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Drug Delivery Technology Market is worth $224.2 Billion By 2017 - 0 views

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    The drug delivery technology market is segmented on the basis of route of administration into nine categories - oral, pulmonary, transdermal, injectable, ocular, nasal, topical, implantable, and transmucosal
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Dental Care is Fun at Smile Reef - 0 views

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    Teaching children to brush and floss is a great step in helping them have healthy teeth and gums. Just as important is taking them to a pediatric dentist on a regular basis. But how many children actually get excited for every visit? Not too many. For many children, a visit to the dentist is associated with a lot of pain and discomfort.
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Windows tech support number 1-800-485-4057 - 0 views

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    Windows support number 1-800-485-4057 helps you to resolve your queries, our services will always accessible 24 hours basis and also visit our websites as http://technicalsupportnumberforwindows.com/
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Tynor Elbow Support - 0 views

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    Tynor Wrist Brace with Double Lock is designed with a double lock that will make it simple to apply and remove. Its double lock feature gives rigid support to the wrist. It partially keeps the wrist immobilized. It can easily adjust the compression around the affected area as per the desire. It provides the warming feel to the injured area to allay the local pain and inflammation. It has a high modulus of elasticity which works for a long time, even if use this on a regularl basis. It has striped elastic webbing which is of high quality material. This double lock wrist brace is strong, rigid and comfortable to wear. Its material is porous in nature which keeps the affected area air ventilated. It can adjust the compression pressure according to the will. Its double hook loop locking system is easy to apply and remove as well as comes with universal sizing. This wrist brace provides strength and support to the wrist and keep the wrist protected against the further injury or damage. Tynor Wrist Brace with Double Lock Wrist brace with double lock is designed to support, protect and partially immobilize the wrist. It compresses the area and retain the body heat to allay local pain and inflammation. Extra grip. Extra porous Controlled compression. Easy application. Tynor Wrist Brace with Double Lock Features High quality, striped elastic webbing Strong and durable Porous and comfortable High modulus of elasticity- Retains shape and size for a long time. Excellent compressive strength, better support Hook loop Double locking Easy to apply and remove Ensures optimal compression Better fitting and universal sizing. Tynor Elbow Support Elbow support provides firm compression, warmth & support to the forearm and the elbow joint, to allay pain inflammation and stiffness, generally associated with old age, arthritis, sports injury etc. Light weight Four way stretch Freely breathable Soft and comfortable Tynor Elbow Support Features Anatom
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PLOS ONE: Increased Risk of Non-Fatal Myocardial Infarction Following Testosterone Ther... - 0 views

  • For all TT prescription subjects combined, the post/pre prescription rate ratio for MI (RR)was 1.36
  • In men aged 65 years and older the RR was 2.19 (1.27, 3.77), while in men under age 65 years the RR was 1.17
  • increasing RR with increasing age.
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  • The RRs were 0.95 (0.54, 1.67) under 55 years
  • 1.35 (0.77, 2.38) at 55–59
  • 1.29 (0.71, 2.35) at 60–64,
  • 1.35 (0.44, 4.18) at 65–69, 1.62
  • 3.43 (1.54, 7.66) at 75 years and older
  • The adjusted post/pre RR for PDE5I across all ages was 1.08
  • For TT prescription, in men under age 65 years, the RR was 2.90 (1.49, 5.62) for those with a history of heart disease and 0.90 (0.61, 1.34) for those without
  • In men aged 65 year and older, the RR was 2.16 (0.92, 5.10) for those with a history of heart disease and 2.21 (1.09, 4.45) for those without.
  • Among men aged 65 years and older, we observed a two-fold increase in the risk of MI in the 90 days after filling an initial TT prescription
  • Among younger men with a history of heart disease, we observed a two to three-fold increased risk of MI in the 90 days following an initial TT prescription and no excess risk in younger men without such a history
  • Among older men, the two-fold increased risk was associated with TT prescription regardless of cardiovascular disease history
  • our own findings appear consistent with a higher frequency of thrombotic events following TT prescription among men with more extensive coronary vascular disease.
  • Our findings are consistent with a recent meta-analysis of placebo-controlled randomized trials of testosterone therapy lasting 12 or more weeks among mainly older men, which reported that testosterone therapy increased the risk of adverse cardiovascular-related events (OR = 1.54, 95%CI:1.09, 2.18), as well as serious adverse cardiovascular-related events (OR = 1.61, 95%CI:1.01, 2.56) which included myocardial infarction along with other conditions
  • This association appeared unrelated to average baseline testosterone level (p = 0.70) but varied by source of funding (p = 0.03), with a stronger summary effect in a meta-analysis of studies not funded by the pharmaceutical industry (OR = 2.06, 95%CI:1.34, 3.17) compared with studies funded by the pharmaceutical industry
    • Nathan Goodyear
       
