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Lottie Peppers

Outbreak! - National Center for Case Study Teaching in Science (NCCSTS) - 0 views

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    "This case study uses a PowerPoint presentation to guide students through two activities designed to teach them about the basics of coronavirus diagnosis and transmission. The first activity involves a set of five "clicker questions" that students answer using either a personal response system, online polling application, or show of hands as they consider symptoms and test results of a hypothetical patient. The second activity is an outbreak simulation in which students consider the spread of a pathogen in various geographical settings and from different perspectives. Students work together to draft a list of precautions that could be taken to limit the spread of the disease and minimize healthy individuals' risk of contracting it. The simulation is designed for a biology lesson pertaining to outbreaks. Although coronavirus is used as the model, the concepts of disease transmission and prevention covered in this case are relevant to many diseases."
Lottie Peppers

The Red Hot Debate about Transmissible Alzheimer's - Scientific American - 0 views

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    For Collinge, this led to a worrying conclusion: that the plaques might have been transmitted, alongside the prions, in the injections of growth hormone-the first evidence that Alzheimer's could be transmitted from one person to another. If true, that could have far-reaching implications: the possibility that 'seeds' of the amyloid-β protein involved in Alzheimer's could be transferred during other procedures in which fluid or tissues from one person are introduced into another, such as blood transfusions, organ transplants and other common medical procedures.
Lottie Peppers

Can humans get norovirus from their dogs? | EurekAlert! Science News - 0 views

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    Washington, D.C. - April 10, 2015 - Human norovirus may infect our canine companions, according to research published online April 1 in the Journal of Clinical Microbiology, a publication of the American Society for Microbiology. That raises the possibility of dog-to-human transmission, said first author Sarah Caddy, VetMB, PhD, MRCVS, a veterinarian and PhD student at the University of Cambridge, and Imperial College, London, UK. Norovirus is the leading cause of food-borne illness in the United States, according to the Centers for Disease Control and Prevention (CDC).
Lottie Peppers

ViralZone: Human viruses table - 0 views

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    The table below displays the list of human viral pathogens, with transmission and general facts about associated pathologies.
Lottie Peppers

Got Blood? - National Center for Case Study Teaching in Science - 0 views

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    The Aedes aegypti mosquito is the major vector for transmission of numerous viral diseases, including yellow fever, dengue, and now, Zika. Interestingly, different subspecies of A. aegypti are known to exist in close proximity but with considerable genetic divergence between them. One major difference between a "forest" form and a "domestic" form is a strong preference in the latter subspecies for human over non-human blood biting. This difference was explored with genetic and neurophysiological approaches by a research group at Rockefeller University and published in a 2014 paper in Nature. This flipped case study uses parts of the Nature paper to focus on elements of the scientific method as well as evolutionary questions raised by the difference in biting preference between the two subspecies. Students prepare for class by watching a video that provides background information about the published study that forms the basis for the case. In class students then work in groups to develop a hypothesis, predictions and proposed experiments to test the idea of different biting preferences.
Lottie Peppers

The Dilution Effect - National Center for Case Study Teaching in Science - 0 views

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    In this case study students are provided with information for piecing together the story of how forest fragmentation and biodiversity loss can affect the risk of Lyme disease transmission to humans. The case introduces the dilution effect, a widely accepted theory-and one of the most important ideas in disease ecology-which suggests that disease risk for humans decreases as the diversity of species in an area increases. It also explains how landscape fragmentation, one of the most common threats to biodiversity, can influence the risk of Lyme disease for humans. Students interpret and discuss various figures to develop a concept map that connects all the individual results of the story. Students gain an appreciation for the complexity of species interactions in an ecosystem, the effects of forest fragmentation on these interactions and the possible consequences for human health. This activity was developed for an undergraduate introduction to environmental sciences course under the topic of biodiversity and conservation, but would also be suitable for interdisciplinary studies interested in examining the connections between conservation and public health.
Lottie Peppers

