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Janos Haits

Expression Atlas < EMBL-EBI - 0 views

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    "The Expression Atlas provides information on gene expression patterns under different biological conditions. Gene expression data is re-analysed in-house to detect genes showing interesting baseline and differential expression patterns."
Erich Feldmeier

Tung, Barreiro, Johnson, Gilad Social stress affects immune system gene expression in m... - 0 views

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    "Previous research on rhesus macaques discovered that social rank influenced components of the stress response, brain, and immune system. With gene chip technology for measuring the expression of over 6,000 different genes, Tung, Gilad and colleagues at Yerkes, Emory University, and Johns Hopkins looked for the first time in primates at the effects of social rank on genetic function. Comparing 49 different female monkeys of different rank revealed significant changes in the expression of 987 genes, including 112 genes associated with immune system function. The result fits with data in monkeys where low rank and chronic stress lead to compromised immune function, and, more loosely, with human studies linking low socioeconomic status and high social stress to elevated disease risk."
Janos Haits

Kismet - 0 views

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    The Sociable Machines Project develops an expressive anthropomorphic robot called Kismet that engages people in natural and expressive face-to-face interaction. Inspired by infant social development, psychology, ethology, and evolution, this work integrates theories and concepts from these diverse viewpoints to enable Kismet to enter into natural and intuitive social interaction with a human caregiver and to learn from them, reminiscent of parent-infant exchanges.
Erich Feldmeier

Cory Abate-Shen: A Molecular Signature Predictive of Indolent Prostate Cancer - 0 views

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    Many newly diagnosed prostate cancers present as low Gleason score tumors that require no treatment intervention. Distinguishing the many indolent tumors from the minority of lethal ones remains a major clinical challenge. We now show that low Gleason score prostate tumors can be distinguished as indolent and aggressive subgroups on the basis of their expression of genes associated with aging and senescence. Using gene set enrichment analysis, we identified a 19-gene signature enriched in indolent prostate tumors. We then further classified this signature with a decision tree learning model to identify three genes-FGFR1, PMP22, and CDKN1A-that together accurately predicted outcome of low Gleason score tumors. Validation of this three-gene panel on independent cohorts confirmed its independent prognostic value as well as its ability to improve prognosis with currently used clinical nomograms. Furthermore, protein expression of this three-gene panel in biopsy samples distinguished Gleason 6 patients who failed surveillance over a 10-year period. We propose that this signature may be incorporated into prognostic assays for monitoring patients on active surveillance to facilitate appropriate courses of treatment.
Erich Feldmeier

Alex Kogan, Dacher Keltner: Thin-slicing study of the oxytocin receptor (OXTR) gene and... - 0 views

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    "Individuals who are homozygous for the G allele of the rs53576 SNP of the oxytocin receptor (OXTR) gene tend to be more prosocial than carriers of the A allele. However, little is known about how these differences manifest behaviorally and whether they are readily detectable by outside observers, both critical questions in theoretical accounts of prosociality. In the present study, we used thin-slicing methodology to test the hypotheses that (i) individual differences in rs53576 genotype predict how prosocial observers judge target individuals to be on the basis of brief observations of behavior, and (ii) that variation in targets' nonverbal displays of affiliative cues would account for these judgment differences. In line with predictions, we found that individuals homozygous for the G allele were judged to be more prosocial than carriers of the A allele. These differences were completely accounted for by variations in the expression of affiliative cues. Thus, individual differences in rs53576 are associated with behavioral manifestations of prosociality, which ultimately guide the judgments others make about the individual. "
Janos Haits

The Open Biological and Biomedical Ontologies - 0 views

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    The OBO Foundry is a collaborative experiment involving developers of science-based ontologies who are establishing a set of principles for ontology development with the goal of creating a suite of orthogonal interoperable reference ontologies in the biomedical domain. The groups developing ontologies who have expressed an interest in this goal are listed below, followed by other relevant efforts in this domain.
Janos Haits

ChronoZoom - 0 views

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    ChronoZoom is an intuitive on-line tool used to visualize all of time, from the Big Bang to today, using the concept of zooming along the timeline to express distance to highlight the scope of time. 
Erich Feldmeier