      This supports prior analysis that studies done by pharmaceutical corps will be more favorable to their product(s) than those independently funded.  This is called bias.
  • the evidence supports an association between testosterone therapy and risk of serious, adverse cardiovascular-related events–including non-fatal myocardial infarction–in men
  • there is some evidence that low endogenous testosterone levels may also be positively associated with cardiovascular events
  • effects of endogenous and exogenous testosterone may differ. Exogenous testosterone (TT) is associated with physiologic changes that predispose to clotting and thrombotic disorders including increased blood pressure [18], polycythemia [19], reductions in HDL cholesterol [18], [20], and hyperviscosity of the blood and platelet aggregation. [20]–[23]; TT also increases circulating estrogens [24], [25] which may play a role in the observed excess of adverse cardiovascular-related events, given that estrogen therapy has been associated with this excess in both men and women
  • did not include information on the serologic or diagnostic indications for treatment.
  • no association between PDE5I prescriptions and the risk of MI
  • Recently TT has been increasing extraordinarily rapidly, including among younger men and among those without hormone measurement
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    New cohort study finds increased risk of Testosterone in men > 65 and those : these are based in marketing-based medicine not evidence based medicine.
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Choosing Correct Power wheel chair - 0 views

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    Power wheel chair is one type of wheel chairs which is also referred and known as Electric Power Wheel Chair or (EPW). An Power wheel chair is used to move such wheel chairs instead of pushing by some attendant or by hand rims. It also has navigational controls so that it can be moved to any desired direction. Power wheel chairs are suitable for those, who are weaker to move the manual wheel chair using the hand rims and also provides its users a level of comfort. The user can control its speed and direction by a joystick sort of control while sitting on the chair. There are many different types of Power wheel chair and finding the appropriate one will depend on each individual's medical condition. Wheelchairs can be manual or electrically powered. Manual wheelchairs can come in either a folding or rigid design. Rigid type wheelchairs tend to be lighter and more easily maneuvered and should be used by more active wheelchair users. Folding wheelchairs would be an excellent choice for individuals needing to use the wheelchair for travel on a frequent basis. Many people have disabilities that make it difficult to propel themselves in a manual wheelchair and in this situation an electrically powered wheelchair may prove more useful. Power chairs are little bit more complex and the user can control it with minimum effort. This kind of chair will give extraordinary maneuverability, stability and power and it is perfect for people who want more from their wheelchairs. Better Life Mobility Center offers various models, so sure that won't have problem to choose one that will suit completely. All the power chairs that offer are the result of the extensive research and designed with the user's needs in mind. Karma latest power standing wheelchair is now available in India. Power Wheelchairs For Sale - Increase freedom Stand up again improve independence and be find of body. Karma KP 10.2 Power Wheelchair: Features: Seat, base & battery quickly detach f
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Choosing Correct Power wheel chair - 0 views

