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Nathan Goodyear

Enhanced dendritic cell maturation by the B-chain of Korean mistletoe lectin (KML-B), a... - 0 views

pubmed.ncbi.nlm.nih.gov/24859056

dendritic cell Mistletoe dendritic cells

shared by Nathan Goodyear on 14 Sep 23 - No Cached
  • Nathan Goodyear on 14 Sep 23
     
    Mistletoe increases dendritic cell activation.
Nathan Goodyear

Repurposing Drugs in Oncology (ReDO)-chloroquine and hydroxychloroquine as anti-cancer ... - 0 views

www.ncbi.nlm.nih.gov/...PMC5718030

chloroquine hydroxychloroquine cancer repurposed drugs

shared by Nathan Goodyear on 03 May 21 - No Cached
  • HCQ, doses for long-term use range between 200 and 400 mg per day.
  • Short-term administration of CQ or HCQ rarely causes severe side effects
  • Short-term administration of CQ or HCQ rarely causes severe side effects
  • ...24 more annotations...
  • bone marrow suppression
  • cardiomyopathy
  • irreversible retinal toxicity
  • hypoglycaemia
  • daily doses up to 400 mg of HCQ or 250 mg CQ for several years are considered to carry an acceptable risk for CQ-induced retinopathies, with the exception of individuals of short stature
  • chronic CQ or HCQ therapy be monitored through regular ophthalmic examinations (3–6 month intervals), full blood counts and blood glucose level checks
  • long-term HCQ exposure, skeletal muscle function and tendon reflexes should be monitored for weakness
  • both CQ and HCQ, specific caution is advised in patients suffering from impaired hepatic function (especially when associated with cirrhosis), porphyria, renal disease, epilepsy, psoriasis, glucose-6-phosphate dehydrogenase deficiency and known hypersensitivity to 4-aminoquinoline compounds
  • CQ and HCQ can effectively increase the efficacy of various anti-cancer drugs
  • CQ can prevent the entrapment of protonated chemotherapeutic drugs by buffering the extracellular tumour environment and intracellular acidic spaces
  • This study recommends an adjuvant HCQ dose of 600 mg, twice daily.
  • HCQ addition was shown to produce metabolic stress in the tumours
  • HCQ (400 mg/day)
  • important effects of CQ and HCQ on the tumour microenvironment
  • The main and most studied anti-cancer effect of CQ and HCQ is the inhibition of autophagy
  • the expression levels of TLR9 are higher in hepatocellular carcinoma, oesophageal, lung, breast, gastric and prostate cancer cells as compared with adjacent noncancerous cells, and high expression is often linked with poor prognosis
  • TLR9-mediated activation of the NF-κB signalling pathway and the associated enhanced expression of matrix metalloproteinase-2 (MMP-2), MMP-7 and cyclo-oxygenase 2 mRNA
  • HCQ can activate caspase-3 and modulate the Bcl-2/Bax ratio inducing apoptosis in CLL, B-cell CLL and glioblastoma cells
  • In triple-negative breast cancer, CQ was shown to eliminate cancer stem cells through reduction of the expression of Janus-activated kinase 2 and DNA methyl transferase 1 [106] or through induction of mitochondrial dysfunction, subsequently causing oxidative DNA damage and impaired repair of double-stranded DNA breaks
  • CQ or HCQ would be considered for use in combination with immunomodulation anti-cancer therapies
  • Therapies used in combination with CQ or HCQ include chemotherapeutic drugs, tyrosine kinase inhibitors, various monoclonal antibodies, hormone therapies and radiotherapy
  • Most studies hypothesise that CQ and HCQ could increase the efficacy of other anti-cancer drugs by blocking pro-survival autophagy.
  • daily doses between 400 and 1200 mg for HCQ are safe and well tolerated, but two studies identified 600-mg HCQ daily as the MTD
  • HCQ is often administered twice daily to limit plasma fluctuations and toxicity
Nathan Goodyear

Hydroxychloroquine induced lung cancer suppression by enhancing chemo-sensitization and... - 0 views

jeccr.biomedcentral.com/...s13046-018-0938-5

hydroxychloroquine M1 macrophages M2 macrophages TME tumor microenvironment cancer repurposed drugs

shared by Nathan Goodyear on 28 Nov 22 - No Cached
  • Nathan Goodyear on 28 Nov 22
     
    hydroxychloroquine induces chemo-sensitivity and pushes M2 to M1 macrophage polarization. Effects occur within the TME to increase CD8+ activity within the TME.
Nathan Goodyear

Photodynamic therapy: a means to enhanced drug delivery to tumors - PubMed - 0 views

pubmed.ncbi.nlm.nih.gov/14678965

photodynamic therapy PTD cancer chemotherapy

shared by Nathan Goodyear on 02 Nov 22 - No Cached
  • Nathan Goodyear on 02 Nov 22
     
    Increases tumor uptake via effect on vascular permeability.
Nathan Goodyear

Tumor Vasculature Targeted Photodynamic Therapy for Enhanced Delivery of Nanoparticles ... - 0 views

pubs.acs.org/...nn501134q

PTD cancer photodynamic therapy

shared by Nathan Goodyear on 02 Nov 22 - No Cached
  • Nathan Goodyear on 02 Nov 22
     
    Increase tumor permeability, delivery, of nanoparticles.
Nathan Goodyear

Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer ... - 0 views

pubmed.ncbi.nlm.nih.gov/30688660

cancer stem cells breast cancer CSC LDH lactate dehydrogenase stress cancer epinephrine

shared by Nathan Goodyear on 22 Jul 22 - No Cached
  • Nathan Goodyear on 22 Jul 22
     
    Epinephrine increases LDH-A in breast cancer
Nathan Goodyear

Utilization of Pharmacological Ascorbate to Enhance Hydrogen Peroxide-Mediated Radiosen... - 0 views

www.ncbi.nlm.nih.gov/...PMC8509557

radiation fenton reaction High dose IV vitamin C vitamin C ascorbic acid high dose vitamin C H2O2 pharmacologic vitamin C

shared by Nathan Goodyear on 11 Aug 22 - No Cached
  • Nathan Goodyear on 11 Aug 22
     
    Conclusion: the data presented in this review show synergistically increased DNA damage with combination treatment of RT and P-AscH−, associated with H2O2 formation
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