Holger Sondermann: biofilms - 0 views

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    "Bacterial signaling controlling biofilm formation and pathogenicity Opportunistic bacterial pathogens cause a variety of infectious diseases. Their ability to sense and respond to different microenvironments, particularly during the transition from a free-living to an indwelling pathogenic lifestyle, is largely dependent on a variety of adaptational strategies (Hall-Stoodley et al., 2004). Examples include phenotypic variation, biofilm formation, resistance to antibiotic treatments and virulence gene expression, suggested to be interlinked phenotypes largely dependent on bacterial signaling and changes in their transcription profiles "
Erich Feldmeier

Olivia Diem, Prof. Christine Leib-Mösch: Antipsychotika können die Aktivitä... - 0 views

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    "Die Aktivität humaner endogener Retroviren (HERVs) in Gehirnzellen von Patienten mit Schizophrenie oder bipolaren Erkrankungen kann durch die Behandlung mit antipsychotischen Medikamenten verstärkt werden. Wissenschaftler des Helmholtz Zentrums München zeigen in der aktuellen Ausgabe des Fachjournals PLoS ONE, dass Medikamente wie Valproinsäure wahrscheinlich über epigenetische Veränderungen im Genom die HERV Expression beeinflussen."
Janos Haits

Semantic eScience Framework | Tetherless World Constellation - 0 views

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    The goals of this effort is to design and implement a configurable and extensible semantic eScience framework. Configuration will require some research into accommodating different levels of semantic expressivity and user requirements from use cases. Extensibility will be achieved in a modular approach to the semantic encodings (i.e. ontologies) performed in a community setting, i.e. an ontology framework into which specific applications all the way up to communities can extend the semantics for their needs.
Janos Haits

OpenCog - 0 views

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    Here at OpenCog, we're creating an open source Artificial General Intelligence framework, intended to one day express general intelligence at the human level and beyond.
David Corking

Wolfram Blog : Is Mathematica for K-12 Education? You Bet! - 0 views

  • let students explore concepts by manipulating an expression—or a graphical representation of an expression—with things like sliders, buttons, and checkboxes. When you wrap the Manipulate command around an existing calculation, Mathematica automatically creates a sophisticated interface that lets you and your students change values and see what happens in real time. It’s truly empowering! Now students can interact with everything from two-dimensional trajectory paths… to Riemann sums… to the phases of the planets… to almost anything else you can imagine. See the Wolfram Demonstrations Project for thousands of free ready-to-use examples.
  • Mathematica for the Classroom for only $49.
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    sounds like good value proprietary science + math software for schools
Skeptical Debunker

If bonobo Kanzi can point as humans do, what other similarities can rearing reveal? - 0 views

  • The difference between pointing by the Great Ape Trust bonobos - the only ones in the world with receptive competence for spoken English - and other captive apes that make hand gestures is explained by the culture in which they were reared, according to the paper's authors: Janni Pedersen, an Iowa State University Ph.D. candidate conducting research for her dissertation at Great Ape Trust; Pär Segerdahl, a scientist from Sweden who has published several philosophical inquires into language; and William M. Fields, an ethnographer investigating language, culture and tools in non-human primates. Fields also is Great Ape Trust's director of scientific research. Because Kanzi, Panbanisha and Nyota were raised in a culture where pointing has a purpose - The Trust's hallmark Pan/Homo environment, where infant bonobos are reared with both bonobo (Pan paniscus) and human (Homo sapiens) influences - their pointing is as scientifically meaningful as their understanding of spoken English, Fields said. The pointing study supports and builds on previous research on the effect of rearing culture on cognitive capabilities, including the 40-year research corpus of Dr. Duane Rumbaugh, Dr. Sue Savage-Rumbaugh and Fields, which is the foundation of the scientific inquiry at Great Ape Trust. Those studies included the breakthrough finding that Kanzi and other bonobos with receptive competence for spoken English acquired language as human children do - by being exposed to it since infancy. The bonobos adopted finger-pointing behavior for the same reasons, because they were reared in a culture where pointing has meaning.
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    You may have more in common with Kanzi, Panbanisha and Nyota, three language-competent bonobos living at Great Ape Trust, than you thought. And those similarities, right at your fingertip, might one day tell scientists more about the effect of culture on neurological disorders that limit human expression. Among humans, pointing is a universal language, an alternative to spoken words to convey a message. Before they speak, infants point, a gesture scientists agree is closely associated with word learning. But when an ape points, scientists break rank on the question of whether pointing is a uniquely human behavior. Some of the world's leading voices in modern primatology have argued that although apes may gesture in a way that resembles human pointing, the genetic and cognitive differences between apes and humans are so great that the apes' signals have no specific intent. Not so, say Great Ape Trust scientists, who argued in a recently published scientific paper, "Why Apes Point: Pointing Gestures in Spontaneous Conversation of Language-Competent Pan/Homo Bonobos," that not only do Kanzi, Panbanisha and Nyota point with their index fingers in conversation as a human being might, these bonobos do so with specific intent and objectives in mind.
thinkahol *

