leucine) help to reverse the catabolic, hyperglucagonemic state of cirrhosis both by stimulating insulin release from the pancreatic β cells and by decreasing insulin resistance allowing for better glucose utilization
Coadministration of BCAAs and glucose has been found to be particularly useful
BCAA supplementation improves protein-energy malnutrition by improving utilization of glucose, thereby diminishing the drive for proteolysis, inhibiting protein breakdown, and stimulating protein synthesis
Cirrhotic patients have impaired immune defense, characterized by defective phagocytic activity and impaired intracellular killing activity
another effect of BCAA supplementation is improvement of phagocytic function of neutrophils and possibly improvement in natural killer T (NKT) cell lymphocyte activity
BCAA supplementation may reduce the risk of infection in patients with advanced cirrhosis not only through improvement in protein-energy malnutrition but also by directly improving the function of the immune cells themselves
BCAA administration has also been shown to have a positive effect on liver regeneration
A proposed mechanism for improved liver regeneration is the stimulatory effect of BCAAs (particularly leucine) on the secretion of hepatocyte growth factor by hepatic stellate cells
BCAAs activate rapamycin signaling pathways which promotes albumin synthesis in the liver as well as protein and glycogen synthesis in muscle tissue
Chemical improvement with BCAA treatment is demonstrated by recovery of serum albumin and lowering of serum bilirubin levels
long-term oral BCAA supplementation was useful in staving off malnutrition and improving survival by preventing end-stage fatal complications of cirrhosis such as hepatic failure and gastrointestinal bleeding
The incidence of death by any cause, development of liver cancer, rupture of esophageal varices, or progression to hepatic failure was decreased in the group that received BCAA supplementation
Patients receiving BCAA supplementation also have a lower average hospital admission rate, better nutritional status, and better liver function tests
patients taking BCAA supplementation report improved quality of life
BCAAs have been shown to mitigate hepatic encephalopathy, cachexia, and infection rates, complications associated with the progression of hepatic cirrhosis
BCAAs make up 20-25% of the protein content of most foods
Highest levels are found in casein whey protein of dairy products and vegetables, such as corn and mushrooms. Other sources include egg albumin, beans, peanuts and brown rice bran
In addition to BCAAs from diet, oral supplements of BCAAs can be used
Oral supplementation tends to provide a better hepatic supply of BCAAs for patients able to tolerate PO nutrition as compared with IV supplementation, especially when treating symptoms of hepatic encephalopathy
Coadministration of BCAAs with carnitine and zinc has also been shown to increase ammonia metabolism further reducing the encephalopathic symptoms
Cirrhotic patients benefit from eating frequent, small meals that prevent long fasts which place the patient in a catabolic state
the best time for BCAA supplementation is at bedtime to improve the catabolic state during starvation in early morning fasting
A late night nutritional snack reduces symptoms of weakness and fatigability, lowers postprandial hyperglycemia, increases skeletal muscle mass,[25] improves nitrogen balance, and increases serum albumin levels.[26] Nocturnal BCAAs even improve serum albumin in cirrhotic patients who show no improvement with daytime BCAAs
Protein-energy malnutrition (PEM), with low serum albumin and low muscle mass, occurs in 65-90% of cases of advanced cirrhosis
hyperglucagonemia results in a catabolic state eventually producing anorexia and cachexia
BCAAs are further depleted from the circulation due to increased uptake by skeletal muscles that use the BCAAs in the synthesis of glutamine, which is produced in order to clear the ammonia that is not cleared by the failing liver
patients with chronic liver disease, particularly cirrhosis, routinely have decreased BCAAs and increased aromatic amino acids (AAAs) in their circulation
Maintaining a higher serum albumin in patients with cirrhosis is associated with decreased mortality and improved quality of life
the serum BCAA concentration is strongly correlated with the serum albumin level
Histamine intolerance can develop through both increased availability of histamine and impaired histamine degradation
increased availability may be an endogenous histamine overproduction caused by allergies, mastocytosis,
bacterias, gastrointestinal bleeding, or increased exogenous ingestion of histidine or histamine by food or alcohol
Other
biogenic amines, such as putrescine, may also be involved in displacing histamine from its mucosal mucine linkage, which results
in an increase of free absorbable histamine in circulation
the main cause of histamine intolerance is an impaired
enzymatic histamine degradation caused by genetic or acquired impairment of the enzymatic function of DAO or HNMT
The
main enzyme for metabolism of ingested histamine is diamine oxidase (DAO)