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    Power wheel chair is one type of wheel chairs which is also referred and known as Electric Power Wheel Chair or (EPW). An Power wheel chair is used to move such wheel chairs instead of pushing by some attendant or by hand rims. It also has navigational controls so that it can be moved to any desired direction. Power wheel chairs are suitable for those, who are weaker to move the manual wheel chair using the hand rims and also provides its users a level of comfort. The user can control its speed and direction by a joystick sort of control while sitting on the chair. There are many different types of Power wheel chair and finding the appropriate one will depend on each individual's medical condition. Wheelchairs can be manual or electrically powered. Manual wheelchairs can come in either a folding or rigid design. Rigid type wheelchairs tend to be lighter and more easily maneuvered and should be used by more active wheelchair users. Folding wheelchairs would be an excellent choice for individuals needing to use the wheelchair for travel on a frequent basis. Many people have disabilities that make it difficult to propel themselves in a manual wheelchair and in this situation an electrically powered wheelchair may prove more useful. Power chairs are little bit more complex and the user can control it with minimum effort. This kind of chair will give extraordinary maneuverability, stability and power and it is perfect for people who want more from their wheelchairs. Better Life Mobility Center offers various models, so sure that won't have problem to choose one that will suit completely. All the power chairs that offer are the result of the extensive research and designed with the user's needs in mind. Karma latest power standing wheelchair is now available in India. Power Wheelchairs For Sale - Increase freedom Stand up again improve independence and be find of body. Karma KP 10.2 Power Wheelchair: Features: Seat, base & battery quickly detach f
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Choosing Correct Power wheel chair - 0 views

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    Power wheel chair is one type of wheel chairs which is also referred and known as Electric Power Wheel Chair or (EPW). An Power wheel chair is used to move such wheel chairs instead of pushing by some attendant or by hand rims. It also has navigational controls so that it can be moved to any desired direction. Power wheel chairs are suitable for those, who are weaker to move the manual wheel chair using the hand rims and also provides its users a level of comfort. The user can control its speed and direction by a joystick sort of control while sitting on the chair. There are many different types of Power wheel chair and finding the appropriate one will depend on each individual's medical condition. Wheelchairs can be manual or electrically powered. Manual wheelchairs can come in either a folding or rigid design. Rigid type wheelchairs tend to be lighter and more easily maneuvered and should be used by more active wheelchair users. Folding wheelchairs would be an excellent choice for individuals needing to use the wheelchair for travel on a frequent basis. Many people have disabilities that make it difficult to propel themselves in a manual wheelchair and in this situation an electrically powered wheelchair may prove more useful. Power chairs are little bit more complex and the user can control it with minimum effort. This kind of chair will give extraordinary maneuverability, stability and power and it is perfect for people who want more from their wheelchairs. Better Life Mobility Center offers various models, so sure that won't have problem to choose one that will suit completely. All the power chairs that offer are the result of the extensive research and designed with the user's needs in mind. Karma latest power standing wheelchair is now available in India. Power Wheelchairs For Sale - Increase freedom Stand up again improve independence and be find of body. Karma KP 10.2 Power Wheelchair: Features: Seat, base & battery quickly detach f
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Heavy Duty Wheelchair - 0 views