5 Things That Internet Porn Reveals About Our Brains | Sex & the Brain | DISCOVER Magazine - 1 views

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    With its expansive range and unprecedented potential for anonymity, (the Internet gives voice to our deepest urges and most uninhibited thoughts. Inspired by the wealth of unfettered expression available online, neuroscientists Ogi Ogas and Sai Gaddam, who met as Ph.D. candidates at Boston University, began plumbing a few chosen search engines (including Dogpile and AOL) to create the world's largest experiment in sexuality in 2009. Quietly tapping into a billion Web searches, they explored the private activities of more than 100 million men and women around the world. The result is the first large-scale scientific examination of human sexuality in more than half a century, since biologist Alfred Kinsey famously interviewed more than 18,000 middle-class Caucasians about their sexual behavior and published the Kinsey reports in 1948 and 1953. Building on the work of Kinsey, neuroscientists have long made the case that male and female sexuality exist on different planes. But like Kinsey himself, they have been hampered by the dubious reliability of self-reports of sexual behavior and preferences as well as by small sample sizes. That is where the Internet comes in. By accessing raw data from Web searches and employing the help of Alexa-a company that measures Web traffic and publishes a list of the million most popular sites in the world-Ogas and Gaddam shine a light on hidden desire, a quirky realm of lust, fetish, and kink that, like the far side of the moon, has barely been glimpsed. Here is a sampling of their fascinating results, selected from their book, A Billion Wicked Thoughts.
Janos Haits

BIBFRAME - Bibliographic Framework Initiative (Library of Congress) - 0 views

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    "Initiated by the Library of Congress, BIBFRAME provides a foundation for the future of bibliographic description, both on the web, and in the broader networked world. This site presents general information about the project, including presentations, FAQs, and links to working documents. In addition to being a replacement for MARC, BIBFRAME serves as a general model for expressing and connecting bibliographic data. A major focus of the initiative will be to determine a transition path for the MARC 21 formats while preserving a robust data exchange that has supported resource sharing and cataloging cost savings in recent decades."
Janos Haits

HTTP/2 - 0 views

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    "HTTP/2 is a replacement for how HTTP is expressed "on the wire." It is not a ground-up rewrite of the protocol; HTTP methods, status codes and semantics are the same, and it should be possible to use the same APIs as HTTP/1.x (possibly with some small additions) to represent the protocol."
Janos Haits

BabelNet™ | A very large multilingual encyclopedic dictionary and semantic ne... - 0 views

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    BabelNet is both a multilingual encyclopedic dictionary, with lexicographic and encyclopedic coverage of terms, and a semantic network which connects concepts and named entities in a very large network of semantic relations, made up of more than 9 million entries, called Babel synsets. Each Babel synset represents a given meaning and contains all the synonyms which express that meaning in a range of different languages.
kingwinny

acid protease - 0 views

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    1g solid enzyme powder (or 1mL liquid enzyme), at 40 C, pH 3.0 (disodium hydrogen phosphate - citric acid buffer), hydrolyzes casein and produces 1ug tyrosine within 1 minute, that is, a unit of enzyme activity, expressed as U/g (U/mL).
Ilmar Tehnas

Mars Express radar gives strong evidence for former Mars ocean - 1 views

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    Would be nice to see the actual strata that has been identified. As such, it is a statement with no supporting evidence. Has a paper been written?
Erich Feldmeier

@biogarage @vbioev @aba_biologie Perla Karliman: Gene expression changes with meditation - 0 views

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    ""Most interestingly, the changes were observed in genes that are the current targets of anti-inflammatory and analgesic drugs," says Perla Kaliman"
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