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Introduction to the major concepts related to emerging and re-emerging infectious diseases, and impact on society.

The world is becoming more urban every day, and the process has been ongoing since the industrial revolution in the 18th century. The United Nations now estimates that 3.9 billion people live in urban centres. The rapid influx of residents is however not universal and the developed countries are already urban, but the big rise in urban population in the next 30 years is expected to be in Asia and Africa. Urbanization leads to many challenges for global health and the epidemiology of infectious diseases. New megacities can be incubators for new epidemics, and zoonotic diseases can spread in a more rapid manner and become worldwide threats. Adequate city planning and surveillance can be powerful tools to improve the global health and decrease the burden of communicable diseases.

Emerging diseases and potential pandemics make the news nearly every year. Students (and everyone else) may wonder where new infectious diseases come from, how scientists assess the risk of a pandemic, and how we might go about preventing one. This case study uses a PowerPoint presentation to explore these questions by focusing on HIV, a pandemic that began as an emerging disease. The storyline progresses backwards through time as scientists attempt to unravel the origins of a new, mysterious plague. Much of the case relies on audio excerpts from an episode produced by Radiolab, an acclaimed radio show that explores a variety of topics in science and culture (www. radiolab.org). Students use graphics, animations, and sound clips presented in the PowerPoint slides to discuss several sets of questions. The case is suitable for a wide range of high school and college introductory biology courses, as well as undergraduate microbiology, ethics, and public health courses.

For the second time in four months, researchers have reported autopsy results that suggest Alzheimer's disease might occasionally be transmitted to people during certain medical treatments-although scientists say that neither set of findings is conclusive. The latest autopsies, described in the Swiss Medical Weekly on January 26, were conducted on the brains of seven people who died of the rare, brain-wasting Creutzfeldt-Jakob disease (CJD). Decades before their deaths, the individuals had all received surgical grafts of dura mater-the membrane that covers the brain and spinal cord. These grafts had been prepared from human cadavers and were contaminated with the prion protein that causes CJD.

Scientists and healthcare professionals initially exhibited little concern over the Zika virus even after evidence of human infection was first identified in 1952; Zika appeared to be both rare and unassociated with morbidity or mortality. Around 2015 all of this changed as journalists, scientists, public health officials, and laypeople scrambled to learn about its varied modes of transmission and devastating consequences (e.g., birth defects and autoimmune disorders). Although research continues to rapidly evolve, this case study directs students to reliable scientific sources (e.g., Centers for Disease Control and World Health Organization) that will likely continue to provide the most current information in order to explore questions such as: Where did the virus come from? How does it spread? What can we do to prevent it? Students will also consider the public health challenges and possible solutions associated with emerging infectious diseases. The case was originally written for an upper-level biology or public health course in which students already have some basic background knowledge regarding viruses, vaccines, and infectious disease.

A deadly disease known as African sleeping sickness has puzzled doctors for decades. It would disappear from villages without a trace, only to re-emerge weeks or months later with no known cause. Frustrated health officials wondered how sleeping sickness could persist when not a single villager or animal-the disease's only carriers-tested positive for the insect-borne parasite that causes it. Now, scientists may have an answer at last: They've discovered the disease was hiding in plain sight this whole time, living in and even transmitting via human skin.

This activity guides the analysis of a published scientific figure from a study that modeled the impact of an infectious fungal disease on a bat population. In 2006, a disease called white-nose syndrome (WNS) began wiping out bat populations in North America. Because many of these bats eat insect pests, the spread of WNS may devastate ecosystems and increase pest control costs. In this study, scientists mathematically modeled the effects of WNS to estimate extinction probabilities for the little brown bat (Myotis lucifugus) population in the northeastern United States. This figure shows these probabilities projected for five annual rates of population decline. Each projection is simulated up to 100 years after WNS emerged in the population. The "Educator Materials" document includes a captioned figure, background information, graph interpretation, and discussion questions. The "Student Handout" includes a captioned figure and background information.

Now eight years old, USAID PREDICT is a collaborative effort to monitor, predict and prevent emerging diseases, many of them zoonotic, from becoming devastating global pandemics the likes of Ebola. It's led by Jonna Mazet, an epidemiologist at the University of California at Davis's One Health Institute and School of Veterinary Medicine, and also partners with the Wildlife Conservation Society, Metabiota, EcoHealth Alliance and the Smithsonian Institution's Global Health Program.

Activity A Better Fire!! Activity Advanced Fire Activity Directable Fire!! Activity Fire!! Activity Life Activity Life Lite Activity Spread of Disease Discussion about Agent Modeling Discussion about Chaos Discussion about Chaos is Everywhere Worksheet Emerging Patterns Worksheet Worksheet Emerging Patterns Worksheet (doc) Worksheet Rabbits and Wolves Exploration Questions Worksheet Rabbits and Wolves Exploration Questions (doc)  

A nationwide outbreak of a respiratory virus last fall sent droves of children to emergency departments. The infections have now subsided, as researchers knew they would, but they have left behind a frightening mystery. Since August, 103 children in 34 states have had an unexplained, poliolike paralysis of an arm or leg. Each week, roughly three new cases of so-called acute flaccid myelitis are still reported to the Centers for Disease Control and Prevention.

Student friendly online "your world" magazines, on a variety of topics.