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Nathan Goodyear

Mistletoe and Immunomodulation: Insights and Implications for Anticancer Therapies - 0 views

www.hindawi.com/...5893017

NK cells cancer immune system Th1 immunotherapy mistletoe

shared by Nathan Goodyear on 16 Oct 20 - No Cached
  • Nathan Goodyear on 16 Oct 20
     
    Mistletoe increases CD4:CD8 due to increase in Th1 but decrease in Treg; also increase in NK cells. Very important immunomodulatory effect.
Nathan Goodyear

IL-2: The First Effective Immunotherapy for Human Cancer | The Journal of Immunology - 0 views

www.jimmunol.org/...5451

cancer IL-2 Treg immune system immunology

shared by Nathan Goodyear on 17 Apr 18 - No Cached
  • IL-2 is a 15.5-kDa cytokine secreted predominately by Ag-simulated CD4+ T cells, but it can also be produced by CD8+ cells, NK cells, and activated dendritic cells
  • IL-2 is the predominant factor responsible for the maintenance of CD4+ regulatory T cells
  • A generalized capillary leak syndrome was induced by IL-2 in vivo that resulted in interstitial pulmonary infiltrates and substantial weight gain in patients
  • ...4 more annotations...
  • The side effects were transient and returned to baseline following treatment
  • Tumors do not express IL-2 receptors and thus the antitumor activity was the result of IL-2 stimulation of immune cell
  • Patients with metastatic melanoma or metastatic renal cell cancer were uniquely responsive to high-dose IL-2 administration, and except for patients with advanced non-Hodgkin’s lymphomas (35) only rare responses were seen in patients with other tumor types
  • The underlying toxicity of IL-2 results from a capillary leak that leads to fluid extravasation into visceral organs that can compromise their function
  • Nathan Goodyear on 17 Apr 18
     
    Great review of the history of IL-2 in the treatment of cancer.  IL-2 stimulates the immune system to attack cancer.  Don't reinvent the wheel; use what is already present and available.
Nathan Goodyear

Immunomodulatory effects of Vitamin D in multiple sclerosis - 0 views

brain.oxfordjournals.org/...1146.long

Vitamin D MS multiple Sclerosis multiple sclerosis Th17 T reg T-reg

shared by Nathan Goodyear on 12 Aug 13 - No Cached
  • Nathan Goodyear on 12 Aug 13
     
    Vitamin D has an important immunomodulating role in MS.  Vitamin D increases Treg cells and decreases IL-6, but more importantly IL-17.
Nathan Goodyear

Antitumor immunity of low-dose cyclophosphamide: changes in T cells and cytokines TGF-b... - 0 views

www.ncbi.nlm.nih.gov/...PMC7034239

IL-10 TGF-beta Treg low-dose chemotherapy cancer

shared by Nathan Goodyear on 19 Aug 20 - No Cached
  • Nathan Goodyear on 19 Aug 20
     
    Low dose cytoxan effects both local and systemic immune system.
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