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Many newly diagnosed prostate cancers present as low Gleason score tumors that require no treatment intervention. Distinguishing the many indolent tumors from the minority of lethal ones remains a major clinical challenge. We now show that low Gleason score prostate tumors can be distinguished as indolent and aggressive subgroups on the basis of their expression of genes associated with aging and senescence. Using gene set enrichment analysis, we identified a 19-gene signature enriched in indolent prostate tumors. We then further classified this signature with a decision tree learning model to identify three genes-FGFR1, PMP22, and CDKN1A-that together accurately predicted outcome of low Gleason score tumors. Validation of this three-gene panel on independent cohorts confirmed its independent prognostic value as well as its ability to improve prognosis with currently used clinical nomograms. Furthermore, protein expression of this three-gene panel in biopsy samples distinguished Gleason 6 patients who failed surveillance over a 10-year period. We propose that this signature may be incorporated into prognostic assays for monitoring patients on active surveillance to facilitate appropriate courses of treatment.

In 1967, Simon Kochen and Ernst Specker proved mathematically that even for a single quantum object, where entanglement is not possible, the values that you obtain when you measure its properties depend on the context. So the value of property A, say, depends on whether you chose to measure it with property B, or with property C. In other words, there is no reality independent of the choice of measurement. It wasn't until 2008, however, that Alexander Klyachko of Bilkent University in Ankara, Turkey, and colleagues devised a feasible test for this prediction. They calculated that if you repeatedly measured five different pairs of properties of a quantum particle that was in a superposition of three states, the results would differ for the quantum system compared with a classical system with hidden variables. That's because quantum properties are not fixed, but vary depending on the choice of measurements, which skews the statistics. "This was a very clever idea," says Anton Zeilinger of the Institute for Quantum Optics, Quantum Nanophysics and Quantum Information in Vienna, Austria. "The question was how to realise this in an experiment." Now he, Radek Lapkiewicz and colleagues have realised the idea experimentally. They used photons, each in a superposition in which they simultaneously took three paths. Then they repeated a sequence of five pairs of measurements on various properties of the photons, such as their polarisations, tens of thousands of times. A beautiful experiment They found that the resulting statistics could only be explained if the combination of properties that was tested was affecting the value of the property being measured. "There is no sense in assuming that what we do not measure about a system has [an independent] reality," Zeilinger concludes.

Brain, bodily awareness, and the emergence of a conscious self: these entities and their relations are explored by Germanphilosopher and cognitive scientist Metzinger. Extensively working with neuroscientists he has come to the conclusion that, in fact, there is no such thing as a "self" -- that a "self" is simply the content of a model created by our brain - part of a virtual reality we create for ourselves. But if the self is not "real," he asks, why and how did it evolve? How does the brain construct the self? In a series of fascinating virtual reality experiments, Metzinger and his colleagues have attempted to create so-called "out-of-body experiences" in the lab, in order to explore these questions. As a philosopher, he offers a discussion of many of the latest results in robotics, neuroscience, dream and meditation research, and argues that the brain is much more powerful than we have ever imagined. He shows us, for example, that we now have the first machines that have developed an inner image of their own body -- and actually use this model to create intelligent behavior. In addition, studies exploring the connections between phantom limbs and the brain have shown us that even people born without arms or legs sometimes experience a sensation that they do in fact have limbs that are not there. Experiments like the "rubber-hand illusion" demonstrate how we can experience a fake hand as part of our self and even feel a sensation of touch on the phantom hand form the basis and testing ground for the idea that what we have called the "self" in the past is just the content of a transparent self-model in our brains. Now, as new ways of manipulating the conscious mind-brain appear on the scene, it will soon become possible to alter our subjective reality in an unprecedented manner. The cultural consequences of this, Metzinger claims, may be immense: we will need a new approach to ethics, and we will be forced to think about ourselves in a fundamentally new way. At

AMRIT FESTIVAL OF INDEPENDENCE "A Tribute to Heroes of Indian Freedom Struggle"

Project Meshnet is an organization that aims to build a versatile, decentralized network built on secure protocols for routing traffic over private mesh or public networks independent of a central supporting infrastructure. the free content wiki for project meshnet and supporting projects. 132 articles in English

Project Meshnet is an organization that aims to build a versatile, decentralized network built on secure protocols for routing traffic over private mesh or public networks independent of a central supporting infrastructure. the free content wiki for project meshnet and supporting projects. 132 articles in English

Awadh Bihari was a nationalist and freedom fighter. He was actively involved in revolutionary activities against the British rule. Awadh Bihari took the front in Uttar Pradesh and Punjab against the British rule.

"In this study, we compared the ability of undergraduate students and guppies to discriminate the same numerical ratios, both within and beyond the small number range. In both students and fish the performance was ratio-independent for the numbers 1-4, while it steadily increased with numerical distance when larger numbers were presented."

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(USRA) is an independent, nonprofit research corporation where the combined efforts of in-house talent and university-based expertise merge to advance space science and technology.

"The CoLaborator will be set up in an independent building of 800 square meters at the Bayer research campus in Berlin. There will be about 420 square meters of space for laboratories. Attractively designed laboratory and office modules and shared infrastructure such as a conference room offer ideal conditions for nascent companies - at manageable investment costs. A new home will be established for start-ups in life sciences whose ideas, developments and technology platforms are related to Bayer HealthCare's research interests."