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    Bariatric wheelchairs (often referred to as extra wide wheelchairs or heavy duty wheelchairs) are strong enough to accommodate almost any user. Just like lighter manual chairs, bariatric wheelchairs are all foldable and feature armrests and swing-away footrests - but they differ quite a bit in their construction. While lightweight wheelchairs often employ materials like aluminum or titanium alloy, a bariatric wheelchair is usually fashioned from steel. Karma 8020 X Heavy Duty Wheelchair: It comes with detachable swing away footrests. The wheel chair has flip-back armrests. It comes with centre of gravity adjustment. The wheel chair has wide profile casters. Seat Size 20'' inch & 22'' inch Total Weight 17 K.G. Heavy duty wheelchairs (often referred to as extra wide wheelchairs or bariatric wheelchairs) are sturdy enough to accommodate almost any user. Just their lighter cousins, manual chairs, heavy duty models all fold and feature arm rests and swing-away footrests - but they differ quite a bit in their construction. Heavy duty wheelchairs require more strength to push by the caregiver and by the user, if the chair is self-propelled. In some cases, it may be wise for the caregiver to ask for assistance from another person in order to push the wheelchair safely. Karma 8520 Heavy Duty Wheelchair: It comes with detachable swing away footrests. The wheel chair has flip-back armrests. It comes with centre of gravity adjustment. The wheel chair has wide profile casters. Seat Size 20'' inch & 22'' inch Total Weight 17 K.G. Features: Dual, reinforced steel cross braces. Supports individuals maximum weight. Reinforced steel frame provides added support. Heavy duty, nylon reinforced upholstery with a back carry pouch. Removable, reversible desk length arms. Adjustable leg support.
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Molecular basis of cadmium toxicity. [Prog Food Nutr Sci. 1984] - PubMed result - 0 views

  • Cadmium inhibits protein synthesis, carbohydrate metabolism and drug metabolizing enzymes in liver of animals.
  • Cadmium affects both humoral and cell mediated immune response in animals
  • cadmium nephropathy
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  • produces hypertension
  • It causes an alterations of cellular functions in lungs
  • Cadmium is also toxic to central nervous system
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    for you biochemistry junkies, the molecular pathophysiology of cadmium oxicity
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Net Neutrality: Battle to 'save the Internet' - 0 views

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    Net neutrality is one of the biggest issue debated globally by the telecom regulators and it is also in the process of finalising what will be a landmark recommendation for Indian telecom. The important aspects of Net neutrality are: Internet service providers should enable access to all content and applications regardless of the source. The Internet service provider from whom buy internet pack, should not under any circumstance be able to control how exactly use it and it's upto how you use the data. All websites can co-exist without hampering others and all websites are accessible at the same speed and no particular website of application is favoured. All web sites and content creators are treated equal, and it don't have to pay extra for faster Internet speed to a particular site/service. The concept of net neutrality doesn't exist legally but most companies have Net Neutrality is simply the Internet Freedom - Free, Fast and Open Internet for all. Net Neutrality is the principle that Internet service providers (ISPs) should give consumers access to all and every contents and application on an equal basis, treating all Internet traffic equally. Today, if there's something that makes everyone across the world "Equal" is nothing but the Internet. Equality over the Internet means, the richest man in the world has the same rights to access the Internet as the poorer. And this is what "Net Neutrality" aims at adhered to it until now. With the Internet taking the world into its folds, Internet Service Providers across the world are trying to encash this potent commodity and trying to control the traffic. Karma Healthcare KP-80 Standing Wheelchair is a compact and fully powered wheelchair designed for budget. The front-wheel drive provides agile control for the chair to negotiate various indoors and out. It comes with the innovative seat and wide range of power backrest angle adjustment (80~120 degree).
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Power Standing Wheelchair Support Motor And Battery - 0 views