CAMEL Question: Can Applied Math Extend Life? - National Center for Case Study Teaching... - 0 views

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    This directed case study examines differences between the exponential and logistic growth models in biology and how they are applied to solve real life problems. The narrative follows a student returning to the United States as he tries to assess his possible exposure to Middle East Respiratory Syndrome (MERS). To better understand his risk, James needs to get up to speed on a variety of topics including the difference between infection, transmission, virulence, etc., and how these topics can be mathematically modeled not only in relation to MERS, but also with respect to Ebola and influenza. This case was designed for use in the second semester of a biocalculus course or a course involving ordinary differential equations, which are appropriate for second year undergraduate students majoring in biology, pre-med, and bio-mathematics. These students typically have completed a semester of calculus and one year of general biology. The case provides an opportunity for students to develop their understanding of differential equations and increase their appreciation of mathematics as it applies to solving a problem of biology.
Lottie Peppers

When Work Makes You Sick - National Center for Case Study Teaching in Science - 0 views

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    This case study was inspired by a real-life scenario, and follows the story of Roberto, a migrant farmworker whose health is impacted by the usage of pesticides on a farm.  With the help of a health care provider, Roberto becomes aware of the effects of pesticides on his well-being. Students utilize a database and draw conclusions from data in order to answer the case questions.  The case concludes with an activity that uses the "intimate debate" technique in which students use scientific data as evidence to argue whether or not the pesticide under discussion should be banned from usage.  This case was originally developed for undergraduate anatomy and physiology or toxicology courses. Students are expected to have some background knowledge in nerve structure and function as well as the mechanics of neural transmission before starting the case.
Lottie Peppers

The Habitable Planet - Interactive Labs - 0 views

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    Simulators which display cummulative generation graphs for variables.  Very cool data rich resource!  Includes Carbon cycle, demographis (human populations), Disease transmission, ecology, and energy simulations.
Lottie Peppers

The Habitable Planet - Disease Lab - Overview - 2 views

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    This lab will let you explore various diseases: Kold, a caricature of the common cold; Impfluenza, which resembles influenza; Neasles, with the high transmission rate of measles; and Red Death, a fast-spreading epidemic with a high mortality rate. What factors come into play in the spread of these diseases? And what can we do to counter them?
Lottie Peppers

Pit Bull Spreads Plague to Four People - NBC News - 0 views

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    An outbreak of plague that affected four people and a dog in Colorado might be the first instance of person-to-person transmission of plague in the United States in 90 years, officials said Thursday. It started with a sick pit bull, and its owner, two vet techs and a close personal contact of the dog's owner all ended up infected. The dog died but all four people were treated with antibiotics and are okay.
Lottie Peppers

Exponential Outbreaks: The Mathematics of Epidemics - NYTimes.com - 0 views

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    In this lesson, students explore the fundamental mathematical concepts underlying the spread of contagious diseases. Using a simple exponential model, students compare and contrast the effects of different transmission rates on a population and develop an understanding of the nature and characteristics of exponential growth. Students can then compare their projections with actual Ebola data from West Africa, to create context for analyzing the strengths and limitations of this simplified model.
Lottie Peppers

Virus in bats homologous to retroviruses in rodents and primates - 0 views

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    Scientists discovered a new retrovirus "fossil" found in the common vampire bat which is homologous to retroviruses in rodents and primates. The results suggest the recent circulation of an active infectious retrovirus and cross-species transmission. The study has been published in the scientific journal Journal of Virology.
Lottie Peppers

New compound protects 100 percent of ferrets, mice, from H5N1 - 0 views

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    Since 2003, the H5N1 influenza virus, more commonly known as the bird flu, has been responsible for the deaths of millions of chickens and ducks and has infected more than 650 people, leading to a 60 percent mortality rate for the latter. Luckily, this virus has yet to achieve human-to-human transmission, but a small number of mutations could change that, resulting in a pandemic. Now a team of investigators from St. Jude Children's Research Hospital, Stanford University Medical Center, and MacroGenics have developed an antibody which has proven 100 percent protective against the virus in two species of animal models.
Lottie Peppers