The Santa Fe Institute is a private, not-for-profit, independent research and education center founded in 1984, for multidisciplinary collaborations in the physical, biological, computational, and social sciences. Understanding of complex adaptive systems is critical to addressing key environmental, technological, biological, economic, and political challenges.

"Renegade husband and wife philosophers Pat and Paul Churchland met forty years ago in a college Plato class. Their instincts as philosophers - then and now - run outside the philosophy mainstream. Where most philosophers looked to reason and logic to apprehend the human mind, the Churchlands looked - and look - to science. There is no independent "mind", these two practically say, just the human brain, three pounds of tissue and water, firing away behind all our emotions, beliefs, actions. Consciousness itself, they say, is straight biology, a machine. Once, that sounded esoteric. Now, it's on the frontline of debate over law, soul and life."

A new study in The Lancet rates the harmfulness of 20 psychoactive drugs according to 16 criteria and finds that alcohol comes out on top. Although that conclusion is generating headlines, it is not at all surprising, since alcohol is, by several important measures (including acute toxicity, impairment of driving ability, and the long-term health effects of heavy use), the most dangerous widely used intoxicant, and its abuse is also associated with violence, family breakdown, and social estrangement. A group of British drug experts gathered by the Independent Scientific Committee on Drugs (ISCD) rated alcohol higher than most or all of the other drugs for health damage, mortality, impairment of mental functioning, accidental injury, economic cost, loss of relationships, and negative impact on community. Over all, alcohol rated 72 points on a 100-point scale, compared to 55 for heroin, 54 for crack cocaine, and 33 for methamphetamine. Cannabis got a middling score of 20, while MDMA (Ecstasy), LSD, and psilocybin mushrooms were at the low end, with ratings of 9, 7, and 6, respectively.

The conventional view of human evolution and how early man colonised the world has been thrown into doubt by a series of stunning palaeontological discoveries suggesting that Africa was not the sole cradle of humankind. Scientists have found a handful of ancient human skulls at an archaeological site two hours from the Georgian capital, Tbilisi, that suggest a Eurasian chapter in the long evolutionary story of man.

Recent formulations of sexual selection theory emphasise how mate choice can be affected by environmental factors, such as predation risk and resource quality. Women vary greatly in the extent to which they prefer male masculinity and this variation is hypothesised to reflect differences in how women resolve the trade-off between the costs (e.g., low investment) and benefits (e.g., healthy offspring) associated with choosing a masculine partner. A strong prediction of this trade-off theory is that women's masculinity preferences will be stronger in cultures where poor health is particularly harmful to survival. We investigated the relationship between women's preferences for male facial masculinity and a health index derived from World Health Organization statistics for mortality rates, life expectancies, and the impact of communicable disease. Across 30 countries, masculinity preference increased as health decreased. This relationship was independent of cross-cultural differences in wealth or women's mating strategies. These findings show non-arbitrary cross-cultural differences in facial attractiveness judgments and demonstrate the utility of trade-off theory for investigating cross-cultural variation in women's mate preferences.

Educational researchers at the Technical University of Munich (TUM) have found that schoolchildren can independently develop strategies for solving complex mathematical tasks, with weaker students proving just as capable as their stronger classmates. Researchers in mathematics education worked with approximately 1600 8th grade high-school students in various German states. Following an introduction to the general topic by their teachers, the school children were given a workbook of geometric tasks that they had to solve on paper and using a computer over four school periods. Calculating the surface area of Gran Canaria was one of the real-world, free-form assignments the students had to tackle. The workbook material included explanations and examples of various problem-solving approaches. The teachers took a back seat during the session but were on hand to answer questions from the children, who worked in pairs. After testing the students' skills before and after the session, the researchers recorded a significant improvement in their capabilities. The students learned to apply mathematics more effectively, the researchers said. The students were also able to call on these skills in a further test three months later. "We expected students who were weaker at math to benefit more from a greater degree of guidance through the module," said professor Kristina Reiss.  "But we didn't see a significant difference between these and stronger students." The researchers also found that there were also no differences between boys and girls. "We now know that students - also those who are weaker in math - have the skills to master even very complex subject matters at their own pace," said Reiss. Topics: Cognitive Science/Neuroscience

Geppetto.org is a web-based multi-algorithm, multi-scale simulation platform engineered to support the simulation of complex biological systems and their surrounding environment. A completely modular platform. Engineered together with scientists, Geppetto lets you integrate different simulators and models. Independent modules allow the user to read different standard modeling formats and to simulate different aspects of reality. An open-source revolution. Geppetto is entirely open source and engineers, scientists and developers are welcome to contribute to its development by adding functionality to existing modules or by creating new ones!

"SOCIAL insects are often dismissed as slaves to the collective mind of the hive. But individual members of colonies do have brains and are technically capable of making their own decisions. Indeed, several studies have shown that insects such as ants and bees sometimes ignore shared information in favour of what they individually know. What drives them to act independently has been something of a mystery. New research shows that when a tasty source of food is available the hive mentality is blatantly ignored"

As a high-tech incubator, Xiongjin Biotechnology (Shanghai) Co., Ltd. has an independent enzyme preparation research and development team. It tracks the textile industry all the year round and specializes in the application of enzyme technology in the textile industry.