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    Power mobility allows people to move within their home and community and it can help maximize independence for those with limited mobility. The two main types of power mobility available are in the form of electric scooters or power wheelchairs. The choice to use either an electric scooter versus an electric wheelchair depends on the users' needs and abilities. Knowing some of the benefits of power wheelchairs can help in making the right decision. Power wheelchairs also can be classified on the basis of the location of the drive wheels. There are three types of power wheelchairs: front-wheel drive, mid- or centre-wheel drive, and rear-wheel drive. Traditionally, rear-wheel drive powerwheelchairs were preferred because of their similarity to manual wheelchairs in design and maneuverability. However, centre-wheel drive wheelchairs have gained popularity because they provide increased maneuverability. Variety of Power Wheelchairs: Karma KP 10-2 Power Wheelchair Karma KP 10-3 Power Wheelchair Karma KP 80 Power Wheelchair GM Lite Power Wheelchair Bronco Wheelchair Angel Wheelchair Karma KP 10.3 S Power Wheelchair Ergonomic seat system provides comfortable seating Tool-free disassembled into 3 parts for traveling and transportation Quick-release battery pack Washable upholstery Height adjustable and flip back armrest 2-level adjustable back angle KARMA KP 80 POWER WHEELCHAIR are propelled by a motor and battery. They are very sophisticated. They are operated with a joy stick or push buttons. Some power wheelchairs use advanced technology and can climb up stairs, move across gravel and even raise up to give access to high shelves. Power wheelchairs need strong frames to support the motor and battery so they are very heavy and also quite expensive. KARMA KP 80 POWER WHEELCHAIR Karma KP 80 POWER STANDING WHEELCHAIR Karma latest power standing wheelchair is now available in India. Power Standing wheelchair - Increase your freedom Stand up ag
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PET a Very Crucial Raw Material For Packaging - 0 views

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    PET has been in use from quite a long time, but recent years showed a great surge in the demand worldwide. Easy availability of the PET material has great emphasis on packaging due to high-quality production with reduced costs. According to a forecast from Smithers Pira, there will be a sustained annual growth of 4.6 percent year-on-year basis in next five years. Other than established economies, transitional and emerging ones become prominent players in the marketplace.
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Top Ophthalmologist of Delhi Improve Vision & Reduce Degenerative Vision Diseases - 0 views

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    Famous eye care center in Delhi display the performance and first-class requirements maintained at the hospital on an everyday basis.
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The endocrinology of sexual arousal - 0 views

  • A number of age-related changes may be relevant: altered negative feedback of testosterone and hence less increase in luteinizing hormone (LH) with falling testosterone levels, increased sex hormone binding globulin (SHBG) and hence relatively reduced free testosterone and the likelihood of an age-related decline in testosterone receptor sensitivity
  • In the older male, the picture is complicated by various aging effects, including altered hypothalamo–pituitary feedback, increased testosterone binding and reduced receptor sensitivity
  • The neurophysiological basis of NPT is still disputed, but one plausible explanation is that REM sleep is associated with a ‘switching off’ of the noradrenergic cells in the locus coeruleus
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  • the impact of testosterone on the emergence of sexual arousability is less clear
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    Good discussion of the arousal/sexual response differences between men and women from a physiological perspective.  
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Estrogen Actions in the Brain and the Basis for Differential Action in Men and Women: A... - 0 views

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    Different effects of estrogen on the brains of men and women.
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Telomerase at the intersection of cancer and aging - 0 views

