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4:30 video View full lesson: http://ed.ted.com/lessons/why-it-s-so...↵↵In 2008, something incredible happened: a man was cured of HIV. In over 70 million HIV cases, this was a first, and, so far, a last, and we don't yet understand exactly how he was cured. But if we can cure people of various diseases, like malaria and hepatitis C, why can't we cure HIV? Janet Iwasa examines the specific traits of the HIV virus that make it so difficult to cure.↵↵Lesson by Janet Iwasa, animation by Javier Saldeña.

Five people living with HIV are currently free of the detectable virus after taking part in a new vaccine-based therapy.  The patients are also not taking daily antiretroviral drugs, with one having been drug free for a total of seven months; a milestone moment in a move towards a future where HIV treatment doesn't require ART.

In a first, scientists led by Kamel Khalili, director of the Comprehensive NeuroAIDS Center at Temple University, report in the journal Gene Therapy that they have for the first time successfully eliminated HIV genes from the genomes of mice and rats infected with the virus.

HIV jumped from apes to humans at least four times, as evidenced by genetically distinct groups of the virus that have been detected: M, N, O, and P. While N and P have had little impact, M is responsible for the pandemic affecting millions of individuals, and O has infected another 100,000.

Scientists said Wednesday a new drug tested on monkeys provided an astonishingly effective shield against an animal version of the AIDS virus, a major gain in the quest for an HIV vaccine. Macaque monkeys given the drug were able to fend off high, repeated doses of the simian version of the human immunodeficiency virus (HIV), they reported in the journal Nature.

HIV is a disease of the gut, a concept that's easy to lose sight of with all the attention paid to sexual transmission and blood measurements of the virus and the CD4+ T cells it infects and kills. But the bottom line is that about two thirds of all T cells reside in the lymphoid tissue of the gut, where the virus spreads after exposure, even before it shows up in blood.

This interrupted case study for the flipped classroom applies evolutionary genetics research to human health. Students learn about a naturally occurring, but rare, allele of the CCR5 gene, CCR5-Δ32, which provides resistance to HIV. They use data from primary literature sources to predict and interpret worldwide patterns of CCR5-Δ32 frequency distribution. They then discuss how these allele frequency patterns may have been driven by selection imposed by various diseases or by other evolutionary mechanisms. Next, they test published data using Hardy-Weinberg equilibrium to examine if CCR5-Δ32 also provides genetic resistance to West Nile virus. Finally, they complete a jigsaw discussion of Nature News articles that report on how CCR5 research is being used to develop therapies to treat HIV. Originally written for the evolution portion of a yearlong biology series for undergraduate majors, the case is also appropriate for some non-majors biology courses or, with added complexity, upper-level evolution, genetics, or cell biology courses.

Hans Rosling unveils data visuals that untangle the complex risk factors of one of the world's deadliest (and most misunderstood) diseases: HIV. By following the data, he suggests a surprising key to ending the epidemic.

Science denial has real, societal consequences. Denial of the link between HIV and AIDS led to more than 330,000 premature deaths in South Africa. Denial of the link between smoking and cancer has caused millions of premature deaths. Thanks to vaccination denial, preventable diseases are making a comeback.

Emerging diseases and potential pandemics make the news nearly every year. Students (and everyone else) may wonder where new infectious diseases come from, how scientists assess the risk of a pandemic, and how we might go about preventing one. This case study uses a PowerPoint presentation to explore these questions by focusing on HIV, a pandemic that began as an emerging disease. The storyline progresses backwards through time as scientists attempt to unravel the origins of a new, mysterious plague. Much of the case relies on audio excerpts from an episode produced by Radiolab, an acclaimed radio show that explores a variety of topics in science and culture (www. radiolab.org). Students use graphics, animations, and sound clips presented in the PowerPoint slides to discuss several sets of questions. The case is suitable for a wide range of high school and college introductory biology courses, as well as undergraduate microbiology, ethics, and public health courses.

If thinking about the billions of bacteria taking up residence in and on your body gives you the willies, you probably won't find it comforting that humans are also full of viruses. These maligned microbes are actually intertwined in the very fibers of our being-about 8 percent of our genetic material is made up of absorbed forms of retroviruses, the viral family to which HIV, the pathogen that causes AIDS, belongs.

Viruses have a huge impact on our lives, and we're making great strides into understanding how to protect ourselves from the flu and HIV. But one thing that scientists have struggled to agree on is whether or not viruses are alive.

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Online textbook with accompanying case studies, lesson plans, and interactives.

comprehensive data repository and analysis tools with many data sources to graph and investigate

Highlighting role of animal research in human health.  A visually appealing website with an array of research summaries.

Evolutionary biologists have developed many techniques to analyze how male and female mating preferences have co-evolved. These studies combine animal behavior, sensory biology, phylogenetics, and neurobiology to observe the effects of male trait biases based on female receiver systems; that is, the "attractiveness" of the male trait to potential female mating partners.

DNA to Darwin allows 16-19 year-old school students to explore the molecular evidence for evolution through practical bioinformatics activities that use data analysis tools and molecular data. Each of the activities on this web site centres around an engaging story from recent research in molecular genetics encompassing microbiology, plant and animal biology and human evolution.

Lessons on the immune systems and disease. Print and go!