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NIH Genetic Variation Activity- Are you susceptible? Dice rolling game to model cardiovascular risk. -pdf for handouts

New ways of visualizing scientific and medical data and concepts can enhance discovery and learning. The NIH 3D Print Exchange provides access to a community-contributed database of bioscientific 3D-printable files. Download a model and print it with your own 3D printer or through a 3D print service provider.

269 page  Curriculum Supplement from NIH 5 lessons  Ideas about the role of evolution in medicine Investigating lactose intolerance and evolution evolutionary processes and patterns inform medicine Using evolution to understand influenza Evaluating evolutionary explanations

NIH publication

NIH web portion of lessons on cell and molecular biology

Web activities supporting NIH Supplement on Evolution and Medicine

Adrenoleukodystrophy fact sheet, NIH Neurological disorders and stroke 

NIH module on Sickle cell anemia.  A bit dated but provides a nice visual on sickling

dice rolling game lesson plan for multifactorial disease cardiovascular risk

Cell Biology and Cancer-developed with the National Cancer Institute (NCI)-is a creative, inquiry-based instruction program, designed to promote active learning and stimulate student interest in medical topics. This curriculum supplement will: Deepen students' awareness of the importance of basic research to advances in medicine and health Foster students' abilities to think critically Help students understand the effects of scientific discoveries on their own lives Encourage students to take more responsibility for their own health

Introduction to the major concepts related to emerging and re-emerging infectious diseases, and impact on society.

WASHINGTON - The National Institutes of Health is sending its last remaining research chimpanzees into retirement - as soon as a federal sanctuary has room for them. The government already had declared that the use of humans' closest relative as a test subject was coming to an end. In 2013, the NIH said it would retire most of the several hundred government-owned chimps still living at research laboratories. But it set aside 50 animals to be on standby just in case they still were needed for a public-health emergency or some other extreme situation. Wednesday, the agency said those chimps' lab days are over, too.

Panobinostat is a new type of drug that works by blocking an enzyme responsible for modifying DNA at the epigenetic level. Epigenetics refers to chemical marks on DNA itself or on the protein "spools" called histones that package DNA. These marks influence the activity of genes without changing the underlying sequence, essentially acting as volume knobs for genes. Earlier genomic studies showed that about 80 percent of DIPG tumors carry a mutation that alters a histone protein, resulting in changes to the way DNA is packaged and tagged with those chemical marks. This faulty epigenetic regulation results in activation of growth-promoting genes that should have been turned off, and shutdown of others that should have acted as brakes to cell multiplication. Cancer is the result. Panobinostat appears to work by restoring proper functioning of the cells' chemical tagging system.

This 5 lesson unit, which was designed by teachers in conjunction with scientists, ethicists, and curriculum developers, explores the scientific and ethical issues involved in stem cell research. The unit begins with an exploration of planaria as a model organism for stem cell research. Next, students identify stages in the development of human embryos and compare the types and potency of stem cells. Students learn about a variety of techniques used for obtaining stem cells and the scientific and ethical implications of those techniques. While exploring the ethics of stem cell research, students will develop an awareness of the many shades of gray that exist among positions of stakeholders in the debate. Students will be provided an opportunity to become familiar with policies and regulations for stem cell research that are currently in place in the United States, the issues regarding private and public funding, and the implications for treatment of disease and advancement of scientific knowledge. The unit culminates with students developing a position on embryonic stem cell research through the use of a Decision-Making Framework. Two culminating assessments are offered: In the individual assessment, students write a letter to the President or the President's Bioethics Committee describing their position and recommendations; In the group assessment, students develop a proposal for NIH funding to research treatment for a chosen disease using either embryonic or 'adult' stem cells.

Middle school resources for environmental health

FEBRUARY 20, 2015-A diverse group of experts from academia, industry and advocacy convened by a Georgetown researcher is offering recommendations to the National Institutes of Health (NIH) regarding how to address the overreliance of male cells and animals used in preclinical studies. The recommendations come as the federal research institution works to increase the inclusion of female animal models and achieve a balance in the use of male and female cells and animals in lab research.

More than 400 scientists, bioethicists, and historians from 20 countries on 6 continents have gathered this week in Washington, DC, for the Human Gene Editing Summit. The attendees are a veritable who's who of genome editing: Jennifer Doudna of the University of California, Berkeley, Emmanuelle Charpentier of Max Planck Institute for Infection Biology, and Feng Zhang of the Broad Institute of MIT and Harvard-the three discoverers of the CRISPR-Cas9 system's utility in gene editing-plus dozens of other big names in genome science. Cal Tech's David Baltimore along with the heads of the four national societies hosting the meeting (US National Academy of Sciences, US National Academy of Medicine, Chinese Academy of Sciences, and the U.K.'s Royal Society) provided opening remarks on Tuesday (December 1). And as I sat stage right in the NAS auditorium, I noticed the unmistakable rear profile of Harvard Medical School's George Church three rows in front of me. Church was scheduled to speak at a session later that afternoon about the application of CRISPR and other new precision gene editing techniques to the human germline-a hot-button topic since April, when a Chinese group published it had successfully modified the genomes of human embryos, and the National Institutes of Health (NIH) said it would not fund such research. Then in September, the U.S./U.K.-based Hinxton Group, an international consortium of scientists, policy experts, and bioethicists, said it supported the use of genetic editing in human embryos for limited applications in research and medicine.  

On September 15, the Washington University School of Medicine published a study in The American Journal of Psychiatry revealing that schizophrenia, commonly thought of as a single mental disorder, is actually a group of eight distinct afflictions. People with schizophrenia are typically diagnosed in their 20s, which is when symptoms (such as delusions and hallucinations) begin to manifest. The brain disorder affects about 1 percent of the population, and it is highly genetic: According to the NIH, having a relative diagnosed with schizophrenia increases one's chances of developing the disorder by 10 percent, while having an identical twin with the disorder raises the risk to 40 to 65 percent.

Links to reliable genetics resources for teachers and students.

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