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Nathan Goodyear

Hyperinsulinemia enhances transcriptional activity of nuclear factor-kappaB induced by ... - 0 views

pubmed.ncbi.nlm.nih.gov/11055977

insulin NF-kappaB cancer inflammation hyperinsulinemia

shared by Nathan Goodyear on 19 Dec 20 - No Cached
  • Nathan Goodyear on 19 Dec 20
     
    insulin potentiates NF-kappaB-dependent transcriptional activity induced by hyperglycemia
Nathan Goodyear

Anti-angiogenic action of hyperthermia by suppressing gene expression and production of... - 0 views

www.ncbi.nlm.nih.gov/...PMC2746582

angiogenesis vasculogenesis VEGF hyperthermia cancer

shared by Nathan Goodyear on 14 Feb 21 - No Cached
  • Nathan Goodyear on 14 Feb 21
     
    Hyperthermia inhibits VEGF and thus angiogenesis and vasculogenesis
Nathan Goodyear

Low-dose Interleukin-2 in the Treatment of Autoimmune Disease | touchONCOLOGY - 0 views

www.touchoncology.com/...2-treatment-autoimmune-disease

cancer autoimmune disease Tregs Treg cells Treg immune system disease IL-2

shared by Nathan Goodyear on 04 Apr 18 - No Cached
Amol kashikar liked it
  • affect approximately 5 to 8 % of the US population
  • the incidence and prevalence of autoimmune diseases are rising
  • Type 1 diabetes (T1D), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and inflammatory bowel disease (IBD) account for the majority of the patients with autoimmune diseases
  • ...9 more annotations...
  • Autoimmune diseases are characterized by a breakdown of mechanisms that allow the immune system to distinguish between self and nonself and maintain immunologic self-tolerance
  • Tregs, which are important in the maintenance of peripheral immune tolerance.
  • Several subtypes of Tregs exist, the most well studied being CD4+ cells that express high-level CD25 and the transcription factor forkhead box P3 (FOXP3)
  • Treg deficiency or dysfunction is associated with autoimmune disease
  • In clinical studies, decreased levels of circulating CD25+CD4+ T cells have been reported in patients with autoimmune disease
  • These data have led to the hypothesis that augmentation of Tregs may be a useful therapeutic strategy in autoimmune disease
  • Treg augmentation has resulted in clinical improvements in numerous animal models of autoimmune diseases
  • the administration of in vitro expanded CD4+CD25highCD127-Tregs has been found to be safe and may help to preserve β-cell function in children with T1D
  • ability of IL-2 to augment the numbers and function of CD4+ Tregs.
  • Nathan Goodyear on 04 Apr 18
     
    Great article.  Immune dysfunction plays role in autoimmune disease and cancer.  Treg cells sit at the center of autoimmunity.  This artice highlights the different uses: low dose IL2 therapy to augment Tregs and reduce autoinflammation and high dose IL2 to augment Treg cells in the fight against cancer.
Nathan Goodyear

Artesunate inhibits angiogenesis and downregulates vascular endothelial growth factor e... - 0 views

europepmc.org/...17581794

VEGF angiogenesis cancer artesunate

shared by Nathan Goodyear on 06 Aug 20 - No Cached
  • Nathan Goodyear on 06 Aug 20
     
    Artesunate has anti-angiogenic activity
Nathan Goodyear

Artesunate inhibits angiogenesis and downregulates vascular endothelial growth factor e... - 0 views

europepmc.org/...17581794

VEGF angiogenesis cancer artesunate

shared by Nathan Goodyear on 06 Aug 20 - No Cached
  • Nathan Goodyear on 06 Aug 20
     
    Artesunate has anti-angiogenic activity
Nathan Goodyear

Dihydroartemisinin downregulates vascular endothelial growth factor expression and indu... - 0 views

www.researchgate.net/...ic_myeloid_leukemia_K562_cells

artemisinin cancer angiogenesis dihydroartemisin artesunate

shared by Nathan Goodyear on 06 Aug 20 - No Cached
  • Nathan Goodyear on 06 Aug 20
     
    Dihydroartemisin, a metabolite of artesunate, inhibits angiogenesis.
Nathan Goodyear

Hypoxia-inducible factor 1 and breast cancer metastasis - 0 views

www.ncbi.nlm.nih.gov/...PMC4288942

cancer CTC metastasis circulating tumor cells HIF-1alpha

shared by Nathan Goodyear on 08 Jul 20 - No Cached
  • Nathan Goodyear on 08 Jul 20
     
    Great review of HIF-1alpha implications in metastasis and the how.
Nathan Goodyear

The Potential Role of Hypoxia Inducible Factor 1α in Tumor Progression after ... - 0 views

cancerres.aacrjournals.org/...5496.long

cancer cisplatin hypoxia HIF-1alpha metastasis

shared by Nathan Goodyear on 08 Jul 20 - No Cached
  • Nathan Goodyear on 08 Jul 20
     
    Cisplatin increases HIF-1alpha VEGF which increases metastatic potential.
Nathan Goodyear

Insulin-like growth factor receptor-1 (IGF-IR) as a target for prostate cancer therapy - 0 views

www.ncbi.nlm.nih.gov/...PMC4096322

IGF-1 insulin insulin receptors IGF-1 receptors

shared by Nathan Goodyear on 10 Dec 20 - No Cached
  • Nathan Goodyear on 10 Dec 20
     
    Insulin and IGF-1 receptors show 70% homology.
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