  • The anti-aging role of telomerase has been demonstrated to be largely mediated by its canonical role in elongating telomeres, which prevents the accumulation of critically short telomeres and loss of tissue homeostasis
  • Short telomeres, and subsequent DDR activation, could occur both in cancer and aging
  • increased abundance of short telomeres correlates with higher genomic instability and decreased longevity in various organisms, including mice, zebrafish, and yeast
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  • mice deficient for telomerase or for telomere binding proteins are characterized by accelerated age-related defects
  • In humans, short telomeres are considered good indicators of an individual’s health status and correlate with both genetic and environmental factors
  • Although recent findings strongly support the idea that short telomeres drive several age-related diseases 38 we cannot exclude the possibility that in some situations short telomeres may be a consequence of the disease itself.
  • the current view is that telomerase deficiency may contribute to the early steps of cancer development by fueling chromosomal instability, while subsequent activation of telomerase may be necessary to allow tumor growth and tumor progression towards more malignant states
  • telomerase activation can be an early event in cancer, it is not necessary for cancer initiation
  • telomerase can stimulate tumor progression by ensuring maintenance of telomeres above a critically short length, thus preventing induction of cellular senescence or apoptosis
  • Almost all human cancers present activation of telomerase as a hallmark, most likely as a mechanism to allow unlimited cell proliferation of tumor cells
  • recent evidence demonstrated that short telomeres alone could lead to genomic instability and cancer
  • Getting rid of telomerase can also be problematic; the lack of telomerase could lead to increased chromosomal instability, which in turn could be at the basis for cancer initiation when tumor suppressor barriers are bypassed
  • telomerase activation is a potential therapeutic strategy for the treatment of age-related diseases
  • telomerase activation in adult or old mice by means of a gene therapy strategy was shown to be sufficient to improve metabolic fitness, neuromuscular capacity, and prevent bone loss, as well as significantly increase both median and maximum longevity, without increased cancer incidence
  • These studies suggest that telomerase expression could be considered a feasible approach to reverse tissue dysfunction and extend healthy lifespan without increasing cancer incidence
  • humans almost completely lose telomerase activity from somatic tissues in the adulthood
  • a change of paradigm seems to be occurring in telomerase biology, with a switch from viewing telomerase as fueling cancer to reversing aging
  • Telomerase expression in a background of high levels of tumor suppressors or in aged organisms seems to prevent its expected pro-cancer activity and yet it still functions as an anti-aging factor
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    Telomerase activity and longer telomere length is shown to correlated inversely with many chronic diseases of aging.  In contrast, telomerase activity is found to be involved in carcinogenesis.  Increased carcinogenic potential of telomerase activity has not borne out in studies.  In addition, increased CD8 cell activity as a result of telomerase activation will actually decrease carcinogenic potential via NK activation.
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Deficient Glutathione in the Pathophysiology of Mycotoxin-Related Illness - 0 views

  • Decreased function of the enzymes of glutathione production results in a microenvironment depleted of glutathione on a chronic basis
  • In humans, deficiency of glutathione can lead to chronic conditions [97], including chronic asthma
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    Mycotoxins deplete glutathione production and this depletion of glutathione is a portion go the toxicity/ill effects related to mycotoxins.  This article also points to evidence that glutathione can actually be employed in the treatment of mycotoxin related conditions/illnesses.
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Nutrigenomic basis of beneficial effects of... [Mol Cell Biochem. 2008] - PubMed - NCBI - 0 views

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    Chromium improves insulin resistance.
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Androgens and prostate disease Cooper LA, Page ST - Asian J Androl - 0 views

  • intraprostatic androgens are not concomitantly increased when serum androgen levels are raised.
  • The "saturation model" proposes that the prostate is sensitive to very low concentrations of circulating androgens, but that once maximal AR binding is achieved, which occurs at relatively low concentrations of circulating T, further increases in serum T have little impact
  • men with metastatic prostate cancer given T who had been previously treated with castration had worsening of disease, whereas those without prior castration did not
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  • There is little data to support the withholding of T therapy on the basis of concern for precipitating prostate cancer.
  • Both intervention data and physiology studies point to minimal effects on the prostate gland when serum T levels are increased to the mid-normal range with T therapy
  • an individualized care plan to assess the possible risks and benefits of T therapy for each patient is critical to optimizing the use of androgens in male health.
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    Nice review of the mixed data on Testosterone and Prostate disease. It is clear that Testosterone does not precipitate prostate cancer.  The intraprostatic hormone milieu likely is different than that present in the serum.  No surprise there.  5alpha reductase decreases prostate volume, PSA, and low-grade prostate cancer, but actually increases aggressive prostate cancer. Supraphysiologic doping in young men associated with no increase in prostate disease. PSA no longer to be followed in men < 55.  Mortality rate not changed.  PSA change of 1.4 ng/ml is appropriate for additional prostate evaluation.  Testosterone therapy on average increased 0.5 ng/ml. Still, no mention of aromatase activity in this article.  Why is it that hormone sensitive disease in men is only with regards to androgens and women estrogen.
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