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Nathan Goodyear

Inhibition of in vitro vascular endothelial cell proliferation and in vivo ne... - 0 views

onlinelibrary.wiley.com/...anr.1780320903

low-dose chemotherapy RA rheumatoid arthritis angiogenesis

shared by Nathan Goodyear on 24 Aug 20 - No Cached
  • Nathan Goodyear on 24 Aug 20
     
    Low-dose methotrexate is anti-angiogenic.
Nathan Goodyear

Low-dose Interleukin-2 in the Treatment of Autoimmune Disease | touchONCOLOGY - 0 views

www.touchoncology.com/...2-treatment-autoimmune-disease

cancer autoimmune disease Tregs Treg cells Treg immune system disease IL-2

shared by Nathan Goodyear on 04 Apr 18 - No Cached
Amol kashikar liked it
  • affect approximately 5 to 8 % of the US population
  • the incidence and prevalence of autoimmune diseases are rising
  • Type 1 diabetes (T1D), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and inflammatory bowel disease (IBD) account for the majority of the patients with autoimmune diseases
  • ...9 more annotations...
  • Autoimmune diseases are characterized by a breakdown of mechanisms that allow the immune system to distinguish between self and nonself and maintain immunologic self-tolerance
  • Tregs, which are important in the maintenance of peripheral immune tolerance.
  • Several subtypes of Tregs exist, the most well studied being CD4+ cells that express high-level CD25 and the transcription factor forkhead box P3 (FOXP3)
  • Treg deficiency or dysfunction is associated with autoimmune disease
  • In clinical studies, decreased levels of circulating CD25+CD4+ T cells have been reported in patients with autoimmune disease
  • These data have led to the hypothesis that augmentation of Tregs may be a useful therapeutic strategy in autoimmune disease
  • Treg augmentation has resulted in clinical improvements in numerous animal models of autoimmune diseases
  • the administration of in vitro expanded CD4+CD25highCD127-Tregs has been found to be safe and may help to preserve β-cell function in children with T1D
  • ability of IL-2 to augment the numbers and function of CD4+ Tregs.
  • Nathan Goodyear on 04 Apr 18
     
    Great article.  Immune dysfunction plays role in autoimmune disease and cancer.  Treg cells sit at the center of autoimmunity.  This artice highlights the different uses: low dose IL2 therapy to augment Tregs and reduce autoinflammation and high dose IL2 to augment Treg cells in the fight against cancer.
Nathan Goodyear

Sub-lethal hyperthermia promotes epithelial-to-mesenchymal-like transition of breast ca... - 0 views

pubs.rsc.org/...c8ra08472f

EMT hyperthermia epithelial to mesenchymal transition cancer

shared by Nathan Goodyear on 25 Feb 21 - No Cached
  • Nathan Goodyear on 25 Feb 21
     
    Study points to EMT from sub-lethal hyperthermia.
Nathan Goodyear

Anti-cancer peptides from ras-p21 and p53 proteins - PubMed - 0 views

pubmed.ncbi.nlm.nih.gov/21728981

PNC27 PNC-28 peptides PNC28 cancer p53 PNC PNC-27

shared by Nathan Goodyear on 14 Aug 21 - No Cached
  • Nathan Goodyear on 14 Aug 21
     
    PNC-27 and 28, contain HDM-2-protein-binding domain sequences from the tumor suppressor p53 to induce pore formation in the membranes of a wide range of cancer cells but not any normal cells tested
Nathan Goodyear

Glucose-6-Phosphate Dehydrogenase Is Not Essential for K-Ras-Driven Tumor Growth or Met... - 0 views

aacrjournals.org/...Dehydrogenase-Is-Not-Essential

cancer glucose 6 phosphate dehydrogenase G6PD lung seeding

shared by Nathan Goodyear on 24 Jul 22 - No Cached
  • Nathan Goodyear on 24 Jul 22
     
    Interesting point here: G6PD involved in lung seeding.
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