WHO | Vector control and insecticide resistance - 0 views

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    Vector control is a fundamental element of the existing global strategy to fight malaria. Vector control interventions have a proven track record of successfully reducing or interrupting disease transmission, particularly in areas that are highly prone to malaria. Indoor residual spraying (IRS) and long-lasting insecticidal nets (LLINs) are the two core, broadly applicable malaria vector control measures. This section covers both core and supplementary vector control methods and discusses the action that is required to prevent and manage the increasing challenge of malaria vector resistance to insecticides.
Lottie Peppers

More Evidence Emerges for "Transmissible Alzheimer's" Theory - Scientific American - 0 views

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    For the second time in four months, researchers have reported autopsy results that suggest Alzheimer's disease might occasionally be transmitted to people during certain medical treatments-although scientists say that neither set of findings is conclusive. The latest autopsies, described in the Swiss Medical Weekly on January 26, were conducted on the brains of seven people who died of the rare, brain-wasting Creutzfeldt-Jakob disease (CJD). Decades before their deaths, the individuals had all received surgical grafts of dura mater-the membrane that covers the brain and spinal cord. These grafts had been prepared from human cadavers and were contaminated with the prion protein that causes CJD.
Lottie Peppers

How Gut Microbiota Impacts HIV Disease - Scientific American - 0 views

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    HIV is a disease of the gut, a concept that's easy to lose sight of with all the attention paid to sexual transmission and blood measurements of the virus and the CD4+ T cells it infects and kills. But the bottom line is that about two thirds of all T cells reside in the lymphoid tissue of the gut, where the virus spreads after exposure, even before it shows up in blood.
Lottie Peppers

Genetics of bipolar disorder - 0 views

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    Bipolar disorder is a common, complex genetic disorder, but the mode of transmission remains to be discovered. Many researchers assume that common genomic variants carry some risk for manifesting the disease. The research community has celebrated the first genome-wide significant associations between common single nucleotide polymorphisms (SNPs) and bipolar disorder. Currently, attempts are under way to translate these findings into clinical practice, genetic counseling, and predictive testing. However, some experts remain cautious. After all, common variants explain only a very small percentage of the genetic risk, and functional consequences of the discovered SNPs are inconclusive. Furthermore, the associated SNPs are not disease specific, and the majority of individuals with a "risk" allele are healthy. On the other hand, population-based genome-wide studies in psychiatric disorders have rediscovered rare structural variants and mutations in genes, which were previously known to cause genetic syndromes and monogenic Mendelian disorders.
Lottie Peppers

The Path of a Pathogen - National Center for Case Study Teaching in Science - 0 views

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    Scientists and healthcare professionals initially exhibited little concern over the Zika virus even after evidence of human infection was first identified in 1952; Zika appeared to be both rare and unassociated with morbidity or mortality. Around 2015 all of this changed as journalists, scientists, public health officials, and laypeople scrambled to learn about its varied modes of transmission and devastating consequences (e.g., birth defects and autoimmune disorders). Although research continues to rapidly evolve, this case study directs students to reliable scientific sources (e.g., Centers for Disease Control and World Health Organization) that will likely continue to provide the most current information in order to explore questions such as: Where did the virus come from? How does it spread? What can we do to prevent it? Students will also consider the public health challenges and possible solutions associated with emerging infectious diseases. The case was originally written for an upper-level biology or public health course in which students already have some basic background knowledge regarding viruses, vaccines, and infectious disease.
Lottie Peppers

How do germs spread (and why do they make us sick)? - Yannay Khaikin and Nicole Mideo -... - 0 views

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    5:06 video, Germs are found on almost every surface we come in contact with, which makes it incredibly common for our bodies to be exposed to them. But why are some of these germs relatively harmless, while others can be fatal?
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